ObeseBody shape phenotypesElectronic phenotypeAdipose tissueMetabolicInsulin-resistantSASPFetal2023Tissue-specific insulinCardiovascular DiseasesGenotypeNHANESLongitudinalMiceClinicalHypertensionAdultEpidemiologyAllergicChronic DiseaseCardiometabolic healthTumorMethodsInsightsInfantDiagnosisDiabetesInterventionsCancerDieteticsEcologyAfrican AmericansSpeciesCholesterolHealthyPrecision nutritionAssociationRESEARCHDietOutcomesIncidenceArticleMainGeneticBased on the presenceHealth
Obese6
- Albumin was associated inversely with HI in women, but matched the pattern of free testosterone in obese men (lowest for "wide", highest for "slim" phenotype). (nature.com)
- Metabolic syndrome (MetS) is prevalent not only among the overweight and obese but also normal weight individuals, and the phenotype is referred to as a metabolically unhealthy phenotype (MUHP). (jefferson.edu)
- Besides normal weight individuals, overweight/obese individuals are also protected from MetS, and the phenotype is known as a metabolically healthy phenotype (MHP). (jefferson.edu)
- Investigators at the Grand Forks Human Nutrition Research Center had shown in a previous study that maternal undernutrition such as a low protein diet causes the offspring to become obese. (usda.gov)
- To determine the correlates of the "metabolically healthy obese" (MHO) phenotype and the longitudinal risks of diabetes and cardiovascular disease (CVD)/stroke associated with this phenotype. (diabetesjournals.org)
- Diabesity phenotypes were defined in six categories based on the presence of diabetes (normal (NG), prediabetes and diabetes) and obesity (obese, non-obese). (bvsalud.org)
Body shape phenotypes2
- Using data from UK Biobank, we have previously described the associations of body shape phenotypes based on ABSI and HI with allometric body-composition indices, which similarly to ABSI and HI normalise body composition measurements for weight and height 11 . (nature.com)
- In the current study, we have examined the association of body shape phenotypes based on allometric indices with serum levels of oestradiol and testosterone and their binding proteins (SHBG and albumin) and have explored heterogeneity by BMI, separately in men and women from the UK Biobank cohort, defining in men subgroups according to age and in women subgroups according to menopausal status and use of hormone replacement therapy (HRT). (nature.com)
Electronic phenotype3
- Applying varying criteria resulted in hypertension prevalence es- electronic phenotype development process and proposes an optimal defin- ition for EHR-based hypertension. (cdc.gov)
- SEPTEMBER 2023 posed electronic phenotype generates hypertension prevalence es- tension prevalence and control. (cdc.gov)
- We aimed to develop an electronic phenotype (e-phenotype) for hypertension surveillance. (cdc.gov)
Adipose tissue1
- factors and nutrition that affect insulin resistant phenotypes in adipose tissue. (purdue.edu)
Metabolic10
- Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. (ljmu.ac.uk)
- The research in this thesis demonstrates, for the first time, that refining the current general dietary guidelines according to metabolic phenotype (specifically, tissue-specific insulin resistance) may lead to greater health benefits, independent of weight loss. (wur.nl)
- Therefore, our findings support precision nutrition based on metabolic phenotype as a promising strategy for the prevention of cardiometabolic diseases. (wur.nl)
- Additionally, our work illustrates that further refinement of metabolic phenotypes and personalised dietary advice may optimise the effectiveness of precision nutrition, for example, based on biomarkers of lipid metabolism in the blood. (wur.nl)
- Correlations between Coffee Consumption and Metabolic Phenotypes, Plas" by Pratibha V Nerurkar, Krupa Gandhi et al. (jefferson.edu)
- Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006. (jefferson.edu)
- Our objective was to investigate the correlation between coffee consumption, metabolic phenotypes, plasma folate, and vit. (jefferson.edu)
- B12, and metabolic phenotypes. (jefferson.edu)
- Associations among coffee consumption metabolic phenotypes, plasma folate, and vit. (jefferson.edu)
- Coffee consumption was not associated with metabolic phenotypes, but negatively correlated with several metabolic variables, including BMI ( p (jefferson.edu)
