IVDs are composed of two distinct components: The inner gel-like core nucleus pulposus (NP) and the outer firm annulus fibrosus (AF). (spandidos-publications.com)
The intervertebral disc (IVD) consists of a central gelatinous nucleus pulposus (NP) encircled by an elastic, ligamentous annulus fibrosus (AF) and is flanked superiorly and inferiorly by cartilaginous endplates. (biomedcentral.com)
Herniated nucleus pulposus is prolapse of an intervertebral disk through a tear in the surrounding annulus fibrosus. (msdmanuals.com)
Spinal vertebrae are separated by fibrocartilaginous disks consisting of an outer annulus fibrosus and an inner nucleus pulposus. (msdmanuals.com)
When degenerative changes (with or without trauma) result in protrusion or rupture of the nucleus through the annulus fibrosus in the lumbosacral or cervical area, the nucleus is displaced posterolaterally or posteriorly into the extradural space. (msdmanuals.com)
Intervertebral disc (IVD) consists of a soft gelatinous material in its center, the nucleus pulposus (NP), bounded peripherally by fibrocartilage, annulus fibrosus (AF). (elsevierpure.com)
The disc is composed of the annulus fibrosus and nucleus pulposus. (piedmont.org)
Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus. (bvsalud.org)
and collagen type II (COL2A1) gene expressions were determined with quantitative real-time polymerase chain reaction (qRT- PCR ) analysis to show the effects of IGF-1 /BMP-2 administration on annulus fibrosus cell (AFC)/ nucleus pulposus cell (NPC) cultures . (bvsalud.org)
Numerous investigations on disc degeneration have been performed on cells from annulus fibrosus (AF) and nucleus pulposus (NP) of the intervertebral disc (IVD) in cell culture experiments utilising a broad variety of basal culture media. (biomedcentral.com)
The IVD is a cartilage-like tissue and consists of two compartments, the inner nucleus pulposus (NP) and the surrounding annulus fibrosus (AF). (biomedcentral.com)
The discs contain both annulus fibrosus and nucleus pulposus. (cdc.gov)
The annulus seals the nucleus and maintains flexibility, allowing for bending and twisting without rupture. (spine-health.com)
Rupture of the annulus fibroses causing leaking of the nucleus pulposus into the intradural space. (ecopolitan.com)
Hernia Nucleus2
ABSTRAK Pendahuluan: Hernia Nucleus Pulposus yaitu terdorongnya Nucleus Pulposus yang berada diantara ruas-ruas tulang belakang, ke arah belakang baik lurus maupun ke arah kanan atau kiri menekan sumsum tulang belakang atau serabut - serabut sarafnya, hal ini dapat memicu masalah keperawatan nyeri akut. (unmuhjember.ac.id)
Kesimpulan: penulis karya tulis ilmiah menunjukkan bahwa implementasi Teknik relaksasi benson sangat efektif untuk mengatasi nyeri akut terutama pada klien Hernia Nucleus Pulposus. (unmuhjember.ac.id)
Degenerative7
Degenerative disc disease (DDD) is a common degenerative condition initiated mainly within the nucleus pulposus (NP). (spandidos-publications.com)
Lian C, Gao B, Wu Z, Qiu X, Peng Y, Liang A, Xu C, Su P and Huang D: Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells. (spandidos-publications.com)
Low Intensity Pulsed Ultrasound Promotes the Extracellular Matrix Synthesis of Degenerative Human Nucleus Pulposus Cells through FAK/PI3K/AktPathway. (qigonginstitute.org)
To investigate the effect of low intensity pulsed ultrasound (LIPUS) on the extracellular matrixsynthesis of degenerative human nucleus pulposus cells and explorethe molecular mechanism. (qigonginstitute.org)
LIPUS has been used successfully for bone fracture healing and been proved to be effective instimulatingextracellular matrix metabolismin animal intervertebraldisc cells.However, whether LIPUS also exerts an anabolic effect on degenerative human nucleus pulposuscells and the possible molecular mechanism is yet unclear. (qigonginstitute.org)
The degenerative human nucleus pulposus cells were cultured in calcium alginate beads. (qigonginstitute.org)
LIPUS promotes the extracellular matrix synthesis of degenerative human nucleus pulposus cells through activation of FAK/PI3K/Akt pathway. (qigonginstitute.org)
Extrusion1
Magnetic resonance imaging findings were consistent with an acute, non-compressive nucleus pulposus extrusion of the L5-L6 intervertebral disc. (avmi.net)
Prosthesis1
The aim of the present study was to assess biomechanically the behaviour of a novel nucleus pulposus prosthesis (NPP) in situ and its ability to restore functionality to the canine IVD after nuclectomy alone or after combined dorsal laminectomy and nuclectomy. (londonspine.com)
Acute1
The simplest and most obvious example is herniated nucleus pulposus with acute monoradicular or myelopathic symptoms. (nih.gov)
