Occur induced induce blastema cells. Medical search. Frequent questions

In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
Epimorphic regeneration can be thought of as occurring in two phases: wound healing and cell proliferation. (biomedcentral.com)
Both oncogenes and tumor-suppressors are expressed during regeneration, and it has been hypothesized that an efficient control of cell proliferation avoids that the blastema is turned into a tumor outgrowth. (bvsalud.org)

In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
Neural control of growth and size in the axolotl limb regenerate [2] "Upon the completion of the developmental stages of regeneration, when the regenerative organ known as the blastema completes patterning and differentiation, the limb regenerate is proportionally small in size. (edu.au)

Epimorphic regeneration is the process by which complete regeneration of a complex structure such as a limb occurs through production of a proliferating blastema. (biomedcentral.com)
This type of regeneration is rare among vertebrates but does occur in the African clawed frog Xenopus laevis , traditionally a model organism for the study of early development. (biomedcentral.com)
Furthermore, the underlying mesenchyme remains rounded and does not expand to form a cone shaped blastema, a normal feature of successful regeneration. (biomedcentral.com)
We have developed a heat shock inducible transgenic line ( N1 ) of Xenopus in which the BMP antagonist Noggin can be induced at a specific time during either development or regeneration, repressing BMP signalling [ 10 , 12 ]. (biomedcentral.com)
We have used this line to show that BMP function is not only required for appendage regeneration but that it is specifically needed to generate a proliferating blastema while being dispensable for wound healing [ 12 ]. (biomedcentral.com)
BACKGROUND: accumulating evidence indicates that during tail regeneration in lizards the initial stage of regenerative blastema is a tumor-like proliferative outgrowth that rapidly elongates into a new tail composed of fully differentiated tissues. (bvsalud.org)
Histological studies focusing on the early cephalic tentacle regeneration in P. canaliculata, have demonstrated that wound closure and blastema formation took place within 24 h post amputation (hpa). (unimore.it)
The complete integumentary organ system (IOS) regeneration and scarless wound healing mechanism, which occurs in specific species, body sites and developmental stages, clearly shows that mechanical stress signals and immune responses play important roles in determining the wound healing mode. (mdpi.com)

Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)
therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. (biomedcentral.com)
Consequently, because of the increased rate of RF in terminal stage and few alternative treatments, new investigations focused on regenerative medicine have been developed, including the use of stem cells (SCs) [ 7 ]. (biomedcentral.com)

N1 transgenic hindlimbs, which do not regenerate, do not form an apical epithelial cap or cone shaped blastema following amputation. (biomedcentral.com)
After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail Pomacea canaliculata. (unimore.it)

METHODS: in order to determine whether functional tumor-suppressors are present in the growing blastema we have utilized protein extracts collected from early regenerating tails of 3-5 mm that have been tested for a potential anti-tumor effect on in-vitro culture by using cancer cell lines from human mammary gland (MDA-MB-231) and prostate cancer (DU145). (bvsalud.org)

Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)
Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)

Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

In the present study, we studied the influence of L-ENK on seasonal and FSH-induced ovarian recrudescence during the breeding and non-breeding phases of the cycle in the tropical and subtropical gecko Hemidactylus frenatus. (bvsalud.org)

The processes of blood plasma filtration, tubular reabsorption and tubular secretion occur in the kidneys, and urine formation is a result of these processes. (wikipedia.org)
Congenital absence of one or both kidneys, known as unilateral or bilateral renal agenesis , can occur. (wikidoc.org)

The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)

According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)

The idiosyncratic relationship between diagnostic delay and stage of oral squamous cell carcinoma. (tractorgallery.net)

Many conditions do not appear to be induced entirely by environmental factors and so genetic profiles have been studied to determine why some individuals are more susceptible to particular diseases. (biomedcentral.com)

Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)

Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)

These genes, acquired at conception or mutated during life, make the affected person prone to most cancers by altering or impairing several processes: & Production of nuclear transcription factors that control cell growth. (ehd.org)

After the injection of clodronate liposomes, a specific computer-assisted image analysis protocol still evidenced the presence of granular hemocytes in the tentacle blastema. (unimore.it)

Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)

In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

When a sufficiently extensive chronic renal injury occurs, whatever the cause, kidney function progressively declines until reaching terminal renal failure with no treatment capable of reversing the process [ 5 ]. (biomedcentral.com)

ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

This effect correlates with a severe impairment of Bmp signalling in osteoblasts, likely by suppressing the expression of the ligand bmp2a in the surrounding mesenchymal cells. (tu-dresden.de)
Lim-1 is required for the aggregation of the mesenchymal cells of the intermediate mesoderm into the primary nephric ducts. (clinicalgate.com)
This marks the transformation of the induced mesenchymal cells into an epithelium-the specialized podocytes , which ultimately surround the vascular endothelium of the glomerulus. (clinicalgate.com)

From our results, we conclude that propolis is a potent antioxidant and, when given in combination with paclitaxel, offers maximum protection against DMBA induced mammary carcinogenesis. (propoleo.cl)
Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)

At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
Gradient scaling and amplitude power‑laws are signatures of growth control by time derivatives of morphogenetic signalling: cell division correlates with the fold change over time of the cellular signalling levels. (tu-dresden.de)
The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. (mdpi.com)
Its cellular organization is rather simple, with two cell layers, the ectoderm and the endoderm separated by an extracellular collagenoeous matrix, the mesogolea. (unige.ch)

This is the first report of propolis-induced acute renal failure. (propoleo.cl)
This case indicates that propolis can induce acute renal failure and emphasizes the need for vigilance and care when propolis is used as a medicine or dietary supplement. (propoleo.cl)

The processes of blood plasma filtration, tubular reabsorption and tubular secretion occur in the kidneys, and urine formation is a result of these processes. (wikipedia.org)
Hydra differentiates all cell types required for neuro-muscular transmission, digestion, secretion and sexual reproduction. (unige.ch)

In vivo delivery of TK-NTR and administration of prodrugs led to the effective killing of both targeted cells and surrounding tumor cells via TK-NTR-mediated conversion of co-delivered prodrugs into active cytotoxic agents. (regenerativemedicine.net)
In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)
These results suggest that MC delivery via microvesicles can mediate gene transfer to an extent that enables effective prodrug conversion and tumor cell death such that it comprises a promising approach to cancer therapy. (regenerativemedicine.net)

RESULTS: SPT, which diverts dietary fatty acids and amino acids into the biosynthetic pathway that produces ceramides and other sphingolipids, is a critical modulator of intestinal stem cell homeostasis. (bvsalud.org)

Phosphorylation of β-catenin on a conserved sequence within the N-terminus (referred to as a phosphodegron sequence) induces βTrcp-dependent ubiquitylation and proteasomal degradation. (wormbook.org)
We previously demonstrated that microvesicles can functionally deliver plasmid DNA to cells and showed that plasmid size and sequence, in part, determine the delivery efficiency. (regenerativemedicine.net)

These different cell types differentiate from three distinct stem cell populations: myoepithelial cells located in the ectoderm, myoepithelial cells located in the endoderm and interstitial cells that are multipotent stem cells giving rise to neurons, mechano-sensory cells (nematocytes or cnidocytes), gland cells and gametes [3, 4]. (unige.ch)

Senescence in adult tissues can be classified in two main subcategories, based on the underlying molecular mechanism: replicative (or intrinsic), caused by telomere shortening, and stress-induced, in response to reactive oxygen species (ROS) and/or oncogenes [ 7 - 9 ]. (hindawi.com)
The molecular response by the intermediate mesoderm is the expression of the transcription factors Pax-2 and Pax-8 , which then induce Lim-1 (Lhx-1) in the intermediate mesoderm. (clinicalgate.com)

Conversely, CKI depletion in S2 cells impairs Expanded degradation downstream of Crumbs. (sdbonline.org)

In this review we focus on the crucial early events that occur during wound healing, the neural-epithelial interactions that drive the formation of the early blastema, and how these mechanisms differ from those of other species that have restricted regenerative potential, such as humans. (nih.gov)

To obtain insights into the mechanism of cholesteryl hemiester-induced pathological changes in lysosome function and induction of inflammation in vitro and assess their impact in vivo. (tu-dresden.de)

BALB/c mouse with CT26 cells implantation was used as a syngeneic in vivo model for evaluation of treatment and toxicity end points. (propoleo.cl)

During the development of complex multicellular organisms, series of cell fate decisions and morphogenetic movements generate the different tissues and organs of the embryo. (wormbook.org)