Insulin-resistant1
- In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. (ljmu.ac.uk)
SASP3
- Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. (wikipedia.org)
- Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
- introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)
Fetal4
- Appropriate fetal growth, regulated by maternal nutrition and nutrient transport across the placenta, is a critical factor for adult offspring long-term health. (manchester.ac.uk)
- In this study, we investigate the impact of maternal nutrition on post-implantation trophoblast phenotype and fetal growth. (manchester.ac.uk)
- These data demonstrate that early post-implantation embryos modify trophoblast phenotype to regulate fetal growth under conditions of poor maternal nutrition. (manchester.ac.uk)
- and the impact of disruptions in gestation on the ecology of fetal and infant phenotypes, milk composition, and lactation. (nutrition.org)
20231
- The current findings of each of the five Working Groups, along with an executive summary, have been published in a May 2023 Supplement to The American Journal of Clinical Nutrition ( AJCN ). (nutrition.org)
Tissue-specific insulin1
- We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. (ljmu.ac.uk)
Cardiovascular Diseases2
- Healthy nutrition plays an important role in the prevention of cardiometabolic diseases such as type 2 diabetes and cardiovascular diseases. (wur.nl)
- Impact of diabesity phenotype on cardiovascular diseases, major cardiovascular events and all-cause mortality. (bvsalud.org)
Genotype1
- Platelets were isolated for phenotype analysis, and DNA was isolated from lymphocytes for genotype determination. (aacrjournals.org)
NHANES6
- An analogous approach, normalising body composition measurements for height, BMI, and waist circumference has been used for the 1999-2006 United States National Health and Nutrition Examination Survey (NHANES) 12 . (nature.com)
- B12 were assessed in a cross-sectional study of 2201 participants, 18 years or older, from 2003-2004 and 2005-2006 National Health and Nutrition Examination Surveys (NHANES). (jefferson.edu)
- We sampled never smokers and those with lower smoking exposure from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 dataset. (populationmedicine.org)
- We compared AEMR-US estimates of hypertension prevalence and control against those from the National Health and Nutrition Examination Survey (NHANES) 2017-18, which defined hypertension as BP 130/80mmHg or 1 antihypertensive medication. (cdc.gov)
- The selected three-criteria e-phenotype (1 diagnosis code, 2 BP measurements of 130/80mmHg, or 1 antihypertensive medication) yielded similar trends in hypertension prevalence as NHANES: 42.2% (AEMR-US) vs. 44.9% (NHANES) overall, 39.0% vs. 38.7% among women, and 46.5% vs. 50.9% among men. (cdc.gov)
- Serum IgE levels among U.S. workers - National Health and Nutrition Examination Survey (NHANES), 2005-2006. (cdc.gov)
Longitudinal1
- To investigate the longitudinal association of different phenotypes of diabetes and obesity with the incidence of cardiovascular disease (CVD), CVD- and all-cause mortality . (bvsalud.org)
Mice1
- We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
Clinical6
- 2 In addition, the varied clinical presentations of MND also include (i) progressive muscle atrophy (PMA, ~ 10% of MND cases), a clinically pure lower motor neuron (LMN) phenotype, (ii) primary lateral sclerosis (PLS, 1-3% of MND cases), a clinically pure upper motor neuron (UMN) phenotype and (iii) progressive bulbar palsy (PBP, 1-2% of MND cases), an isolated bulbar phenotype with relative preservation of spinal motor neurons. (acnr.co.uk)
- 3,4 Despite the clinical heterogeneity, median survival of MND remains three years, although the atypical phenotypes exhibit a longer survival. (acnr.co.uk)
- The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands. (biomedcentral.com)
- Welcome to the Clinical Nutrition Research Centre (CNRC), Singapore. (a-star.edu.sg)
- With vast clinical problems persisting in the world today, the role of nutrition for overall health, and prevention and treatment of diseases may sometimes be overlooked. (nestlenutrition-institute.org)
- Further, Gary Frost presented results from a clinical trial showing how metabolomic phenotypes can be used to predict responses to dietary interventions. (lu.se)
