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ObesityGlutamatesReceptors, GlutamateGlutamic AcidGlutamate DehydrogenaseReceptors, Metabotropic GlutamateObesity, MorbidSodium GlutamateObesity, AbdominalAmino Acid Transport System X-AGGlutamate SynthasePediatric ObesityGlutamate Plasma Membrane Transport ProteinsReceptor, Metabotropic Glutamate 5Body Mass IndexVesicular Glutamate Transport ProteinsExcitatory Amino Acid AntagonistsExcitatory Amino Acid Transporter 2Vesicular Glutamate Transport Protein 2Vesicular Glutamate Transport Protein 1Receptors, AMPAExcitatory Amino Acid AgonistsReceptors, N-Methyl-D-AspartateExcitatory Amino Acid Transporter 1Glutamate DecarboxylaseAspartic AcidOverweightGlutamineReceptors, Ionotropic GlutamateExcitatory Amino Acid Transporter 3Kainic AcidNeuronsRats, Sprague-DawleyGlutamate Dehydrogenase (NADP+)Body WeightAdipose TissueSynaptic TransmissionHippocampusLeptinN-MethylaspartateReceptors, Kainic AcidRisk FactorsInsulin Resistancealpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCycloleucineSynapsesAmino Acid Transport Systems, AcidicPrevalenceExcitatory Postsynaptic PotentialsQuisqualic Acidgamma-Aminobutyric AcidAstrocytesDiet6-Cyano-7-nitroquinoxaline-2,3-dioneEnergy MetabolismWeight LossAnti-Obesity AgentsPatch-Clamp TechniquesAdiposityRats, WistarKetoglutaric AcidsDizocilpine MaleateGlutamate-Ammonia LigaseMice, Inbred C57BLWaist CircumferenceQuinoxalinesWeight GainMicrodialysisAmino Acids2-Amino-5-phosphonovalerateInsulinMetabolic Syndrome XCross-Sectional StudiesDietary FatsCerebral CortexNeurotransmitter AgentsCells, CulturedPresynaptic TerminalsDiabetes Mellitus, Type 2BrainTime FactorsEatingThinnessAminobutyratesMotor ActivityObesity Hypoventilation SyndromeMice, ObeseBody CompositionBlood GlucoseWaist-Hip RatioSynaptosomesExcitatory Amino AcidsGlutaminaseAmino Acid Transport System y+Feeding BehaviorAnthropometryKineticsCalciumHyperphagiaNeurotoxins
Monosodium L-glutamateSodiumFree glutamateRatsEpidemicFlavorAnti-obesityAmino acidsType 2 diabetRisk of obesityExcitotoxinsExcitatory neurotransmitterInsulinOverweight and ObesityUmamiAspartameCardiovascularDiabetes and obesityManagement of obesityPrevalenceMetabolic syndromeChildhood obesityOnsetPhenotypeMetabolismCommonlyNaturallyFoodIngestionImbalanceImpactsReproductiveRenalTriggersSocioeconomicCausalAmountsInterventionsBehavioralMicrobiomeProteinAppetiteBrainExcessiveAffectsDepressionFoodsHealthyLiverDiseaseHighHealthBodies
Monosodium L-glutamate1
  • It is known that rats treated, at neonatal age, with monosodium L-glutamate (MSG) develop neuroendocrine and metabolic abnormalities, resulting in a phenotype of hypothalamic obesity, characterized by increased adiposity, corticosteronemia and leptinemia. (nel.edu)
Sodium8
Free glutamate2
  • MfG AND OBESITY Without MfG (manufactured free glutamate, also called MSG), processed food wouldn't sell-and there would be no obesity epidemic. (westonaprice.org)
  • Excess free glutamate can, as argued by neuroscientists, lead to many disease states. (ubc.ca)
Rats5
  • Fenugreek Seed Extract Prevents Fat Deposition in Monosodium Glutamate (MSG)-Obese Rats. (greenmedinfo.com)
  • Aim: To evaluate the preventive effects of an aqueous extract of Trigonella foenum-graecum seeds (AqE-TFG) on fat deposition and dyslipidemia in monosodium glutamate (MSG)-obese rats. (greenmedinfo.com)
  • and b) recovery of hypercorticosteronemia in, 35 day-AE, MSG rats fully restored this phenotype of hypothalamic obesity. (nel.edu)
  • When rats were given MSG laden food they ate more of it, linking this "flavor enhancer" to obesity. (foodbabe.com)
  • An international study published recently in the journal Brain and led by a research team from Lund University in collaboration with University of Rome La Sapeinza and Washington University at St. Louis, shows promising results in mice and rats that were treated with a class of substances that inhibit the metabotropic glutamate receptor (mGluR5), a receptor that regulates communication in the brain's nerve cell network. (lu.se)
Epidemic6
  • According to the World Health Organization, an escalating global epidemic of obesity and overweight is taking over many countries. (naturalnews.com)
  • Natural News) Obesity has become a global epidemic. (naturalnews.com)
  • Obesity is an epidemic health problem that is linked to many medical conditions. (naturalnews.com)
  • The relevance of human obesity to Olney's work is evidenced by the onset of what is now called "the obesity epidemic," which manifested after 1957, when virtually unlimited amounts of MfG because available, accessible and widely used in processed and ultra-processed food. (truthinlabeling.org)
  • The "obesity epidemic" is a global health concern, with more than a billion people affected by obesity and many more overweight. (scitechdaily.com)
