• The results are in accord with the general observation that with increasing temperature, the role of electrostatic interactions in protein stability increases. (nih.gov)
  • Phosphopeptides with homology to the treacle protein (TCOF1) were disproportionately increased in progenitor cells, compared to their radiosensitive counterparts. (cdc.gov)
  • We determined the sequence of pig Reelin mRNA and protein and identified a high degree of homology to human Reelin. (biomedcentral.com)
  • Amino acid analysis of the seven sorghum genotypes resulted in high homology with senescence-inducible chloroplast SGR-protein 1 from Zea mays and SGR-chloroplastic of Setaria italica . (sabraojournal.org)
  • The SGR gene sequence contains a conservative region and has high homology with the senescence-inducible chloroplast stay-green protein 1 and stay-green chloroplast proteins. (sabraojournal.org)
  • As the truncated protein lacks the N-terminal Mad homology 1 (MH1) domain, these results show that SMAD3 DNAbinding activity as well as SMAD2 are dispensable for normal FSH synthesis in vivo. (elsevierpure.com)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • In order to characterise this syndrome better, facilitate the diagnosis, and provide targeted health care for affected individuals, we have studied 33 patients (32 new observations) with a pure 22q13 partial monosomy, using molecular and cytogenetic methods. (bmj.com)
  • Our results showed that the relative binding energies estimated by molecular docking were in good correlation with the experimental activities. (conicet.gov.ar)
  • Preliminary classical molecular dynamics results on selected P-gp/modulator complexes were also performed in order to understand the nature of the prevalent molecular interactions and the possible main molecular features that characterize a modulator. (conicet.gov.ar)
  • Our observations suggest that the hydrophobicity and molecular flexibility are the main features related to the inhibitory activity. (conicet.gov.ar)
  • And while the evidence for evolution itself remains persuasive -- especially the homologies that are found in comparative anatomy and molecular biology of many different species -- much of the empirical evidence that was formerly believed to support the neo-Darwinian mechanism of chance mutation coupled with natural selection has melted away like snow on a spring morning, through better observation and more careful analysis. (bibliotecapleyades.net)
  • Furthermore, we show that integration of two separate phylogenomic pipelines yields increased accuracy, suggesting that their sources of error are independent, and finally, we leverage the resulting annotation of homologous genes to study the functional impact of gene duplication and loss in the context of rich gene expression and functional genomic datasets of the modENCODE, mouse ENCODE, and human ENCODE projects. (biorxiv.org)
  • An observation on a conservative region with the SGR domain noticed SGR genes, derived from sorghum genotypes, clustered separately with those from other SGR genes available in the GenBank database. (sabraojournal.org)
  • otherwise they are distinct non-trivial homology spheres. (wikipedia.org)
  • A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
  • Anatomical homologies - Throughout the domains of life, organisms show a distinct pattern of constraints based on homology in the development and construction of the body. (rationalwiki.org)
  • These two genetic defects result in both similar and distinct physical and pathologic findings. (medscape.com)
  • In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. (springer.com)
  • A small percentage of AND-34 −/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. (molvis.org)
  • In this work, homology models of both proteins were constructed and analyzed for a number of structural properties. (nih.gov)
  • All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)
  • The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
  • However, largely as a result of the spirochetes, we validated the use of sequence analysis of demise of the clothing louse Pediculus humanus , it is now an intragenic spacer (IGS) region for typing these spiro- restricted to areas where clothing lice are still common- chetes ( 3 ). (cdc.gov)
  • Based on the observations that all of these gene versions are remarkably similar in sequence, have related functions, and are incredibly widespread (animals all across the tree of life have them), scientists have concluded that they must be homologous and must have been inherited from the common ancestor of all these animals. (berkeley.edu)
  • Many computational methods for gaining functional insights from sequence data are based on the simple, but powerful, observation that functionally important nucleotides tend to remain unchanged over evolutionary time, because mutations at these sites generally reduce fitness and are therefore eliminated by natural selection 7 - 15 . (biorxiv.org)