Hypertension2
- Suggested citation for this article: Hohman KH, Zambarano B, phenotype for hypertension. (cdc.gov)
- CONCLUSIONS: Using an EHR dataset of 11 million adults, we constructed a hypertension e-phenotype using three criteria, which can be used for surveillance of hypertension prevalence and control. (cdc.gov)
Adult2
Epidemiology1
- Smith-Lemli-Opitz syndrome: phenotype, natural history, and epidemiology. (harvard.edu)
Allergic1
- Ritchlin draws inspiration from pulmonology, which subtyped asthma into various phenotypes (for example, eosinophilic, allergic, intrinsic, exercise-induced) and "drilled down" on understanding underlying mechanisms to guide more specific treatment. (medscape.com)
Chronic Disease1
- Their unique phenotype provides new insights into how diets influence the etiology of chronic disease. (a-star.edu.sg)
Cardiometabolic health1
- The findings in this dissertation have provided leads for possible mechanisms that may be involved in the diverging effects of nutrition on cardiometabolic health. (wur.nl)
Tumor1
- MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
Methods1
- Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)
Insights1
- The careful analysis of biochemical, genetic, and anthropomorphic characteristics that constitute hallmarks of each group provides detailed insights into the characteristics of each group, contributing to unravel the complexity of FH and dyslipidaemic phenotypes. (medrxiv.org)
Infant2
- In response, in 2020, the National Institute of Child Health and Human Development (NICHD) launched the Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN) Project, with a mission to explore all the factors underlying the synthesis, composition, and most effective use of human milk. (nutrition.org)
- This Supplement, Breastmilk Ecology: Genesis of Infant Nutrition: BEGIN Project , is open access so that all readers regardless of subscription status may access all the articles at no charge. (nutrition.org)
Diagnosis1
- However, leading researchers in rheumatology and dermatology believe that they're turning the corner toward a day when therapies are phenotype-targeted and diagnosis can be made early and treatment begun well before inflammation worsens and pain and joint damage ensue. (medscape.com)
Diabetes2
- These findings can contribute to the development of future precision nutrition interventions for the prevention of type 2 diabetes and other chronic conditions. (wur.nl)
- These findings were sex -specific and only in men with a phenotype of abdominal obesity -diabetes, a positive link was observed for CVD incidence (HR = 1.60, 95% CI 1.01, 2.52). (bvsalud.org)
Interventions1
- But while interventions can be tailored to some extent to these domains, or phenotypes, there are limitations without an understanding of the different pathophysiology and mechanisms driving the heterogeneity in tissue involvement. (medscape.com)
Cancer4
- Prospective Investigation into Cancer and Nutrition. (who.int)
- Legume intake and Investigation into Cancer and Nutrition (EPIC). (who.int)
- This study will better determine the prevalence of known hereditary breast cancer syndromes in Latin America, and will help identify patients bearing specific hereditary breast cancer phenotypes. (who.int)
- PRECAMA is coordinated by the Section of Nutrition and Metabolism at the International Agency for Research on Cancer ( IARC ). (who.int)
Dietetics1
- The implications of genetic variations in shaping individual nutritional requirements have been recognised and conclusively proven, yet routine use of genetic information in nutrition and dietetics practice is still far from being implemented. (mdpi.com)
Ecology1
- Nevertheless, this limitation does not substantially reduce the great utility of this volume to those interested in ecology, microbiology, medicine, or nutrition. (cdc.gov)
African Americans1
- Thus, the most convincing evidence to date is that phenotype continues to matter for African Americans. (encyclopedia.com)
Species2
- While exposure to environmental conditions doesn't typically affect an organism's genetic code, previous research has shown that a range of factors including toxicants, stress and nutrition can developmentally alter the phenotype of a variety of species through epigenetics. (eurekalert.org)
