Nucleotide transporter nucleotide transport proteins. Medical search. Frequent questions

To investigate the possibility of a founder effect in these four families, we conducted haplotype analysis, and 14 single nucleotide polymorphisms (SNPs) throughout the SLC26A4 gene were genotyped. (nih.gov)
Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population. (geneticsmr.com)
Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. (geneticsmr.com)

This protein functions in the cellular export of its substrate, cyclic nucleotides. (wikipedia.org)
3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
These transporters, many of which are sodium-coupled, have been shown to use an elevator mechanism of transport, but exactly how substrate binding is coupled to sodium ion binding and transport is not clear. (elifesciences.org)
Here, we solve the crystal structure at 2.3 Å of a transporter from Neisseria meningitidis (ASBT NM ) in complex with pantoate, a potential substrate of ASBT NM . (elifesciences.org)
The manuscript represents an important contribution to an ongoing discussion about the substrate binding site and mechanism of the Bile Acid Sodium Symporter (BASS) family of transporters. (elifesciences.org)
Structural and biochemical analysis of a bacterial homolog, ASTBnm, in complex with its native substrate (not bile acids, but a vitamin A precursor, pantoate) show a new binding site that is consistent with classical proposals for elevator-type transport mechanisms. (elifesciences.org)
Molecular dynamics (MD) simulations highlight the improved stability for the substrate in the active site when ions are present, suggesting a binding order during the transport cycle. (elifesciences.org)
Heide van der T., and Poolman, B. (2002) ABC transporters: one, two or four extracytoplasmic substrate-binding sites? (rug.nl)
The NBDs in ABCG2 remain in contact with one another even without a bound substrate, providing greater substrate specificity as the entrance to the transporter is not as globular as other ABC transporters like ABCB1 or ABCC1. (proteopedia.org)
The protein is in the inward-facing conformation with Cavity 1 open to the cytosol for substrate recruitment, the Leucine Plug intact, and Cavity 2 completely occluded. (proteopedia.org)
which is occluded when the protein in is the inward-facing conformation, is now open to the extracellular space and able to release the substrate. (proteopedia.org)
Glutathione as a conjugation partner or co-transported substrate plays multiple and partially undefined roles in the transport mechanism of MRPs, especially of MRP2. (solvobiotech.com)
2009 identified 21 families of these substrate capture proteins, each with a different specificity predicted by genome context analyses. (tcdb.org)
2009 have a dedicated energizing module, but in 459 cases distributed among almost 100 gram-positive bacteria, different and unrelated substrate capture proteins share the same energy-coupling module. (tcdb.org)

Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
This domain occurred 43 times on human genes ( 94 proteins). (umbc.edu)
And what Fred asked me to do was to sequence the proteins that were encoded in the genes that he was sequencing because he wanted to be sure about the accuracy of his DNA sequencing methods. (lindau-nobel.org)
And again my task was to try to identify the protein genes that were. (lindau-nobel.org)
the genes encoding proteins in that genome. (lindau-nobel.org)
Identification and biochemical characterization of Saccaromyces cerevisiae and of Arabidopsis thaliana genes coding for inner mitochondrial membrane transporters. (cnr.it)
Many bioY genes are located at loci encoding biotin biosynthesis or are unlinked to either biotin synthesis or other biotin transport genes. (tcdb.org)
1] "Construction and properties of Escherichia coli mutants defective in two genes encoding homologous membrane proteins with putative roles in anaerobic C4-dicarboxylic acid transport. (tcdb.org)
Nucleotide sequences of the fumarase (fumC) and aspartase (aspA) genes of Escherichia coli K12. (tcdb.org)

This protein is a member of the MRP subfamily which is involved in multi-drug resistance. (wikipedia.org)
The ABCG2 multidrug transporter or abc subfamily G member 2 is a membrane protein from the A TP- B inding C assette (ABC) transporter family, specifically the G-subfamily. (proteopedia.org)
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C. MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. (umbc.edu)
MRP4 is an ATP-dependent, unidirectional efflux transporter belonging to the C subfamily of the ABC protein superfamily. (solvobiotech.com)

