• H&E stained sections: (A) Serrated adenocarcinoma: epithelial serrations or tufts (thick blue arrow), abundant eosinophilic or clear cytoplasm, vesicular basal nuclei with preserved polarity. (wikipedia.org)
  • Prostate xanthomas may mimic high-grade prostatic acinar adenocarcinoma with foamy cytoplasm, as well as adenocarcinoma with posthormonal therapy effect, particularly androgen deprivation therapy. (medscape.com)
  • Foamy gland carcinoma of the prostate features cells with abundant finely vacuolated cytoplasm and pyknotic hyperchromatic nuclei. (medscape.com)
  • They may show abundant clear-to-vacuolated, foamy cytoplasm with hyperchromatic nuclei without nucleolar prominence. (medscape.com)
  • Proteasomes are multicatalytic enzymatic complexes located in both nucleus and cytoplasm that aid in intracellular protein homeostasis by degradation and recycling of proteins [ 9 ]. (hindawi.com)
  • Conclusion: GEA can be identified cytologically based on the presence of flat, honeycomb-like sheets of tumor cells possessing vesicular nuclei, prominent nucleoli, and abundant vacuolated cytoplasm. (iiarjournals.org)
  • Presumably the C-terminal domain is essential for transport of the 9-1-1 complex from the cytoplasm into the nucleus, for activation of the G2 checkpoint signalling cascade [ 12 ]. (biomedcentral.com)
  • Inactivation of CIP2A-TOPBP1 caused acentric fragments to disperse throughout the mitotic cytoplasm, stochastically partition into the nucleus of both daughter cells and aberrantly misaccumulate as cytoplasmic DNA. (nature.com)
  • Histologically, they consist of a single layer of cuboidal glycogen-rich cells with round nuclei and clarified cytoplasm (1-3). (spg.pt)
  • Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. (umbc.edu)
  • Induced by LKB1CAMPK signaling, phosphorylated HDAC10 is usually transported from your the nucleus to the cytoplasm and further enhances the expression of glucose-6-phosphate dehydrogenase (G6PD). (geogise.com)
  • Common solid tumors that have been linked to cancer-induced TMA include gastric, breast, lung, and prostate adenocarcinomas, with gastric adenocarcinoma being the most reported. (hindawi.com)
  • Most often epithelial cancer cells will look like adenocarcinoma, which is a type of lung cancer. (jeffreysglassman.com)
  • [ 1 , 2 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • EGFR downstream signaling promotes constitutive activation of TKIs domain due to the mutation in exon 19 and exon 21 (L858R point mutation), which leads to cell proliferation, invasion, metastasis, and angiogenesis, causing lung adenocarcinoma. (lidsen.com)
  • We studied whether cellular senescence induced by HDAC inhibitor sodium butyrate in E1a+cHa-Ras -transformed rat embryo fibroblasts (ERas) and A549 human Ki-Ras mutated lung adenocarcinoma cells would enhance the tumor suppressor effect of MEK/ERK inhibition. (aging-us.com)
  • These processes contributes to the growth of lung malignancy spheres via SOX9-mediated stem-like properties, suggesting that HDAC10-TGF-SOX9-SLUG/CD44 axis plays an essential role in lung adenocarcinoma [30]. (geogise.com)
  • These results suggest that PAX2 immunoreactivity may be useful to (1) distinguish mesonephric hyperplasia from minimal deviation adenocarcinoma, (2) to distinguish lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma, and (3) to distinguish endocervical tubal metaplasia or cervical endometriosis from endocervical adenocarcinoma in situ. (nih.gov)
  • The sensitivity of Papanicolaou smears for detecting endocervical adenocarcinoma in situ (AIS) is very low. (cytojournal.com)
  • Background/Aim: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. (iiarjournals.org)
  • We examined the differences between the cytological features of GEA and usual-type endocervical adenocarcinoma (UEA). (iiarjournals.org)
  • Endocervical adenocarcinoma (EAC) accounts for 20-25% of all cervical carcinomas ( 7 ). (iiarjournals.org)
  • The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)
  • In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
  • Nodal metastasis and distant spread are rare, occurring in less than 1% of cases. (pso-hns.org)
  • This demonstrates that distant metastasis can occur during the early phase of tumor growth in these aggressive lesions. (biomedcentral.com)
  • Distant metastasis of NECs mostly occurred in the viscera, while cases of scalp metastasis were rarely reported. (biomedcentral.com)
  • DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
  • Fungating carcinoma of the colon Edges and margins of an intestinal tumor Adenocarcinoma is a malignant epithelial tumor, originating from superficial glandular epithelial cells lining the colon and rectum. (wikipedia.org)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant epithelial tumor characterized by cytologic uniformity, morphologic diversity, an infiltrative growth pattern, and low metastatic potential. (pso-hns.org)
