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  • mRNA
  • This response involves transcriptional processes (loss of Kip1 mRNA) as well as accelerated degradation of existing protein (increase in pThr187-phosphorylation mediating polyubiquitinylation and proteasomal degradation of Kip1). (frontiersin.org)
  • histone
  • Indeed, a previous study demonstrated that butyric acid produced by anaerobic Gram-negative bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum induces KSHV lytic gene expression and replication by inhibiting class-1/2 histone deacetylases (HDACs) ( 7 ), supporting a link between periodontal disease and KSHV replication in the oral cavity. (asm.org)
  • Acetylation of histone H3 at lysine 9 is linked to corresponds to transcriptional activation and occurs in response to mitogenic and hormonal stimulation in mammalian cells. (activemotif.com.cn)
  • KSHV
  • These new findings provide mechanistic support that SCFAs from periodontal pathogens stimulate KSHV replication and infection in the oral cavity and are potential risk factors for development of oral Kaposi's sarcoma (KS). (asm.org)
  • These new findings provide mechanistic support that periodontal pathogens create a unique microenvironment in the oral cavity that contributes to KSHV replication and development of oral KS. (asm.org)
  • Accumulating evidence supports the notion that periodontal disease creates an oral microenvironment that stimulates KSHV replication and infection, contributing to oral KS development. (asm.org)
  • pombe
  • In the fission yeast Schizosaccharomyces pombe , the transcriptional-regulatory network that governs flocculation remains poorly understood. (prolekare.cz)
  • Stem Cells
  • Megakaryopoiesis and subsequent thrombopoiesis occur through complex biologic steps: megakaryocyte precursors that developed from hematopoietic stem cells initially proliferate, then differentiate into mature polyploid megakaryocytes, and finally release platelets. (springer.com)
  • Furthermore
  • Furthermore, both USP7 and PCNA are recruited to sites of DNA replication independently of the presence of DNMT1, and there is no evidence that DNMT1 is degraded in cycling cells after S phase. (biomedcentral.com)
  • mitosis
  • Syncytial embryos lacking NOPO exhibit a shorter interphase during cycle 11, suggesting that they may enter mitosis prior to the completion of DNA replication. (biologists.org)
  • mitotic
  • CHK2-mediated mitotic arrest has been previously shown to occur in response to mitotic entry with DNA damage or incompletely replicated DNA. (biologists.org)
  • embryo
  • Zygotic genome activation ( ZGA ) is thought to occur gradually, with the initial steps of zygote and embryo development being primarily maternally controlled, and subsequent steps being governed by the zygotic genome. (plantcell.org)
  • novel
  • Aside from inheriting half of the genome of each of our parents, we are born with a small number of novel mutations that occurred during gametogenesis and postzygotically. (biomedcentral.com)
  • In fact, the occurrence of novel mutations in each generation explains why these reproductively lethal disorders continue to occur in our population. (biomedcentral.com)
  • multiple
  • i.e. , the repressed transcriptional state is generally present through multiple generations of a growing clonal population, but it is occasionally reversed in a stochastic manner. (genetics.org)
  • degradation
  • We propose that, in cycling cells, Dup destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup levels to prevent pre-RC reformation when Dup degradation fails. (biologists.org)
  • state
  • The fact that under normal circumstances the preexisting transcriptional state is most often inherited despite this competition indicates the existence of some mechanism to favor the status quo through the successive cell cycles. (genetics.org)
  • cell division
  • During the maturation step, megakaryocytes undergo polyploidization characterized by repeated rounds of DNA replication without concomitant cell division. (springer.com)