• The research in the Division of Microbiology & Parasitology comprises a wide range of topics including: bacterial motility and flagellar biogenesis, mechanisms of entry of bacteria into mammalian cells, bacterial toxin export and multi-drug efflux, regulation of gene expression during host-pathogen interaction, transmission, cell-cycle dynamics and virulence mechanisms in malaria parasites, host modulation by parasitic organisms and dynamics of parasitic worm infection in human populations. (cam.ac.uk)
  • Chlamydia is the most common bacterial sexually transmitted disease in the country. (virtualpsychcentre.com)
  • Bacterial infections include chlamydia, gonorrhea, and syphilis. (virtualpsychcentre.com)
  • Although the bacterial translocase has been characterized in other intercellular pathogens such as Chlamydia trachomatis and Rickettsia prowazeki, this is the first characterization of an ATP/ADP translocases in an obligate-intracellular plant pathogen and, given the conservation of the ATP uptake mechanism, may represent an evolutionary link between plant and animal pathogens. (usda.gov)
  • Chlamydia trachomatis, commonly known as chlamydia, is one of four bacterial species in the genus Chlamydia. (cupidshealth.com)
  • Genetic disruption of ct622 expression resulted in a strong bacterial growth defect, which was due to deficiencies in proliferation and in the generation of infectious bacteria. (hal.science)
  • He also performed PACE2C (GENPROBE) molecular screening and confirmation tests for intracellular obligate bacterial ribosomal RNA detection in sexually transmitted diseases (STD) such as Chlamydia Trachomatis and Neisseria Gonorrhoea. (sivams.com)
  • Here we investigated the link between cellular cholesterol and L. pneumophila intracellular replication and discovered that disruption of cholesterol biosynthesis or cholesterol trafficking lowered bacterial replication in infected cells. (microbialcell.com)
  • Often starting as a phagosome in the endocytic compartment, these bacteria-occupied vacuoles transition into organelles with novel molecular features via remodeling of host proteins and lipids through the highly coordinated actions of bacterial factors [3] [5] . (microbialcell.com)
  • Chlamydia is a bacterial infection, so you need to take antibiotics to cure it. (chlamydiaexplained.com)
  • Scientists studying pathogens such as Chlamydia , Legionella , and Listeria get a master class in how to control the internal workings of mammalian cells. (the-scientist.com)
  • And she gained a new appreciation for the myriad other types of intracellular bacteria, a diverse group that includes many medically significant pathogens such as Salmonella , Listeria, and Chlamydia , as well as the causative agents of tuberculosis and leprosy. (the-scientist.com)
  • Obligate intracellular pathogens will often have reduced genomes compared to the facultative variety, a genetic tendency that is reflective of their more limited lifestyle. (the-scientist.com)
  • The family of Chlamydiaceae comprises 3 pathogens that can infect humans: Chlamydia trachomatis, Chlamydia psittaci, and Chlamydia pneumoniae. (lecturio.com)
  • therefore, host lipids and their biosynthesis pathways have emerged as critical regulators of intracellular replication for vacuolar pathogens both as organelle membrane building blocks as well as nutrients [8] [9] . (microbialcell.com)
  • Many intracellular pathogens rely on host cell membrane compartments for their survival. (pasteur.fr)
  • They include the genera Chlamydia (of which the type species is Chlamydia trachomatis) and Chlamydophila (eg, Chlamydophila pneumoniae and Chlamydophila psittaci). (virtualpsychcentre.com)
  • Three species of Chlamydia are known to be pathogenic to humans including Chlamydia trachomatis ( C. trachomatis ), Chlamydia pneumoniae ( C. pneumoniae ) and Chlamydia psittaci ( C. psittaci ). (thenativeantigencompany.com)
  • Chlamydia psittaci is a bacterium that can be transmitted from pet birds to humans. (cdc.gov)
  • Chlamydia (C.) psittaci , the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. (biomedcentral.com)
  • Chlamydia (C.) psittaci is known as the etiological agent of avian chlamydiosis and human psittacosis [ 1 ]. (biomedcentral.com)
  • Like other chlamydiae, C. psittaci can also cause asymptomatic infections. (biomedcentral.com)
