AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Rats, ZuckerPeriodicals as TopicJournal Impact FactorObesityPharmacologyPharmacology, ClinicalPublishingBibliometricsJournalism, MedicalThinnessPeer Review, ResearchAuthorshipBody WeightInsulinInsulin ResistanceBlood GlucoseRats, Mutant StrainsEatingDatabases, BibliographicPublicationsAbstracting and Indexing as TopicMuscle, SkeletalAdipose TissuePhysical Conditioning, AnimalBibliography as TopicHypoglycemic AgentsThiazolidinedionesGlucosePeer ReviewBiomedical ResearchDisease Models, AnimalLiverTriglyceridesOrgan SizeThiazolesLibraries, MedicalBooksPyridoxamineLibrary Collection DevelopmentHyperinsulinismReceptors, LeptinMEDLINEGlucose Tolerance TestManuscripts as TopicDiabetes Mellitus, Type 2Book SelectionLibrary SurveysMonosaccharide Transport ProteinsResearchKidneyAccess to InformationFatty Acids, NonesterifiedHistory, 20th CenturyGlucose Transporter Type 4Lipid MetabolismLeptin2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineRNA, MessengerBlood PressureAdipose Tissue, BrownFatty AcidsConflict of InterestWritingCopyrightDiabetes Mellitus, ExperimentalHydrazinesThioctic AcidDose-Response Relationship, DrugHistory, 21st CenturyKidney CortexGlycogenReference BooksMuscle ProteinsMetabolic Syndrome XResearch ReportScientific MisconductLipidsInterlibrary LoansCannabinoid Receptor AntagonistsDiabetes MellitusFeeding BehaviorTime FactorsWeight GainChromansAllied Health OccupationsVasodilationSerial PublicationsNeuropeptide YLibraries, DigitalRetroperitoneal SpaceEvidence-Based MedicineMicrocirculationBenchmarkingReview Literature as TopicResearch DesignVasoconstrictor AgentsPubMedTerminology as TopicScienceDrug Industry
ToxicologyPhysiology and PharmacologyObesityDiabetic fatty ratsSkeletal muscleWistarBiochemistryGlucoseLeanMetabolicLipidColloid and Interface ScienceClinicalKidneyLiverInsulinCardiacExperimentalSignificantlyStudyPharmacyEthnopharmacologyCapacitySubjectsAntioxidantInternational JournalSimilarEffectsNormalBody WeightAffectsFoodHeartMedicineScientific
Toxicology2
  • This award offers an opportunity to share your research, learn from and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies and pharmaceutical companies. (hesiglobal.org)
  • An article that included best practices for use of stem cell cardiomyocytes in cardiac safety assessments was published in Regulatory Toxicology and Pharmacology . (hesiglobal.org)
Physiology and Pharmacology1
  • University of Granada researchers (from the Institute for Neuroscience of the Department of Pharmacology of the Faculty of Medicine), conducted this research in collaboration with the Clinical Trial Service of the University Hospital San Cecilio, Granada, the department of Physiology and Pharmacology of the University of Salamanca, the department of Pharmacology of the University of Jordan and the Service of Endocrinology of the Hospital Carloss III, Madrid. (sciencedaily.com)
Obesity6
  • Researchers in Spain have analyzed the effects of melatonin on obesity, dyslipidemia and high blood pressure in young diabetic obese rats. (sciencedaily.com)
  • University of Granada researchers have analyzed in young Zucker diabetic obese rats the effects of melatonin on obesity, dyslipidemia and high blood pressure associated with obesity. (sciencedaily.com)
  • International Journal of Obesity, 37, 576-583. (scirp.org)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • Bradykinin elicited substantial dilation in coronary arterioles, with a similar magnitude in obese and non-obese patients (to 10 -8 M: 55 ± 5% vs. 46 ± 5%, P = 0.20), but with significantly enhanced sensitivity in obesity (EC50: 8.2x10 -9 M vs. 1.9x10 -8 M, respectively, P = 0.03). (biomedcentral.com)
  • Despite the anticipated deleterious effects of obesity on cardiovascular outcomes, several studies have revealed that in specific clinical settings, obese patients with advanced IHD exhibit reduced morbidity and mortality compared to disease-matched lean patients. (biomedcentral.com)
Diabetic fatty rats3
  • A manuscript was submitted detailing a study investigating the effects of doxorubicin in Zucker diabetic fatty rats. (hesiglobal.org)
  • In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. (duke.edu)
  • Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes esterify FFA, store them as TG, and later oxidize them intracellularly via an 'indirect pathway' of intracellular fatty acid metabolism controlled by leptin. (duke.edu)
Skeletal muscle5
  • In vivo hyperleptinemia, induced in normal rats by adenovirus gene transfer, depleted TG content in liver, skeletal muscle, and pancreas without increasing plasma FFA or ketones, suggesting intracellular oxidation. (duke.edu)
  • Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise. (ac.ir)
  • We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK, and glucose transport activity in epitrochlearis skeletal muscle from insulin-resistant Zucker ( fa/ fa ) rats. (diabetesjournals.org)
  • Insulin-stimulated glucose transport in isolated skeletal muscle was reduced 47% in obese versus lean rats, with a parallel 42% reduction in tyrosine-associated PI 3-kinase activity. (diabetesjournals.org)
  • Contraction and hypoxia elicited normal responses for glucose transport in skeletal muscle from insulin-resistant obese rats. (diabetesjournals.org)
Wistar1
  • Wistar rats) [155], failed to influence food intake during a 1 h ad libitum feeding period, moderate to high doses of CBD (4.4 mg·kg −1 , i.p. [58]. (researchgate.net)
Biochemistry2
