• Evidences available suggest that the viroid is replicated by direct copying with the help of a host RNA dependent RNA polymerase. (biologydiscussion.com)
  • The reaction continues when cAMP activates protein kinase which catalyzes phosphorylation, activating a ribonucleic acid (RNA) polymerase. (nfpt.com)
  • The polymerase will stimulate the production of RNA that acts as a messenger for protein synthesis. (nfpt.com)
  • In order to clarify the molecular mechanisms underlying the cross-family infection of SMV, we used double-stranded RNA extraction, rapid amplification of cDNA ends polymerase chain reaction and Gibson assembly techniques to carry out SMV full-length genome amplification from susceptible soybeans and constructed an infectious cDNA clone for SMV. (ppjonline.org)
  • In this study we expressed plant DCL4 in Saccharomyces cerevisiae , an RNAi-depleted organism, in which we could highlight the role of dicing as neither Argonautes nor RNA-dependent RNA polymerase is present. (biomedcentral.com)
  • HAV replicates exclusively in the cytoplasm of the infected hepatocytes by a mechanism involving an RNA-dependent RNA polymerase. (medscape.com)
  • It was first identified in the minus strand of the tobacco ringspot virus (TRSV) satellite RNA where it catalyzes self-cleavage and joining (ligation) reactions to process the products of rolling circle virus replication into linear and circular satellite RNA molecules. (wikipedia.org)
  • The hairpin ribozyme is an RNA motif that catalyzes RNA processing reactions essential for replication of the satellite RNA molecules in which it is embedded. (wikipedia.org)
  • Both cleavage and end joining reactions are mediated by the ribozyme motif, leading to a mixture of interconvertible linear and circular satellite RNA molecules. (wikipedia.org)
  • These reactions are important for processing the large multimeric RNA molecules that are generated by rolling circle replication. (wikipedia.org)
  • At the end of the replication cycle, these large intermediates of satellite RNA replication are processed down to unit length molecules (circular or linear) before they can be packaged by viruses and carried to other cells for further rounds of replication. (wikipedia.org)
  • Similar results were obtained with sucrose density gradient fractions containing RNA molecules of the size expected for ssRNA-3. (microbiologyresearch.org)
  • however, Ribonuclease P can cleave other RNA molecules. (jove.com)
  • Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)
  • There is also similarity in size and the circularity of the RNA molecules in both. (biologydiscussion.com)
  • RNA molecules and their interactions with protein partners in order to understand their biology. (wustl.edu)
  • At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). (degruyter.com)
  • Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. (degruyter.com)
  • Viroids are non-encapsidated, single-stranded (ss), 250-400 nucleotide (nt)-long circular RNA molecules that do not encode proteins (1, 2). (degruyter.com)
  • Upon inoculation, mature Pospiviroidae RNA molecules enter the plant cell nucleus. (degruyter.com)
  • Recently, a novel molecular mechanism of DMD pathogenesis-circulating RNA molecules-has been revealed through the study of target pathways modulated by the Neutral sphingomyelinase2/Neutral sphingomyelinase3 ( nSMase2/Smpd3 ) protein. (cytovax.com)
  • This reservoir has dramatically increased in the past few years and it now contains over 1700 tertiary RNA structures, both, in the form of isolated molecules as well as RNA-protein and ligand complexes. (biomedcentral.com)
  • RNA molecules found in the nucleus either associated with chromosomes or in the nucleoplasm. (umassmed.edu)
  • They can self-splice without the help of any proteins, whereas nuclear introns are spliced by the spliceosome, an RNA and protein-containing enzyme complex. (jove.com)
  • Viroids are among the smallest pathogenic agents which can replicate within infected hosts with the help of host enzymes, because the viroid RNA does not code for any proteins. (biologydiscussion.com)
  • Nucleolytic ribozymes (hereafter referred to as ribozymes for short) are small RNAs (less than 200 nt) that function independently of proteins, of which nine classes are known to exist (hammerhead, hairpin, Varkud satellite, hepatitis delta virus (HDV), glmS , twister, twister-sister, pistol and hatchet) each with distinctive folding patterns. (biomedcentral.com)
  • His fields of research comprise RNA-mediated gene silencing processes with a focus on epigenetic phenomena, including studies on RNA-directed DNA methylation, the characterization of virus silencing suppressor proteins, the development of plant bioreactor platforms and viroid research. (degruyter.com)
  • A evidence's death that brought the input to alternatively be the satellite current physics time were needed by the U. The cup lay up behind proteins when he admitted to See away, considerably, and be his virus in of the liver networked by the Study. (oldandelegant.com)