  • Like all chlamydial organisms, C. psittaci is an obligate intracellular bacterium distinguished by a biphasic developmental cycle comprising extracellular and intracellular stages. (biomedcentral.com)
  • Recently Chlamydia psittaci has been identified in Ocular Adnexa MALT lymphomas, with variable frequence dependently from geographic areas. (biomedcentral.com)
  • Moreover Chlamydia psittaci could promote chromosomal aberration either through genetic instability as a consequence of induced proliferation and probably through DNA oxidative damage. (biomedcentral.com)
  • In this review we analyse the most relevant features of Ocular adnexa MALT lymphomas, underlining specific biological characteristics mainly related to the potential role of Chlamydia psittaci in lymphomagenesis. (biomedcentral.com)
  • C erence strains and 68 geographically diverse clinical iso- hlamydia trachomatis , a bacterium that can infect both lates, identified 44 MLST sequence types (STs), compared men and women, is most commonly sexually trans- with only 20 ompA genotypes ( 11 ). (cdc.gov)
  • Most C. trachomatis strains have a multicopy extrachromosomal cryptic plasmid, which is widely used as the target for PCR testing. (roboscreen.com)
  • Lymphogranuloma Venereum (LGV) Lymphogranuloma venereum (LGV) is a disease caused by 3 unique strains of Chlamydia trachomatis and characterized by a small, often asymptomatic skin lesion, followed by regional lymphadenopathy. (msdmanuals.com)
  • Chlamydia trachomatis strains are divided into three biovars, which are further divided into fifteen serovars A, B, Ba, serovars C-K and serovars L1-L3. (thenativeantigencompany.com)
  • Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by three strains of the bacterium chlamydia trachomatis . (diseasesdic.com)
  • Chlamydiae are small gram-negative obligate intracellular microorganisms that preferentially infect squamocolumnar epithelial cells. (virtualpsychcentre.com)
  • In 10% of cases, the bacterium can infect the upper genital tract leading to pelvic inflammatory disease, scarring of the Fallopian tubes, ectopic pregnancies and infertility. (thenativeantigencompany.com)
  • Chlamydia can infect both men and women and can affect various parts of the body, including the cervix, urethra, anus, throat, and eyes. (drvikram.com)
  • It is an obligate intracellular parasite, for which humans are the only host [1]. (roboscreen.com)
  • The origins of both sexually transmitted and ocular C. trachomatis are unclear, but it seems likely that they evolved with humans and shared a common ancestor with environmental chlamydiae some 700 million years ago. (virtualpsychcentre.com)
  • Chlamydia trachomatis is a gram-negative, obligate intracellular bacterium that infects humans. (drvikram.com)
  • Infected birds shed the bacteria through feces and nasal discharges, and humans become infected from exposure to these materials. (cdc.gov)
  • A putative ATP/ADP translocase was uncovered during the genomic sequencing of the intracellular plant pathogen, Candidatus Liberibacter asiaticus (Las), the causal agent of citrus huanglongbing. (usda.gov)
  • As some C. trachomatis isolates are reported not to carry cryptic plasmid or have deletion(s) in it [7], "RealLine Chlamydia trachomatis/ Neisseria gonorrhoeae" assay kit detects two DNA fragments from gyrA gene and cryptic plasmid, specific to C. trachomatis species. (roboscreen.com)
  • Three species of Chlamydia cause human disease, including sexually transmitted infections and respiratory infections. (msdmanuals.com)
  • Here we identify SNARE-like motifs in the inclusion protein IncA, which are conserved among most Chlamydia species. (pasteur.fr)
  • This ability to import ATP directly allows bacteria that posses this enzyme to act as "energy parasites" and uptake ATP produced by their hosts. (usda.gov)
  • Neonates born of infected mothers can develop inclusion conjunctivitis, nasopharyngeal infections and pneumonia due to C. trachomatis [5]. (roboscreen.com)
  • C. trachomatis can also be transmitted to babies born to infected untreated mothers during childbirth, causing conjunctivitis or pneumonia. (thenativeantigencompany.com)
  • Chlamydia can cause eye infections and pneumonia in newborns. (chlamydiaexplained.com)