  • Evolutionary turnover may cause inconsistencies between sequence orthology and functional homology that substantially limit this type of analysis. (biorxiv.org)
  • We describe the predatory sequence of P. phalangioides when using gumfoot lines, and discuss possible behavioural homologies between pholcids and araneoids. (bvsalud.org)
  • As discussed earlier, there are two basic evolutionary explanations for similarities: homology and analogy. (berkeley.edu)
  • This is also important in order to hypothesize primary homologies ( sensu de Pinna, 1991, 1997), that is, topographical similarities based on Remane's criteria of homology (adapted to the behavioural domain - see Greene, 1994). (bvsalud.org)
  • A major strength of these conservation- or constraint-based approaches is that they sidestep thorny questions about the relationship between the out-comes of biochemical experiments and fitness-influencing functional roles 16 - 19 by getting at fitness directly through observations of evolutionary change. (biorxiv.org)
  • This is indeed a problem about a basic question in evolutionary analyses, that is, the statement of homology. (bvsalud.org)
  • Simplicial homology applies to finite data in real space, and thus it is mainly used in applications. (helsinki.fi)
  • Being a spherical 3-manifold, it is the only homology 3-sphere (besides the 3-sphere itself) with a finite fundamental group. (wikipedia.org)
  • Building on results from ordinary derandomization and finite model theory, we show that it is possible to deterministically construct, in polynomial time, graphs and relational structures that are statistically indistinguishable from random structures by any sentence of first order or least fixed point logics. (tuckerfoltz.com)
  • Notably, however, we discovered that the recombined Smad3 allele produces a transcript that encodes the entirety of the SMAD3 C-terminal Mad homology 2 (MH2) domain. (elsevierpure.com)
  • The third form of Griscelli syndrome, whose expression is restricted to the characteristic hypopigmentation, results from mutation in the gene that encodes melanophilin, MLPH , the ortholog of the gene mutated in leaden mice. (medscape.com)
  • The comparison of the models reveals that the higher stability of HydSL can be attributed to increased inter-subunit electrostatic interactions: the homology models reliably predict that HydSL contains at least five more inter-subunit ion pairs than HupSL. (nih.gov)
  • The results of these analyses suggest that CGPs are central to information exchange and propagation, and that their topological organization supports fundamental biological processes of neoplasia. (biomedcentral.com)
  • We also constructed, by homology modeling, a theoretical structure of the pUL105 N-terminal domain which indicates that the mutated conserved amino acids in this domain could be involved in ATP hydrolysis. (frontiersin.org)
  • Our main theoretical result is that, surprisingly, the geometric target is always feasible with respect to arbitrarily diverging data sets on how voters are distributed. (tuckerfoltz.com)
  • Comparative observations were made on over 4500 individual lizards, noting such features as times of activitiy, hunting methods, diet, micro- and macrohabitat, refuges used and body temperature. (podarcis.de)
  • c) structural homologies. (hstreasures.com)
  • These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
  • 2010 ). PRDM9 includes several functional domains, such as a DNA-binding zinc finger array, a histone lysine methyltransferase PR/SET (PRDI-BF1 and RIZ1 homology) domain, and a Krüppel-associated box (KRAB)-related domain. (springer.com)
  • 5) Infection appears to be selective for specific neuronal populations, resulting in a characteristic clinical syndrome of lower motor neuron paralysis. A diagnosis of enterovirus encephalomyelitis is made by virus isolation from the central nervous system of pigs showing neural signs(5) The disease was first described as Teschen disease. (askjpc.org)
  • This need is further intensified by the human ENCODE (ENCyclopedia Of DNA Elements), mouse ENCODE, and modENCODE (model organism ENCODE) projects, to enable systematic use of the results and to further studies of functional conservation and divergence across the human, mouse, fly, and worm genomes. (biorxiv.org)
  • A rational homology sphere is defined similarly but using homology with rational coefficients. (wikipedia.org)
  • Further experiments will be required to uncover the physiological role of the interaction suof Oxr1 with the V-ATPase, and whether the observations obtained for the yeast system are conserved in higher organisms, including humans. (upstate.edu)