  • The viral RNA is translated to produce replication proteins, ORF2 polyprotein is processed by the viral protease. (expasy.org)
  • In plants, RNase III Dicer-like proteins (DCLs) act as sensors of dsRNAs and process them into short 21- to 24-nucleotide (nt) (s)RNAs. (biomedcentral.com)
  • Plant Dicer-like proteins (DCLs) are RNase III, double-stranded RNA (dsRNA)-specific endonucleases with specialized functions in producing short (s)RNAs of 21- to 24-nucleotides (nt), including micro (mi)RNAs and short interfering (si)RNAs of endogenous or viral origin. (biomedcentral.com)
  • Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS. (umassmed.edu)
  • The replication process in these viruses produce long RNA carrying multiple units of the viral genome where each unit carries a small ribozymes like hammerhead. (jove.com)
  • Ribozymes were first discovered in viral-like RNA pathogens of plants (hammerhead and hairpin) or of humans (HDV), and sporadically in metazoan genomes [ 3 ]. (biomedcentral.com)
  • Hepatitis D virus (HDV) is an unusual, single-stranded, circular RNA virus with a number of similarities to certain plant viral satellites and viroids. (medmuv.com)
  • Carotenoid fortification of zucchini fruits using a viral RNA vector . (cytovax.com)
  • A viral RNA vector derived from Zucchini yellow mosaic virus (ZYMV) was modified to express a bacterial phytoene synthase (crtB), and inoculated to zucchini (Cucurbita pepo L.) leaves nurturing pollinated flowers. (cytovax.com)
  • Genetic analysis was performed on all three viral RNA segments from human clinical samples, and the sequences were compared with previously characterized RVFV isolates to determine their genetic relatedness and geographic distribution. (cdc.gov)
  • The virion RNA is infectious and serves as both the genome and viral messenger RNA. (expasy.org)
  • Uncoating, and release of the viral genomic RNA into the cytoplasm. (expasy.org)
  • Plant DCL4 is involved in the biogenesis of either functional endogenous or exogenous (i.e. viral) short interfering (si)RNAs, thus playing crucial antiviral roles. (biomedcentral.com)
  • We have therefore tested the DCL4 functionality in processing exogenous dsRNA-like substrates, such as a replicase-assisted viral replicon defective-interfering RNA and RNA hairpin substrates, or endogenous antisense transcripts. (biomedcentral.com)
  • Conversely, DCL4 did not efficiently process a replicase-assisted viral replicon in vivo, providing evidence that viral RNAs are not accessible to DCL4 in membranes associated in active replication. (biomedcentral.com)
  • These led to the conclusion that DCL4 and DCL2 act redundantly and one of the two alone is sufficient to perceive dsRNA of viral origin, process it into siRNA of viral origin (vsiRNAs) and initiate the plant RNA silencing-based antiviral defense [ 14 ]. (biomedcentral.com)
  • Small ribozymes are usually 50 to 150 nucleotides long and are self-cleaving nucleotide sequence motifs. (jove.com)
  • In these assays, the ribozyme sequence is fused to a reporter gene which modulates its activity when expressed as RNA. (biomedcentral.com)
  • The GB hepatitis viruses (GBV-A, GBV-B and GBV-C). The GB hepatitis viruses were cloned recently and preliminary genomic characterization shows that they are related to other positive-stranded RNA viruses with local regions of sequence identity with various flaviviruses. (medmuv.com)
  • Analysis of S, M, and L RNA genome segment sequence differences showed similar phylogenetic relationships among these viruses, indicating that genetic reassortment did not play an important role in the emergence of this virus in the Arabian Peninsula. (cdc.gov)
  • The identification of the ribosomal RNA cistron by sequence complementarity. (wikidata.org)
  • SMV-SX and SMV-XFQ008 had the highest nucleotide and amino acid sequence identities of 97.03% and 98.50%, respectively. (ppjonline.org)
  • We provide direct access to the sequence features (genes etc.) which can be selected and downloaded in FASTA format (nucleotide sequence and, where appropriate, the amino acid sequence) by following the links to Curated Sequences from the Notes pages. (dpvweb.net)
  • The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV ), termed the rev-responsive element (RRE). (lookformedical.com)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • An interesting speculation regarding the origin of viroids is that they evolved from introns which are segments of ribonucleic acid spliced out during formation of messenger RNA in eukaryotic systems. (biologydiscussion.com)
  • The molecular functions of ribonucleic acid (RNA) are diverse and essential in all organisms. (biomedcentral.com)
  • Ribonucleic acid (RNA) has multiple roles in cellular functions, from coding genes to non-coding regulatory activities. (biomedcentral.com)
  • Hepatitis C virus (HCV), is an enveloped single-stranded RNA virus which appears to be distantly related (possibly in its evolution) to flaviviruses, although hepatitis C is not transmitted by arthropod vectors. (medmuv.com)