2009 proposed the name energy-coupling factor transporters for the new class of putative ABC membrane transporters. (tcdb.org)

This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. (wikipedia.org)
Yet risks of renal failure and renal replacement therapy were similar in patients treated with nucleoside analogues versus nucleotide analogues in real-life setting. (medscape.com)
These agents are classified according to their chemical structures: the three nucleoside analogues include lamivudine, telbivudine and entecavir, whereas the two nucleotide analogues include adefovir dipivoxil, tenofovir disoproxil fumarate (TDF), [ 2 ] and the newly approved tenofovir alafenamide (TAF). (medscape.com)
Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in this website by year, and whether "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in Profiles. (umassmed.edu)

Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene. (wikipedia.org)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)
It is caused by a point mutation (G→T) at nucleotide position 559 of the gene, bovine solute carrier family 35 member 3 (SLC35A3). (researchgate.net)
The SLC34A1 gene provides instructions for making a protein called sodium-dependent phosphate transporter 2A (NaPi-IIa), which plays a role in the regulation of phosphate levels in the body (phosphate homeostasis). (medlineplus.gov)
The SLC34A1 gene mutations that cause infantile hypercalcemia 2 lead to production of an altered NaPi-IIa channel that cannot transport phosphate across kidney cell membranes. (medlineplus.gov)
As in infantile hypercalcemia (described above), the gene mutations that cause these health conditions prevent the NaPi-IIa transporter from functioning, reducing phosphate absorption in the kidneys and causing hypophosphatemia. (medlineplus.gov)
Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. (ox.ac.uk)
Existing studies of the effect on infant temperament of the 48 base pair variable number of tandem repeats polymorphism in exon 3 of the dopamine D4 receptor gene, DRD4 VNTR, and the serotonin transporter-linked polymorphic region, 5-HTTLPR, have provided contradictory results, and age seems to be an important factor. (ox.ac.uk)
Furthermore, gene overexpression is also frequently associated to antifungal resistance as well as an increase in the activity of proteins that reduce oxidative damage. (intechopen.com)
Cystic fibrosis is also associated with cystic fibrosis transmembrane conductance regulator (CFTCR) gene mutation results in the abnormal expression of cystic fibrosis transmembrane conductance regulator (CFTCR) protein, which is a cyclic adenosine monophosphate (cAMP)-activated chloride channel present on the surface of many types of epithelial cells. (nursingpaperslayers.com)
Expression of truncated bio transport operons, each with one gene deleted, resulted in stable BioMN complexes but revealed only low amounts of BioMY and BioNY aggregates in the absence of the respective third partner. (tcdb.org)
His Biochemistry research focuses on Gene isoform, Yeast, Mitochondrial matrix, Gene and Membrane transport protein. (research.com)
His work deals with themes such as Amino acid, Transport protein, Nucleotide, Gene and Stereochemistry, which intersect with Inner mitochondrial membrane. (research.com)
8] "Nucleotide sequence of the FNR-regulated fumarase gene (fumB) of Escherichia coli K-12. (tcdb.org)

2023 ). (1) the BioMNY complex with ATPase (BioM) and transmembrane protein (BioN). (tcdb.org)
2023 demonstrated that BioY linked to BioB can transport not only biotin but also dethiobiotin, and the combination of BioY and BioB contributes to the growth of A. caulinodans ORS571 in a biotin-deficient but dethiobiotin-sufficient environment. (tcdb.org)