  • The cells are uniform in size, round to oval, and have bland cytologic features, with vesicular nuclei and inconspicuous nucleoli (Figure 4). (pso-hns.org)
  • The nuclei are bland and vesicular, with occasional small inconspicuous nucleoli. (pso-hns.org)
  • Invasive adenocarcinoma commonly displays: Varying degrees of gland formation with tall columnar cells Frequently desmoplasia Dirty necrosis, consisting of extensive central necrosis with granular eosinophilic karyorrhectic cell detritus. (wikipedia.org)
  • Other paraneoplastic syndromes that commonly occur with AN include tripe palms and the sign of Leser-Trélat (which are discussed below). (medscape.com)
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
  • It occurs more commonly in middle-aged or older women and are usually diagnosed incidentally. (spg.pt)
  • Despite the declining incidence of cervical carcinoma, the proportion of adenocarcinomas arising from the uterine cervix has risen steadily ( 8 , 9 ). (iiarjournals.org)
  • 4 cases of villoglandular papillary adenocarcinoma of uterine cervix admitted from 2001 to 2009 in Children's Hospital, Shanxi Provincial People's Hospital were analysed retrospectively, including detailed clinical data. (biomedres.info)
  • Villoglandular Papillary Adenocarcinoma (VGPA), also named Villoglandular Adenocarcinoma (VGA), refers to a rare welldifferentiated adenocarcinoma of uterine cervix. (biomedres.info)
  • Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
  • 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
  • In 1994, it was classified as the pathological type of cervical cancer by WHO in 1994, which is a subtype of cervical adenocarcinoma. (biomedres.info)
  • Most (11 of 15) stage II endometrial endometrioid adenocarcinomas lacked PAX2 expression but 1 of 10 grade 1 tumors and 3 of 5 grade 2 tumors did express PAX2. (nih.gov)
  • In children under 14 years old, CNS tumors are the most frequent solid tumors, and half of the cases occur in infants 0-4 years old [ 1 - 3 ]. (hindawi.com)
  • When these tumors occur in children, however, they are more often infratentorial, intraventricular, or intraparenchymal than in adults. (medscape.com)
  • however, PAX2 should not be interpreted in isolation from the architectural and cytologic features of the lesion as it may be expressed in some stage II endometrial adenocarcinomas involving the cervix. (nih.gov)
  • The differential diagnosis of exuberant mesonephric hyperplasia includes minimal deviation adenocarcinoma of the cervix, a tumor with deceptively bland morphology for which no reliable diagnostic biomarkers currently exist. (nih.gov)
  • 1. Adenocarcinoma: papillary, mucoid, trabecular (well-differentiated). (poznayka.org)
  • To explore the clinical and pathological features, diagnosis and therapy of Villoglandular Papillary Adenocarcinoma (VGPA). (biomedres.info)
  • With the exception that papillary meningiomas are more common in children, meningiomas are rather uncommon in children and almost never occur in infants. (medscape.com)
  • This domain occurred 356 times on human genes ( 810 proteins). (umbc.edu)
  • many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
  • Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
  • Tunnel clusters have been separated by Fluhmann into two subcategories: Type Aand Type B. Although type A and B tunnel clusters are often intermixed, their distinctionis important as they each pose their own relatively unique problems in the discriminationfrom invasive adenocarcinoma. (fliphtml5.com)
  • Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)
  • Once stabilized, β-catenin accumulates and translocates to the nucleus, where it complexes with TCF/LEF to activate transcription of target genes, such as MYC and CCND1 . (plos.org)
  • The AhR canonical genomic signaling pathway occurs as follows: upon ligand binding, the complex undergoes conformational changes and translocates into the nucleus. (invivogen.com)
  • If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
  • [ 4 ] This is especially the case when they occur in seemingly infiltrating nests, cords, or single cells on small biopsy specimens. (medscape.com)
  • Increased hRad9 protein was observed in breast cancer cells nucleus compared to non-tumor epithelium. (biomedcentral.com)
  • Finding of hyperphosphorylated forms of hRad9 in the nucleus of cancer cells is in keeping with its function in ameliorating DNA instability, whereby it inadvertently assists tumor growth. (biomedcentral.com)
  • Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
