Nup153 nuclear pore complex proteins. Medical search. Frequent questions

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. (wikipedia.org)
These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. (wikipedia.org)
Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. (openrheumatologyjournal.com)
The nuclear pore complex (NPC) serves as the sole gate between the nucleoplasm and the cytoplasm and contains several different nuclear pore proteins such as nucleoporin p62. (openrheumatologyjournal.com)

Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. (wikipedia.org)
In order to establish infection, the virus must reverse transcribe its single stranded RNA genome into double stranded DNA, traverse the cytoplasm and cross the nuclear membrane, after which it integrates into the host chromosome ( Bukrinsky, 2004 ). (elifesciences.org)
The study incorporates disciplines such as Cytoplasm, Mutation, Sterile alpha motif, Wild type and Fusion protein in addition to Molecular biology. (research.com)
Following the entry of the HIV-1 viral core into the cytoplasm of a target cell, reverse transcription of the retroviral RNA into a linear double strand cDNA copy takes place within the reverse transcription complex (RTC) [ 1 , 2 ]. (biomedcentral.com)

Interestingly, Nup153 levels are also known to be high in cells with elevated levels of a mobile protein called Sox2, a transcription factor that floats around the nucleus and binds to genes and turns them on or off. (neurosciencenews.com)

Another Salk professor and a coauthor on the paper, Martin Hetzer, previously found that proteins in the nuclear membrane influence gene expression in different kinds of cancer cells. (neurosciencenews.com)
Research from my lab has found that the nuclear membrane is a dynamic structure that plays a key role in developmental gene regulation," says Hetzer, Salk's chief science officer and holder of the Jesse and Caryl Philips Foundation Chair. (neurosciencenews.com)
In the precursors, they discovered high numbers of a protein called Nup153, which is part of a multiprotein complex that forms a gatekeeping pore in the nuclear membrane, controlling what goes in or out. (neurosciencenews.com)
Due to the substantial progress in elucidation of the structure of the nuclear membrane and pore complex, recently novel autoantigens localised within the nucleus and the nuclear envelope have been investigated in more detail. (openrheumatologyjournal.com)
2 ] differentiate the nuclear envelope (NE) into five regions, the outer nuclear membrane (ONM), an inter membrane space, the inner nuclear membrane (INM), the underlying nuclear lamina and the nuclear pore complex (NPC). (openrheumatologyjournal.com)

Felipe Diaz-Griffero has researched Molecular biology in several fields, including Mutant, CDC2 Protein Kinase, Phosphorylation, RNA-binding protein and Binding site. (research.com)
The scientist's investigation covers issues in Cell biology, Capsid, Cell cycle, Transmembrane protein and Phosphorylation. (research.com)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)
SMAD phosphorylation by active receptors, and constitutive SMAD dephosphorylation by nuclear phosphatases, are coupled through nucleocytoplasmic shuttling of SMADs. (nature.com)

Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. (elifesciences.org)
This complex is transported to the nucleus where the viral cDNA integrates into a host cell chromosome, a key step that is under the control of the retroviral enzyme IN [ 7 - 9 ]. (biomedcentral.com)

In addition, nuclear accumulation of active nuclear SMAD complexes is dynamically maintained in strict accordance with the degree of receptor activation at any time of signalling. (nature.com)

More recently, two studies point toward Dicer-dependent nuclear RNAi in mammals by demonstrating that nuclear, chromatin-associated Dicer impairs expression of the microtubule-binding protein Doublecortin in mouse adult neural stem cells [ 14 ] and transactivation of the human secreted frizzled-related protein 1 promoter in cholangiocarcinoma cells [ 15 ]. (prolekarniky.cz)

The fact that we were able to connect transcription factors, which are mobile switches, to the pore complex, which is a very stable structure, offers a clue as to how cells maintain their identity through regulated gene expression," says Tomohisa Toda, a Salk research associate and first author of the paper. (neurosciencenews.com)
The authors showed that transfection of exogenous small interfering (exo-si)RNA triggers silencing of a subset of protein-coding gene promoters. (prolekarniky.cz)

Whereas the recombinant HIV-1 IN protein is sufficient to catalyze the 3' processing and strand transfer activities for in vitro integration, functional interactions between IN and host cell factors are required during the early events of HIV-1 replication in vivo [ 10 - 12 ]. (biomedcentral.com)

A fluorescent microscopy image shows Nup153 (red) in pore complexes encircling and associating with Sox2 (green) in a precursor cell nucleus. (neurosciencenews.com)

This methodology is predicated on metabolic labeling of a clickable analog of palmitic acid by parasitic cells, adopted by CuAAC (Copper-catalyzed Alkyne-Azide Cycloaddition response) Click on Chemistry to render palmitoylated proteins fluorescent. (yeastevolution.com)

Characterization of bioactive cell penetrating peptides from human cytochrome c: protein mimicry and the development of a novel apoptogenic agent. (immuquest.com)
The polymerization of amino acids into peptides and interactions between peptides are of interest because peptides and proteins participate in complex interaction networks in extant biology. (bvsalud.org)

Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce neurons. (neurosciencenews.com)
Next, the team wants to explore how the interaction of the pore complex with other transcription factors affects neuronal function, which could yield insights into the underlying causes of certain neurological disorders. (neurosciencenews.com)
Our functional analysis of HIV-1 IN mutants reveals distinct structural basis for TNPO3 interaction and suggests that the interaction between IN and TNPO3 is not a major determinant of nuclear import but could take place at a nuclear step prior to integration. (biomedcentral.com)

We established that the tailored contractile response constitutes a nuclear ruler based signaling pathway involved in migratory cell behaviors. (regenerativemedicine.net)

Unexpectedly, CN shows SLiM-dependent proximity to centrosomal and nuclear pore complex (NPC) proteins-structures where Ca 2+ signaling is largely uncharacterized. (nih.gov)

CN dephosphorylates human and yeast NPC proteins and promotes accumulation of a nuclear transport reporter, suggesting conserved NPC regulation by CN. (nih.gov)
Signalling then converges to nuclear accumulation of transcriptionally active SMAD complexes and gives rise to a plethora of specific functional responses in both embryos and adult organisms. (nature.com)

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells. (research.com)

Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. (nih.gov)

This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. (regenerativemedicine.net)

Gage's team conducted screens in cells from mice and rats to see which genes were being transcribed into proteins in precursor cells, immature neurons and astrocytes. (neurosciencenews.com)
In addition, nuclear Dicer fosters termination of RNAPII transcription [ 11 ] and alternative polyadenylation at a subset of protein-coding genes [ 12 ]. (prolekarniky.cz)

Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev". J. Virol. (wikipedia.org)
SSSGTSFSGRKIKTAVRRRK, corresponding to amino acids 1456-1475 of Human Nup153 (P49790). (immuquest.com)
Human Dicer may also interact with the nuclear pore complex component NUP153 [ 7 ]. (prolekarniky.cz)
These findings are in line with previous studies, reporting the existence of nuclear RNAi in human cells [ 13 ]. (prolekarniky.cz)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)

Because all three cell types have roughly the same number of nuclear pores, the team concluded that Nup153 levels influence cell type and that a high level is necessary to maintain cells' precursor status. (neurosciencenews.com)
By fluorescently tagging Nup153 and Sox2 in the different cells types, they observed that Nup153 was interacting with Sox2. (neurosciencenews.com)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development. (regenerativemedicine.net)

It is filamentous and it contains three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. (wikipedia.org)

NUP153 has been shown to interact with SENP2 and KPNB1. (wikipedia.org)

In vivo , palmitoylation of proteins is catalyzed by palmitoyl acyltransferases (PATs or DHHC-PATs) . (yeastevolution.com)

A protein shell called a capsid protects the virus during this journey. (elifesciences.org)
Felipe Diaz-Griffero has included themes like Cyclophilin A, Plasma protein binding, Reverse transcriptase and Avidity in his Capsid study. (research.com)

In short, our modeling has highlighted challenges and opportunities toward understanding the behaviors of complex prebiotic chemical experiments. (bvsalud.org)

Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. (wikipedia.org)

Palmitoylation refers back to the modification of the cysteine thiols in proteins by fatty acids, mostly palmitic acid, via 'thioester bond' formation. (yeastevolution.com)

It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. (wikipedia.org)

Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)

Most of the mutant viruses were essentially impaired for the integration step whereas the amount of 2-LTR circles, reflecting the nuclear import of the viral DNA, was not significantly affected. (biomedcentral.com)

Polyphosphate-mediated peptide bond formation is central to protein synthesis in modern organisms, but a simpler form of activation likely preceded the emergence of proteins and RNA. (bvsalud.org)

Our data indicate evolutionary conservation of nuclear Dicer localisation and function in mammals in response to DNA damage. (prolekarniky.cz)

Summary: Study provides insight into why imbalance between Sox2 and Nup153 may contribute to neurodegenerative and mental illnesses. (neurosciencenews.com)
His biological study spans a wide range of topics, including Autophagy, TRIM5alpha and Fusion protein. (research.com)

How can this protein shell be strong enough to remain intact as it enters a host cell, and yet quickly open up to release the viral genome after replication? (elifesciences.org)

A series of studies imply nuclear localisation of mammalian Dicer and association with chromatin. (prolekarniky.cz)

Anatomy5

Organisms3

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes8

Information Science2

Nucleoporin4

Cytoplasm4

Interestingly1

Membrane5

Phosphorylation4

CDNA2

Receptor1

Chromatin-associated1

Gene2

Recombinant1

Nucleus1

Fluorescent1

Peptides2

Interaction3

Pathway1

Structures1

Accumulation2

Translocation1

Interactions1

Envelope1

Genes2

Human5

Cells4

Motifs1

Interact1

Vivo1

Capsid2

Behaviors1

Sequence1

Modification1

Basket1

Regulation1

Import1

Activation1

Response1

Study2

Strong1

Association1