• RECENT FINDINGS: Increasing the intake of dietary polyphenols might reduce oxidative stress and inflammation and thus alleviate the risk of metabolic, endothelial, and cardiovascular disorders. (bvsalud.org)
  • The most important risk factors are diet (particularly sugar-sweetened beverage consumption), genetics, aging, sedentary behavior or low physical activity, disrupted chronobiology/sleep, mood disorders/psychotropic medication use, and excessive alcohol use. (wikipedia.org)
  • Obesity and associated metabolic disorders (e.g., cardiovascular disease and type 2 diabetes) are major public health concerns. (iasvn.org)
  • These studies demonstrate that ABHD6 plays a non-redundant enzymatic role in promoting the metabolic disorders induced by high-fat feeding, and suggest that ABHD6 inhibition may be effective in preventing obesity, nonalcoholic fatty liver disease, and type II diabetes. (lacbiosafety.org)
  • SGLT2i's cardioprotective impact is independent of its hypoglycemic effect, which is why it's been utilized to treat a range of different disorders, with obesity being the most common [ 6 , 7 ]. (biomedcentral.com)
  • Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
  • My studies show the promising potential of functional foods against life-style associated metabolic disorders. (edu.au)
  • A research review found that ginger could benefit obesity and related metabolic disorders. (medicalnewstoday.com)
  • The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. (frontiersin.org)
  • Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
  • Risk for obesity and metabolic disorders begins during perspective can inform more effective and sustainable gestation (1). (cdc.gov)
  • Feeding low-protein diets to pregnant rats produces a increased more than in children not exposed to tobacco in broad spectrum of disorders in their offspring (7): hyper- utero. (cdc.gov)
  • Another study found pregnancy has been associated with low birth weight, a that smoking during the 12 months before birth of a child marker of risk for obesity and other metabolic disorders was associated with adolescent overweight (21). (cdc.gov)
  • Other risk factors include heart disease, obesity, a family history of CKD, inherited kidney disorders, past damage to the kidneys, and older age. (cdc.gov)
  • 11]. metabolic disorders including dyslipid This was a crosssectional study. (who.int)
  • The metabolic syndrome (MetS) is a constellation of metabolic risk factors (including hypertension, dyslipidaemia, abdominal obesity and impaired glucose metabolism), which is associated with a twofold increased risk of cardiovascular disease (CVD) (Ford, 2005), and an even higher risk of T2DM (Grundy, 2008). (bhma.org)
  • Methods: This study has characterized the structural, functional, and electrical characteristics of the cardiovascular system throughout the lifespan in male and female spontaneously hypertensive rats (SHRs), a genetic model of chronic hypertension-induced cardiovascular remodeling, and age- and gender-matched normotensive controls, to determine whether ageing SHRs mimic the changes seen in ageing humans. (edu.au)
  • nonsmokers included those and hypertension, all of which are as with metabolic syndrome who were who had never smoked and those who sociated with cardiovascular disease referred to the Endocrinology Clinic of had not smoked for 5 years. (who.int)
  • To induce metabolic syndrome, young male Wistar rats were fed with a high-carbohydrate high-fat diet for 16 weeks while corn starch served as control diet. (edu.au)
  • Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
  • We extracted their altitude information from their residential addresses and determined if they had metabolic syndrome by the presence of three or more of the following components: abdominal obesity, reduced high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, elevated glucose, and high blood pressure at recruitment. (bvsalud.org)
  • Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). (wikipedia.org)
  • HPA-axis dysfunction may explain the reported risk indication of abdominal obesity to cardiovascular disease (CVD), type 2 diabetes and stroke. (wikipedia.org)
  • Meanwhile, they found that there was no significant difference between the weight loss effects of these diets, but that the Mediterranean diet, when consumed in combination with exercise, lead to the maximum loss in abdominal obesity or excess fat around the stomach area. (ndtv.com)
  • From the abstract: ' In our study, all of the 203 young adults with abdominal obesity had some rare variant in the genes associated with obesity. (cdc.gov)
  • The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity. (cdc.gov)
  • In addition to these, it was suggested that chronic low-grade inflammation and oxidative stress are the underlying mechanisms of PCOS-mediated metabolic consequences and might trigger cardio-metabolic risk in women with PCOS. (bvsalud.org)
  • citation needed] Recent research indicates prolonged chronic stress can contribute to metabolic syndrome by disrupting the hormonal balance of the hypothalamic-pituitary-adrenal axis (HPA-axis). (wikipedia.org)
  • Similarly, a neutral, peripherally restricted CB 1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. (iasvn.org)