  • Understanding the extent and dynamics of PfCSP genetic diversity in different transmission settings will help to interpret the results of current RTS,S efficacy and Phase IV implementation trials conducted within and between populations in malaria-endemic areas such as Ghana. (biomedcentral.com)
  • Yet, regions with X-Y homology and genetic exchange, termed the pseudoautosomal regions (PARs), still persist across placental mammals. (biomedcentral.com)
  • This thesis aims to introduce the theories behind persistent homology and its application, image completion algorithm. (helsinki.fi)
  • The results are discussed in the framework of theories on perceptual learning. (mpi.nl)
  • Immunohistochemical analysis showed the highest expression of Reelin in the Cajal-Reztius cells of the marginal zone, in resemblance with observations for the developing brain in humans and other mammalian species. (biomedcentral.com)
  • Sanides developed this hypothesis based on his observations of the cortex of humans, non-human primates, cats, and rats and on the works of Raymon Dart ( 1934 ) on the cortex of reptiles and Andrew A. Abbie ( 1940 , 1942 ) on the cortex of marsupials and monotremes [see Table 2 in García-Cabezas et al. (springer.com)
  • The study sought to analyze the homology of the stay-green gene fragment in Indonesian sorghum cultivars, comparing it with the SGR gene sequences in the GenBank database. (sabraojournal.org)
  • These results prove that the SGR gene family in Indonesian sorghum cultivars is SGR-like ( SGRL ). (sabraojournal.org)
  • Furthermore, the observation that deletion of proximal exons does not remove all SMAD3 function may facilitate interpretation of divergent phenotypes previously described in different Smad3 knockout mouse lines. (elsevierpure.com)
  • It has also been shown that an identical phenotype to Griscelli syndrome type 3 results from the deletion of the MYO5A F-exon, an exon with a tissue-restricted expression pattern. (medscape.com)
  • Our results demonstrate a novel mechanistic model for ROS-mediated inhibition of Orai1 and identify a candidate residue for pharmaceutical intervention. (nature.com)
  • Our empirical results, which use real election data and maps of six US states, demonstrate that the geometric target is always feasible, and that imposing it as a fairness constraint comes at almost no cost to three well-studied optimization objectives. (tuckerfoltz.com)
  • CONCLUSIONS -Our results demonstrate the protective potential of transgenic PD-L1 in autoimmune diabetes and illustrate its role in downregulating diabetogenic T-cells in NOD mice. (diabetesjournals.org)
  • Persistent homology is motivated by the question of which scale is the most essential to study data shape. (helsinki.fi)
  • Results: Several key themes emerged from the study, shedding light on various aspects of the experiences of TB patients during the COVID-19 pandemic. (bvsalud.org)
  • RESULTS: The study highlighted three main competencies needed by Indonesian nurses, which are physical, psychological, and managerial. (bvsalud.org)
  • Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of AMR have lacked a holistic view combining all aspects into one study. (europa.eu)
  • A more optimized cavity system and amino acid replacements resulting in increased conformational rigidity may also contribute to the higher stability of HydSL. (nih.gov)
  • A filtration contains all scales we want to explore, and thus it is an essential tool of persistent homology. (helsinki.fi)
  • The microornamentation of the scales (oberhautchen) has been studied by means of enamel casts (in negative), or with detached skin pieces (positive cast in the upper face or negative in their lower face of the scales) and its observation by transparency with optical microscopy at 40x, 400x and 1000x. (podarcis.de)
  • In light of the results obtained, it seems that the use of the microornamentation of the scales in taxonomy is limited. (podarcis.de)
  • 5) These later diseases were described as resulting in lower morbidity and mortality, the clinical syndrome expressed as paresis and ataxia (which seldom progresses to complete paralysis). (askjpc.org)
  • The anticipated results may guide clinical and policy decisions to ultimately reduce the burden of AMR in Europe. (europa.eu)
  • This resembles observations for human brain development. (biomedcentral.com)
  • We have generated fitCons scores for three human cell types based on public data from EN-CODE. (biorxiv.org)
  • Conversely, observations in human patients have contributed to the recognition of an increased spectrum of disease manifestations in animals. (vin.com)
  • These and other historical factors resulted in substantial limitations in our understanding of infections caused by members of the genus Ehrlichia . (vin.com)
