Observed in skeletal muscle. Medical search. Frequent questions

More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organized muscle tissue that restores normal muscle weight and function in a rodent model of muscle defect injury. (nature.com)
These approaches have achieved bioengineered skeletal muscle tissue fabrication with cellular alignment in vitro, and some showed a degree of therapeutic potential in vivo. (nature.com)
In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
The temporal pattern of metabolic alterations in muscle tissue during total ischaemia and reperfusion are not well-characterized in humans with respect to glutathione, amino acids and energy-rich compounds. (portlandpress.com)
This mostly means being a selective agonist of androgen receptors in bone and muscle tissue only. (thecni.org)
S-23 and RAD-140 are the main SARMs that are very potent and closer to steroids because they less easily target muscle and bone tissue receptors. (thecni.org)
This appears to be the driver for an enhanced metabolic rate, with fatty acid transport into skeletal muscle tissue being enhanced. (thecni.org)
Results We investigated the alteration of genome-wide transcription in mouse skeletal muscle tissue (rectus femoris muscle) during aging using a high-throughput sequencing technique. (figshare.com)
Moreover, isolated muscle progenitor cells retained both mitochondrial functional deficits and gene suppression observed in the tissue. (jci.org)
The main aim of this thesis was to characterize the role of the cannabinoid receptors and free fatty acid receptor 1 (GPR40) in cell signalling in human and rat skeletal muscle tissue and primary cultured myotubes. (nottingham.ac.uk)
When global gene expression profiles were further examined it was evident that whilst cultured myotubes retained many characteristics of skeletal muscle tissue, the phenotype appeared to be closer to fetal than adult muscle. (nottingham.ac.uk)
Multinuclear muscle fibers have been shown with cine technique to result from both myoblast fusion and polar extension of preformed (explanted) muscle tissue. (rupress.org)
This paper provides a step-by-step protocol describing how to handle the tissue, conduct the imaging, and use stereological methods to obtain unbiased and quantitative data on fiber type-specific subcellular glycogen distribution in skeletal muscle. (jove.com)
The levels of o thiobarbituric acid reactive substances and oxidized dichlorofluorescein were significantly increased, both in skeletal muscle tissue and erythrocytes preparations, and the combined PRP and CWI minimized these parameters . (bvsalud.org)
Rhabdomyolysis is a breakdown of muscle tissue that results in severe muscle weakness. (medlineplus.gov)
The destruction of muscle tissue releases a protein called myoglobin, which is processed by the kidneys and released in the urine (myoglobinuria). (medlineplus.gov)
Rhabdomyolysis Rhabdomyolysis is a clinical syndrome involving the breakdown of skeletal muscle tissue. (msdmanuals.com)

Sarcopenia is generally defined as the progressive loss of skeletal muscle mass and strength that occurs with aging ( 2 , 3 ). (frontiersin.org)
7 Skeletal muscle dysfunction seems to be clinically relevant in COPD, as loss of skeletal muscle mass and strength are associated with poor health status, 8 increased healthcare use 9 and even mortality, 2 10 independent of lung function parameters. (bmj.com)
A loss of skeletal muscle mass is frequently observed in older adults. (diabetesjournals.org)

We previously showed that bioprinted human skeletal muscle constructs were able to form multi-layered bundles with aligned myofibers. (nature.com)
We also demonstrated the feasibility of using these 3D bioprinted human skeletal muscle constructs to treat critical-sized muscle defect injuries with structural and functional restoration in a rodent model 2 . (nature.com)
Gene expression profiling of human skeletal muscle and cultured myotubes and myoblasts indicated that the cannabinoid receptor CB1 and GPR40 were expressed at low levels and these results were confirmed using Taqman QRTPCR. (nottingham.ac.uk)

Abstract Background Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. (figshare.com)

