Obese and lean zucker rats rats zucker. Medical search. Frequent questions

To determine if the CB1 receptor antagonist Rimonabant affected basal or activated insulin secretion we researched isolated islets from low fat siblings and obese Zucker (ZF) and Zucker Diabetic Fatty (ZDF) rats that were Drospirenone incubated for 24 h and exposed to 11 mmol/l glucose plus 0.3 mmol/l palmitate (GL) with or without Rimonabant. (bioskinrevive.com)
The abbreviations used for the Zucker RICTOR obese (312-415 g) Drospirenone and Zucker Diabetic Fatty (260-340 g) rats are ZF and ZDF respectively. (bioskinrevive.com)
We investigated the changes in serum levels of trace elements and inflammation markers in fatty livers using two rat models of NAFLD, the methionine and choline deficient (MCD) diet model and Obese-Zucker rats. (unipv.it)
The "resistant obese" people experienced almost no rise at all in the level of fatty acids in their bloodstreams. (fathead-movie.com)
Resistant obese" people, on the other hand, don't release extra fatty acids when they eat less or not at all, and therefore don't make up for the calorie deficit by tapping and burning their body fat - at least not to nearly the degree the thin people do. (fathead-movie.com)
Meanwhile, the naturally-lean people released lots of fatty acids and burned them for fuel soon after they stopped eating - including that twenty-five year-old woman who couldn't gain weight in spite of her "excellent" appetite. (fathead-movie.com)
Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker diabetic fatty (ZDF) rat. (nature.com)

In order to investigate whether the impaired GH secretion associated with obesity is due to a pituitary disorder we studied GH mRNA levels by in situ hybridization in genetically obese and lean Zucker rats. (omeka.net)
The genetically obese Zucker rat is a widely used model of early-onset obesity. (omeka.net)
These results show that despite low GH secretion, genetically obese Zucker rats have 1) normal linear (nasoanal) growth, 2) normal or increased circulating levels of IGF-I and IGFBP-3, and 3) increased plasma IGF-I responses to exogenous GH. (omeka.net)
Hearts from 50 wk-old genetically obese female Zucker rats (624 ± 13 g) and their lean littermate controls (275 ± 5 g) were isolated during ether anesthesia, supported metabolically by retrograde aortic perfusion (6 ml/min, 35° C) with physiological solution containing suspended canine erythrocytes (hematocrit, 20%), and the ventricles were paced at 180 beats/min. (edu.au)

Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain n -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. (uib.no)

Needlessly to say basal secretion was considerably raised in islets from obese or GL-treated low fat rats whereas the collapse upsurge in GSIS was reduced. (bioskinrevive.com)
Nonetheless it reduced GSIS in islets from low fat rats without influencing basal secretion. (bioskinrevive.com)
In contrast it appears to decrease stimulated secretion in islets from lean animals but not in obese or GL-exposed islets. (bioskinrevive.com)
As expected basal secretion was significantly elevated in islets from obese or GL-treated lean rats whereas the fold increase in GSIS was diminished. (bioskinrevive.com)
Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. (omeka.net)

The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)

were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)

Material and methods NAFLD was induced in male Wistar rats by 3-week MCD diet administration, after which, blood samples were collected. (unipv.it)
A total of 80 male albino rats(Wistar strain) were used in this study. (edu.pk)
Twenty four Wistar rats obtained from the same commercial supplier in two separate shipment batches underwent either subtotal nephrectomy or sham procedures. (biomedcentral.com)
We obtained 24 wild-type outbred Wistar International Genetic Standard (IGS) rats in two shipment batches, 3 weeks apart, from the same supplier (Charles Rivers, Kent, UK). (biomedcentral.com)

Conclusions The serum concentrations of trace elements change significantly only in MCD rats, which spontaneously progress to NASH. (unipv.it)

METHODS AND PROCEDURES Animals Islets were isolated from 7- to 11-week-old male ZF and Zucker diabetic rats and their lean siblings. (bioskinrevive.com)
Figure 3: Macrophage content and Nlrp3 expression in islets of lean and diabetic rats. (nature.com)

all forms of GRP reduce food intake in obese and lean adult Zucker rats similar to Bn in weanling rats. (genscript.com)
Like obese humans, adult OZR become hyperinsulinemic with poor glycemic control. (unthsc.edu)
We sought to determine if left ventricular (LV) function of the heart from the adult, chronically obese animal is impaired. (edu.au)
Here we show that beta cell failure in adult ZDF rats is not associated with CB 1 R signaling in beta cells, but rather in M1 macrophages infiltrating into pancreatic islets, and that this leads to activation of the Nlrp3-ASC inflammasome in the macrophages. (nature.com)

