Nucleotide residues. Medical search. Frequent questions

This sequence agrees with available kinetic data for non-cognate nucleotide insertions, with the exception of A:dGTP, which may be more sensitive to the template sequence. (nyu.edu)
Oligonucleotides are characterized by the sequence of nucleotide residues that make up the entire molecule. (wikipedia.org)
ST.26 also accommodates a greater variety of sequence information relating to non-standard sequence features, and thus reflects the growing use of non-standard sequence types and residues in patent applications. (blogspot.com)
Moreover, nucleotide (nt) deletion analysis found twelve deletion sites throughout the genome other than previously reported deletions at coding sequence of the ORF8 (open reading frame), spike, and ORF7a proteins, specifically in polyprotein ORF1ab (n = 9), ORF10 (n = 1), and 3´-UTR (n = 2). (nature.com)
Sequence coordinates are from 1 to the sequence length.The range includes the residue at the To coordinate. (nih.gov)
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. (nih.gov)
coding sequence is 767 nucleotides long with an intron at 61. (yeastgenome.org)

Stencil for nucleotide and amino acid residues. (graffletopia.com)
The amino acid residues Asp30, Glu32, Asp112 and Asp251 are the 3'-5' exonuclease active sites of IME199 DNAP, while residues Asp596 and Tyr639 are essential for DNA synthesis by IME199 DNAP. (bvsalud.org)
Partial Order Optimum Likelihood (POOL), a machine learning method that uses input features from Theoretical Microscopic Titration Curve Shapes (THEMATICS), was used to identify amino acid residues most likely involved in catalytic activity. (bvsalud.org)

2. Organic Phosphate is contributed by human excreta (feces) and food residues. (ufl.edu)
NTPDase-1 hydrolyzes the beta - and gamma phosphate residues of nucleotides, preferring ATP as the substrate. (rndsystems.com)
They preferentially cleave single-stranded RNA molecules between purine and uridine residues to generate two nucleotide fragments with 2'3'-cyclic phosphate adenosine/guanosine terminus and uridine residue, respectively. (frontiersin.org)

In general, oligonucleotide sequences are usually short (13-25 nucleotides long). (wikipedia.org)
The GISAID contains 4,440,705 genome sequences and we analyzed single nucleotide variants (SNV) for residues involved in drug binding. (elifesciences.org)
Nucleotide sequences of the ALS gene from the rice cultivars were identical. (weedscience.com)
Originally, it only contained data on the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. (bvsalud.org)
MODOMICS has been linked extensively to RCSB Protein Data Bank, and sequences of experimentally determined RNA structures with modified residues have been added. (bvsalud.org)

The nucleotide binding mode was corroborated by the replacement of critical residues. (rcsb.org)
or =5 somatic mutations also likely indicate functionally critical residues, even though P0.05. (nih.gov)

A modified version of the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding, termed 18-14 and 1-5-10 based on the position of conserved hydrophobic residues, are proposed. (embl.de)
Upon ATP binding, large structural changes within the nucleotide-binding and transmembrane regions push conserved hydrophobic residues at the substrate entry site towards the periplasm and provide a model for polysaccharide translocation. (tcdb.org)

Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)
This report describes the use of computational tools to predict the effects of single nucleotide polymorphism variants on pol kappa activity. (bvsalud.org)

Likely via a radical-pair mechanism 12 , T 1 reacts within microseconds to the signaling state, characterized by a covalent thioadduct between a highly conserved cysteine residue in the LOV photosensor and the C4a atom of the flavin isoalloxazine ring system. (nature.com)

Nucleoside organothiophosphate (PS) analogs of nucleotides give oligonucleotides some beneficial properties. (wikipedia.org)
Both cidofovir and adefovir are nucleoside phosphonate analogs, a class of novel antivirals structurally related to natural nucleotides (Fig. 1 ). (aspetjournals.org)

Now we use C1' atoms for superposition when there are three or more nucleotides, and when there are two nucleotides, we use C1' and C3' atoms. (bgsu.edu)

Key beneficial properties that PS backbones give nucleotides are diastereomer identification of each nucleotide and the ability to easily follow reactions involving the phosphorothioate nucleotides, which is useful in oligonucleotide synthesis. (wikipedia.org)

That most of these "gate-keeper" residues are located farther apart from the upstream primer in pol μ, compared to other X family members, also suggests an interesting relation to pol μ's ability to incorporate nucleotides when the upstream primer is not paired. (nyu.edu)

Here, we present the NMR structure of the AMP-PNP-bound nucleotide binding domain KdpBN of the Escherichia coli Kdp-ATPase at high resolution. (rcsb.org)
The conservative mutation F377Y produced a high residual nucleotide binding capacity, whereas replacement by alanine resulted in low nucleotide binding capacities and a considerable loss of ATPase activity. (rcsb.org)
Similarly, mutation K395A resulted in loss of ATPase activity and nucleotide binding affinity, even though the protein was properly folded. (rcsb.org)
We present a schematic model of the nucleotide binding mode that allows for both high selectivity and a low nucleotide binding constant, necessary for the fast and effective turnover rate realized in the reaction cycle of the Kdp-ATPase. (rcsb.org)
Our findings show that RNF213 represents an undescribed type of a transthiolation E3 enzyme and is regulated by adenine nucleotide concentration via its ATPase core, possibly allowing it to react to changing metabolic conditions in the cell. (biorxiv.org)