Objective -To investigate whether protein kinase C (PKC) isoforms are expressed in equine skeletal muscle and determine their distribution in various types of fibers by use of immunofluorescence microscopy. (avma.org)
The histochemical assays performed on biopsies taken from proximal and distal parts of the TB muscle, before and after the SES program, showed that the distribution of fibers typed by ATPase was unaffected. (nih.gov)
Skeletal Muscle Fibers (Cells) showing Striations, Teased apart-100X. (genengnews.com)
Shows: 6 skeletal muscle fibers (cells), striations and multinucleate cells. (genengnews.com)
This method provided optically ideal conditions for the study of muscle fibers with oil immersion, phase contrast time-lapse cinematography at 1 frame per minute without apparent damage for periods as long as 10 days. (rupress.org)
It is suggested that this phenomenon may be responsible for numerous reports of amitosis in the genesis of muscle fibers. (rupress.org)

Simply writing, "R/O polymyositis" or "weakness", or worse, "muscle weakness" (we would not be concerned about weakness of character here, so using the term muscle weakness in this context seems oddly redundant) does not provide the pathologist with any useful clinical information and is a disservice to the patient. (medscape.com)
4 Cross-sectional studies have typically demonstrated muscle weakness 5 and reduced endurance, 6 particularly of the lower limbs, in COPD compared with age-matched controls. (bmj.com)
Patients with adult-onset glycogen-storage disease type II typically present with proximal muscle weakness between the second and sixth decades of life. (medscape.com)
Storage in skeletal muscle leads to hypotonia and weakness. (medscape.com)
Muscle weakness can also lead to skeletal abnormalities such as hand and foot deformities and abnormal curvature of the spine. (medlineplus.gov)
The muscles may take up to a year to recover, and the episodes may worsen the muscle weakness caused by the neuropathy. (medlineplus.gov)
The rare and chronic autoimmune neuromuscular disorder of gMG causes debilitating and potentially life-threatening muscle weakness and significantly impaired independence and quality of life. (medscape.com)
Symptoms and signs include muscle weakness, myalgias, and reddish-brown urine, although this triad is. (msdmanuals.com)

Given that young adults born premature also demonstrate skeletal muscle dysfunction, future studies are merited to determine whether this dysfunction as well as reduced aerobic capacity is due to reduced mitochondrial oxidative capacity and metabolic dysfunction. (frontiersin.org)
Debate continues as to the relative importance of systemic and local factors in the aetiology of skeletal muscle dysfunction in COPD. (bmj.com)

Abnormalities associated with cancer cachexia include anorexia, weight loss, muscle loss and atrophy, anemia and alterations in carbohydrate, lipid and protein metabolism ( 2 , 3 ). (spandidos-publications.com)
Two sisters with a syndrome of ocular, skeletal, and abdominal abnormalities (OSA syndrome). (bmj.com)

By examining the transcriptome and epigenome of individual muscle stem cells simultaneously, we found that DNA transcribes* more chaotically in older muscle stem cells compared to those in younger mice. (pasteur.fr)
This matrix protein is decreased in muscle stem cells in old mice thereby destabilising contact with the fibre. (pasteur.fr)
We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. (frontiersin.org)
In studies, Activation of Rev-Erba in mice increased exercise capacity by increasing mitochondria counts in skeletal muscle. (thecni.org)
Mice studies observed that even with the same daily food intake, mice lost around 10% of their bodyweight. (thecni.org)
The functional benefits of exercise on SOCE, constitutive Ca 2+ entry and muscle force production were lost in mice with muscle-specific loss of Orai1 function. (elifesciences.org)
In addition to the increased muscle protein degradation found during cancer growth, the presence of the tumor also induces an increased rate of DNA fragmentation in skeletal muscle in both rats and mice ( 8 ). (spandidos-publications.com)
Analysis revealed significant transcriptional changes between skeletal muscles of mice at 3 (young group) and 24 (old group) months of age. (figshare.com)
Here, we demonstrate that supraphysiological activation of TAK1 in skeletal muscle of adult mice stimulates translational machinery, protein synthesis, and myofiber growth. (genengnews.com)

Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. (frontiersin.org)
confirming that pecans modulate adipose tissues lipolysis and mitochondrial oxidative metabolism in the liver and skeletal muscle. (worldhealth.net)

Age- and load-dependent variations in apoptotic quantification and localization with skeletal muscle adaptation and maladaptation. (cdc.gov)
Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca 2+ entry (SOCE). (elifesciences.org)

