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  • fatty
  • The free fraction (fp) of phenytoin was significantly higher in the obese rat (fp = 0.177) compared to its lean littermate (fp = 0.136), apparently due to displacement by free fatty acids. (nih.gov)
  • Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats)," Japanese Journal of Pharmacology , vol. 85, no. 4, pp. 416-422, 2001. (hindawi.com)
  • Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system. (eurekaselect.com)
  • In this context, the present study was undertaken to determine whether 6 wk of exercise training and 6 wk of administration of the ACE inhibitor trandolapril, in combination, could improve the glucose intolerance, insulin resistance of muscle glucose metabolism, and dyslipidemia (as reflected by plasma free fatty acid levels) associated with the obese Zucker rat to a greater degree than either intervention used individually. (physiology.org)
  • Microcirculation
  • With the concomitant development of additional complicating factors, including obesity, hypertension and dyslipidemia, a multi-pathology state develops: the metabolic Syndrome X. The obese Zucker rat (OZR) provides an excellent model for examining the impact of Syndrome X on the peripheral microcirculation, as owing to chronic hyperphagia, OZR sequentially develop type II DM, hypertriglyceridemia, and moderate hypertension. (grantome.com)
  • hypertensive rats
  • Numerous reports have shown that natriuretic response to the exogenously infused or endogenously produced dopamine is blunted in spontaneously hypertensive rats (SHR), 10,11 ⇓ owing to a defective D1 receptors in proximal tubules. (ahajournals.org)
  • Altered vascular reactivity and KATP channel currents in vascular smooth muscle cells from deoxycorticosterone acetate (DOCA)-salt hypertensive rats. (nih.gov)
  • Mediators
  • Xu ZG, Lanting L, Vaziri ND, Li Z, Sepassi L, Rodriguez-Iturbe B, Natarajan R (2005) Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: reversal by angiotensin II type 1 receptor blockade. (springer.com)
  • significantly
  • In rosiglitazone-treated obese rats, the inhibitory effect of dopamine on Na,K-ATPase was significantly restored. (ahajournals.org)
  • Previously, we have reported that a high-isoflavone soy protein isolate (HISPI) diet is associated with significantly heavier body weights and reduced liver steatosis in obese Zucker rats (OZR) compared to a casein diet. (rsc.org)
  • The plasma clearance of both MRL-I and MRL-II was significantly lower in obese Zucker rats (4- and 2-fold, respectively) compared with Sprague-Dawley rats, but without any significant change in the volume of distribution, which resulted in a dramatic increase in the half-life (7- and 3-fold, respectively). (aspetjournals.org)
  • chronic
  • 22 On the basis of these studies, we hypothesized that reduction in D1 receptor number and inability of dopamine to inhibit sodium transporters in obese Zucker rats may have been caused by chronic hyperinsulinemia, which if corrected may lead to the restoration in D1 receptor numbers and its function in obese rats. (ahajournals.org)
  • Exercise training or chronic treatment with angiotensin-converting enzyme (ACE) inhibitors can ameliorate glucose intolerance, insulin resistance of muscle glucose metabolism, and dyslipidemia associated with the obese Zucker rat. (physiology.org)
  • angiotensin
  • Angiotensin II at1 receptor blockade decreases lipopolysaccharide-induced inflammation in the rat adrenal gland," Endocrinology , vol. 149, no. 10, pp. 5177-5188, 2008. (hindawi.com)
  • metabolism
  • This information should be considered when comparing pharmacokinetic and efficacious doses in the obese Zucker rats, used as a pharmacological model, with those in Sprague-Dawley rats, which are used widely for drug metabolism and toxicology studies. (aspetjournals.org)
  • Metabolism and disposition of bladder carcinogens in rat and guinea pig: possible mechanism of guinea pig resistance to bladder cancer. (nih.gov)
  • increases
  • Micropuncture studies revealed that the increase in GFR in obese Zucker rats was attributable to the increases in the single nephron plasma flow rate and glomerular transcapillary hydraulic pressure. (kjim.org)
  • Studies in these rats demonstrated that increases in GFR in type I diabetes were caused by increases in single nephron plasma flow and in the glomerular transcapillary hydraulic pressure difference 3 ) . (kjim.org)
  • Levels
  • It is the applicant's contention that this knowledge can only be effectively garnered by extracting multiple phenotypes, at numerous levels of resolution from individual rats exhibiting Syndrome X and under conditions where the manifestation of Syndrome X is manipulated experimentally. (grantome.com)
  • Neonatal capsaicin treatment depleted the substance P levels in the splanchnic nerve of adult rats by 70% and prevented the insulin-induced hypoglycaemia from evoking release of adrenaline. (semanticscholar.org)
  • control
  • Male Zucker rats (5-week old) were supplemented with vehicle (control) and HCA-SX in drinking water for 7 weeks. (springer.com)
  • Hypercholesterolemic obese Zucker fa/fa rats were fed diets containing 25% protein from baked cod fillet and 75% protein from casein (Baked Cod Diet), or casein as the sole protein source (Control Diet) for four weeks. (mdpi.com)
  • develops
  • As a result, the OZR rapidly becomes obese and develops extreme insulin resistance and hypertriglyceridemia, which is accompanied by a clinically relevant hypertension and a prothrombotic and proinflammatory state ( 5 , 16 , 20 , 22 , 28 , 36 ). (physiology.org)
  • plasma
  • After tracheostomy, PE-50 catheters were inserted in the right and left jugular veins for infusion of rat plasma, saline and radiolabeled inulin. (kjim.org)