1961 - Trinidad - 1/3rd of women over 25 were obese with an average Calorie intake below 2000/day. (physicality.info)

Based on an assumption of metabolic similarity between experimental animals, we sought to investigate this 'gut-kidney axis' in a rodent model of uraemia, by demonstrating the effect of experimental uraemia on the urinary metabolome and gut microbiota of rats, purchased from the same supplier in two separate shipment batches for logistical reasons. (biomedcentral.com)

Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats. (genscript.com)
These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. (genscript.com)
12-week old Obese (fa/fa) and Lean (fa/-) male Zucker rats were also used. (unipv.it)
In the present study, we investigated linear growth and its hormonal control in Zucker rats (male and female) from 4-20 weeks of age. (omeka.net)

Second, an unidentified mechanism impairs transport in obese mice even when BBB transport is assessed by brain perfusion, a method that removes the immediate effects of blood-borne substances. (clubalthea.com)
The inability of obese mice to respond to peripherally administered leptin while responding to centrally administered leptin is likely caused by a defect in leptin transport across the BBB. (clubalthea.com)
Results: Animals with an ad-libitum-diet were found to increase body weight significantly at the age of six weeks in comparison with lean mice. (ijbs.com)
At the age of twenty weeks the obese mice were almost twice as heavy as the lean mice. (ijbs.com)
High weight-bearing insignificantly improved all trabecular bone parameters in the obese mice. (ijbs.com)

We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK, and glucose transport activity in epitrochlearis skeletal muscle from insulin-resistant Zucker ( fa/ fa ) rats. (diabetesjournals.org)
Insulin-stimulated glucose transport in isolated skeletal muscle was reduced 47% in obese versus lean rats, with a parallel 42% reduction in tyrosine-associated PI 3-kinase activity. (diabetesjournals.org)
Contraction and hypoxia elicited normal responses for glucose transport in skeletal muscle from insulin-resistant obese rats. (diabetesjournals.org)

The relation between cerebrospinal fluid and serum levels of leptin in obese humans (17,18) suggests that defective BBB transport accounts for more of the overall resistance to leptin than the receptor/postreceptor defects (19). (clubalthea.com)

The serum level of IGF-binding protein-3 (IGFBP-3) measured by Western ligand blotting was not significantly different in lean vs, obese rats. (omeka.net)
For example, researchers found that 43 bacterial taxa were significantly different between Chinese obese individuals with T2DM and healthy people by LEfSe analysis, and Acidaminococcales , Bacteroides plebeius and Phascolarctobacterium sp. (frontiersin.org)

Figure 1: Effects of peripheral CB 1 R blockade on body weight, adiposity, hepatic lipogenesis and glycemic control in ZDF rats. (nature.com)
Figure 4: Effects of macrophage depletion on glycemic control and proinflammatory signaling in islets of ZDF rats. (nature.com)

Voluntary resistance exercise training with obese and lean Zucker rats. (cdc.gov)
2014). Loss of ovarian estrogens causes only mild deterioration of glucose homeostasis in female ZDF rats preventable by voluntary running exercise. (umontreal.ca)

Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. (uni-regensburg.de)

However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. (uni-regensburg.de)

Figure 6: Proinflammatory gene and protein expression in human macrophages and rat and human isolated islets treated with AEA, IL-1β or high glucose. (nature.com)

Although female rats may develop salt-induced sensitization of the RVLM, we hypothesize estrogen enhances NTS function to combat impairment of sympatho-inhibitory reflexes in early stages of metabolic syndrome. (unthsc.edu)

It was observed that protein malnutrition had an adverse though reversibleeffect on the thyroid follicular cell size of the albino rats. (edu.pk)

Cannabinoid CB1 and CB2 receptors have been identified in isolated mouse rat and human pancreatic islets with CB1 receptors mainly expressed in non-β-cells and CB2 receptors expressed in both β- and non-β cells (24-27). (bioskinrevive.com)

This diminished ability to develop systolic stress from the same end-diastolic volumes suggests that the hypertrophied LV of the middle-aged obese rat's heart is dilated or that its contractility is depressed, or both. (edu.au)