To observe, record and correlate motor unit recruitment with the increased power of skeletal muscle contraction. (biopac.com)
L6 myoblasts received either electrical pulse stimulation (EPS) to induce muscle contraction or were unstimulated to serve as controls, and were then treated with an inhibitor of the ATG4 enzyme which catalyzes the initial step of autophagy NSC185058 (NSC, 100 μM) or DMSO as a vehicle control (VC). (wku.edu)
Despite reductions in DEPTOR, mTOR activity was blunted in EPS+NSC cells, indicating that mTOR mediated anabolic signaling requires autophagy post muscle contraction. (wku.edu)
While the decrease in LC3II/I ratio and accumulation of P62 seen after EPS are likely due to inhibition of autophagy due to mTOR activity, our data indicate that inhibition of ATG4 by NSC185058 blunts mTOR activity after muscle contraction. (wku.edu)

Similar vacuoles can be observed in a variety of settings, including glycogen storage disease, colchicine toxic myopathy, critical care myopathy, the periodic paralyses, and technical artifact, among others. (medscape.com)
Examination of biopsies from the semitendinosus and biceps femoris muscles showed no alteration in water content or glycogen concentration with treatment. (bl.uk)
Pompe observed the abnormal accumulation of glycogen in all tissues examined and described the cardinal pathologic features. (medscape.com)

The article Skeletal Muscle - Structure and Histology provides a review of normal skeletal muscle histology and ultrastructure, including the histologic appearance of normal muscle with some of the various stains that are used for the processing of muscle biopsies. (medscape.com)
The effect of strength and endurance exercise on skeletal muscle ultrastructure was investigated in 3 Thoroughbreds and 1 Heavy Hunter using various fixation procedures. (bl.uk)

Despite the mounting evidence of both skeletal muscle and glucose handling impairments after premature birth, the specific skeletal muscle metabolic alterations underlying these physiologic changes in preterm born adults have not been well-identified. (frontiersin.org)
During the reperfusion part of the study, no differences attributable to the infusion of mannitol or glucose were observed. (portlandpress.com)
Insulin resistance in skeletal muscle is of particular importance because muscle is the major site of insulin stimulated glucose uptake. (nottingham.ac.uk)
Skeletal muscle is one of the major insulin sensitive organs and it is responsible for 80% of insulin stimulated glucose disposal as well as fatty acid oxidation. (nottingham.ac.uk)

The objective of this study was to evaluate whether postnatal hyperoxia exposure in rats could recapitulate the skeletal and metabolic phenotype of premature birth, and to characterize the subcellular metabolic changes associated with postnatal hyperoxia exposure, with a secondary aim to evaluate sex differences in this model. (frontiersin.org)

Neural input into this bioprinted skeletal muscle construct shows the improvement of myofiber formation, long-term survival, and neuromuscular junction formation in vitro. (nature.com)
In vitro , formoterol is a potent airway smooth muscle relaxant with high efficacy and high affinity and selectivity for the β 2 -adrenoceptor ( 17 ). (spandidos-publications.com)

The remainder of this article addresses the key clinical characteristics and pathologic findings on muscle biopsy of selected examples of disorders from 4 different categories of muscle disease: immune-mediated (inflammatory) myopathies, muscular dystrophies, metabolic myopathies, and congenital myopathies. (medscape.com)
Most muscle biopsies exhibit a constellation of pathologic findings that must be synthesized to arrive at a diagnosis. (medscape.com)
Here is an example to illustrate the lack of specificity of histopathologic findings and the importance of clinical information for interpretation of a muscle biopsy: A biopsy might exhibit myofibers that contain clear vacuoles on hematoxylin and eosin (H&E) sections. (medscape.com)
specifically, nuclei distinct from skeletal muscle may contribute to these findings. (cdc.gov)
These findings suggest that LEA may have negative consequences for skeletal muscle adaptations and highlight the importance of ensuring adequate energy availability in female athletes. (nih.gov)
This is corroborated by biopsy findings of muscle fibre atrophy and muscle fibre shift from type I to type II fibres. (bmj.com)
Their findings are published in the journal Nature Communications in a paper titled, " Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy . (genengnews.com)
Our findings demonstrate that targeted inactivation of TAK1 causes derangement of neuromuscular junctions and severe muscle wasting, very similar to muscle wasting observed during nerve damage, aging, and cancer cachexia. (genengnews.com)
These findings indicate that muscle tissues from claudicating patients and non-PAD controls were similar in both their bioenergetics profile and mitochondrial phenotypes. (jci.org)
The present findings provide novel insights on inflammation-induced stimulation of IL-6 promoter activity in skeletal muscle which is an important but non-traditional component of the innate immune system. (dovepress.com)