  • Infusion of sodium HCO 3 is not indicated for chronic hypoventilation syndromes. (medscape.com)
  • One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
  • In premenopausal women, ovarian hyperandrogenism likely increases risk by inducing chronic anovulation and progesterone deficiency. (scienceopen.com)
  • The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (scienceopen.com)
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Obesity has reached epidemic proportions globally and is a major contributor to the global burden of chronic diseases. (researchpaper.sbs)
  • Some researchers believe that essential oils may also help counteract more than 20 chronic diseases and health conditions that obesity may contribute to. (medicalnewstoday.com)
  • Alterations in gut microbiota composition are associated with metabolic syndrome and chronic inflammatory diseases such as inflammatory bowel disease. (nature.com)
  • Panchakarma is used in Ayurvedic medicine to treat almost all diseases, particularly those that are chronic, metabolic or stress-related in origin. (encyclopedia.com)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
  • With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress. (biomedcentral.com)
  • Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
  • Its ability to provide relief to chronic pain sufferers, to induce an increase in appetite, to alleviate nausea, and to ease anxiety are only some of the common uses for hemp. (medscape.com)
  • Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
  • At this point, there is substantial evidence to suggest that various non-nutrient food components modulate cardio-metabolic health together with inflammation and oxidative stress. (bvsalud.org)
  • The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. (biomedcentral.com)
  • Furthermore, the independent association of systemic adipokine levels with knee osteoarthritis severity supports a role for adipose-associated inflammation in the molecular pathogenesis of obesity-induced osteoarthritis. (biomedcentral.com)
  • Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)
  • Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
  • They found that MSG induces obesity and diabetes by causing liver inflammation and the accumulation of fats in mice. (msg.news)
  • Animals that consumed MSG demonstrated signs of nonalcoholic steatohepatitis, a type of fat accumulation in the liver linked to metabolic syndrome - a precursor to diabetes - along with inflammation. (msg.news)
  • Diet is important in the development of metabolic syndrome assisted by increased oxidative stress and inflammation. (edu.au)
  • Such diseases include inflammatory bowel diseases (IBD) and diseases characterized by low-grade inflammation, such as metabolic syndrome. (nature.com)
  • ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)
  • However, adipose tissue growth also has limits, and the excess of energy induces inflammation, helped by the ineffective intervention of the immune system. (medscape.com)
  • Inflammation is one of Sina Hospital, Tabriz from April 2007 tional intake data were collected using the features of metabolic syndrome, to April 2008. (who.int)
  • The mechanisms of the complex pathways of metabolic syndrome are under investigation. (wikipedia.org)
  • Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. (iasvn.org)
  • 2010). However, the physiological substrates and products for these lipid metabolizing enzymes and their broader role in metabolic pathways remain largely uncharacterized. (lacbiosafety.org)
  • GO and KEGG analysis showed that genes regulated by E2 and/or HFD are mainly responsible for immune response, inflammatory response and metabolic pathways. (scienceopen.com)
  • Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. (springer.com)
  • From the abstract: ' In this Review, we discuss advances in the genetics of obesity from the past decade-with emphasis on developments from the past 5 years-with a focus on metabolic consequences, and their potential implications for precision management of the disease. (cdc.gov)
  • India and many other countries in South-East Asia are currently going through the so-called nutrition transition which is associated with a change in the structure of the diet and rapid increase in the prevalence of obesity. (researchpaper.sbs)
  • PURPOSE OF REVIEW: Polycystic ovarian syndrome (PCOS) is a common endocrine disease characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology and causing various reproductive, metabolic, cardiovascular, oncological, and psychological complications. (bvsalud.org)
  • Simple measures of gestational weight gain provide insufficient detail of the underlying physiological and metabolic adaptations occurring in pregnancy, and should be complemented by measures of body composition, metabolic and endocrine responses. (karger.com)
  • The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
  • She is also an active researcher and her interests include endocrine physiology and endocrine and metabolic diseases of dogs and cats. (rossu.edu)
  • therefore, here, we evaluated the effect of IFC-305 in an experimental model of metabolic syndrome in rats induced by a high-fat diet and 10% sucrose in drinking water for 18 weeks. (bvsalud.org)