This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. (wikipedia.org)
Based on 3-d structures of APC superfamily members, Rudnick ( 2011 ) has proposed the pathway for transport and suggested a 'rocking bundle' mechanism of transport. (tcdb.org)
This is then converted to GlcNAc-1P (N-acetylglucosamine 1-phosphate) by PGM3/AGM1 (phosphoglucomutase) and further to UDP-GlcNAc (uridine diphosphate N-acetylglucosamine) by UAP/AGX1 (UDP-N-acetylhexosamine pyrophosphorylase), utilizing UTP from the nucleotide metabolism pathway. (biomedcentral.com)
Possibly, these two transmembrane proteins comprise the pathway for transmembrane transport. (tcdb.org)

Furthermore, the effect of a recently discovered single nucleotide polymorphism which modulates the 5-HTTLPR (rs25531) was investigated in relation to infant temperament. (ox.ac.uk)

When evidence suggests that homologous membrane transport proteins of the ABC2 type couple transport to ATP hydrolysis using a homologue of the ABC-type ATPases, we list these proteins in the ABC superfamily. (tcdb.org)

Given its ability to transport important intra- and intercellular mediators such as cyclic nucleotides and eicosanoids, the physiological repertoire of MRP4 is thought to cover platelet aggregation, cell migration and proliferation, angiogenesis, and cardiomyocyte contraction. (solvobiotech.com)

Transporters such as organic anion-transporting polypeptide 1A2, P-glycoprotein, human organic cation transporter 1, and multidrug and toxin extrusion protein 1 are involved in the pharmacokinetics of LVX. (dovepress.com)

ABC (ATP binding cassette) transporters catalyze the transport of a wide variety of molecules across lipid bilayers into or out of cells and organelles. (rug.nl)
[2] ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). (proteopedia.org)

How does crowding affect mobility of proteins and lipids? (rug.nl)
Since the HBP utilizes major macromolecules such as nucleotides, amino acids, carbohydrates, and lipids to produce UDP-GlcNAc, cells may use it as a 'sensor' of energy availability that influences a large number of functional targets that contribute to cancer phenotypes (Fig. 2 ). (biomedcentral.com)
Glucose is a direct energy source, and galactose may be used as a component of complex proteins or lipids (glycoproteins and glycolipids). (researchgate.net)

ABC proteins transport various molecules across extra- and intra-cellular membranes. (wikipedia.org)
The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. (elifesciences.org)
These compositional characteristics were reflected in a functional enrichment in membrane transport, signal transduction, signaling molecules and interaction. (frontiersin.org)
Simultaneously, the method also records changes in the molecules the protein interacts with - in this case ATP. (nanowerk.com)
An enclosed structure that transports proteins and other molecules around the cell or to the cell surface. (cdghub.com)
ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. (umbc.edu)
It may also be important in limiting CNS and hematopoietic cell exposure to xenobiotics, and as a transporter of cell signaling molecules. (solvobiotech.com)
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. (lu.se)
Expression of TAP1 is down-regulated by human Epstein-Barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. (lu.se)

Transporters in the APC superfamily influence ferroptosis which may inhibit bone formation and promote bone absorption through oxidative stress, thus leading to osteoporosis. (tcdb.org)
Families 2.A.88 and 2.A.87 which are part of a superfamily, and 3.A.1.26, are homologous but function as secondary versus primary active transporters, respectively. (tcdb.org)

Thesis: "Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae . (cnr.it)

The results suggest a mechanistically novel group of membrane transporters. (tcdb.org)
2] "Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membrane transporters (DcuA and DcuB) distinct from the aerobic dicarboxylate transport system (Dct). (tcdb.org)

Nucleotide binding to the homodimeric MJ0796 protein: a computational study of a prokaryotic ABC transporter NBD dimer. (ox.ac.uk)
The smaller proteins are generally of prokaryotic origin while the larger ones are of eukaryotic origin. (tcdb.org)
2006 ) revealed the similarity of BioMN to homologous modules of prokaryotic transporters mediating uptake of metals, amino acids and vitamins. (tcdb.org)

