Nucleosomes genome. Medical search. Frequent questions

A single nucleosome consists of about 150 base pairs of DNA sequence wrapped around a core of histone proteins. (genome.gov)
Huge complex proteins called nucleosomes facilitate this DNA compaction so that eventually the DNA is coiled in an ordered manner to form chromosomes. (sciencedaily.com)
These LRC are the signature of the DNA-histone proteins interactions within the nucleosomes, the basic units for DNA compaction in eukaryotic cell nuclei, that constitute a regulatory factor for accessibility to genetic material. (ens-lyon.fr)
DNA is initially coiled around proteins known as histones, to form a structure called the nucleosome. (pasteur.fr)
Our results provide new information on the chromatin engagement of two central players in transcription elongation and emphasize the importance of the nucleosome core as a hub for proteins that regulate chromatin during transcription. (biorxiv.org)
At the heart of epigenetics is the question of how cells control which stretches of DNA are accessible to be read out and translated into proteins, and which sequences are spooled away and archived on nucleosomes. (ucsf.edu)
The dominant model in the field portrays nucleosomes as passive spindles, themselves 'octamers' made up of eight blocks of rigid histone proteins that snap together like Lego pieces when wrapped in DNA, and which must break apart or slide out of the way to allow their archived DNA to become active again. (ucsf.edu)
Toward this objective, ChIP-Seq data of 14 S/MAR binding proteins were analyzed and the binding site coordinates of these proteins were used to prepare a non-redundant S/MAR dataset of human genome. (researchgate.net)
Over the past decade, genome-wide assays and new imaging approaches have enabled a greater understanding of how access to the genome is regulated by nucleosomes and associated proteins. (rockefeller.edu)
Chromatin consists of repeating nucleosomes, which contain approximately 147 base pairs of DNA surrounding an octamer of histone proteins H2A, H2B, H3, and H4. (pitt.edu)
Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. (dissertations.se)
DNA is wrapped around histone proteins forming a single repeating unit called the nucleosome. (mpg.de)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)

Nucleosomes serve both as barriers that restrict access to the genome and as a medium to accumulate epigenetic marks. (tu-dresden.de)
But a new UCSF study promises to overturn this understanding, demonstrating that nucleosomes actively change their shape as part of the larger process of epigenetic regulation of gene expression. (ucsf.edu)
Altering the shape of the nucleosome, a fundamental building block of the chromosome, could in principle have large effects on processes ranging from genome organization to epigenetic inheritance. (ucsf.edu)
Epigenetic hallmarks of the cancer genome. (creativebiomart.net)
Many general epigenetic changes in cancer cells are accompanied by atypical nucleosome dynamics, for example, outside of the promoter region in breast and prostate cancer cell lines, hypermethylation is accompanied by nucleosome occupancy of insulators and enhancers. (creativebiomart.net)
However, vast portions of the human genome are subject to transcriptional and epigenetic regulation, and many noncoding regulatory DNA elements are thought to regulate the spatial organization of interphase chromosomes. (nih.gov)
To date, however, epigenetic studies in the human brain are mostly limited to the exploration of DNA methylation and posttranslational modifications of the nucleosome core histones. (nih.gov)
We predict that the exploration of three-dimensional genome architectures and function will open up new frontiers in human brain research and psychiatric genetics and provide novel insights into the epigenetic risk architectures of regulatory noncoding DNA. (nih.gov)
Here we undertake a genome-scale analysis of these interactions in a genetically diverse population to systematically identify global genetic-epigenetic interaction, and reveal constraints imposed by chromatin structure. (elifesciences.org)
With 176 samples profiled for genotype, gene expression, and open chromatin, we used regression modeling to infer genetic-epigenetic interactions on a genome-wide scale. (elifesciences.org)
Yet the interacting effects that genetic and epigenetic factors produce on gene transcription are rarely studied at a genome-wide scale, leaving us without global information on a key step between the genetic code and the phenotype. (elifesciences.org)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
Altered epigenetic features in circulating nucleosomes in idiopathic pulmonary fibrosis. (cdc.gov)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