  • In the experimental model, increases in body mass, serum triglycerides and proinflammatory cytokines were induced in rats, and the adenosine derivative significantly prevented these changes. (bvsalud.org)
  • In highii carbohydrate, high-fat fed rats, leuprolide treatment worsened metabolic syndrome symptoms and cardiovascular function, and orchidectomy produced greater responses. (edu.au)
  • This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
  • The increased 11β-HSD1 activity in adipose tissue in obese rats and in some but not all studies of obese humans causes visceral obesity and its metabolic consequences [ 3 ]. (biomedcentral.com)
  • The key sign of metabolic syndrome is central obesity, also known as visceral, male-pattern or apple-shaped adiposity. (wikipedia.org)
  • In the CENTRAL 18-month intervention trial, a Mediterranean/low-carbohydrate diet induced a greater decrease in hepatic fat content than a low-fat diet, conferring beneficial health effects that were beyond the favorable effects of visceral fat loss. (ndtv.com)
  • This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
  • Correlation studies cannot distinguish between cause and effect relationships between whether low testosterone induces visceral fat deposition or whether a large visceral fat deposit leads to low testosterone levels. (bhma.org)
  • Diagnosis of metabolic a 24hour dietary recall for 3 days (2 which originates from excess visceral syndrome was based on World Health workdays and 1 holiday) by a trained adipose tissue [2]. (who.int)
  • Further, waste products from coffee production are a potential source for new interventions in diet-induced cardiovascular and metabolic diseases. (edu.au)
  • They've led to an associated increase in so-called "diseases of civilization," including cardiovascular disease, obesity , and a variety of metabolic diseases and cancers. (medscape.com)
  • Therefore, it has been suggested that the modulation of gut microbiota could be a reliable tool to prevent metabolic and inflammatory diseases. (springer.com)
  • Nowadays, there are an increasing number of studies related to the effects of dietary polyphenols on PCOS and its accompanying cardio-metabolic disturbances. (bvsalud.org)
  • Currently, there is a cumulative number of studies connected to the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances. (bvsalud.org)
  • However, there is a lack of knowledge in combining the probable mechanisms of dietary polyphenols on PCOS and related cardio-metabolic consequences. (bvsalud.org)
  • Thus, the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances need to be discussed and evaluated with underlying mechanisms. (bvsalud.org)
  • Consequently, this review was written to reveal the potential effects of dietary polyphenols on PCOS and related metabolic and cardiovascular risk factors in all their aspects. (bvsalud.org)
  • High susceptibility to dietary obesity was associated with increased osteoarthritic changes in the knee and impaired musculoskeletal force generation and motor function compared with controls. (biomedcentral.com)
  • Aims: In this parallel randomized controlled trial study, an energy-restricted healthy diet and two dietary challenges were used to assess the effect of weight loss on phenotypic flexibility. (westminster.ac.uk)
  • Weight loss correlated with the magnitude of changes in metabolic responses to the dietary challenges. (westminster.ac.uk)
  • Conclusion: Application of dietary challenges increased sensitivity to detect metabolic response to weight loss intervention. (westminster.ac.uk)
  • The objectives were to find the prevalence of overweight and obesity in the urban population of Jamnagar and to explore the effect of dietary factors on the weight status of the people. (researchpaper.sbs)
  • Total calorie intake as well as composition of diet was the important dietary factor affecting weight gain. (researchpaper.sbs)
  • The Dietary Guidelines for Americans recommend a Mediterranean diet for promoting health and minimizing disease. (medscape.com)
  • Conversely, dietary changes could be more effective to induce lasting changes in the composition of gut microbiota. (springer.com)
  • Within this context, the prebiotic effect of dietary fibres might be a feasible strategy to prevent T2D, through the modulation of metabolic response. (springer.com)
  • This review is focused on the fate of dietary glucose under conditions of chronically high energy (largely fat) intake, evolving into the metabolic syndrome. (medscape.com)
  • We are not prepared for excess dietary energy, our main defenses being decreased food intake and increased energy expenditure, largely enhanced metabolic activity and thermogenesis. (medscape.com)
  • Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. (medscape.com)
  • Dietary transition refers to consuming foods with high energy density and low nutritional value, which are contributing causes of overweight, obesity, and NCDs 3 . (bvsalud.org)
  • In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. (hindawi.com)
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