  • A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
  • The tissue was composed of cells containing elongated nucleus, with discrete pleomorphism and rare stroma. (vin.com)
  • For example, a dog taken into a certain room and given good food will show activation Inhibitors,research,lifescience,medical of the nucleus accumbens cells. (wee1signaling.com)
  • HT29-Lucia™ AhR cells are engineered from the human HT-29 colon adenocarcinoma cell line for the study of the aryl hydrocarbon receptor (AhR) genomic signaling induction (see details), by monitoring the activity of the Lucia luciferase reporter protein. (invivogen.com)
  • Upon phosphorylation, R-SMADs recruit the co-SMAD SMAD-4 to form protein complexes that translocate into the nucleus and exhibit transcriptional activity. (springer.com)
  • It also contains a nuclear localization sequence (NLS) that targets the hRad9 protein into the nucleus [ 11 ]. (biomedcentral.com)
  • The serine/threonine protein kinase BRAF is an important player in the mitogen-activated protein kinase (MAPK) signaling pathway that transduces mitogenic signals from activated cell-surface growth factor receptors to the cell nucleus and as a result modulates many important cellular processes, such as tumor growth, differentiation, proliferation, and angiogenesis. (hindawi.com)
  • The clinical data and histomorphologic features characterized by architectural diversity yet cytologic blandness lead us to the diagnosis of polymorphous low-grade adenocarcinoma. (pso-hns.org)
  • The lattercan be particularly alarming if one is not aware that this type of change can occur (4).The main differential diagnosis is with extremely well-differentiated endocervicaladenocarcinoma (adenoma malignum). (fliphtml5.com)
  • Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. (umbc.edu)
  • Depending on glandular architecture, cellular pleomorphism, and mucosecretion of the predominant pattern, adenocarcinoma may present three degrees of differentiation: well, moderately, and poorly differentiated. (wikipedia.org)
  • These nuclei are focal points for responses to the environment and for constructing behaviors. (wee1signaling.com)
  • For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
  • Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
  • however, cases have been discovered mostly in prostate core biopsy specimens, which suggests that prostatic xanthomas occur in men in the same age range as those with prostate cancer. (medscape.com)
  • The most common AIS was the typical type (41 cases, 67.2%) among all cytologically-diagnosed AIS or adenocarcinoma cases (61 cases). (cytojournal.com)
  • However, they are both clinically and histologically heterogeneous, and tumor recurrence or anaplastic progression occurs in some cases [ 6 ]. (hindawi.com)
  • To investigate the role of achaete-scute complex-like 2 (ASCL2) in stomach adenocarcinoma (STAD), we analyze whether ASCL2 suppression could retard cancer development and further observe the relevance between ASCL2 and inflammation via Toll-like receptor 4 (TLR4) activation in STAD, both in vitro and in vivo. (biomedcentral.com)
  • Genomic instability seems to be a fundamental property of neoplastic progression that develops before the onset of cancer, and a large body of evidence now suggests that most oesophageal adenocarcinomas arise in association with a process of gain or loss of whole chromosomes or large portions of chromosomes ( Reid et al, 2010 ). (nature.com)
  • Parathyroid cancer is a rare cancer that usually affects people in their forties or fifties and occurs in one of the four parathyroid glands. (medlineplus.gov)
  • Advantages of ICM over flow cytometry include low set up cost, smaller number of nuclei required and greater sensitivity for non-diploid cell populations. (nature.com)
  • [ 8 , 9 ] Meningiomas associated with neurofibromatosis type 2 (NF2) tend to occur in younger individuals and with equal distribution between males and females. (medscape.com)
  • Thus, the possibility of distant metastases should be assessed in the initial work up to avoid mistaken clinical staging especially when distant metastases occur only in skin. (biomedcentral.com)
  • If the mucus remains inside the tumor cell, it pushes the nucleus at the periphery, this occurs in "signet-ring cell. (wikipedia.org)
  • TGF-β1 activated accumulation of phosphorylated SMAD2 (pSMAD2-C) at centrioles of motile cilia and at cell nuclei. (springer.com)
  • In summary, we demonstrate a role of motile cilia in TGF-β1 sensing and showed that TGF-β1 disturbs TJ permeability of conductive airway epithelia by redistributing CLDN3 from TJs into cell nuclei. (springer.com)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)