Two-color MRP1 transport activity was normal, as shown by vesicular transport of [ 3 H]17 β -estradiol-17- β -(d-glucuronide) and doxorubicin efflux in AAV-293 cells. (sdstate.edu)
tenofovir AF will decrease the level or effect of letermovir by P-glycoprotein (MDR1) efflux transporter. (medscape.com)

In the simulation with ATP present at both NBDs, the dimeric protein interacts with the nucleotides in a symmetrical manner. (ox.ac.uk)
Significantly, CLC4 is expressed on endosomes and the ER, and likely interacts with related CLC-3 channels which facilitate sorting of CLC-4 proteins into endosomal compartments. (metrionbiosciences.com)
A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. (empiregenomics.com)

Over the next five years, our goals are to (1) identify novel recycling receptors required at different Golgi compartments and establish a systematic map of the intra-Golgi recycling network, (2) determine how the transmembrane receptors engage with their cargos, and (3) define the novel functions of a disease-associated membrane transporter in solute transport and protein recycling in the Golgi. (cornell.edu)

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. (empiregenomics.com)

have presented the crystal structure of apo-ApcT, a proton-coupled broad-specificity amino acid transporter, at 2.35 Å resolution. (tcdb.org)
A subunit of a larger biomolecule, e.g. a single amino acid in a protein or a specific sugar in an oligosaccharide. (cdghub.com)
And I was using skills that I'd developed in protein chemistry to study enzymes that were involved in making the amino acid methionine. (lindau-nobel.org)
His studies in Saccharomyces cerevisiae, Transport protein, Amino acid, Carnitine and Oxoglutarate dehydrogenase complex are all subfields of Biochemistry research. (research.com)

Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. (geneticsmr.com)

Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. (nanowerk.com)
A structural genomics approach is used to determine to the structures of proteins belonging to other classes of ABC transporters. (rug.nl)
To quantify MRP1 structural dynamics, we engineered a "two-color MRP1" construct by fusing green fluorescent protein (GFP) and TagRFP to MRP1 nucleotide-binding domains NBD1 and NBD2, respectively. (sdstate.edu)
The results demonstrate the utility of the two-color MRP1 construct for investigating ATP-binding cassette transporter structural dynamics, and it holds great promise for high-throughput screening of chemical libraries for unknown activators, inhibitors, or transportable substrates of MRP1. (sdstate.edu)

Also known as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain , blood-testis , and maternal-fetal barriers. (proteopedia.org)
transgenic and knock-out lines isolation, physiological characterization, determination of organ distribution and subcellular localization of transport systems, GUS technology, fluorescence and confocal microscopy. (cnr.it)
Moreover, iron interactions with N-terminally acetylated α S, the physiologically relevant form of the human protein, will be addressed to shed light on the current understanding of protein dynamics and the physiological environment in the disease state. (hindawi.com)
The mitochondrial transporter family (SLC25): physiological and pathological implications. (research.com)

We investigate the mobility of proteins in the bacterial cytoplasm and cytoplasmic membrane as well as membrane model systems, using optical microscopy-based techniques such as fluorescence correlation spectroscopy (FCS) and pulsed-FRAP (panel a). (rug.nl)

As an ABC Transporter , ABCG2 exhibits ATPase activity and uses the energy of ATP hydrolysis to facilitate transport. (proteopedia.org)
BioMNY-mediated biotin uptake was severely impaired by replacement of the Walker A lysine residue of BioM, demonstrating dependency of high-affinity transport on a functional ATPase. (tcdb.org)

So the mitochondria contain about 2,000 different proteins in human cells and only 13 of them are encoded in the mitochondrial genome. (lindau-nobel.org)
His studies in Transport protein integrate themes in fields like Glycerol-3-phosphate dehydrogenase, NAD+ kinase, Membrane transport, Genome and Membrane protein. (research.com)