PURPOSE: The purpose of this study was to determine if apoptosis plays a role in age-dependent adaptation and maladaptation in young and old skeletal muscle of rats, respectively, following chronic high-intensity mechanical loading via stretch-shortening contractions (SSCs). (cdc.gov)
METHODS: Left dorsiflexor muscles of young (3 mo, N=6) and old (30 mo, N=6) Fischer 344 x BN rats, were loaded 3 times/week for 4.5-weeks using a protocol of 80 maximal SSCs per exposure in vivo. (cdc.gov)
Moreover, ELISA data revealed chronic SSC-loading increased cell death -95% in young rats' skeletal muscle, while old rats' cell death significantly increased -105% (p (cdc.gov)
Additionally, aging increased the volume density of TUNEL-positive myonuclei in both control (-125%) and SSC-loaded (-200%) TA muscles compared with young rats (p (cdc.gov)
Interestingly, no increase in TUNEL -positive myonuclei was observed following chronic SSC loading in young or old rats. (cdc.gov)
One of the most relevant characteristics of cachexia is that of asthenia, which reflects significant muscle wasting noted in cachectic cancer patients The aim of the present study was to assess whether the β2-adrenergic agonist formoterol is associated with an improvement in physiological parameters such as grip force and total physical activity in cachetic rats. (spandidos-publications.com)
Administration of the β2-agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights. (spandidos-publications.com)
The anti-wasting effects of the drug were also observed in terms of total physical activity and grip force, thus resulting in an improvement in physical performance in cachectic tumor-bearing rats. (spandidos-publications.com)
Combined platelet-rich plasma and cold water immersion treatment minimize the damage following a skeletal muscle stretch injury in rats. (bvsalud.org)
This study investigated the effects of isolated or combined PRP and/or CWI on the oxidative damage determined by a stretch injury induced in gastrocnemius muscle of rats . (bvsalud.org)

Using genetic approaches, the researchers demonstrated that TAK1 is indispensable for maintaining healthy neuromuscular junctions, which are involved in transmitting nerve impulses to skeletal muscle and allowing muscle contractions. (genengnews.com)

A bioengineered skeletal muscle construct that mimics structural and functional characteristics of native skeletal muscle is a promising therapeutic option to treat extensive muscle defect injuries. (nature.com)
In conclusion, these studies have shown that at a high therapeutic dose, nandrolone phenylpropionate had little effect on the skeletal musculature of both resting and exercising Thcroughbreo horses. (bl.uk)
In contrast, CLI patient limb skeletal muscles harbor a unique skeletal muscle mitochondriopathy that represents a potentially novel therapeutic site for intervention. (jci.org)

However a significant increase in the proportion of fast twitch low oxidative fibres of the biceps femoris was observed. (bl.uk)

In stem cells in aged individuals, both transcriptional and epigenetic changes associated with ageing have been observed. (pasteur.fr)

This article first presents and contrasts neurogenic and general myopathic features on muscle biopsy. (medscape.com)

Deplection of lean body mass is one of the main consequences of cachexia which involves not only skeletal muscle but also affects cardiac proteins, resulting in alterations in heart performance. (spandidos-publications.com)

Also, a vascularization strategy using co-culture with endothelial cells (ECs) and fibroblasts improved the survival of the bioengineered skeletal muscle tissues 20 , 21 . (nature.com)
The Adipoq-Cre exhibited no observable recombination in any other tissues examined, whereas both aP2-Cre lines resulted in recombination in endothelial cells of the heart and nonendothelial, nonmyocyte cells in the skeletal muscle. (diabetesjournals.org)

Has settled, but the hearing may from dihydrotestosterone (DHT) assess skeletal muscle protein breakdown rates, we observed lower plasma and muscle BCAA levels when. (ncfy.com)