  • I became mysteriously, seriously ill and learned of my own allergies in 1981 with the US obesity/diabetes epidemic presenting by 1990 (CDC/NCHS data), with it going global with the so-called "Western Diet" ever since. (scitechdaily.com)
Flavor4
  • The flavor enhancer is only known as glutamate during this state. (naturalpedia.com)
  • An Organic Authority article cites a Japanese study demonstrating that the flavor enhancer triggered the onset of obesity and liver issues in animal models. (naturalpedia.com)
  • Monosodium glutamate (MSG) is a food flavor enhancer that can be found in many commercial foods, and it can sometimes be used as a substitute to table salt. (scielo.br)
  • Monosodium glutamate (MSG) has been used as a flavor enhancer for over a century. (ubc.ca)
Anti-obesity1
Amino acids3
  • Glutamate is essential factor in the biosynthesis of several key amino acids. (naturalpedia.com)
  • Natural News) Certain amino acids in the blood are linked to both obesity and the composition of the gut microbiome, a new study from Lund University in Sweden has revealed. (naturalnews.com)
  • Ingested glutamate is absorbed through the intestines, where it is transaminated and subsequently, metabolized by the liver leading to the release of glucose, glutamine, lactate, and other amino acids into the blood circulation. (ubc.ca)
Type 2 diabet1
  • Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
Risk of obesity1
  • Monosodium glumate increases the risk of obesity and is particularly detrimental to heart health. (naturalpedia.com)
Excitotoxins3
  • He had campaigned for greater regulation of monosodium glutamate (MSG), aspartame and other excitotoxins for over twenty years. (wikipedia.org)
  • Monosodium Glutamate (MSG) is an excitotoxins. (aboutamom.com)
  • Excitotoxins increase heart rates, cause excitability, obesity and have an adverse affect on the neuro-endocrine system. (aboutamom.com)
Excitatory neurotransmitter2
  • Excess glutamate, acting as an excitatory neurotransmitter, causes over stimulation in the brain prolonging the migraine attacks. (ubc.ca)
  • This is because the major excitatory neurotransmitter in the brain is glutamate (in very tiny, precisely controlled amounts! (hipplanet.com)
Insulin1
Overweight and Obesity1
Umami2
  • Umami is the term that identifies the taste of glutamate, and is an important taste element in foods. (msgfacts.com)
  • The umami taste has characteristic qualities that differentiate it from other tastes, including a taste-enhancing synergism between two umami compounds, L-glutamate and 5′-ribonulceotides. (msgfacts.com)
Aspartame1
  • These are chemical additions, such as MSG and aspartame (monosodium glutamate). (visitpare.com)
Cardiovascular1
Diabetes and obesity2
Management of obesity1
  • Despite steady progress in the management of obesity and its comorbidities, preventive and therapeutic strategies sometimes prove ineffective, and the long-term maintenance of weight loss is particularly challenging. (biomedcentral.com)
Prevalence3
  • The rising prevalence of obesity is likely to result from contemporary environmental and lifestyle factors such as increased access to palatable foods and reduced requirements for physical exercise, when compared with ancient hunter-gatherer lifestyles characterised by unpredictable periods of feast and famine. (hindawi.com)
  • Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. (mdpi.com)
  • In Italy, the predicted 2025 prevalence of obesity in adults has been estimated at 25.5% in men and 22.9% in women [ 2 ]. (biomedcentral.com)
Metabolic syndrome1
Childhood obesity2
  • The challenge of childhood obesity is therefore a bit different than in Western cultures ( Appetite 2007;48(3):377-383 ), as grandparents' attitudes toward food and their beliefs regarding the proper feeding of children is added to that of the child's parents. (drgourmet.com)
  • several investigations have identified breastfeeding as a protective factor for rapid infant weight gain and childhood obesity while other studies have found that this protective effect could be the result of confounding factors. (isciii.es)
Onset2
  • Monosodium glutamate triggers the onset of mental and behavioral issues. (naturalpedia.com)
  • In summary, maternal calorie restriction during the last third of pregnancy disrupts energy and metabolic hormones in milk, induces pup hyperleptinemia and hyperghrelinemia, and upregulates their hypothalamic GHSR, thus suggesting that the hypothalamic neuroendocrine circuitry may be working to address the early onset of obesity. (bvsalud.org)
Phenotype3
  • We explored whether adrenal manipulations could result in the reversion of this phenotype of hypothalamic obesity. (nel.edu)
