• A small number of drugs targeted to nucleotide metabolism, by virtue of their effect on folate biosynthesis and recycling, have been successfully used against apicomplexan parasites such as Plasmodium and Toxoplasma for many years, although resistance is now a major problem in the prevention and treatment of malaria. (pubmedcentralcanada.ca)
  • Replication of DNA and its transcription to the various RNA species necessitate a constant and substantial supply of the constituent nucleotides, a particularly demanding requirement in the case of rapidly dividing cells or pathogens, for example cancer cells or malaria parasites. (pubmedcentralcanada.ca)
  • Individual nucleotides also play important roles in cell metabolism. (encyclopedia.com)
  • Results from pulse-chase experiments indicate that a rapid turnover of dTTP to thymidine may be involved in limiting the level of thymine nucleotides in the cell. (rupress.org)
  • Expanding upon DNA's complement of four chemical nucleotides, or "letters" (A, T, C and G), the scientists concocted a totally unnatural pair of nucleotides, dubbed X and Y. As reported in Nature in May, the team inserted the two into a bacterial cell, a strain of E. coli. (discovermagazine.com)
  • Cell factories, their DNA tweaked by different combinations of nucleotides, may one day generate therapeutic proteins that could be tested against each other in cultures. (discovermagazine.com)
  • At each site, Rns recognizes asymmetric nucleotide sequences in two regions of the major groove and binds along one face of the DNA helix. (asm.org)
  • Analysis of Rns-nucleotide interactions at each site suggests that binding sites for Rns and related virulence regulators are not easily identified because they do not bind palindromic or repeated sequences. (asm.org)
  • He promises it could never survive outside the lab because the foreign nucleotides, deprived of their chemical feedstock, would quickly be deleted. (discovermagazine.com)