Also observed was increased gene expression in skeletal muscle. (thecni.org)
We observed several interesting gene expression changes in the elderly, many of which have not been reported before. (figshare.com)

Inspiratory muscle training may improve inspiratory muscle strength and endurance following weaning, potentially improving dyspnoea and quality of life in this patient group. (bmj.com)

The respiratory muscles are also affected, resulting in hypoventilation and progressive respiratory compromise. (medscape.com)

The lesson uses a hand dynamometer to demonstrate the use of skeletal muscle when recording the maximum grip strength for both hands and also allows students to record EMG while inducing muscle fatigue. (biopac.com)
We demonstrate that supraphysiological activation of TAK1 in skeletal muscle stimulates translational machinery, protein synthesis, and myofiber growth," explained Ashok Kumar, the UH College of Pharmacy Else and Philip Hargrove endowed professor and chair, department of pharmacological and pharmaceutical sciences. (genengnews.com)

We conducted a randomized controlled trial to investigate the impact of LEA on daily integrated myofibrillar and sarcoplasmic muscle protein synthesis in trained females. (nih.gov)
We found that LEA reduced daily integrated myofibrillar and sarcoplasmic muscle protein synthesis compared with OEA. (nih.gov)
We investigated the impact of 10 days of LEA on daily integrated myofibrillar and sarcoplasmic muscle protein synthesis in young, trained females. (nih.gov)
We show that LEA impairs myofibrillar and sarcoplasmic muscle protein synthesis in trained females performing exercise training. (nih.gov)

Perhaps one of the most relevant characteristics of cachexia is that of asthenia, which reflects the significant muscle wasting that occurs in the cachectic cancer patient ( 7 ). (spandidos-publications.com)

Studies of ocular lesions are not so many, compared with those of the muscle and CNS. (intechopen.com)
Two adult sisters are described who had a unique association of facial, ocular, and skeletal defects, and abdominal muscle hypoplasia, indicating autosomal recessive inheritance. (bmj.com)

Increased skeletal muscle nuclear apoptosis has been suggested to be involved with age-related pathological remodeling that contributes to sarcopenic states. (cdc.gov)
Previous studies carried out in our laboratory demonstrated that formoterol treatment in tumor-bearing animals resulted in an amelioration of muscle loss through different mechanisms that include muscle apoptosis and proteolysis ( 19 ). (spandidos-publications.com)

In no case was mitosis, amitosis, or nuclear "budding" observed in the course of muscle development. (rupress.org)

Specifically, genes associated with energy metabolism, cell proliferation, muscle myosin isoforms, as well as immune functions were found to be altered. (figshare.com)

In a previous study, we have demonstrated that Lactobacillus plantarum TWK10 (TWK10), a probiotic strain isolated from Taiwanese pickled cabbage, improved muscle strength, exercise endurance, and overall body composition in healthy humans. (frontiersin.org)
This longitudinal study was designed to document the extent of change in body composition (including muscle mass, fat mass and bone mineral composition) in older men and women, identify possible clinical conditions that accelerate these changes and examine the health impact of these changes on strength, endurance, disability and weight-related diseases of old age. (bmj.com)

BSL EMG lesson II explores the role of skeletal muscle in performing mechanical tasks. (biopac.com)

Muscle biopsy often contributes significantly to the evaluation of patients with neuromuscular disease. (medscape.com)
Knowledge of the fundamentals of muscle biopsy pathology is useful to promote understanding of the pathogenesis of many types of neuromuscular disorders and assists the non-pathologist clinician to understand reports that he or she receives for the muscle biopsies from his or her patients. (medscape.com)
Knowledge of the basic foundation of muscle biopsy also helps the clinician to understand in what situations a muscle biopsy would be expected to be helpful in assessment of the patient with neuromuscular disease and to be familiar with the types of information that it can provide. (medscape.com)
this will not present instruction on the subtleties of advanced muscle biopsy diagnosis. (medscape.com)
The article Muscle Biopsy and Clinical and Laboratory Features of Neuromuscular Disease provides information about the procedure of muscle biopsy and background about the general features of the clinical presentations of neuromuscular disorders. (medscape.com)
Interpretation of a muscle biopsy can be a challenging task. (medscape.com)
Procedure -In each horse, 2 biopsy specimens were obtained from the vastus lateralis muscle. (avma.org)
Isolate a small specimen from the muscle biopsy or whole muscle which has a maximum diameter of one millimeter in any direction and is longer longitudinally than cross-sectionally. (jove.com)