  • To investigate the mechanism of cardiac injury induced by obesity and the cardioprotective effect of empagliflozin, we employed proteomic techniques to examine cardiac protein expression in obese mice and the changes in protein expression after empagliflozin intervention. (biomedcentral.com)
  • A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. (oregonstate.edu)
  • Therefore, GF male Tac:SW mice developed several detrimental effects of obesity and MetS from a high-fat, calorie dense diet. (oregonstate.edu)
  • Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)
  • With reduced levels of daily physical activity and diets high in refined carbohydrate, we are seeing a rise in the rate of metabolic syndrome (MetS) among men globally. (bhma.org)
  • There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
  • There is evidence that the endothelial dysfunction induced by hyperglycemia is associated with the enhanced nitrooxidative stress. (hindawi.com)
  • It also inhibits vascular endothelial growth factor (VEGF) release, which further induces angiogenesis. (straitsresearch.com)
  • We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
  • In addition to their marginal effects, many genetic factors are thought to alter susceptibility by environmental factors, such as high-fat diet (HFD), accelerating the development of T2DM 3 . (researchsquare.com)
  • Such complex interactions between various genetic risk factor combinations and specific diet or lifestyle characteristics make clinical studies on the effects of AA on T2DM difficult to design. (researchsquare.com)
  • In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
  • Together, these data indicate that glucocorticoids recruit peripheral endocannabinoid signaling to promote metabolic dysregulation, with hepatic endocannabinoid signaling being especially important for changes in lipid metabolism. (iasvn.org)
  • We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
  • AA plays an important role in improving WAT development and HFD-induced metabolic dysregulation in GLUT10 G128E mice. (researchsquare.com)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • Approximately 80% of patients with metabolic syndrome have some degree of fatty liver disease. (bvsalud.org)
  • CB 1 R −/− mice are also protected against the CORT-induced increase in ( G ) liver weight, ( H ) plasma cholesterol, ( I ) alanine aminotransferase (ALT), ( J ) triglycerides, and ( K ) hepatic triglycerides. (iasvn.org)
  • A study has showed one of the most ideal diets to reduce fat accumulation in the liver is the Mediterranean diet. (ndtv.com)
  • Fatty liver disease is on the rise and the study has indicated that one of the most ideal diets to reduce fat accumulation in the liver is Mediterranean diet, which is also low in carbs and rich in fresh fruits and vegetables, as well as healthy sources of fats like olive oil, seeds and nuts. (ndtv.com)
  • The researchers found that Mediterranean diet significantly reduced hepatic fat- the fat that accumulates around the liver, pancreas and the heart. (ndtv.com)
  • 0.0001) and induced significant reduction in total and regional adipose tissue as well as ectopic fat in the liver. (westminster.ac.uk)
  • [ 1 ] Tripodi et al reported that in nonalcoholic fatty liver disease (NAFLD), a procoagulant imbalance progresses from steatosis to metabolic cirrhosis, which may be caused by an increase in factor VIII and a reduction of protein C. (medscape.com)
  • Many mechanisms of ethanol-induced fatty liver have been proposed. (medscape.com)
  • The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver injury in mice. (medscape.com)
  • This may be related to mitochondrial proteins that regulate apoptosis and necrosis and that are shown to be induced in mouse fatty liver models. (medscape.com)
  • The condition most commonly associated with fatty liver disease is metabolic syndrome. (medscape.com)
  • Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. (mdpi.com)
  • A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. (cassiopaea.org)
  • In particular, widely used beverage coffee showed relevant actions against most signs of metabolic syndrome. (edu.au)
  • The prevalence of overweight and obesity was found to be 22.04% and 5.20%, respectively. (researchpaper.sbs)
  • However, one study identified a population of African children who had a high prevalence of overweight/obesity at the time of arrival, 5 and other data have identified overweight/obesity and associated medical consequences in the newly arriving Iraqi population. (cdc.gov)
  • 10 This trend may reflect the overall rising global prevalence of overweight/obesity and/or the changing socioeconomic status of newly arriving refugees. (cdc.gov)
  • We carried out a cross-sectional study of 195 patients with metabolic syndrome. (who.int)
  • central regulators of metabolism and adipogenesis). (iasvn.org)
  • The specific mechanisms by which GCs modulate these processes remain largely unknown, but GCs increase production of endocannabinoids-potent central and peripheral regulators of appetite, energy balance, and metabolism. (iasvn.org)
  • 2010). Most recently, studies in cell and animal models have revealed important functions for ABHD proteins in glycerophospholipid metabolism, lipid transmission transduction, and metabolic disease (Long et al. (lacbiosafety.org)