  • Efforts to update the reporting system initiated in the early 2000s (i.e., simplification of reporting forms and transition to electronic reporting) resulted in a substantial increase in reporting compared with the late 1990s. (cdc.gov)
  • Furthermore, it was clearly shown that disturbances in the hydraulic regime such as water hammers, operation of valves and rapid increases in flow velocity can result in enhanced PAH concentrations by the destabilisation of the biofilm matrix or high shear forces affecting the pipe walls resulting in the release of particles highly contaminated with PAHs which may be responsible for the contamination of the drinking water. (who.int)
  • Since the fundamental group of the 3-sphere is trivial, this shows that there exist 3-manifolds with the same homology groups as the 3-sphere that are not homeomorphic to it. (wikipedia.org)
  • These observations suggest SHP-2 to be a key enzyme in the control of angiogenesis. (uni-muenchen.de)
  • Based on these observations we suggest that gumfoots are basal in pholcid phylogeny. (bvsalud.org)
  • We will found that these provide sufficient tools to consider homology classes birth and deaths, but they are not particularly easy to use in practice. (helsinki.fi)
  • Enterovirus detections by serotype with specimen type, collection date, and demographic information are reported monthly by participating laboratories to CDC, which summarizes the data and disseminates the results. (cdc.gov)
  • We provide a complete classification of when this is possible for first order logic, fixed point logic, and fixed point logic with parity, and provide partial results and conjectures for first order logic with parity. (tuckerfoltz.com)
  • In 2008, astronomers found the best orientation on the sky for the model and confirmed some of the predictions of the model, using three years of observations by the WMAP spacecraft. (wikipedia.org)
  • Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
  • The infrequent diagnosis of ehrlichiosis in cats may be related to a number of factors including a general under-recognition of tick-borne diseases in cats, decreased pathogenicity of tick-borne pathogens in cats as compared to other species, or the more rapid removal of ticks from cats resulting in decreased opportunity for disease transmission. (vin.com)
  • The more promising results with metformin have been in the diseases of these organs. (cancer.gov)
  • The results are good and mainly as could be expected. (helsinki.fi)
  • no good homologies were observed with any class of beta-lactamase. (bl.uk)
  • See Seifert-Weber space for a similar construction, using more "twist", that results in a hyperbolic 3-manifold. (wikipedia.org)
  • We found that its components' and essential homology classes' birth and death times correspond. (helsinki.fi)
  • RESULTS: twenty-eight studies evaluating UPF intake and risk of depression were finally selected, 21 of which had a cross-sectional design, 6 studies had a cohort design, and 1 had a case-control design. (cdc.gov)
  • We also included instances more likely to be zoonotic than those that are not (1,3), of accidental laboratory infection but excluded infections confirming an association between these characteristics resulting from deliberate exposure in the laboratory. (cdc.gov)
  • Alternatively, the Poincaré homology sphere can be constructed as the quotient space SO(3)/I where I is the icosahedral group (i.e., the rotational symmetry group of the regular icosahedron and dodecahedron, isomorphic to the alternating group A5). (wikipedia.org)
  • More intuitively, this means that the Poincaré homology sphere is the space of all geometrically distinguishable positions of an icosahedron (with fixed center and diameter) in Euclidean 3-space. (wikipedia.org)
  • The results are in correspondence with observations made in real distribution systems where enhanced PAH concentrations were observed during disinfection processes. (who.int)
  • There's latest proof that gossypol can induce autophagy also, which in a few complete situations results in autophagic cell death [24]. (islamophobiacon.com)
  • Griscelli syndrome (GS) is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and the hair (silver hair), the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. (medscape.com)
  • Radiotherapy for head and neck cancers can result in extensive damage to the salivary glands, significantly affecting patient quality of life. (cdc.gov)
  • More generally, surgery on a link gives a homology sphere whenever the matrix given by intersection numbers (off the diagonal) and framings (on the diagonal) has determinant +1 or −1. (wikipedia.org)
  • The algorithm utilize this observation to complete images. (helsinki.fi)
  • These results confirm earlier observations that OXA-2 and OXA-3 beta-lactamases are related. (bl.uk)