  • In an attempt to advance our knowledge of the gut-microbiome-brain axis in the obese phenotype, we thoroughly characterized the gut microbiome signatures of obesity in a well-phenotyped Italian female cohort from the NeuroFAST and MyNewGut EU FP7 projects. (biomedcentral.com)
  • To this end, a systems biology-oriented approach that elucidates the different components of the obesity phenotype and their interactions is strongly advocated, for practical advancement in obesity research towards precision and personalized medicine [ 3 , 5 ]. (biomedcentral.com)
Metabolism2
  • Unlocking the Secrets of Brown Fat Brown fat is a 'nutrient sink' that could play an important role in glucose and even glutamate metabolism, and may offer a target for tackling obesity and potentially even cancer, suggests US research. (medscape.com)
  • The gut microbiome has recently emerged as a key modifier of human health that can affect the development and progression of obesity, largely due to its involvement in the regulation of food intake and metabolism. (biomedcentral.com)
Commonly2
  • Monosodium glutamate, more commonly referred to as MSG, is a widely used flavoring in many dishes. (naturalpedia.com)
  • For example, monosodium glutamate, or more commonly known as MSG, is added to almost every fast food and take-out meal we eat. (ubc.ca)
Naturally4
  • Glutamate occurs naturally in various food sources, especially in animal protein. (naturalpedia.com)
  • The glutamate naturally present in food and the glutamate derived from MSG are identical and our bodies treat glutamate in exactly the same way, irrespective of its source. (msgfacts.com)
  • Glutamate is naturally made in the human brain and present within the muscle, kidney, and liver. (ubc.ca)
  • The MSG manufacturers argue that processed MSG is a pure salt exactly the same as the glutamate in our bodies, whereas, the MSG antagonists argue that processed MSG is impure and also contains a different isomerism, a mirror image of glutamate from the ones naturally made in our bodies. (ubc.ca)
Food11
  • Glutamate added to food as seasoning represents a very small proportion of the glutamate we consume each day as part of a normal diet. (msgfacts.com)
  • This study investigated the effects of adding monosodium glutamate (MSG) to carrot soup with or without whey protein, on subjective appetite, food intake and satiety hormones in healthy young men. (msgfacts.com)
  • Global study reveals obesity is skyrocketing in rural areas: Is a lack of affordable, nutritious food to blame? (naturalnews.com)
  • Natural News) A landmark study led by the Imperial College London found that obesity rates are increasing faster in rural areas, and researchers believe this is due to the quality of food available outside large cities. (naturalnews.com)
  • Analogous to other addictive behaviors, neurochemical changes in those with depression and/or T2DM are thought to cause individuals to increase their food intake to obtain the same reward leading to binge eating, weight gain and obesity. (frontiersin.org)
  • We can alter this trajectory if we spread as much information about the chemicals in food as possible - specifically the chemicals that can be directly linked to obesity and cancer and that are slowly poisoning us and making us suffer as a society. (foodbabe.com)
  • The amount of Monosodium Glutamate "MSG" that can end up in your food is not regulated by the FDA and soup manufacturers like Campbell's know this. (foodbabe.com)
  • Monosodium Glutamate (MSG) is put into our food to make it taste better. (aboutamom.com)
  • Here are some views on monosodium glutamate from 7 food industry experts. (lovingpho.com)
  • In many cases the glutamate is the reason why the food is so delicious and we cannot stop eating all sorts of junk food like chips, snacks, prepared soups and more. (myamazingstuff.com)
  • Oddly, the growth in obesity and cancer during the same period of time coincided with the expansion of fast food outlets starting in the 1940s. (visitpare.com)
Ingestion1
  • Glutamate is not considered to be an essential amino acid since we are able to produce it ourselves, but constant excess of glutamate from oral ingestion could lead to other problems. (ubc.ca)
Imbalance2
  • Butyrates rectify the glutamate-GABA imbalance. (vitamindwiki.com)
  • Her work investigates neuronal serotonin and glutamate systems in relation to impulsivity and if rebalancing these systems may ultimately support behavioral recovery in disorders marked by impulsivity concomitant with an imbalance in the reward system and reactivity to reward conditioned cues (e.g., addiction, binge eating disorder, and obesity). (utmb.edu)
Impacts2
  • Monosodium glutamate impacts the muscles, the urinary tract and the reproductive health. (naturalpedia.com)
