One of the most versatile defense mechanisms against the accumulation of DNA damage is nucleotide excision repair, in which, among others, the Xeroderma pigmentosum group C (XPC) and group A (XPA) proteins are involved. (aacrjournals.org)
Adducts2
These platinum induced adducts are fixed by nucleotide excision fix program (NER) [6 7 the mismatch fix (MMR) program and recombination fix (RR) [8]. (healthdisparitiesks.org)
The model carcinogen N-2-acetylaminofluorene covalently binds to the C8 position of guanine to form two adducts, the N-(2'-deoxyguanosine-8-yl)-aminofluorene (G-AF) and the N-2-(2'-deoxyguanosine-8-yl)-acetylaminofluorene (G-AAF). (cnrs.fr)
Guanine1
The NarI restriction site sequence 5′-G1G2CG3CX-3′ in Escherichia coli is a well-known mutational hotspot, in which lesioning of acetylaminofluorene (AAF) at G3* induces a greater −2 deletion frequency than that at other guanine sites. (jascoinc.com)
Polymerase10
Influence of local sequence context on damaged base conformation in human DNA polymerase iota: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion. (neb.com)
Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing? (neb.com)
Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase. (neb.com)
Nucleotide selectivity opposite a benzo[a]pyrene-derived N2-dG adduct in a Y-family DNA polymerase: a 5'-slippage mechanism. (neb.com)
Increased flexibility enhances misincorporation: temperature effects on nucleotide incorporation opposite a bulky carcinogen-DNA adduct by a Y-family DNA polymerase. (neb.com)
Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies. (neb.com)
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). (neb.com)
Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension. (neb.com)
The spacious active site of a Y-family DNA polymerase facilitates promiscuous nucleotide incorporation opposite a bulky carcinogen-DNA adduct: elucidating the structure-function relationship through experimental and computational approaches. (neb.com)
Four tagged single-nucleotide polymorphisms (SNPs) of HMGB1 were detected by a TaqMan-based real-time polymerase chain reaction (PCR) in patients. (jcancer.org)
This work out unveiled the involvment of CYB5A in vitamin C metabolism, metabolism of water soluble nutritional vitamins and cofactors, metabolic process of vitamins and cofactors, transport, L ascorbic acid meta bolic process, electron transport chain, small mole cule metabolic system, aldo keto reductase action, amino sugar and nucleotide sugar metabolic process. (kspinhibitors.com)
Cancer1
Papain Inhibitor HNSCC may be the sixth Papain Inhibitor most regularly occurring cancer world-wide and makes up about 2% of most cancer death each year. (healthdisparitiesks.org)
Acid2
His research interest is focused on the application of electron spin resonance (ESR) to: 1) Study the dynamics of nucleic acids and nucleic acid - protein complexes, and 2) Detect genes by PCR/ESR. (uc.edu)
A) Application of electron paramagnetic resonance (EPR) spectroscopy: 1) to study dynamic features of nucleic acids and nucleic acid - protein complexes, and 2) to detect free radical damage in biological systems. (uc.edu)
Synthetase1
2. phenylalanyl-trna synthetase activity is found with the 60s subunit, 80s monoribosome and individual polyribosomes. (liverpool.ac.uk)
Liver3
2. p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice. (nih.gov)
14. Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (nih.gov)
Hepatology 2013;58:1569-1579) Hepatitis C virus (HCV) infection is a leading cause of liver disease, with at least 2%-3% of the world's population chronically infected. (smadpathway.com)
Protein1
that mutations in cathepsin B may cause inept localization of cathepsin B protein in zymogen granules that could lead to premature activation of trypsinogen.43 Type 2 diabetes (T2D)-associated polymorphisms in selleck chemical transcription factor 7 like protein 2 (TCF7L2, OMIM 602228) were screened in TCP and fibro calculus pancreatic diabetes (FCPD) patients. (smadpathway.com)
Repair1
The role of nucleotide excision DNA repair (NER) system in mammalian cells. (nih.gov)
Mechanism1
Objective To investigate the effects of high glucose on expression of angiopoietin 2 (Ang2) and tyrosine kinase receptor (Tie2) in human umbilical vascular endothelial cells （HUVECs）cultured in vitro , and explore the possible mechanism of peritoneal angiogenesis in patients with peritoneal dialysis. (shsmu.edu.cn)
Expression1
In support of the in vivo data, As exposure decreased ERCC1 mRNA expression and enhanced levels of DNA damage after a 2-AAAF challenge in cell culture. (nih.gov)