Phosphate is needed for many functions including the breakdown of substances (metabolic processes), signaling between cells, and the production of DNA building blocks (nucleotides) and fats. (medlineplus.gov)
ABC transporters are membrane proteins that transport various substances from one side of the cell membrane to the other. (nanowerk.com)
The transporters are of great medical significance as they play a central role in the multi-drug resistance of cancer cells to chemotherapeutic substances and are associated with various inherited diseases like cystic fibrosis. (nanowerk.com)
Although the architecture of the nanomachines is known, a detailed understanding of how the splitting of the energy carrier ATP dynamically enables the transport of various substances across biological membranes has so far been lacking. (nanowerk.com)
A transport system wherein vesicles are used to move substances around or to the surface of the cell. (cdghub.com)
A large group of proteins that move substances across a membrane, e.g. as part of nutrient uptake or waste disposal. (cdghub.com)

The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)
The recombinant MRP1 protein expressed and trafficked normally to the plasma membrane. (sdstate.edu)
L-Aspartic acid is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. (sigmaaldrich.com)
Heterologous expression of the bioMNY operon and of the single bioY of the α-proteobacterium Rhodobacter capsulatus conferred biotin-transport activity on recombinant E. coli cells. (tcdb.org)

These proteins harness the sodium ion gradient to transport bile acids across the plasma membranes of enterocytes of the terminal ileum and hepatocytes, respectively. (elifesciences.org)
Biochemical assays revealed that the BioM, N, and Y proteins form stable complexes in membranes of the heterologous host. (tcdb.org)

The larger eukaryotic and archaeal proteins possess N- and C-terminal hydrophilic extensions. (tcdb.org)

Ferdinando Palmieri combines subjects such as Inflammation, Transcription factor, Glutamate aspartate transporter and NAD+ kinase with his study of Cell biology. (research.com)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

Ferdinando Palmieri mainly investigates Biochemistry, Mitochondrion, Mitochondrial carrier, Transport protein and Inner mitochondrial membrane. (research.com)

Surprisingly, the sequence analysis of PCR product also revealed the presence of two previously unknown homozygous mutations (TG→CT) at nucleotide positions 554 and 555 in addition to the previously reported heterozygous mutation at position 559. (researchgate.net)
And the importance of this was not just that it was the first protein, but it demonstrated that proteins had a defined sequence which some people doubted. (lindau-nobel.org)
The nucleotide sequence of the PCR product was identical to that published for murine GLUT1. (aai.org)

Nonopsonic phagocytosis of Pseudomonas aeruginosa requires facilitated transport of D-glucose by macrophages. (aai.org)
Glucose transport inhibitors blocked both [3H]-2-deoxy-glucose (2dG) uptake and phagocytosis of P. aeruginosa. (aai.org)
The facilitative glucose transporter GLUT1 mRNA transcript was detected by PCR in preparations from purified macrophages. (aai.org)
We conclude that glucose exerts its effect on the macrophage, not on the bacterium, in the glucose-dependent nonopsonic phagocytosis of P. aeruginosa and that glucose transport via GLUT1 by the macrophages is required to trigger ingestion. (aai.org)
Galactose is a monosaccharide consisting of 6 carbon atoms and it is an epimer of glucose, thus its transporter proteins are also SGLT1 and GLUT 2 (10, 12). (researchgate.net)

MRP4 with its 170-kDa molecular weight is the smallest among the MRP proteins. (solvobiotech.com)
PostDoc fellowship, research activity on "Molecular characterization, function and metabolic role of mitochondrial transport systems in plants", Department of Pharmaco-Biology University of Bari, Italy. (cnr.it)
Given the tight relation between protein structure and function, we present a set of methods to analyze protein topology, implemented in the VLDP program, relying on Laguerre space partitions built from series of molecular dynamics snapshots. (nature.com)

32303) chromosome segregation and condensation protein%2C ScpB CP001857 CDS Arcpr_0039 complement(32287. (go.jp)
32898) chromosome segregation and condensation protein ScpA CP001857 CDS Arcpr_0040 complement(32907. (go.jp)
36314) chromosome segregation protein SMC CP001857 CDS Arcpr_0041 complement(36316. (go.jp)