These results suggest that the 3D bioprinted human neural-skeletal muscle constructs can be rapidly integrated with the host neural network, resulting in accelerated muscle function restoration. (nature.com)
20% of the original mass invariably results in functional impairment with limited regeneration capacity, which requires reconstructive surgical procedures such as autologous muscle flap transfers 1 . (nature.com)
RESULTS: Cell death was increased in both old control (-50%) and old SSC-loaded (-105%) skeletal muscle versus young muscle, as quantified by ELISA (p (cdc.gov)
These results highlight that LEA may negatively affect skeletal muscle adaptations in females performing exercise training. (nih.gov)
Conclusions and Clinical Relevance -Results indicated that PKC isoforms are expressed in equine skeletal muscle in a fiber type-specific manner. (avma.org)
These results indicate that TT association with SR-stacks enhances Orai1-dependent SOCE to optimize Ca 2+ dynamics and muscle contractile function during acute exercise. (elifesciences.org)
Treatment with β 2 -adrenergic agonists results in skeletal muscle hypertrophy ( 11 - 14 ), while they cause a reduction in the body fat content ( 15 , 16 ). (spandidos-publications.com)
Physical activity has been defined as 'any bodily movement produced by skeletal muscles that results in energy expenditure. (cdc.gov)

We have also identified a novel interplay between TAK1 and BMP (Bone Morphogenetic Protein) signaling pathway that promotes muscle growth," said Anirban Roy, PhD, research assistant professor of pharmacology at the University of Houston. (genengnews.com)

The muscle pathologist must analyze and interpret the histopathologic features within the individual clinical context to arrive at a diagnostic formulation that makes sense for a given patient. (medscape.com)
Moreover, formoterol relaxes bronchial smooth muscle and also provides important clinical benefits in symptomatic patients with chronic obstructive pulmonary disease ( 18 ). (spandidos-publications.com)

Importantly, this decrease in releasable Ca 2+ store content observed after exercise was reversed by repetitive high-frequency stimulation, consistent with enhanced SOCE. (elifesciences.org)

However, the role and mechanisms by which TAK1 regulates skeletal muscle mass remain less understood. (genengnews.com)
The mechanisms underlying the development of insulin resistance in skeletal muscle are very complex and are not completely understood. (nottingham.ac.uk)

In 2015 and 2016, we observed 15 malformed calves that were exposed to intrauterine infection with Shamonda virus, a Simbu serogroup orthobunyavirus, in Japan. (cdc.gov)

Cardiac involvement is not observed in the adult form. (medscape.com)

Muscle biopsies were taken from the quadriceps femoris muscle on the operated side preoperatively, at maximal ischaemia and after 24 h of reperfusion. (portlandpress.com)

Most patients with gMG have immunoglobulin G (IgG) antibodies, which are most often directed against skeletal muscle nicotinic acetylcholine receptors. (medscape.com)

Muscle mass drops by ~3-8% per decade after age 30 and its declining rate is accelerated after age 60 ( 4 ). (frontiersin.org)
Concomitant reductions were observed in lean mass, urinary nitrogen balance, free androgen index, thyroid hormone concentrations and resting metabolic rate following LEA. (nih.gov)
Muscle mass and strength in obstructive lung disease: a smoking gun? (bmj.com)
In older people, as in COPD, sarcopaenia (loss of muscle mass and strength associated with ageing) is independently associated with disability and mortality. (bmj.com)
The aim of the study was to investigate the impact of type 2 diabetes on the changes in body composition, with particular interest in the skeletal muscle mass. (diabetesjournals.org)
Now, a mouse study by scientists from the University of Houston (UH) demonstrates how TAK1 regulates skeletal muscle mass. (genengnews.com)
Skeletal muscle mass is regulated through coordinated activation of multiple signaling pathways," the researchers wrote. (genengnews.com)
It was observed an improvement in skeletal muscle mass, resting metabolic rate, as well as the consumption of fresh foods/g and processed food/kcal after the intervention period. (bvsalud.org)