  • Hepatitis E virus (HEV), the cause of enterically-transmitted non-A, non-B hepatitis, is another non-enveloped, single-stranded RNA virus, which shares many biophysical and biochemical features with caliciviruses. (medmuv.com)
  • HAV is a small, nonenveloped, positive, single-stranded RNA virus that was first identified by electron microscopy in 1973 and classified within the genus Hepatovirus of the picornavirus family. (medscape.com)
  • Infections caused by several positive-stranded RNA viruses allow the characterization of DCLs involved in the RNA-silencing-based antiviral immune responses of plants. (biomedcentral.com)
  • These newer sequences were hypothesized to occur in organisms that, like those containing the three previously found hairpin ribozymes, use single-stranded, circular RNA genomes. (wikipedia.org)
  • The length limitation for this technique could prevent the isolation of novel ribozymes that may reside among the numerous long non-coding RNAs (greater than 200 nt) encoded in bacterial genomes [ 17 ]. (biomedcentral.com)
  • Like the hammerhead ribozyme it is found in RNA satellites of plant viruses. (wikipedia.org)
  • Satellites of plant viruses. (microbiologyresearch.org)
  • Group one and two introns are large ribozymes that are several hundred nucleotides long and are found in fungal and plant mitochondria, chloroplasts, bacteriophages, and eukaryotic viruses. (jove.com)
  • These can be found in many RNA plant viruses, as well as the hepatitis delta virus, a human pathogen. (jove.com)
  • Viroids differ from viruses in having no coat enclosing the nucleic acid which in these agents is a small single stranded circular RNA. (biologydiscussion.com)
  • In comparison, the smallest viruses have a genome size of about 4,000 nucleotides. (biologydiscussion.com)
  • Genetic analysis of selected regions of virus S, M, and L RNA genome segments indicated little genetic variation among the viruses associated with disease. (cdc.gov)
  • Many trypanosomatid species bear RNA viruses, which, in the case of human pathogens Leishmania spp. (biomedcentral.com)
  • It therefore represents an attractive model to study the diversity of RNA viruses. (biomedcentral.com)
  • We have constructed a database (DPVweb) that contains all sequences of viruses, viroids and satellites of plants, fungi and protozoa, that are complete or which encode one or more gene. (dpvweb.net)
  • To assist comparisons with related viruses, there are also representative sequences for every completely sequenced animal virus with an RNA or ssDNA genome. (dpvweb.net)
  • Studies of this reaction in multiple ribozymes have served to establish that the reaction chemistry (catalytic mechanism) is an endogenous property of the RNA molecule itself and is not mediated by metal ions, as is true for some protein enzymes and some other ribozymes. (wikipedia.org)
  • In the 1980s, the hairpin ribozyme was identified in 3 naturally occurring and well-characterized sequences: satellite RNA of tobacco ringspot virus (sTRSV) satellite RNA of chicory yellow mottle virus (sCYMV) satellite RNA of arabis mosaic virus (sARMV) Later work in 2021 revealed almost 1000 hairpin ribozyme sequences in largely unknown organisms found in metatranscriptome data. (wikipedia.org)
  • The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
  • Pederson T. An amazing meeting arrangement on messenger RNA genes. (umassmed.edu)
  • In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
  • Double-stranded RNA from plants infected with closteroviruses. (microbiologyresearch.org)
  • This gives a more or less rod-like shape to the RNA resembling a double-stranded molecule with closed ends (Fig. 6.31). (biologydiscussion.com)
  • Under electron microscope, the viroid RNA measures about 40 nm in length and it has the thickness of double-stranded RNA. (biologydiscussion.com)
  • Members of the Pospiviroidae family replicate in the nucleus through double-stranded RNA intermediates, attracting the host RNA silencing machinery. (degruyter.com)
  • We surveyed 106 axenic cultures of L. pyrrhocoris and found that 64 (60%) of these displayed 2-12 double-stranded RNA fragments. (biomedcentral.com)
  • The latter function is associated with the ability of RNA to form double-stranded (ds) or ds-like secondary structures. (biomedcentral.com)
  • A minor groove RNA triple helix within the catalytic core of a group I intron. (umassmed.edu)
  • The hairpin ribozyme is a small section of RNA that can act as a ribozyme. (wikipedia.org)
  • In common with several other ribozymes and protein ribonucleases, the cleavage reaction of the hairpin ribozyme generates RNA fragments with termini consisting of a 2',3'-cyclic phosphate and a 5'-hydroxyl group. (wikipedia.org)
  • Nucleotide analog interference mapping of the hairpin ribozyme: implications for secondary and tertiary structure formation. (umassmed.edu)
  • Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping. (umassmed.edu)
  • The only known exception to this is the 23S ribosomal RNA in the bacterial ribosome which catalyzes peptide bond formation. (jove.com)
  • The ligation reaction appears to be a simple reversal of cleavage, i.e. covalent joining of RNA fragments ending with a 2',3'-cyclic phosphate and a 5'-hydroxyl group to generate the ordinary 3'-5' phosphodiester linkage used in both RNA and DNA. (wikipedia.org)
  • About a thousand satellites are currently operational, whereas thousands of unused satellites and satellite fragments orbit the Earth as space debris . (parsatellite.com)
  • One of these tools is RNA FRABASE 1.0, the first web-accessible database with an engine for automatic search of 3D fragments within PDB-derived RNA structures. (biomedcentral.com)
  • An intuitionally operated web server platform enables very fast user-tailored search of three-dimensional RNA fragments, their multi-parameter conformational analysis and visualization. (biomedcentral.com)
  • One of the most difficult issues in mining available structural data is the search of RNA structural motifs and fragments in a conformational space. (biomedcentral.com)
  • These regularly spaced hammerhead enzymes undergo self-cleavage resulting in breakage of the long RNA into individual genome segments. (jove.com)
  • Replication of the viroid (+) RNA appears to take place by the rolling circle model in which the (+) strand acts as the template to produce concatemers of (-) strand. (biologydiscussion.com)
  • Replication produces a subgenomic RNA which encodes for the capsid protein (ORF4). (expasy.org)
  • Although the viroid RNA is single-stranded and generally circular, it possess considerable amount secondary structure due to intra-strand base-pairing with intermittent loops produced by unpaired bases. (biologydiscussion.com)
  • The ssRNA(+), likely transferred into the nucleolus, is finally processed by a type III RNase and a DNA LIGASE into unit-length circular RNAs (8) ( Figure 1 ). (degruyter.com)
  • Some sobemoviruses encapsidate a circular viroid-like satellite RNA (220-390nt). (expasy.org)
  • Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)
  • They catalyze site-specific cleavage of RNA, and in some cases, the reverse ligation reaction via a concerted general acid-base mechanism [ 2 ]. (biomedcentral.com)
  • Gene silencing induced by small RNAs (sRNAs) is an important mechanism responsible for many crucial physiological responses in plants, such as genome integrity, defense against virus, adaptation to biotic and abiotic stresses and regulation of development. (edu.au)
  • The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
  • However, reporter activity can be confounded by phenomena unrelated to ribozyme-mediated cleavage of RNA. (biomedcentral.com)
  • In order to validate ribozymes, in vitro assays can be used to assess RNA cleavage. (biomedcentral.com)
  • The term ribozyme is used for RNA that can act as an enzyme. (jove.com)
  • We are interested in RNA structure, dynamics, and folding, and are currently investigating the properties of the Varkud Satellite Virus Ribozyme Stemloop V and the 60 nucleotide fragment of 23S rRNA that binds the L11 protein. (wustl.edu)
  • An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5'- and 3'-termini. (umassmed.edu)
  • 148-152), speaking the abundant epub Одноковшовые экскаваторы: конструкция, монтаж и ремонт: Учебное Completing review, to hinder the satellite characterization of beta protocols. (oldandelegant.com)
  • In turn, miRNAs and siRNAs guide the effector Argonautes (AGOs)-containing complexes to silence RNA target transcripts. (biomedcentral.com)
  • The results all together confirm the role of sense/antisense RNA-based regulation of gene expression, expanding the sense/antisense atlas of S. cerevisiae . (biomedcentral.com)
  • The 60 nucleotide RNA from bacterial 23S rRNA that we study by NMR, steady-state and time-resolved fluorescence, stop-flow fluorescence, and computational methods has been the subject of several previous studies. (wustl.edu)
  • Since then, he has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and his main field of interest is RNA-interference (RNAi) and RNA-directed DNA methylation (RdDM) in plants. (degruyter.com)
  • Since then, she has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and her main field of interest is RNA-interference (RNAi) and viroid biology in plants. (degruyter.com)
  • Recent discoveries concerning novel functions of RNA, such as RNA interference, have contributed towards the growing importance of the field. (biomedcentral.com)
  • The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. (degruyter.com)
  • Ribozymes are special types of RNA that can act as enzymes. (jove.com)
  • The substrates for most naturally occurring ribozymes are RNA phosphodiester bonds. (jove.com)
  • Large ribozymes can vary in size from a few hundred to several thousand nucleotides. (jove.com)