These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. (biomedcentral.com)

The NaPi-IIa protein is located in the membrane surrounding kidney cells, where it transports phosphate across the cell membrane. (medlineplus.gov)
We have proposed that under conditions of severe osmotic stress (panel b, lower figure), the cell membrane contacts the nucleoid, which creates pools of proteins and hinders free diffusion through the cell. (rug.nl)
The TMD is responsible for binding and transporting substrates, is embedded in the cell membrane, extends into the extracellular region (Figure 1). (proteopedia.org)
One molecule of ATP is hydrolyzed to transport substrates across the cell membrane while the second molecule of ATP is hydrolyzed to reset the transporter to its inward-facing conformation. (proteopedia.org)

The BASS family, however, transports a wide array of substrates other than bile acids. (elifesciences.org)
The overall shift from inward-facing to outward-facing promotes the transport of substrates through the transporter. (proteopedia.org)
Substrates are transported through ABCG2 via two cavities separated by a leucine plug (Figure 2). (proteopedia.org)
in order to recruit substrates for transport. (proteopedia.org)
After substrates bind in Cavity 1, ATP binds each NBD leading to the transporter shifting from inward-facing to outward-facing. (proteopedia.org)
This means that, for instance, in the liver (where its abundance is relatively low) it effluxes its substrates into the bloodstream, whilst in the kidney (where it is one of the dominating ABC transporters [7]) it effluxes into the urine. (solvobiotech.com)
MRP4 has long been known to require reduced glutathione for the transport of bile acids [20], but the MRP4-mediated extrusion of other substrates such as halobenzoquinones may also depend on GSH, possibly via conjugate formation [21]. (solvobiotech.com)
However, unlike typical ABC transporters (E.I. Sun & M.H. Saier, unpublished results), they use small integral membrane proteins that are postulated to capture specific substrates. (tcdb.org)

Odorants diffuse into the mucous and are transported to the olfactory receptor. (medscape.com)

The nucleotide binding domain shows the highest similarity between all members of the family. (umbc.edu)

These membrane proteins are homologues to ABC-2 exporters. (tcdb.org)

The FepA membrane protein is surrounded by a lipid bilayer separating the extracellular medium and the periplasm. (nature.com)

Absence of extracytoplasmic solute-binding proteins among the members of this group, however, is a distinctive feature. (tcdb.org)

Integrated analyses of an RNA binding protein-based signature related to tumor immune microenvironment and candidate drugs in osteosarcoma. (cdc.gov)

In recent years, researchers have uncovered the 3D structures of several of these transporters at the atomic level. (nanowerk.com)
These structures also illustrated the transporter cycle of ABCG2, the binding locations for inhibitors, and the link between cancer and the ABC transporter family. (proteopedia.org)

The researchers led by Prof. Dr. Eckhard Hofmann and Prof. Dr. Klaus Gerwert from the Biophysics Department report on the results in the current issue of the Journal of Biological Chemistry ( 'Time-resolved Fourier Transform Infrared Spectroscopy of the Nucleotide-binding Domain from the ATP-binding Cassette Transporter MsbA' ). (nanowerk.com)
ATP splitting: The transport protein MsbA (grey) splits ATP (coloured), to generate energy for the transport process. (nanowerk.com)
The Bochum researchers have now dynamically tracked the ATP splitting, called hydrolysis, for the first time in the fat transporter MsbA from the bacterium Escherichia coli. (nanowerk.com)
Using fourier transform infrared spectroscopy, they studied the motor domains of MsbA, i.e. the part of the protein where the ATP splitting takes place. (nanowerk.com)

subunit alpha of MPP mitochondrial signal peptidase heterodimer","protein_coding" "Zm00001e017599_P001","No alias","Zea mays","Protein disulfide isomerase-like 2-2 OS=Oryza sativa subsp. (ntu.edu.sg)
Only the S subunit is required for transport as a secondary porter. (tcdb.org)