The plasma concentration of IGF-I increased between 4-20 weeks of age, and IGF-I levels were normal or slightly higher in the obese animals. (omeka.net)

Hypoxia increased AMPKα1 activity to a similar extent (more than sixfold) in lean and obese rats. (diabetesjournals.org)

Results show that both site-specific upregulation (pharmacological or chemogenetic) and chronic downregulation (RNA interference) of MCH communication to the vHP increases impulsive responding in rats, indicating that perturbing this system in either direction elevates impulsivity. (nature.com)

Title: The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide. (genscript.com)
They also develop sympathetically-driven hypertension with diminished baroreflex control of sympathetic nerve activity (SNA) and heart rate (HR) compared to lean Zucker rats. (unthsc.edu)
Results In MCD rats, a serum increase in Cl, Mg and Na and a decrease in Ca2+, Zn were detected in comparison with control rats. (unipv.it)
The calculated average meridional (or circumferential) peak systolic wall stress in the LV of the obese rat's heart, however, was significantly reduced compared with control. (edu.au)

An increase in only serum Ca2+ was found in Obese-Zucker rats. (unipv.it)
In scientific studies, clen has proven to increase LBM (lean body mass) in animals - such as horses . (muscleandbrawn.com)

2006). PPARg Agonism Prevents the Onset of Type 2 Diabetes in ZDF Rats : A Comparison to PPARaAgonism. (umontreal.ca)
Comparison of the systolic PV relationships demonstrated that the obese rat's heart had greater pressure-generating capability, which probably was a reflection of its increased LV mass (0.96 ± 0.03 vs. 0.72 ± 0.02 g). (edu.au)

The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. (uib.no)

Effects of body weight resistance training on glut4 expression in obese and lean Zucker rats. (cdc.gov)

In this study, the effect of protein malnutrition and its reversal was observed in rats. (edu.pk)
The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results From a Randomized Crossover Intervention Study. (uib.no)
Figure 2: The effect of chronic JD5037 treatment on beta cell survival and function in ZDF rats. (nature.com)
Here, we set out to demonstrate the effect of experimental uraemia on the rat urinary metabolome and gut microbiome but found instead that the effect of vendor shipment batch was larger in both areas than that of uraemia. (biomedcentral.com)

The handful of subjects in the study fell into three categories: 1) naturally thin people, 2) fat people who had previously demonstrated that they could lose weight by restricting calories, and 3) fat people whom the researchers labeled as the "resistant obese. (fathead-movie.com)
The researchers noted that in an earlier study, naturally thin subjects who were restricted to a high-fat diet of 1,000 calories per day showed a sharp rise in blood ketones over the next week, while obese subjects on the same diet showed a much lower rise in ketones. (fathead-movie.com)

Obese and lean Zucker rats respond similarly to intraperitoneal administration of gastrin-releasing peptides. (genscript.com)

Polar lipids and other metabolites extracted from plasma from lean, diabetic, and obese Zucker rats were analyzed by flow injection using high resolution time of flight mass spectrometry. (chromatographyonline.com)

The animals were fed normal rat chow and water until time of sacrifice. (bioskinrevive.com)

Remember that in describing the "resistant obese" subjects, the researchers noted that they had small appetites and failed to lose weight even under observation in a hospital. (fathead-movie.com)
Recently, we and others have demonstrated fibrotic depots in white adipose tissue of obese subjects. (springer.com)

As someone who tried simply eating less and spent many hours on a treadmill (I even bought one for my apartment) without getting leaner, I don't believe losing weight is about character. (fathead-movie.com)

Title: Intravenous infusion of gastrin-releasing peptide-27 and bombesin in rats reveals differential effects on meal size and intermeal interval length. (genscript.com)
Figure 5: Effects of macrophage-selective siRNA knockdown of CB 1 R in ZDF rats. (nature.com)

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Organisms2

Diseases5

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes7

Fatty7

Genetically obese4

Serum and Tissues1

Secretion5

Tissues1

Obesity1

Wistar4

Concentrations1

Diabetic rats2

Adult4

Intake1

Microbiota1

Male4

Mice5

Insulin3

Humans1

Significantly different2

Glycemic control2

Voluntary2

Hypothalamus1

Kidney1

Glucose1

Female1

Adverse1

Receptors1

Suggests1

Levels1

Similar1

Increases1

Control4

Increase2

Comparison2

Adults1

Expression1

Effect4

Study2

Respond1

Plasma1

Animals1

Subjects2

Losing weight1

Effects2