Generally, TdT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. (wikipedia.org)
One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. (biossusa.com)
DNTT1
Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. (wikipedia.org)
Specialized DNA polymerase1
DNA polymerases also play key roles in other processes within cells, including DNA repair, genetic recombination, reverse transcription, and the generation of antibody diversity via the specialized DNA polymerase, terminal deoxynucleotidyl transferase. (definitions.net)
Polymerase15
As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. (wikipedia.org)
Further, TdT is the only polymerase that is known to catalyze the synthesis of 2-15nt DNA polymers from free nucleotides in solution in vivo. (wikipedia.org)
TdIF1 is another protein that interacts with TdT to inhibit its function by masking the DNA binding region of the TdT polymerase. (wikipedia.org)
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (biossusa.com)
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. (lookformedical.com)
This dictionary definitions page includes all the possible meanings, example usage and translations of the word dna polymerase . (definitions.net)
Cells contain several types of DNA polymerase, some of which are required for replication of DNA, and are indispensable for multipliation and division of cells. (definitions.net)
DNA polymerase is an enzyme that plays a crucial role in DNA replication, assisting in the process of duplicating DNA strands accurately and efficiently. (definitions.net)
DNA polymerase also possesses proofreading capabilities, allowing it to correct any potential mistakes made during the replication process. (definitions.net)
A DNA polymerase is a cellular or viral polymerase enzyme that synthesizes DNA molecules from their nucleotide building blocks. (definitions.net)
DNA polymerases are widely used in molecular biology laboratories, notably for the polymerase chain reaction, DNA sequencing, and molecular cloning. (definitions.net)
How to say dna polymerase in sign language? (definitions.net)
Are we missing a good definition for dna polymerase ? (definitions.net)
Molecule1
DNA polymerases are essential for DNA replication, and usually function in pairs while copying one double-stranded DNA molecule into two double-stranded DNAs in a process termed semiconservative DNA replication. (definitions.net)
Enzyme4
The preferred substrate of this enzyme is a 3'-overhang, but it can also add nucleotides to blunt or recessed 3' ends. (wikipedia.org)
an enzyme that catalyzes the formation of DNA from deoxyribonucleoside triphosphates. (definitions.net)
This enzyme synthesizes new strands of DNA by adding nucleotides to a pre-existing DNA strand or RNA primer, following the rules of base pairing. (definitions.net)
Vitro1
In vitro, this behaviour catalyzes the general formation of DNA polymers without specific length. (wikipedia.org)
Bind3
The differences between TdTS and TdTL occur outside regions that bind DNA and nucleotides. (wikipedia.org)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
REPLICATION1
During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING. (lookformedical.com)
Polymerases3
Although TdT was one of the first DNA polymerases identified in mammals in 1960, it remains one of the least understood of all DNA polymerases. (wikipedia.org)
Unlike most DNA polymerases, it does not require a template. (wikipedia.org)
Similar to many polymerases, the catalytic site of TdT has two divalent cations in its palm domain that assist in nucleotide binding, help lower the pKa of the 3'-OH group and ultimately facilitate the departure of the resultant pyrophosphate by-product. (wikipedia.org)
Vivo1
The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)
Adds2
TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional diversity. (wikipedia.org)
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. (lookformedical.com)
Adds N-nucleotides2
TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional diversity. (wikipedia.org)
In this study, we provide further evidence for the role of Abs in HSI using transgenic mice lacking terminal deoxyribonucleotidyltransferase (TdT), which adds N nucleotides to V-D and D-J junctions of the complementary determining region 3 (CDR3) (TdT -/- ) and mice with altered Ab repertoires due to replacement of the complete locus of heavy chain diversity segments (D H ) with an altered D H segment (namely, ΔD-iD). (elsevierpure.com)
Synthesis1
Further, TdT is the only polymerase that is known to catalyze the synthesis of 2-15nt DNA polymers from free nucleotides in solution in vivo. (wikipedia.org)
Enzymes1
Enzymes that catalyze the incorporation of deoxyribonucleotides into a chain of DNA. (bvsalud.org)
Repair1
The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)