The aim of this study was to characterise the impact of a resistance gene against L. maculans infection on residue microbial communities and to identify micro-organisms interacting with this pathogen during residue degradation. (biorxiv.org)
Fungal community structure differed between the two lines at harvest, but not subsequently, suggesting that the presence/absence of the resistance gene influences the microbiome at the base of the stem whilst the plant is alive, but that this does not necessarily lead to differential colonisation of the residues by fungi. (biorxiv.org)

We calculated p16 evolution using amino acid substitution matrices and nucleotide substitution distances. (nih.gov)

Notably, residues of receptor-binding domain (RBD) showing crucial interactions with angiotensin-converting enzyme 2 (ACE2) and cross-reacting neutralizing antibody were found to be conserved among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2020 (EPI_ISL_416320). (nature.com)
Oilseed rape residues are a crucial determinant of stem canker epidemiology, as they support the sexual reproduction of the fungal pathogen Leptosphaeria maculans . (biorxiv.org)

The catalytic site includes residues His 65, His 113, Glu 114, Lys 117, and His 118 ( 4 ). (frontiersin.org)
the key catalytic residues His 65, His 113, Glu 114, Lys 117, and His 118 are shown in magenta. (frontiersin.org)

P-type ATPases are ubiquitously abundant enzymes involved in active transport of charged residues across biological membranes. (rcsb.org)

RNA cleavage is promoted by one to three histidine residues that are located in CAS I and II. (frontiersin.org)

Genome-wide annotations revealed 1,516 nucleotide-level variations at different positions throughout the entire genome of SARS-CoV-2. (nature.com)

Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. (cornell.edu)
In this structure, direct hydrogen bonds were observed between: (i) dF and the incoming dTTP, (ii) dF and residue G568 of the polymerase, and (iii) dF and ordered water molecules surrounding the nascent base pair. (cornell.edu)
Li, Y & Schlick, T 2013, ' "Gate-keeper" Residues and Active-Site Rearrangements in DNA Polymerase μ Help Discriminate Non-cognate Nucleotides ', PLoS computational biology , vol. 9, no. 5, e1003074. (nyu.edu)

In addition, a search engine for chemically similar modified residues has been included that can be queried by SMILES codes or by drawing chemical molecules. (bvsalud.org)

By examining the correlated motions within pol μ complexes, we also observe different patterns of correlations between non-cognate systems and the cognate system, especially decreased interactions between the incoming nucleotides and the nucleotide-binding pocket. (nyu.edu)
This approach could be used to identify and promote micro-organisms with beneficial effects against residue-borne pathogens, and more broadly, to decipher the complex interactions between multi-species pathosystems and other microbial components in crop residues. (biorxiv.org)
The residues E148 and L149 form H-bonds with montelukast, while F157 and L173 forms base stacking interactions. (elifesciences.org)
The residues T151, M174, and R175 form H-bonds with saquinavir, while R171 forms base stacking interactions. (elifesciences.org)

Mutations in these histidine residues lead to the inactivation of RNase T2 both in vivo and in vitro ( Figure 1A ). (frontiersin.org)

Naturally occurring oligonucleotides are easily degraded by nucleases, an enzyme that cleaves nucleotides and is ample in every cell type. (wikipedia.org)

As recently proposed 25 , glutamine reorientation, and signal propagation may be aided by transient rearrangements of two conserved asparagine residues that coordinate the pteridin portion of the flavin. (nature.com)

The BLAST search will apply only to the residues in the range. (nih.gov)

Charged residues at the outer rim of the binding pocket (Arg(317), Arg(382), Asp(399), and Glu(348)) stabilize and direct the triphosphate group via electrostatic attraction and repulsion toward the phosphorylation domain. (rcsb.org)

The maximum length of synthetic oligonucleotides hardly exceeds 200 nucleotide residues. (wikipedia.org)
Length - Length of the selected feature in nucleotides or residues. (dnastar.com)

Completion of a single synthetic cycle results in the addition of one nucleotide residue to the growing chain. (wikipedia.org)
In addition, 2 common synonymous coding single-nucleotide polymorphisms are found and genotyped in samples from 4 ethnic groups. (medscape.com)

Deficient nucleotide excision repair capacity enhances human prostate cancer risk. (cdc.gov)

Range of the feature in nucleotides or residues. (dnastar.com)

A highly conserved glutamine residue in strand Iβ is situated immediately adjacent to the flavin and has been identified as instrumental in reading out the flavin N5 position and eliciting the downstream transitions. (nature.com)
Corroborating NuMTs both span this position and match the nucleotide when aligned. (mitomap.org)

The microbiome associated with the two types of plant residues was characterised by metabarcoding. (biorxiv.org)

The crystal structure of PPR10 from maize chloroplast exhibits dimeric existence both in the absence and presence of the 18-nucleotide psaJ RNA element. (rcsb.org)

ACS's Standard Package lets you stay up to date with C&EN, stay active in ACS, and save. (acs.org)

Most of these residues are located in α3 and α4 regions ( Figure 1D ). (frontiersin.org)

Organic phosphates are present in sugars, phospholipids, and nucleotides. (ufl.edu)

Anatomy7

Organisms11

Diseases1

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes94

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science7

Health Care4

Sequence7

Amino acid residues3

Phosphate3

Sequences5

Critical residues2

Hydrophobic residues2

Variants2

Cysteine1

Nucleoside2

Atoms1

Oligonucleotide1

Upstream1

ATPase5

Gene2

Substitution1

Crucial2

Catalytic2

Enzymes1

Cleavage1

Annotations1

Polymerase3

Molecules1

Interactions4

Mutations1

Enzyme1

Rearrangements1

BLAST1

Domain1

Length2

Addition2

Human1

Range1

Position2

Types1

Element1

Active1

Regions1

Present1