Muscle stem cell from young mouse stained with the transcription factor Pax7 and in contact with the muscle fibre through the extracellular matrix protein M-Cadherin. (pasteur.fr)

To record the force produced by grip muscles, EMG, and integrated EMG when inducing fatigue. (biopac.com)

TAK1 signalosome has been found to be activated in various conditions of muscle atrophy and hypertrophy. (genengnews.com)
The researchers are looking to investigate whether the activation of TAK1 using small molecules is sufficient to promote muscle growth and prevent atrophy in the elderly and various disease states. (genengnews.com)

Daily integrated muscle protein synthesis was measured by deuterium oxide (D 2 O) consumption along with changes in body composition, resting metabolic rate, blood biomarkers and 24 h nitrogen balance. (nih.gov)

These renal and vascular changes were very different from those observed in the acute cryoglobulinemia, characterized by mainly "wire-loop" glomerular lesions and a cutaneous leukocytoclastic form of vasculitis. (unige.ch)

Although skeletal and respiratory involvement is frequently present in the juvenile form, cardiac involvement varies. (medscape.com)

In this study, we investigate the effects of neural cell integration into the bioprinted skeletal muscle construct to accelerate functional muscle regeneration in vivo. (nature.com)

However, the effect of LEA on skeletal muscle protein synthesis in females performing exercise training is still poorly understood. (nih.gov)
3 This limitation in exercise and functional capacity has led to a particular focus upon the skeletal muscle compartment. (bmj.com)
Certainly, a surprisingly high proportion of patients with COPD terminate exercise complaining of muscle effort. (bmj.com)
Here, we report that SOCE, peak Ca 2+ transient amplitude and muscle force production during repetitive stimulation are increased after exercise in parallel with the time course of TT association with SR-stacks. (elifesciences.org)
While much has been discovered about the role autophagy in protein degradation, recent evidence suggests that autophagy is required for muscular adaptations to exercise, hinting at a hitherto unknown cross-talk between autophagic proteolysis and muscle protein anabolism. (wku.edu)

The skeletal muscle stretch injuries are commonly observed in sports . (bvsalud.org)

This is particular to the mTOR pathway, as an increase in MAPK phosphorylation was still observed in EPS+NSC. (wku.edu)

In addition, PKC α and β2 were detected near or in the plasma membrane of muscle cells. (avma.org)

Elevated circulating free fatty acids (FFAs) and their derivatives such as endocannabinoids (ECs) have been described in obesity and are thought to be influential in the development of muscle insulin resistance. (nottingham.ac.uk)

Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. (figshare.com)

Each of these compounds amounts of muscle can achieve his yet the reasons for these obvious sex differences remain poorly understood. (ncfy.com)

However, the constellation of defects observed in these patients appears to represent a previously unreported syndrome and autosomal recessive inheritance is likely. (bmj.com)

Anatomy51

Organisms21

Diseases24

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes56

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena7

Information Science3

Health Care1

Tissue17

Loss of skeletal muscle mass3

Human skeletal muscle3

Abstract1

Fibers6

Weakness8

Dysfunction2

Abnormalities2

Mice9

Mitochondrial oxidative2

Localization2

Contraction4

Glycogen3

Ultrastructure2

Glucose4

Phenotype1

Vitro2

Findings10

Rats10

Junctions1

Therapeutic3

Fibres1

Transcriptional1

Neurogenic1

Alterations1

Tissues2

Breakdown1

Gene2

Potentially1

Respiratory Muscles1

Demonstrate2

Sarcoplasmic4

Characteristics1

Ocular2

Apoptosis2

Nuclear1

Metabolism1

Endurance2

Mechanical1

Biopsy8

Results8

Signaling pathway1

Clinical2

Importantly1

Mechanisms2

20161

Adult1

Biopsies1

Receptors1

Mass8

Transcription1

Grip1

Atrophy2

Body composition1

Lesions1

Cardiac1

Accelerate1

Exercise5

Injuries1

Phosphorylation1

Plasma membrane1

Insulin resistance1

Sarcopenia1

Understood1

Unreported syndrome1