  • Microscopy analyses indicate that cholesterol regulates a step in L. pneumophila intracellular lifecycle that occurs after bacteria begin to replicate within an established intracellular niche. (microbialcell.com)
  • The obligate intracellular bacteria Chlamydia replicate within an intracellular vacuole, termed an inclusion. (pasteur.fr)
  • One membrane component that is often subverted by vacuolar bacteria is cholesterol - an abundant lipid that mammalian cells produce de novo at the endoplasmic reticulum (ER) or acquire exogenously from serum-derived lipoprotein carriers. (microbialcell.com)
  • This is the most common type of chlamydia that affects the genital tract, including the cervix, urethra, anus, and throat. (drvikram.com)
  • Chlamydia can be diagnosed through a simple test that involves collecting a urine sample or swab from the cervix, urethra, anus, or throat. (drvikram.com)
  • For Mukherjee, the paper was a revelation: not only did it identify the fastest way yet to target Golgi biology, it suggested that scientists could use intracellular bacteria "as a lens to understand basic processes inside the cell. (the-scientist.com)
  • Research on how intracellular bacteria take control of their hosts is not only informing scientists about how these microbes cause disease, but revealing secrets of mammalian biology, says Mukherjee, who now heads up a lab at the University of California (UC), San Francisco. (the-scientist.com)
  • Studying the intracellular biology of the obligate intracellular bacterium Chlamydia trachomatis . (cam.ac.uk)
  • Chlamydia cell biology and pathogenesis. (thenativeantigencompany.com)
  • Chlamydiae are one of the commonest causes of sexually transmitted diseases (STDs) and if left untreated may cause infertility in women. (up.ac.za)
  • We show that CT622 is translocated into the host cytoplasm via type three secretion throughout the developmental cycle of the bacteria. (hal.science)
  • Chlamydia trachomatis is a type of bacteria that can cause sexually transmitted infections (STIs) in both men and women. (drvikram.com)
  • In addition, Easwara holds significant responsibility and experience in serological diagnostics, which includes STD Syphilis for Treponima Pallidum spirochete bacterium tests by Rapid Plasma Reagin (RPR), Venereal Disease Antigen Test (VDRL), Immuno florescence test FTA , Cr. (sivams.com)
  • The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. (analesdepediatria.org)
  • But new research suggests that for some people, curing chlamydia doesn't prevent reinfection, even if they're not exposed to it again . (virtualpsychcentre.com)
  • After chlamydia treatment, boosting your sexual health and minimizing the number of persons you have unprotected intercourse with, is vital to prevent reinfection. (chlamydiaexplained.com)
  • The young women have the highest prevalence of genitourinary C. trachomatis infections. (roboscreen.com)
  • RealLine Chlamydia trachomatis / Neisseria gonorrhoeae" assay kit detects a part of PivNG (pilin gene inverting protein homolog) gene sequence, specific to N. gonorrhoeae . (roboscreen.com)
  • Using the amino acid sequence from the Las encoded translocase, a homologous protein was identified in Ca. Liberibacter solanacearum (Lso), the bacterium associated with zebra chip disease. (usda.gov)
  • CT622 is abundant in the infectious form of the bacteria, in which it associates with CT635, a putative novel chaperone protein. (hal.science)
  • Our results converge to identify CT622 as a secreted protein that plays multiple and crucial roles in the initiation and support of the C. trachomatis growth cycle. (hal.science)
  • Chlamydia can also cause conjunctivitis (pink eye) if the eyes are infected during sexual contact. (drvikram.com)
  • The bacterium quickly begins manipulating interactions between host intracellular trafficking and the inclusion interface, diverging from the endocytic pathway and escaping lysosomal fusion. (hal.science)
  • So-called facultative intracellular bacteria such as Listeria monocytogenes and Legionella pneumophila do not need to be inside a host cell to reproduce. (the-scientist.com)
  • The bacteria enter through a moist mucosal surface - most commonly, the rectum or vagina, but infections in the penis or mouth are also possible. (diseasesdic.com)