9] "Topological analysis of DcuA, an anaerobic C4-dicarboxylate transporter of Escherichia coli. (tcdb.org)

The BASS family is characterised by two helices that cross-over in the centre of the protein in an arrangement that is intricately held together by two sodium ions. (elifesciences.org)
These results have implications, not only for ASBT NM but for the BASS family as a whole and indeed other transporters that work through the elevator mechanism. (elifesciences.org)
Some animal proteins, for example, those in the LAT family (TC# 2.A.3.8) including ASUR4 (gbY12716) and SPRM1 (gbL25068) associate with a type 1 transmembrane glycoprotein that is essential for insertion or activity of the permease and forms a disulfide bridge with it. (tcdb.org)
They are members of the rBAT family of mammalian proteins (TC #8.A.9). (tcdb.org)
A high percentage of the ABC family transporters (19 of the 48) transport chemotherapeutic agents out of cells, making expression levels of ABC transporters a major indicator of cancer treatment prognosis. (proteopedia.org)
1251 orc1%2Fcdc6 family replication initiation protein CP001857 CDS Arcpr_0002 1251. (go.jp)
9195) PhoH family protein CP001857 CDS Arcpr_0008 9278. (go.jp)
41666) ExsB family protein CP001857 CDS Arcpr_0048 41748. (go.jp)
45756) PEBP family protein CP001857 CDS Arcpr_0056 45795. (go.jp)
47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes. (geneticsmr.com)
However, the VUT family member, TrpP of Bacillus subtilis (2.A.88.4.1) and the ThiW ABC membrane protein homologue, 3.A.1.26.2, are clearly related by common descent. (tcdb.org)
The mitochondrial transporter family SLC25: identification, properties and physiopathology. (research.com)
His research in Mitochondrial carrier intersects with topics in Membrane transport, ATP-ADP translocase, NAD+ kinase and Solute carrier family. (research.com)
Belongs to the abc transporter family. (lu.se)

The splitting process can be tracked in the infrared spectrum (above), in which the various ATP intermediate products leave characteristic bands (red: ATP, yellow: split-off phosphate, white: protein). (nanowerk.com)
In this way they tracked, how ATP bound to the transport protein, how one of its three phosphate groups split off and was released into the environment without first latching back on to the protein. (nanowerk.com)

However, if ADP is present at one binding site then both NBD-NBD and protein-ATP interactions are enhanced at the opposite site. (ox.ac.uk)
To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)
One of the ABC transporters that is studied in detail is the osmoregulatory ABC transporter OpuA (class D). Osmotic control of OpuA involves gating by intracellular ionic strength and is mediated by lipid-protein interactions. (rug.nl)

Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. (empiregenomics.com)

Anatomy3

Organisms1

Diseases1

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes10

Information Science3

Single nucleotide po3

Substrate14

Genes11

Subfamily4

Putative1

Nucleoside6

Gene14

20232

Pathway4

Polymorphism1

Homologous membrane transpor1

Cyclic nucleotides1

Anion1

Cassette Transporters2

Lipids3

Molecules9

Superfamily2

Aspartate-glutamate1

Membrane transporters2

Prokaryotic3

Efflux2

Interacts3

Solute transport1

Receptors1

Amino acid4

Metabolism1

Structural4

Physiological4

Bacterial1

ATPase2

Genome2

Substances6

Recombinant4

Membranes2

Eukaryotic1

Glutamate1

Target proteins1

Inner mitochon1

Sequence3

Glucose5

Molecular3

Chromosome3

Glycoproteins2

Cell membrane4

Substrates8

Olfactory receptor1

Similarity1

Homologues1

Extracellular1

Extracytoplasmic1

Immune microenvironment1

Structures2

MsbA4

Subunit2

Escherichia1

Family15

Phosphate2

Interactions6

Expression1