Degeneration1
The system can potentially support long-term cultures of cell-seeded constructs in controlled environmental conditions found in vivo to study the mechanobiology of nucleus pulposustissue engineering and the aetiology of IVD degeneration. (lboro.ac.uk)
Tissue3
In the current study, nucleus pulposus tissue was taken from the healthy rabbit intervertebral disc and tested in torsional creep to establish a database of healthy tissue behavior for future use in assessing the functional efficacy of molecular therapy treatments of IDD. (pitt.edu)
Nucleus pulposus tissue was excised from the L5-L6 intervertebral disc, mounted between the cone and plate of an AR1000 Rheometer, and various torsional creep experiments were performed. (pitt.edu)
Further studies could also attempt to use other hydrogel scaffolds, such as agarose, which has been widely used in cartilagetissue engineering studies and hyaluronic acid - a component of the nucleus pulposus ECM. (lboro.ac.uk)
Cells6
Moreover, studies with human disc cells, especially focusing on nucleus pulposus (NP) cells, are seldom found in the literature. (medsci.org)
A critical role of autophagy was identified in rat nucleus pulposus (NP) cells: Inhibition of autophagy suppresses, while activation of autophagy enhances, the catabolic effect of cytokines. (spandidos-publications.com)
HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. (bakerco.com)
To investigate tumor necrosis factor α (TNF α) and interleukin-1β (IL-1 β) regulation of CCL3 expression in nucleus pulposus (NP) cells and in macrophage migration. (shu.ac.uk)
The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus. (ox.ac.uk)
Cells were isolated from the nucleus of bovine discs and from bovine articular cartilage, embedded in alginate beads and cultured at pH levels maintained within the ranges seen in normal and pathological discs: pH 7.4-pH 6.3 for 48 h. (ox.ac.uk)
Unclear1
The mechanisms of immune privilege in human nucleus pulposus (NP) remain unclear. (medsci.org)
Herniation1
[ 7 ] They proposed that herniation of the nucleus pulposus and displacement of nuclear material caused neural irritation, inflammation, and pain. (medscape.com)
Outer1
If the outer edge of the disc ruptures, the center can push through and put pressure on the sciatic nerve, leading to the pain of sciatica (referred to as a herniated nucleus pulposus). (emedicinehealth.com)
Human1
Studies on protein-polysaccharide complex (proteoglycan) from human nucleus pulposus. (wikidata.org)
Disc8
Which of the following symptoms would alert the clinician to the more serious finding of a herniated nucleus pulposus or ruptured disc? (essaysresearch.org)
This causes the nucleus pulposus (jelly-like center of the disc) to leak into the spinal canal. (moviecultists.com)
2011. The nucleus balances weight placed on the disc, transferring pressure outward. (spine-health.com)
The surgical removal of the bulging or extruding disc material ( nucleus pulposus ). (adlergiersch.com)
There is a tough ring around the outside of each disc and a thick jellylike center inside (called a nucleus pulposus). (emedicinehealth.com)
Inflammatory1
The symptoms due to herniated nucleus pulposus (HNP) can ultimately be attributed to the significant inflammatory response it generates inside the spinal canal. (medscape.com)
The cells of the nucleus pulposus (NP) region of the intervertebral disc play a critical role in this tissue's generation and maintenance and alterations in NP cell viability metabolism and phenotype with aging may be key contributors to progressive disc degeneration. (conferencedequebec.org)
There is degeneration of the nucleus pulposus and extrusion/prolapse of disc material dorsally, causing compression of the spinal cord. (nih.gov)
In this section of vertebral column, there is degeneration of the nucleus pulposus and extrusion/prolapse of disc material. (nih.gov)
Intervertebral disc disease is characterized by chondromucinous degeneration of the nucleus pulposus. (nih.gov)
Calcified material within the nucleus pulposus is indicative of disc degeneration, but alone is not of clinical significance . (vin.com)
OBJECTIVE: To investigate the effect of visual acupotomy intervention on intervertebral disc degeneration, nucleus pulposus cell apoptosis and expression of apoptosis related proteins in rabbits with cervical spondylosis (CS), so as to explore its mechanism underlying improvement of CS. (bvsalud.org)
Lumbar7
Restoration of compressive loading properties of lumbar discs with a nucleus implant-a finite element analysis study. (medscape.com)