- The focus of the book, and of the field, is largely on metabolism, but any of the anticipated therapies, especially prebiotics, will select for particular bacterial species or phenotypes. (cdc.gov)
Cholesterol2
- What ApoE phenotype prevents changes in the concentration of cholesterol regardless of diet? (flashcardmachine.com)
- Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/ß-catenin defects in neuronal cholesterol synthesis phenotypes. (harvard.edu)
Healthy3
- Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in the adaptive immune cell populations and phenotypes. (medrxiv.org)
- Proper nutrition can be the best predictor of a long healthy life expectancy and, conversely, when inadequate and/or improper a prognosticator of a sharply curtailed expectancy. (springer.com)
- As good nutrition is recognized as a key component of healthy development, well-being, and disease prevention, nutrition research from all sectors is in the quest of understanding what we need to eat to be healthy across the life course. (springer.com)
Precision nutrition1
- Utilising the precision nutrition toolkit in the path towards precision medicine. (harvard.edu)
Association2
- Nutritional redundancy in the human diet and its application in phenotype association studies. (harvard.edu)
- The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes. (populationmedicine.org)
RESEARCH5
- The challenge right now is that we don't understand the discrete and overlapping endotypes that underlie the phenotypes or domains" of PsA, said Christopher Ritchlin, MD, MPH, professor of medicine in the division of allergy/immunology and rheumatology and the Center of Musculoskeletal Research at the University of Rochester (N.Y.), who spoke about PsA at the annual research symposium of the National Psoriasis Foundation. (medscape.com)
- Similar phenotype-endotype research has been done for chronic obstructive pulmonary disease , he said at the meeting, pointing to a phase 3 randomized controlled trial, published in the New England Journal of Medicine, that found dupilimab (Dupixent) was effective for patients with COPD who had type 2 inflammation as indicated by elevated eosinophil counts. (medscape.com)
- The completion of the Human Genome Project sequence has deeply changed the research of life sciences including nutrition. (mdpi.com)
- With an extensive facilities for human nutrition research, including two whole body calorimeters, our centre is well equipped and has world class expertise to conduct short and long term studies in human nutrition. (a-star.edu.sg)
- In this section you will find extensive research on the therapeutic role of diet, including resources for dietary guidelines and nutrition screening & assessment. (nestlenutrition-institute.org)
Diet2
- The major causes include lack of access to proper nutrition and healthcare services, and often the basic information to make the personal decisions related to diet and healthcare options and opportunities. (springer.com)
- Using a rat model of prenatal low protein (LP, 8% protein) diet followed by a postnatal high fat energy diet (HE, 45% fat) or low fat normal energy diet (NE, 10% fat) for 12 weeks, we investigated the effect of these diets on adiposity, programming of the offspring ATM phenotype, and the associated inflammatory response. (usda.gov)
Outcomes1
- Persistence of a MHO phenotype, which was associated with favorable outcomes, was related to younger age and a more peripheral fat distribution. (diabetesjournals.org)
Incidence1
- The speed of the nutrition and lifestyle transition, and thus the incidence of overweight people and obesity may even gather pace. (univpm.it)
Article1
- Le présent article fait le point sur la recherche dans ce domaine, en comparant les pays à revenu faible et élevé. (who.int)
Main1
- Although the main emphasis of HANES I was on nutrition, a subset of those sample persons aged 25-74 received a more detailed health examination which was continued through October 1975. (cdc.gov)
Genetic1
- Keep in mind that the environment may include nutrition, psychological elements, and other non-genetic factors. (ashg.org)
Based on the presence1
Health2
- Adequate nutrition is essential for optimal bone health in transplant recipients. (medscape.com)
- Now is the time for public health policy to 'not let the perfect be the enemy of the good,' but to progressively make health-promoting nutrition recommendations. (springer.com)