• Single nucleotide polymorphism analysis in support of plant breeding" by Robert J. Henry, Peter C. Bundock et al. (edu.au)
  • VNUT transports various nucleotides in a membrane potential-dependent fashion and is expressed in the various ATP-secreting cells. (elsevier.com)
  • Effect of loss of P2Y 2 receptor gene expression on nucleotide regulation of murine epithelial Cl − transport. (springer.com)
  • This gene terminates two nucleotides before the initiator codon of the coat protein gene. (pnas.org)
  • Within a gene , the sequence of nucleotides along a DNA strand defines a messenger RNA sequence, which in turn defines a protein. (newworldencyclopedia.org)
  • The cobT gene of Salmonella typhimurium encodes the NaMN: 5,6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole, an intermediate in the synthesis of the nucleotide loop of cobalamin. (ebi.ac.uk)
  • Intriguingly, a specific alteration in the DNA sequence near the FMR1 gene-a "single-nucleotide polymorphism" or SNP-has been linked to an increased risk of repeat expansion in some premutation carriers. (newswise.com)
  • For this preclinical study published in the Annals of Neurology , University of Michigan researchers employed nucleotide-based gene silencing to target the SCA3 disease gene, ATXN3. (news-medical.net)
  • It seems to me such a database would be necessary to do a proper analysis, as multiple copies of a single gene would bias the nucleotide frequencies. (bio.net)
  • The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3′-end position. (google.com)
  • The powerful combination of electrophysiology, biochemistry, patch‐clamp fluorometry and X‐ray crystallography has begun to unravel the mystery of how CNG channels are regulated and how the binding of cyclic nucleotides lead to channel opening. (els.net)
  • In experimental biochemistry, nucleotides can be radiolabeled with radionuclides to yield radionucleotides. (wikipedia.org)
  • The salvaged bases and nucleosides can then be converted back into nucleotides. (wikipedia.org)
  • Contrary to common belief, the nucleotides are not synthesized as bases first then attached to a sugar. (wikiversity.org)
  • Specifically defined" means those amino acids other than "Xaa" and those nucleotide bases other than "n" defined in accordance with the World Intellectual Property Organization (WIPO) Handbook on Industrial Property Information and Documentation, Standard ST.25: Standard for the Presentation of Nucleotide and Amino Acid Sequence Listings in Patent Applications (1998), including Tables 1 through 6 in Appendix 2, herein incorporated by reference. (uspto.gov)
  • Modifications, e.g. , methylated bases, may be described as set forth in WIPO Standard ST.25 (1998), Appendix 2, Table 2, but shall not be shown explicitly in the nucleotide sequence. (uspto.gov)
  • A nucleotide is a chemical compound with three components: a nitrogen -containing base, a pentose (five-carbon) sugar (relatively simple carbohydrates ), and one or more phosphate groups. (newworldencyclopedia.org)
  • Nucleotides consist of a pentose sugar (brown), one or more phosphate groups (red), and a heterocyclic base (blue). (newworldencyclopedia.org)
  • A nucleotide is a chemical compound that consists of 3 portions: a heterocyclic base, a sugar, and one or more phosphate groups. (bionity.com)
  • A nucleotide is comprised of a ring of nitrogen, carbon and oxygen atoms, a five carbon sugar (together referred to as a nucleoside) and one or more phosphate groups. (bionity.com)
  • Is anyone interested in trying some new fluorescent nucleotide analogs for fluorescence in situ hybridization, point mutation analysis or genome mapping? (bio.net)
  • In this study, we use 283 parent-offspring trios to estimate the rate of mutation for both single nucleotide variants (SNVs) and short length variants (indels) in humans and examine the mutation process. (nih.gov)
  • We estimate that around 3% of human de novo SNVs are part of a multi-nucleotide mutation (MNM), with 558 (3.1%) of mutations positioned less than 20kb from another mutation in the same individual (median distance of 525bp). (nih.gov)
  • One of the fundamental discoveries in evolutionary genetics is that the distribution of nucleotide substitutions in the genomes of living organisms is not random. (frontiersin.org)
  • Tenofovir DF (TDF) is an experimental nucleotide reverse transcriptase inhibitor being developed by Gilead Sciences of Foster City, CA. Nucleotide reverse transcriptase inhibitors are similar to nucleoside analog (NRTI) drugs such as d4T (Zerit) but do not require the same degree of processing within cells to become active (see full explanation below ). (thebody.com)
  • Data are available from clinical trials in human pregnancy for the nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine, abacavir, lamivudine, didanosine, emtricitabine, and stavudine and the nucleotide NRTI tenofovir disoproxil fumarate (TDF). (nih.gov)
  • The second nucleotide of this mRNA is naturally a G-residue, consistent with the enzyme's nucleotide preference in this position. (esrf.eu)
  • They have now taken this further by investigating whether adult neural stem cells (NSCs) respond to extracellular nucleotide signalling itself (see p. 675 ). (biologists.org)
  • Since the highest pi value is only 0.11%, which is about one order of magnitude lower than those in Drosophila populations, the nucleotide diversity in humans is very low. (genetics.org)
  • The ubiquitous presence of nucleotides from viruses and bacteria to humans reflects a common base and unity among all living organisms despite the remarkable diversity of life. (newworldencyclopedia.org)
  • Passenger mutations are enriched in characteristic nucleotide contexts, whereas driver mutations occur in functional positions, which are not necessarily surrounded by a particular nucleotide context. (broadinstitute.org)
  • Our study provides a resource of driver genes across 28 tumor types with additional driver genes identified according to mutations in unusual nucleotide contexts. (broadinstitute.org)