Meredith DS, Huang RC, Nguyen J, Lyman S. Obesity increases the risk of recurrent herniated nucleus pulposus after lumbar microdiscectomy. (medscape.com)
To examine whether an inflammatory cytokine is expressed in the nucleus pulposus of adolescent patients with lumbar disc herniation. (medscape.com)
However, the expression of TNFα in the nucleus pulposus of adolescent patients with lumbar disc herniation has not been explored. (medscape.com)
The purpose of this study was to examine the existence of TNFα in the nucleus pulposus of adolescent patients with lumbar disc herniation. (medscape.com)
Objective: To evaluate the relationship between gene polymorphism in interleukin 1 receptor antagonist (IL1RN) and response to conservative treatment of lumbar herniated nucleus pulposus (HNP). (johnshopkins.edu)
The LBPP in this study were 30 to 60 years old and had the following medical diagnoses: herniated nucleus pulposus at one or more lumbar levels, degenerative discopathy, lumbosacral strain, and spinal canal and/or foraminal stenosis. (nih.gov)
Gelatinous2
Herniated nucleus pulposus is a condition in which part or all of the soft, gelatinous central portion of an intervertebral disk is forced through a weakened part of the disk, resulting in back pain and nerve root irritation. (medlineplus.gov)
Hydrogels have been widely investigated as a candidate for regeneration of the gelatinous nucleus pulposus due to its architectural resemblance and fluid retention characteristics. (cam.ac.uk)
Spine3
Inside each disc is a gelatin-like material called the nucleus pulposus which acts as the shock absorber for the spine. (paperheart-movie.com)
When we injure the spine we will sometimes tear the disc material which allows the inner nucleus to protrude towards the outside of the disc. (paperheart-movie.com)
Type II collagen is also part of the clear gel that fills the eyeball (the vitreous), the inner ear, and the center portion of the discs between the vertebrae in the spine (nucleus pulposus). (nih.gov)
Cellular1
Introduction: Relatively little is known about cellular subpopulations in the mature nucleus pulposus (NP). (maastrichtuniversity.nl)
Induces2
Puncture of a Disc and Application of Nucleus Pulposus Induces Disc Herniation-Like Changes and Osteophytes. (openorthopaedicsjournal.com)
It has been assumed that nucleus pulposus-induced activation of the dorsal root ganglion (DRG) may be related to an activation of sodium channels in the DRG neurons. (openorthopaedicsjournal.com)
Nerve root4
occurs when the herniated nucleus compresses or irritates the nerve root. (merckmanuals.com)
This may suggest that nucleus pulposus sensitizes the nerve tissue to produce nerve root pain when the nerve tissue is deformed mechanically. (openorthopaedicsjournal.com)
The herniated nucleus pulposus material is seen impinging on the nerve root and the spinal cord. (smartimagebase.com)
Fibrocartilaginous1
The nucleus pulposa undergoes variable degrees of fibrocartilaginous metaplasia and becomes friable, fragmented, or clefted. (nih.gov)
Discs2
Mineralization of the nucleus pulposus is best seen on lateral radiographic views and usually is seen in one or more discs of most chondrodystrophoid dogs more than one year of age. (vin.com)
Injection into the nucleus pulposus was successful in 55 of 78 (71%) of all injected discs. (avmi.net)
Marker1
Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. (jefferson.edu)
Occurs1
In general, this is an age- related lesion that occurs as the result of loss of water and proteoglycans in the nucleus pulposus. (nih.gov)
Spinal cord1
Nucleus pulposus (NP) embolism is an extremely rare cause of spinal cord Infarction. (mssm.edu)
Material2
One may therefore assume that the viscous or liquid herniating nucleus pulposus material is later subject to fibrotic changes that will render it harder. (openorthopaedicsjournal.com)
The incorporation of polymeric reinforcement within the gels increased material stiffness to that comparable to the native nucleus pulposus, however permeability was significantly greater than native values. (cam.ac.uk)
Tear1
If the tear in the disc goes all the way to the outside the nucleus will protrude out into the nerve canal. (paperheart-movie.com)
Application1
In this study these mechanisms were separated by comparing disc puncture with application of nucleus pulposus without disc injury, with superficial disc injury without nucleus pulposus and with application of fat. (openorthopaedicsjournal.com)
Content1
Nucleus Medical Media ("Nucleus") does not dispense medical or legal advice, and the text, illustrations, photographs, animations and other information ("Content") available on this web site is for general information purposes only. (smartimagebase.com)