However, how this nucleosome organization is established and whether this organization is required for replication remain unknown. (nature.com)
Our results establish that ORC, in addition to its canonical role as the MCM loader, has a second crucial function as a master regulator of nucleosome organization at the replication origin, a crucial prerequisite for efficient chromosome replication. (nature.com)
Fig. 1: ORC is a master regulator of nucleosome organization at origins of replication. (nature.com)
Deploying a multi-scale strategy of sharp upwardjump detection in noisy skew profiles, we have identified more than 1000 putative master origins of replications that are central to the Human genome organization. (ens-lyon.fr)
Our findings has provided a new model of gene organization in the human genome, which integrates transcription, replication, and chromatin structure as coordinated determinants of genome architecture. (ens-lyon.fr)
Note that the organization of the nucleosomal assembly results from the confinement of nucleosomes between sequence induced high energy barriers corresponding to the nucleosome free regions observed at the promoters and gene ends. (ens-lyon.fr)
This study provides new information about basic genome organization structures, as well as a method to visualize and model the detailed structure of chromatin. (pasteur.fr)
Remodeling enzymes set up the canonical nucleosome organization of genes. (tu-dresden.de)
Here, we show that chromosome conformation capture, a widely used approach to study higher-order chromatin, is applicable to tissue collected postmortem, thereby informing about genome organization in the human brain. (nih.gov)
The mechanisms by which nucleosome organization is controlled are well understood in regard to transcription initiation and elongation. (pitt.edu)
Nucleus - Internal organization, Nuclear pore complex, Nucleosomes Chromatin. (amrita.edu)

Correspondingly, the locations of nucleosomes in the genome are precisely controlled by so called nucleosome remodeling complexes. (tu-dresden.de)
This new work of Jon Widom's lab, reported in Nature, adds greatly to the ability to measure the locations of nucleosomes with unprecedented accuracy, which is needed to decipher the code in the DNA as reported in our two recent papers," Segal said. (nanowerk.com)

The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. (wikipedia.org)
When further modeling DNA as a semifexible polymer explicitly taking into account the structural disorder induced by the sequence, we have provided some evidence that the observed LRC favor the spontaneous formation as well as the cooperative positioning of nucleosomes along the chromosomes including the nucleosome free regions experimentally observed at gene promoters (see figure below). (ens-lyon.fr)
bottom) Predictions based on a physical modeling of sequence-dependent nucleosome energy profile. (ens-lyon.fr)
The information is mainly transmitted in the primary sequence of the genome (genetic information), but there are heritable traits that are transmitted by other mechanisms. (plos.org)
All of Salzberg's bioinformatics systems have been released as free, open-source software, and he won the 2013 Benjamin Franklin Award for Open Science for his advocacy of open-source software and of open sharing of genome sequence data. (iscb.org)
For example, chromosomal "loopings" are pivotal for the orderly process of gene expression, by enabling distal regulatory enhancer or silencer elements to directly interact with proximal promoter and transcription start sites, potentially bypassing hundreds of kilobases of interspersed sequence on the linear genome. (nih.gov)
Widom, whose research focused on chromatin packaging and gene regulation, and Segal, a computational biologist, continued their studies on sequence preferences for nucleosome formation as part of a project funded by Northwestern's Physical Sciences-Oncology Center. (nanowerk.com)
To test the hypothesis that stable nucleosomes within termination regions are required to act as physical roadblocks to the polymerase, I integrated a "superbinder" DNA sequence to position a stable nucleosome at a candidate locus. (pitt.edu)
The proper copying and repair of DNA to maintain the correct sequence and structure of genomes is critical to the proper function of cells, and repair and replication is frequently disrupted in cancers and targeted by cancer treatments. (birmingham.ac.uk)

We found in our experiments that histones are massively evicted everywhere in the Plasmodium genome, resulting in most of the Plasmodium genes to be transcribed at once," Le Roch said. (sciencedaily.com)
DNA and histones are two components of a nucleosome. (sciencewatch.com)
Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones . (wikidoc.org)
The nucleosome core particle consists of approximately 147 [5] base pairs of DNA wrapped in 1.67 left-handed superhelical turns around a histone octamer consisting of 2 copies each of the core histones H2A , H2B , H3 , and H4 . (wikidoc.org)
[6] Linker histones such as H1 and its isoforms are involved in chromatin compaction and sit at the base of the nucleosome near the DNA entry and exit binding to the linker region of the DNA. (wikidoc.org)
The structure of over 20 different nucleosome core particles have been solved to date [11] , including those containing histone variants and histones from different species. (wikidoc.org)
The structure of the nucleosome core particle is remarkably conserved, and even a change of over 100 residues between frog and yeast histones results in electron density maps with an overall root mean square deviation (r.m.s.d) of only 1.6Å [12] . (wikidoc.org)