  • Journal of Nutritional Biochemistry, 13, 603-610. (scirp.org)
  • Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. (haus-feldmuehle.de)
Glucose1
  • In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
Lean3
  • Contraction increased AMPKα1 activity 2.3-fold in lean rats, whereas no effect was noted in obese rats. (diabetesjournals.org)
  • Hypoxia increased AMPKα1 activity to a similar extent (more than sixfold) in lean and obese rats. (diabetesjournals.org)
  • Serum oxLDL levels are decreased in both lean and obese diabetic animals treated with TZDs. (jci.org)
Metabolic2
  • Melatonin was found to be beneficial for young rats that had not still developed any metabolic or heart disease. (sciencedaily.com)
  • Filipović D, Inderhees J, Korda A, Tadić P, Schwaninger M, Inta D, Borgwardt S. Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites . (uni-luebeck.de)
Lipid2
  • Cho, K.D., Han, C.K. and Lee, B.H. (2013) Loss of Body Weight and Fat and Improved Lipid Profiles in Obese Rats Fed Apple Pomace or Apple Juice Concentrate. (scirp.org)
  • Curcumin attenuates insulin resistance and hepatic lipid accumulation in a rat model of intrauterine growth restriction through insulin signaling pathway and SREBPs. (academic-accelerator.com)
Colloid and Interface Science1
Clinical3
  • To date, at least five clinical trial reports were published in peer-reviewed journals documenting the efficacy and safety of mildronate on the treatments of angina, stroke and chronic heart failure. (wikipedia.org)
  • Journal of Clinical Medicine. (unl.pt)
  • Journal of Radiology and Clinical Imaging 3 (2020): 022-030. (fortuneonline.org)
Kidney1
Liver1
  • 05) expression of peroxisome proliferator-activated receptor α (PPARα) and expressions for Ppara and hormone sensitive lipase (HSL) in the liver of IUGR-C rats than the IUGR rats. (academic-accelerator.com)
Insulin2
  • Therefore, although obese people are predisposed to develop NAFLD, normal weight and overweight people may, through the development of insulin resistance, also show the pathogenic characteristics of NAFLD. (hindawi.com)
  • The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Cardiac2
  • The aim of this study was to evaluate the effect of 12 weeks aerobic training and oral green tea extract on cardiac caspase-3 expression in aged male rats. (ac.ir)
  • 3. Ko I-G, Kim S-E, Kim C-J, Jee Y-S. Treadmill Exercise Alleviates Aging-induced Apoptosis in Rat Cardiac Myocytes. (ac.ir)
Experimental1
  • International Journal of Experimental Pathology, 96 (3). (edu.au)
Significantly2
  • Conclusion: The levels of PPAR-g in patients with type 2 Diabetes Mellitus and Obese cases are significantly lower than normal controls. (edu.pk)
  • Moreover, obese patients with or without statin exhibited significantly increased coronary dilation to bradykinin, when compared to non-obese patients without statin therapy. (biomedcentral.com)
Study2
  • Second, we consider an extension to a stochastic pharmacokinetic model in a preclinical study of nicotinic acid kinetics in obese Zucker rats. (chalmers.se)
  • Methodology: In this study, 32 aged male rats were randomly divided into 4 groups: control, exercise, supplement and exercise + supplement. (ac.ir)
Pharmacy2
Ethnopharmacology2
Capacity1
  • 2002) Comparative Content of Some Bioactive Compounds in Apples, Peaches and Pears and Their Influence on Lipids and Antioxidant Capacity in Rats. (scirp.org)
Subjects2
  • Group-1 with diagnosed type 2 diabetes mellitus, aged 40-65 years, acting as the test group, Group-2 included non-diabetic obese, and Group-3 with normal subjects. (edu.pk)
  • 2018). Eun H.K. and colleagues found that intake of 1800 mg/day of ALA led to modest weight loss in obese subjects (Koh et al . (jmedicalcasereports.org)
Antioxidant1
  • Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. (earthtokathy.com)
International Journal4
Similar1
  • In isolated, pressurized (80 mmHg) coronary arterioles of obese and non-obese patient the active (73±4 vs. 79±13 μm) and passive (111 ± 5.5 vs. 118 ± 5.0 μm) diameters were similar. (biomedcentral.com)
Effects3
  • 6. Kanter M, Aksu F, Takir M, Kostek O, Kanter B, Oymagil A. Effects of low intensity exercise against apoptosis and oxidative stress in Streptozotocin-induced diabetic rat heart. (ac.ir)
  • 2011). Bradley C. and other authors have shown in Zucker rat models that ALA has protective effects against hypercholesterolemia and the accumulation of hepatic fat in conditions of overeating and in case of genetic predisposition. (jmedicalcasereports.org)
  • Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage Mahmood S. Mozaffari, Babak Baban, Rafik Abdelsayed, Jun Yao Liu, Hereward Wimborne, Nancy Rodriguez, Worku Abebe The Journal of Nutritional. (nwlifescience.com)
Normal1
  • The mean values of PPAR in normal, obese and diabetic group were 1.72 SD±0.28, 1.282 SE±0.18 and 1.283 SE±0.18 respectively. (edu.pk)
Body Weight1
  • Furthermore, there was less body weight gain and food intake with S-Amlodipine and Pioglitazone combination in Zucker fa/fa rats. (biomedcentral.com)
Affects1
  • Long-term exercise training affects age-induced changes in HSP70 and apoptosis in rat heart. (ac.ir)
Food1
  • Journal of Medicinal Food, 16, 823-830. (scirp.org)
Heart1
  • Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. (ac.ir)
Medicine2
  • The Journal of Alternative and Complementary Medicine , 13 (1), 103-110. (earthtokathy.com)
  • The American Journal of Emergency Medicine, 26 (1). (edu.au)
Scientific1
  • Editor's Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. (mdpi.com)