Functional analysis shows that ExC2 is required for Ex to promote the phosphorylation and inactivation of Yki in Drosophila cells. (sdbonline.org)

1 Department of Developmental and Cell Biology University of California Irvine California USA. (nih.gov)

Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. (sdbonline.org)

METHODS AND MATERIALS: The effects of CAPE on GSH level, GSH metabolism enzyme activities, NF-kappaB activity, and radiosensitivity in mouse CT26 colorectal adenocarcinoma cells were determined. (propoleo.cl)

Because of its biological properties and expression pattern, XeFGF is a good candidate for an inducing factor with possible roles both in mesoderm induction at the blastula stage and in the formation of the anteroposterior axis at the gastrula stage. (silverchair.com)

RESULTS: CAPE entered CT26 cells rapidly and depleted intracellular GSH in CT26 cells, but not in bone marrow cells. (propoleo.cl)

Wnt proteins are also important regulators of C. elegans development, with functions in processes as diverse as cell fate specification, asymmetric cell division, cell migration and synapse formation. (wormbook.org)

Then, we discuss the mechanics underlying dynamic cell behavior during oriented tissue growth, followed by the connections between signaling at the tissue and organismal levels. (tu-dresden.de)

Wnt proteins trigger a wide variety of responses, ranging from cell fate specification through the activation of specific target genes to the control of cell polarity and migration through pathways that directly modulate the cytoskeleton ( Angers and Moon, 2009 ). (wormbook.org)

The ureter is a urinary conduit composed of inner longitudinal smooth muscle fibers and an outer layer of circular and oblique smooth muscle cells. (medscape.com)
Within the comma, a group of cells farthest from the end of the metanephric duct becomes polarized and forms a central lumen and a basal lamina on the outer surface. (clinicalgate.com)

The effect of propolis along with paclitaxel on 7,12 dimethyl benz(a)anthracene (DMBA) induced experimental breast cancer was investigated in female Sprague Dawley rats. (propoleo.cl)

While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)

In case of the protease inhibitor Kazal1that isspecifically expressed in gland cells of the gastrodermis, RNAi silencing induces a massive autophagy that extends to the digestive cells. (unige.ch)

We demonstrated that MCs can be loaded into shed microvesicles with greater efficiency than their parental plasmid counterparts and that microvesicle-mediated MC delivery led to significantly higher and more prolonged transgene expression in recipient cells than microvesicles loaded with the parental plasmid. (regenerativemedicine.net)

Ptp61F also regulates cell contractility and myosin activation and controls 3D cell shape by reducing cell height and horizontal cell size. (sdbonline.org)

We investigated whether ceramides, which are sphingolipids that serve as a signal of nutritional excess, alter stem cell behaviors to influence cancer risk. (bvsalud.org)
Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages. (tu-dresden.de)

The final results attained below will give you a few guidance for more comprehending the overall performance and operation associated with functional gas cell-thermoelectric power generator crossbreed techniques.In this work, all of us analyze morpho-physiological adjustments shown throughout the allomorphic growth of the aroid vine Rhodospatha oblongata Poepp during its excursion to the natrual enviroment canopy. (syksignaling.com)

Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. (hindawi.com)

We have examined the effects of ChS on macrophages (murine cell lines and primary cultures) in detail. (tu-dresden.de)

Estrogen and progesterone interactive effects in postconfluent MCF-7 cell culture. (edu.au)

Anatomy18

Organisms14

Diseases4

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes13

Disciplines and Occupations1

Information Science2

Proliferation5

Differentiation3

Regeneration8

Regenerative3

Amputation2

Protein1

Wound2

Tissues1

Phases1

Kidneys2

Organ1

Stem cells1

Stage1

Genetic1

Adult1

Distinct1

Production1

Specific1

Present1

Stress1

Process1

Types1

Cancer1

Mesenchymal cells3

Mammary2

Cellular5

Acute2

Secretion2

Tumor3

Homeostasis1

Sequence2

Differentiate1

Molecular2

Degradation1

Mechanisms1

Mechanism1

Vivo1

Morphogenetic1

Drosophila1

Developmental1

Fate decisions1

Metabolism1

Induction1

Bone1

Formation1

Tissue growth1

Specification1

Outer2

Breast cancer1

Development1

Case1

Expression1

Size1

Alter2

Work1

Program1

Primary1

Effects1