  • This is especially concerning since obesity predominantly impacts marginalized racial, ethnic, and socioeconomic groups. (scitechdaily.com)
Reproductive2
  • Monosodium glutamate causes muscle pain, urinary problems, and reproductive issues. (naturalpedia.com)
  • Olney first described that phenomenon in 1969, observing that the MSG inflicted brain damage to the arcuate nucleus of the hypothalamus was followed by gross obesity, reproductive disfunction including infertility, and behavior disorders (5). (truthinlabeling.org)
Renal1
  • Urinary kidney markers are a diverse set of analytes often used to measure many complex and serious medical conditions including: obesity, renal disease, cardiac disease, hypertension, diabetes and hepatic disease. (cdc.gov)
Triggers1
  • For example, glutamate is an excitatory amino acid neurotransmitter, that is, a chemical messenger that triggers the nerve cells to fire. (ubc.ca)
Socioeconomic1
  • Natural News) A recent study published in the journal Obesity has revealed that there is a potential link between socioeconomic status and obesity. (naturalnews.com)
Causal1
  • Mendelian randomization analyses identify bidirectional causal relationships of obesity with psychiatric disorders. (cdc.gov)
Amounts1
  • Some people will react to a meal cooked with monosodium glutamate and served with soy sauce, but will not react to lesser amounts of MfG found in some dairy products. (truthinlabeling.org)
Interventions3
  • Natural News) In this review, researchers from China investigated the potential of acupuncture alone or in combination with lifestyle interventions to treat obesity. (naturalnews.com)
  • however, there are currently no effective pharmacological interventions for obesity. (hindawi.com)
  • Subject to confirmation of the hypotheses herein generated, our work could help guide the design of microbiome-based precision interventions, aimed at rewiring microbial networks to support a healthy diet-microbiome-gut-brain axis, thus counteracting obesity and related complications. (biomedcentral.com)
Behavioral1
  • Although various environmental, biological, and behavioral factors have been implicated in obesity, few consistently effective treatments exist for the disease. (scitechdaily.com)
Microbiome1
  • However, there are still few studies that have in-depth explored the functionality of the human gut microbiome in obesity and even fewer that have examined its relationship to eating behaviors. (biomedcentral.com)
Protein1
  • Moreover, by hydrolyzing vegetable protein, glutamate becomes "free" and is able to act as a neurotransmitter. (ubc.ca)
Appetite1
  • In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity. (hindawi.com)
Brain2
Excessive1
Affects1
  • Monosodium glutamate negatively affects the respiratory tract and digestive profile. (naturalpedia.com)
Depression1
Foods1
  • Many people have problems with consuming monosodium glutamate , or MSG , in their foods. (lovingpho.com)
Healthy1
Liver1
  • In particular, obesity has been linked to increased risk of developing a wide range of non-communicable diseases, such as type 2 diabetes, fatty liver disease, hypertension, dyslipidemia, coronary heart disease, stroke, and cancer [ 3 ]. (biomedcentral.com)
Disease2
  • NaturalNews) The link between breast cancer and obesity has strengthened with two new studies showing that body mass index is correlated with the disease. (naturalnews.com)
  • Obesity is recognized as a complex, multifactorial disease that represents a major risk factor for health, with important consequences on quality of life, life expectancy and healthcare costs [ 3 ]. (biomedcentral.com)
High5
  • Recent weight-loss drugs show promise in treating obesity, but concerns include high costs, health disparities, and potential lifelong commitment. (scitechdaily.com)
  • The high levels of monosodium glutamate or MSG enhance the taste of these noodles. (healthifyme.com)
  • Research shows that high fructose corn syrup leads to metabolic disorders and obesity. (healthifyme.com)
  • It is also used for obesity, altitude sickness, aging skin, high levels of cholesterol or other fats in the blood, and many other purposes, but there is no good scientific evidence to support many of these other uses. (medlineplus.gov)
  • Alcohol use is the fourth leading cause of preventable death in the United States (after smoking, high blood pressure, and obesity). (medscape.com)
Health2
  • Obesity has become endemic in the developed world and is on its way to becoming so in developing nations, producing many health-related problems ( 2 ). (frontiersin.org)
  • Obesity and related co-morbidities represent a major health challenge nowadays, with a rapidly increasing incidence worldwide. (biomedcentral.com)
Bodies1
  • Furthermore, our bodies produce much more glutamate than we get from our diet. (msgfacts.com)