  • ABHD5, also known as CGI-58, has been analyzed quite extensively due to its important role in triacylglycerol (TAG) metabolism, lipid signaling, and genetic association with the human disease YM-90709 Chanarin-Dorfman Syndrome (CDS) (Lefevre et al. (lacbiosafety.org)
  • 2009). Given ABHD5's clear role in nutrient metabolism and lipid transmission transduction, we aimed to test whether the closely related enzyme ABHD6 might play a similar role in lipid signaling and metabolic disease. (lacbiosafety.org)
  • Empagliflozin reduces body weight, improves glucose and lipid metabolism, alleviates obesity-induced cardiac ventricular wall thickening, and lowers cardiac tissue collagen. (biomedcentral.com)
  • Further examination of DEPs revealed that following empagliflozin treatment, the expressions of Apoe, Apoc1, Saa2, Apoa2, and Pon1 altered dramatically, suggesting that these proteins may be the main proteins that empagliflozin uses to treat obesity-induced aberrant lipid metabolism. (biomedcentral.com)
  • Empagliflozin may protect the heart by altering the expression of genes including Apoe, Apoc1, Saa2, Apoa2, and Pon1, which are all involved in lipid metabolism disturbance in obesity. (biomedcentral.com)
  • Therefore, we first used a genetically predisposed mouse model to investigate whether AA effects on metabolism might be influenced by particular genetic and diet. (researchsquare.com)
  • Background: The capacity of an individual to respond to change in food intake so that postprandial metabolic perturbations are resolved, and metabolism returns to its pre-prandial state, is called phenotypic flexibility. (westminster.ac.uk)
  • Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
  • While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
  • Our findings provide novel insights into the mechanism underlying αSyn-induced neuronal pathology, and they suggest that ClpP might be a useful therapeutic target for PD and other synucleinopathies. (springer.com)
  • The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
  • Plant-based diets provide potential therapeutic approaches to metabolic syndrome. (edu.au)
  • Secondary causes of obesity are often sought but rarely found, and few can be addressed by successful therapeutic interventions. (cdc.gov)
  • In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. (biomedcentral.com)
  • Female C57BL/6J mice were fed either a 10% kcal fat or a 45% kcal fat diet from 9 to 54 weeks of age. (biomedcentral.com)
  • We examined the effect of obesity on serological markers and heart function in obese mice treated with or without empagliflozin and used proteomic techniques to investigate alterations in cardiac protein expression. (biomedcentral.com)
  • Here we show that AA has greater metabolic impacts on HFD-fed GLUT10 G128E mice than HFD-fed WT mice. (researchsquare.com)
  • We show, in mice, that repeated injection of flagellin elicits increases in fecal anti-flagellin IgA and alterations in microbiota composition, reduces fecal flagellin concentration, prevents microbiota encroachment, protects against IL-10 deficiency-induced colitis, and ameliorates diet-induced obesity. (nature.com)
  • CB 1 R signaling is required for GC-mediated metabolic abnormalities. (iasvn.org)
  • Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. (who.int)
  • Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
  • This ability may relate to health status better than metabolic markers in a fasting state. (westminster.ac.uk)
  • Through positive changes like awareness of portions or examining the reasons for food cravings, mindfulness can lead to weight loss or other improved markers of metabolic health. (signos.com)
  • In this project, I used a diet-induced obese rat model for examining the nutraceutical effects of some potential functional foods. (edu.au)
  • Early Career Author Prize 2017 from Experimental Physiology to the first author (Marcus Machado) - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
  • Editor's choice in Experimental Physiology - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
  • This comprises a diet that's high in fiber and low in animal protein and saturated fat, and is characterized by a higher ingestion of vegetables, fruits, and healthy fat and a lower intake of red meat and dairy. (medscape.com)
  • Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)
  • the obvious preventive strategy against the calcium-alkali syndrome is to limit the intake of calcium to no more than 1.2 to 1.5 grams per day. (qualitycounts.com)
  • There are several factors that act and interact in the regulation of food intake and energy deposition, contributing to the development and maintenance of obesity, including: endocrinal, adipose, intestinal and neuronal factors 2 . (bvsalud.org)
  • The workshop provided insights of primary measurements for the characterization of sustainable nutritional intervention strategies in the mother, infant and child for preventing obesity in later life. (karger.com)
  • Large inter-individual variation was observed across a wide range of measurements allowing the identification of distinct responses to the weight loss intervention, and mechanistic insight into the metabolic response to weight loss. (westminster.ac.uk)
