• This study aimed to compare the epidemiology of Rickettsia felis infection and malaria in France, North Africa, and sub-Saharan Africa and to identify a common vector. (cdc.gov)
  • Several studies have assessed the effect of fastidious bacterial infections in systemic febrile illness, including Rickettsia felis ( 4 - 6 ), Coxiella burnetii ( 7 ), Tropheryma whipplei ( 3 ), and Borrelia spp. (cdc.gov)
  • Rickettsia felis, an obligate intracellular Gram-negative bacterium belonging to the spotted fever group of Rickettsi a, has been shown to be a common agent of bloodstream infections in among humans Senegal and Kenya, identified in 7% of the population evaluated ( 4 - 6 ). (cdc.gov)
  • The recent detection of Rickettsia felis DNA in dogs in Australia suggests that dogs are potential mammalian reservoir hosts for this emerging rickettsia. (biomedcentral.com)
  • Rickettsia felis was successfully isolated in cell culture from all three cat-flea pools. (biomedcentral.com)
  • One protein from the obligate intracellular bacterial parasite, Rickettsia prowazekii, is of 498 amino acyl residues, and is believed to span the membrane 12 times. (wikipedia.org)
  • We describe here the complete genome sequence (1,111,523 base pairs) of the obligate intracellular parasite Rickettsia prowazekii, the causative agent of epidemic typhus. (nih.gov)
  • Rickettsia, typhus and the mitochondrial connection. (nih.gov)
  • Rickettsia prowazekii, which is the etiologic agent of typhus, lives in the alimentary tract of the louse. (medscape.com)
  • After a patient with typhus is treated with antibiotics and the disease appears to be cured, Rickettsia may linger in the body tissues. (medscape.com)
  • Sporadic cases of active infection with R prowazekii, the etiologic agent of epidemic typhus, have been reported. (medscape.com)
  • Prior infection with Rickettsia typhi provides subsequent and long-lasting immunity to reinfection. (medscape.com)
  • This has direct consequences for the immune response evoked by the host attempting to resolve intracellular infection. (oncohemakey.com)
  • Finally, we examine effects of both adaptive and innate immune mechanisms on long-term effects of intracellular bacterial infection. (oncohemakey.com)
  • We hope this chapter will stimulate an interest in intracellular infection and the unique immunologic insights it can provide. (oncohemakey.com)
  • In fact, acquired resistance against intracellular bacterial infections depends on activation of multiple arms of the immune system. (oncohemakey.com)
  • The R. prowazekii genome contains the highest proportion of non-coding DNA (24%) detected so far in a microbial genome. (nih.gov)
  • We report the 860-kb genome of the obligate intracellular plant pathogen phytoplasma (Candidatus Phytoplasma asteris , OY strain). (nature.com)
  • Phytoplasma is the first obligate intracellular bacterium inhabiting both plant and insect to have its genome sequenced. (nature.com)
  • The Rickettsia travel to the bloodstream and rickettsemia develops. (medscape.com)
  • Some intracellular bacteria, in particular Rickettsia , are introduced directly into the bloodstream by insect bites from where they have ready access to internal tissues. (oncohemakey.com)
  • R prowazekii is also thought to be transmitted by fleas associated with flying squirrels and their nesting material, by inhaling dried louse feces, or by rubbing Rickettsia -containing louse feces inadvertently into eyes, mucous membranes, or in insect bite-associated wounds. (medscape.com)
  • when the host scratches the site, the lice are crushed, and the Rickettsia- laden excrement is inoculated into the bite wound. (medscape.com)
  • 2] The flying squirrel acts as the host for R prowazekii, and transmission to humans is believed to occur via squirrel fleas or lice. (medscape.com)
  • Intracellular bacteria live inside host cells for most of their lives. (oncohemakey.com)
  • Most intracellular bacteria, however, enter the host through the mucosa. (oncohemakey.com)
  • Other opportunistic pathogens with an intracellular lifestyle that are relevant for human health include Legionella pneumophila (Legionnaires disease) and Ehrlichia (ehrlichiosis). (oncohemakey.com)
  • A Rickettsia- harboring louse bites a human to engage in a blood meal and causes a pruritic reaction on the host's skin. (medscape.com)