In other animals, heat shock response is a transcriptional response driven by the heat shock transcription factor 1 ( HSF1 ) and thermal stress can trigger HSP70 expression to protect the organism via HSF1 . (biomedcentral.com)
Here, we identified an ABA-induced gene, MpAITR1, which encoded a nucleus localization transcriptional factor in Pongamia. (bvsalud.org)
Gene6
Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. (wikipedia.org)
In addition, defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. (wikipedia.org)
Among these factors, heat shock factor 1 (HSF1) cooperated with the MMP3 to activate the HSP70B′ gene promoter in reporter gene assays, while a dominant negative HSF1 blocked the role for MMP3 in the trans-activation. (elsevierpure.com)
Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock protein (HSP) 70 under elevated temperatures. (biomedcentral.com)
We identified 150 genes responsive to heat shock including seven HSP genes, six of which belonging to the group of 17 HSP genes enriched in response to heat shock, according to weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)
The results demonstrated that the gene thb encoding the b subunit of the thermosome, as well as hsp14 and hsp20, play crucial roles in the majority of stress conditions. (jcbose.ac.in)
CRYAB1
We found that mRNA levels of HSP family members (HSP70B′, HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload. (elsevierpure.com)
Accumulation1
Although not yet clearly understood, defective chaperone activity is expected to trigger the accumulation of protein aggregates and underlie the development of α-crystallinopathy, or the failure of protein quality control, resulting in protein deposition diseases such as Alzheimer's disease and Parkinson's disease. (wikipedia.org)
HSF13
In addition, we found 48 and 47 genes that were upregulated and downregulated by HSF1 in response to heat shock, respectively. (biomedcentral.com)
In the upregulated genes, we identified one HSP70 potentially regulated by HSF1 in response to heat shock. (biomedcentral.com)
Our results revealed that the expression of HSP70 and HSP20 was initially triggered after 2 h of heat shock, and one of the HSP70 genes was potentially regulated by HSF1 . (biomedcentral.com)
Transmembrane1
Cysteine-rich transmembrane module (CYSTM) proteins constitute small molecular protein families and have been identified across eukaryotes, including yeast, humans, and several plant species. (bvsalud.org)
Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
Vertebrate2
The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. (wikipedia.org)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
TRANSCRIPTION3
We previously reported that human MMP3 could translocate into cellular nuclei and control transcription in human chondrosarcoma-derived cells and in articular cartilage (Eguchi et al. (elsevierpure.com)
Additionally, four common transcription factors: FadR, TFEb, CRISPR loci binding protein, and HTH family protein were consistently overexpressed across all stress conditions, indicating their significant role in managing stress. (jcbose.ac.in)
Apoptosis1
It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. (wikipedia.org)
Family3
Alpha B chain crystallins (αBC) can be induced by heat shock, ischemia, and oxidation, and are members of the small heat shock protein (sHSP also known as the HSP20) family. (wikipedia.org)
Furthermore, based on differentially expressed genes and WGCNA analyses, we found that the hypoxia signaling pathway was enriched under heat shock conditions. (biomedcentral.com)
From these results, it is evident that not all heat-inducible genes were triggered simultaneously in response to heat shock stress. (biomedcentral.com)
Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. (wikipedia.org)
Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (wikipedia.org)
The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)
Small1
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. (affbiotech.com)
Detection1
WB: For western blot detection of denatured protein samples. (affbiotech.com)
Total2
HSP20 Antibody detects endogenous levels of total HSP20. (affbiotech.com)
A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
Development1
And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)
Domain1
In addition, chromobox proteins CBX5/HP1α and CBX3/HP1γ cooperated with the PEX domain in induction of HSP70B′ mRNA. (elsevierpure.com)
Stress1
Furthermore, αBC may confer stress resistance to cells by inhibiting the processing of the pro-apoptotic protein caspase-3. (wikipedia.org)