For this transcription to take place, however, the nucleosomes must first get evicted (removed), a process that opens up the DNA strand to give special "transcription factors" full access to the genes. (sciencedaily.com)
Nucleosome occupancy (white corresponding to large occupancy values) for the 2000 shortest S. Cerevisiae genes ordered by increasing length from top to bottom and aligned on the promoter (null distance). (ens-lyon.fr)
The genome of P. falciparum contains hundreds of genes that show CVGE, such that individual parasites within an isogenic population express these genes at very different levels, often fully active or completely silenced [15] . (plos.org)
Genome-wide studies in Saccharomyces cerevisiae , for example, have revealed that promoters of most actively transcribed genes are depleted of nucleosomes and that histone density is inversely proportional to the transcription rate within coding regions, suggesting that nucleosomes are dynamically disassembled and reassembled at each passage of the polymerase ( 16 ). (asm.org)
In eukaryotic cells, chromatin remodeling factors regulate chromatin structure by altering the assembly, disassembly, and relocalization of nucleosomes, thereby improving the local accessibility of transcription-related factors in their chromatin DNA, which further initiates or suppresses transcription of related genes. (creativebiomart.net)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)

Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)
Nucleosomes form the fundamental repeating units of eukaryotic chromatin [1] , which is used to pack the large eukaryotic genomes into the nucleus while still ensuring appropriate access to it (in mammalian cells approximately 2 m of linear DNA have to be packed into a nucleus of roughly 10 µm diameter). (wikidoc.org)

An acidic patch mutant showed defects in nucleosome positioning and occupancy genome-wide. (biorxiv.org)
The DNA entry-exit site is critical for nucleosome occupancy, a well-studied transcription-coupled histone modification, and prevention of several other transcription-related phenotypes that I have tested. (pitt.edu)
Genome-wide analysis in mutants reveals altered nucleosome occupancy and transcriptional output. (pitt.edu)
Nucleosome occupancy increased substantially at the targeted location and suppressed termination read-through of the locus to the level of a wildtype control. (pitt.edu)

This offers a potential explanation for mysterious histone modifications that would be buried uselessly deep inside the nucleosome according to the traditional model, and suggests a new mechanism for the extreme compaction chromosomes undergo during cell division, and offers potential answers to the chicken-and-egg problem of how cells know how to pull specific DNA sequences out of the archives without being first able to "see" them. (ucsf.edu)
Cross-fire over the nucleosome: molecular basis of post-meiotic male haploid genome compaction]. (bvsalud.org)

Nucleosome positioning via excluding genomic energy barriers. (ens-lyon.fr)
In many types of tumors, such as colon cancer, extensive hypomethylation has been observed in non-coding regions of the genome, which is thought to cause genomic instability, increase mutation rates, and may lead to aberrant activation of oncogenes. (creativebiomart.net)
The Genome Structure Function section of the Institute of Cancer and Genomic Sciences investigates the fundamentals of the active information database that is our genome, in normal and disease states. (birmingham.ac.uk)

Berbenetz, N. M., Nislow, C. & Brown, G. W. Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. (nature.com)
Local regulatory mechanisms within the genome and their interaction with chromatin structure give rise to subtle variations in gene expression. (elifesciences.org)
[9] Histone equivalents and a simplified chromatin structure have also been found in Archea [10] , proving that eukaryotes are not the only organisms that use nucleosomes. (wikidoc.org)

A high-resolution protein architecture of the budding yeast genome. (nature.com)

In addition, the density and positioning of nucleosomes have also been linked to transcriptional regulation. (asm.org)
In the papers by the Segal group, one in Nature Genetics and the other in Nature Biotechnology , Segal and his colleagues developed an elegant experimental system that allows them to accurately measure the effects of DNA sequences that disfavor the formation of nucleosomes on transcriptional regulation. (nanowerk.com)

In forming a chromosome, the nucleosomes repeatedly fold in on themselves to tighten and condense the packaged DNA. (genome.gov)
Kornberg, R. D. & Lorch, Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. (nature.com)