  • Gestational Period become focal points for obesity prevention or intervention. (cdc.gov)
  • This study was conducted to verify the responses of a multi-professional intervention on anthropometric, body composition, and food profile in adolescents with overweight or obesity. (bvsalud.org)
  • It was observed an improvement in skeletal muscle mass, resting metabolic rate, as well as the consumption of fresh foods/g and processed food/kcal after the intervention period. (bvsalud.org)
  • 2011). However, ABHD6 is ubiquitously expressed, and the biochemical and physiological functions of ABHD6 outside of the central nervous system have not been analyzed. (lacbiosafety.org)
  • Controlling for the effects of diet and percentage body fat with a multivariate model revealed a significant association between knee osteoarthritis severity and serum levels of leptin, adiponectin, and IL-1α. (biomedcentral.com)
  • Antagonizing the Leptin Receptor in Obesity. (cdc.gov)
  • Leptin was once hailed as a treatment for most cases of childhood obesity but quickly lost favor when resistance to leptin was noted. (cdc.gov)
  • Most genes causing monogenic obesity are implicated in the central energy regulatory circuits of the leptin-melanocortin pathway. (cdc.gov)
  • Esposito L, Fisher JO, childhood nutrition and obesity should be examined from Mennel a JA, Hoelscher DM, Huang TT. (cdc.gov)
  • First, prenatal and early life perspectives on nutrition and obesity from gestation to experiences influence the trajectory of weight into adult- adolescence. (cdc.gov)
  • infancy, childhood, and adolescence that may lead to Therefore, examining childhood nutrition and obesity from -- or prevent -- obesity. (cdc.gov)
  • These data further our understanding of the role of endocannabinoid signaling to promote not only diet-induced, but also, hormonal-mediated obesity and support the argument that peripheral blockade of endocannabinoid signaling could be a potential treatment for obese conditions. (iasvn.org)
  • Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
  • Herein, we describe that repeated systemic administration of purified flagellin elicits a robust anti-flagellin fecal IgA response that serves to reshape microbiota composition, reduces flagellin expression, and protects against experimental colitis and metabolic syndrome. (nature.com)
  • Against this background, several researches have been carried out to identify potential strategies to induce specific changes in the gut microbiota composition towards microbial species with high fermentative activity. (springer.com)
  • However, to date, there is no conclusive evidence to support this thesis, likely due to the lack of studies focusing primarily on the relationship between the composition of the gut microbiota and metabolic response. (springer.com)
  • These results indicate that diet-induced obesity increases the risk of symptomatic features of osteoarthritis through changes in musculoskeletal function and pain-related behaviors. (biomedcentral.com)
  • however, there is currently no comprehensive explanation for why obesity increases the risk of osteoarthritis at different sites throughout the body. (biomedcentral.com)
  • Their offspring tend to have higher birth weights and more body fat, and carry an increased risk of obesity later in life. (karger.com)
  • 11 Several factors have been identified that increase the risk of obesity among refugees, including length of stay in the host country 12 - 14 , level of acculturation to U.S. lifestyles 15 - 17 , existing cultural beliefs and values 18 , and poor quality of housing. (cdc.gov)
  • 7 - 9 Overweight and obesity are frequently assumed to be associated with assimilation to a U.S. lifestyle (increased availability of high-calorie foods, reduced physical activity), compounded by lack of nutritional education. (cdc.gov)
  • The study titled, "The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content" was published in the Journal of Hepatology and it was conducted by a team of researchers from Ben Gurion University of Negev. (ndtv.com)
  • Mediterranean diet was found to be more effective at reducing hepatic fat, as compared to all other diets with similar calorie budgets. (ndtv.com)
  • 6 Weight loss induced by diet and exercise has also been shown to be effective in resolving NASH and improving hepatic fibrosis. (xiahepublishing.com)
  • Obesity results from a combination of factors that occur exhibit low birth weight and glucose intolerance -- a mul- at different stages during a person's lifetime. (cdc.gov)
  • We know that short-chain fatty acids increase secretion of immunoglobulins, induce regulatory T-cell tissue repair, promote antimicrobial peptides and mucus production, and basically optimize intestinal function and the intestinal barrier integrity. (medscape.com)
  • Therefore, we can say that the short-chain fatty acid derivative from the intestinal microbiome does have central nervous system-related effects. (medscape.com)
  • animals had ad libitum access to food (3 % of calories from lipids, diet 4RF21 GLP, Mucedola, Italy) and water. (biomedcentral.com)
  • Present-day diets are often hyperenergetic, high on lipids, with abundant protein and limited amounts of starchy carbohydrates. (medscape.com)