• In tissues of Robinia pseudoacacia L. which are transferred to heartwood, enhanced activities of glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PCDH) are present. (mpg.de)
  • A genetic aberration in glucose 6-phosphate dehydrogenase, a pivotal enzyme in the PPP, can disrupt this biochemical harmony, underscoring the pathway's indispensability in cellular metabolism and defense mechanisms. (microbiologynote.com)
  • Its formation is a genetically determined, programmed cell death which is characterized by the activation of metabolic pathways which lead to the formation of phenolic heartwood extractives. (mpg.de)
  • In scientific terms, the PPP is an essential metabolic pathway that functions concurrently with glycolysis , presenting itself as a quintessential player in maintaining cellular homeostasis through its diligent role in generating NADPH, pentoses, and ribose 5-phosphate. (microbiologynote.com)
  • Dietary pentose sugars, a derivative of nucleic acid digestion, can be intertwined with the PPP, thereby revealing another layer of metabolic flexibility and adaptability provided by this pathway. (microbiologynote.com)
  • Concurrently, the PPP can transmute the carbon skeletons of dietary carbohydrates into intermediates apt for glycolytic and gluconeogenic pathways, thereby enabling the cell to adeptly navigate through the metabolic intricacies and adapt to varying physiological contexts. (microbiologynote.com)
  • Navigating through the biochemical intricacies of the PPP provides a splendid panorama of how cells masterfully exploit metabolic pathways, in a manner that is attuned to their physiological, biosynthetic, and defensive needs, thereby maintaining a harmonious cellular and systemic physiological state. (microbiologynote.com)
  • In essence, the PPP is a testament to nature's biochemical prowess, revealing how metabolic pathways, through eons of evolutionary fine-tuning, have been sculpted into multifaceted biochemical networks, proficiently catering to the myriad metabolic and defensive demands of the cell. (microbiologynote.com)
  • The Pentose Phosphate Pathway (PPP) is a metabolic pathway parallel to glycolysis that produces NADPH, pentoses (5-carbon sugars), and ribose 5-phosphate, a precursor for nucleotide synthesis. (microbiologynote.com)
  • The Pentose Phosphate Pathway (PPP) primarily resides within the cytosol of cells, which is the aqueous component of the cytoplasm, a matrix in which various cellular organelles are suspended and numerous metabolic reactions transpire. (microbiologynote.com)
  • Metabolic alterations can be the consequence of genetic changes in metabolic pathways, but they also reflect control of enzymatic activities by signaling pathways, catabolism (including membrane turnover) and competitive inhibition or activation by small molecules. (biomedcentral.com)
  • Oxidative pentose phosphate pathway and pyridine nucleotides in relation to heartwood formation in Robinia pseudoacacia L. (mpg.de)
  • In the present paper we report on the key position of the oxidative pentose phosphate pathway (OPP) for this process. (mpg.de)
  • The PPP showcases its role by executing two meticulously orchestrated phases: the oxidative phase, where glucose 6-phosphate is oxidized to produce NADPH and ribulose 5-phosphate, and the non-oxidative phase, which is engaged in the synthesis of 5-carbon sugars, contributing significantly to the synthesis of nucleotides and nucleic acids. (microbiologynote.com)
  • In gluconeogenic cells, aspartate is a carbon source for trehalose production, while in glycolytic cells using trehalose for carbon, aspartate is predominantly a nitrogen source for nucleotide synthesis. (elifesciences.org)
  • In tissues that are enclaves for rapid cellular proliferation, such as bone marrow and certain tumor tissues, the PPP directs its metabolites towards nucleotide synthesis, furnishing the essential precursors for DNA and RNA synthesis, thereby catering to the exigencies of cell proliferation. (microbiologynote.com)
  • Conversely, in tissues where the biosynthetic activities, particularly those related to fatty acid and sterol synthesis, are in full swing, the NADPH produced by the PPP is channeled to support these reductive biosynthetic pathways. (microbiologynote.com)
  • Determining myocardial energetics (high energy phosphates contents, ATP, PCr synthesis, substrate selection simultaneously with heart functions at real time and intracellular pH, Na at whole heart level). (harvard.edu)
  • Our NMR system is a powerful tool to determine myocardial energetics (high energy phosphates contents, ATP, PCr synthesis, substrate selection simultaneously with heart functions at real time and intracellular pH, Na at whole heart level). (harvard.edu)
  • The OPP plays a crucial role in anabolic processes and is involved in the interconversion and rearrangements of sugar-phosphates with the net production of NADPH. (mpg.de)
  • A consequence of these increased enzyme activities is a shift in the pyridine nucleotide pool towards NADP + NADPH at the expense of NAD + NADH. (mpg.de)
  • Embarking on an exploration into cellular metabolism, the Pentose Phosphate Pathway (PPP) commands particular attention, not merely for its role in glucose metabolism but also for its crucial involvement in cellular biosynthesis and antioxidant defenses. (microbiologynote.com)