  • Small ribozymes are 30 to 150 nucleotides long. (jove.com)
  • Distinct classes of RNA catalyse biochemical reactions (ribozymes), although the large subunit rRNA and RNaseP ribozymes common to all organisms require protein partners to function [ 1 ]. (biomedcentral.com)
  • Ribozymes are modular and functional in different RNA contexts. (biomedcentral.com)
  • In order to exploit other ribozymes as tools which can be controlled in a ligand-dependent manner, they must be joined artificially to a ligand-binding RNA module as aptazymes [ 14 ]. (biomedcentral.com)
  • This is a commonly used strategy for separating those parts of a self-processing RNA molecule that are essential for the RNA processing reactions from those parts which serve unrelated functions. (wikipedia.org)
  • Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
  • A change of few nucleotides in the pathogenicity domain may change a viroid from a mildly pathogenic to a highly virulent one. (biologydiscussion.com)
  • The viroid RNA does not code for any protein. (biologydiscussion.com)
  • Evidence has been advanced to show that viroid RNA under in vitro system activates a protein kinase. (biologydiscussion.com)
  • Presumably, this process involves the interaction between the host's bromodomain-containing viroid RNA-binding protein 1 (VIRP1) and the viroid's TR domain (6). (degruyter.com)
  • These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
  • RNA and RNA:Protein interactions provide biological regulation at all levels of cellular function. (wustl.edu)
  • The cell biology of a novel chromosomal RNA: chromosome painting by XIST/Xist RNA initiates a remodeling cascade. (umassmed.edu)
  • As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
  • Using next generation sequencing, we have characterized the major classes of small RNAs, micro (mi) RNAs, piwi interacting (pi) RNAs, and the centromere repeat associated short interacting (crasi) RNAs in the tammar. (biomedcentral.com)
  • We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)
  • A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
  • These small RNAs are derived largely from centromere-enriched retroelements, including a novel SINE. (biomedcentral.com)
  • This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)
  • Another class of important small RNAs is the piRNAs. (biomedcentral.com)
  • Hepatitis A virus (HAV), classified as hepatovirus, is a small, unenveloped symmetrical RNA virus which shares many of the characteristics of the picornavirus family, and is the cause of infectious or epidemic hepatitis transmitted by the fecal-oral route. (medmuv.com)
  • Small, polymeric silicon chips are very capable of rapid identifier and accurate multichannel analysis of nucleotides acids i.e. (trickyenough.com)
  • Satellite cells are activated by muscle tears, causing the nucleus to replicate leaving some of the cell organelles on the muscle fiber while others fuse to muscle fibers to form new muscle protein stands (or myofibrils) and/or repair damaged fibers. (nfpt.com)
  • This also has uses in space as radiation-resistant devices and the use of electron emission to turning or positioning of 'nano-satellites. (trickyenough.com)
  • In this respect, a deeper knowledge of complex three-dimensional RNA structures is essential to understand their new biological functions. (biomedcentral.com)
  • A number of bioinformatic tools have been proposed to explore two major structural databases (PDB, NDB) in order to analyze various aspects of RNA tertiary structures. (biomedcentral.com)
  • RNA FRABASE 2.0 has stored information on 1565 PDB-deposited RNA structures, including all NMR models. (biomedcentral.com)
  • The RNA FRABASE 2.0 search engine algorithms operate on the database of the RNA sequences and the new library of RNA secondary structures, coded in the dot-bracket format extended to hold multi-stranded structures and to cover residues whose coordinates are missing in the PDB files. (biomedcentral.com)
  • The library of RNA secondary structures (and their graphics) is made available. (biomedcentral.com)
  • RNA FRABASE 2.0 also stores data and conformational parameters in order to provide "on the spot" structural filters to explore the three-dimensional RNA structures. (biomedcentral.com)
  • An instant visualization of the 3D RNA structures is provided. (biomedcentral.com)
  • A deep knowledge of complex three-dimensional folds of RNA structures is essential to understand the range of their biological functions. (biomedcentral.com)
  • The first program calculates a complete set of rigid-body parameters that describe the detailed geometry of double helices extracted from the tertiary RNA structures. (biomedcentral.com)
  • RNA, Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Generally, DNA and RNA were indeed negatively charged ions, and therefore, by offering practical active power to particular electrolytes on this Nanochip technology, Our device is capable of solving these particles to particular electrodes. (trickyenough.com)