Nucleosomes are the fundamental building blocks of eukaryotic genome. (sciencewatch.com)

These chromatin loops help structure chromosomes and play an important role in basic genome functions such as gene expression. (pasteur.fr)

In mammalian cells, active and silent rDNA promoters are characterized by specific histone modifications, DNA methylation, and positioning of the promoter-bound nucleosome (reviewed in reference 22 ). (asm.org)
It is mainly manifested in the reduction of whole-genome DNA methylation level, hypermethylation of the promoter region, changes in specific histone modification, abnormal chromatin conformation, changes in non-coding RNA (ncRNA) molecules, etc . (creativebiomart.net)

A functional evolutionary approach to identify determinants of nucleosome positioning: a unifying model for establishing the genome-wide pattern. (harvard.edu)

Physical distance along a linear genome is a common metric for determining whether a putative regulatory element will affect a given gene's transcription. (elifesciences.org)

Here, using genome-scale biochemical reconstitution with approximately 300 replication origins, we screened 17 purified chromatin factors from budding yeast and found that the ORC established nucleosome depletion over replication origins and flanking nucleosome arrays by orchestrating the chromatin remodellers INO80, ISW1a, ISW2 and Chd1. (nature.com)
Nieduszynski, C. A., Knox, Y. & Donaldson, A. D. Genome-wide identification of replication origins in yeast by comparative genomics. (nature.com)
We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)
Viral genome-encoded enzymes that facilitate the replication of RNA VIRUSES. (bvsalud.org)

In Saccharomyces cerevisiae , meiotic DSBs preferentially occur at nucleosome-depleted regions in gene promoters (Ohta et al. (springer.com)

Rtf1 bound to nucleosomes through its histone modification domain, supporting its role as a cofactor in H2B K123 ubiquitylation. (biorxiv.org)

RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. (harvard.edu)

Over the years, he and his group have developed and applied software to many problems in gene finding, genome assembly, comparative genomics, evolutionary genomics, and sequencing technology itself, taking new challenges and developing multiple novel, high-impact computational methods, many of which are in extremely broad use. (iscb.org)
Epigenetics - the study of genome modifications that control cell fate, some of which are thought to reflect environmental influences on the genetics of health and disease - is one of the key frontiers of modern genomics. (ucsf.edu)

Analyses of these interactions has previously been limited, obscuring their regulatory context, and the extent to which they occur throughout the genome. (elifesciences.org)
Our results demonstrate that statistical interactions between genetic variants and chromatin accessibility are common throughout the genome. (elifesciences.org)
Understanding the scope and landscape of these interactions on a genome-wide scale is a vital step towards deciphering the genetic regulation of gene expression and, in turn, the mechanisms of non-coding variation on phenotypic outcomes. (elifesciences.org)
In 'DNA-Protein Interactions: Principles and Protocols, Third Edition', this vital subject is brought up to date with protocols exploring the most cutting-edge developments in the field, including in vivo and genome-wide interaction techniques. (nhbs.com)
The nucleosome contains over 120 direct protein-DNA interactions and several hundred water mediated ones [13] . (wikidoc.org)

A nucleosome is the basic repeating subunit of chromatin packaged inside the cell's nucleus. (genome.gov)
In humans, about six feet of DNA must be packaged into a nucleus with a diameter less than a human hair, and nucleosomes play a key role in that process. (genome.gov)
While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
It allows the centimeters, or even meters, of DNA that constitute a eukaryotic genome to fit inside a micrometer-scale cell nucleus. (dissertations.se)
Many nucleosomes join together to form the "chromatin" located in the nucleus of all cells. (mpg.de)

Made up of histone, a kind of protein, the nucleosomes are repeating units around which the double helix of DNA gets wrapped and vast amounts of genetic information get organized. (sciencedaily.com)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
Less than 1.5% of the human genome encodes protein. (nih.gov)
Six years ago, Widom and Segal reported in Nature the discovery of a second DNA code that explains the placement of nucleosomes, spool-like structures in which the DNA loops around a protein complex. (nanowerk.com)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. (dissertations.se)

Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)

The functional importance of the nucleosome-organizing activity of the ORC was demonstrated by orc1 mutations that maintained classical MCM-loader activity but abrogated the array-generation activity of ORC. (nature.com)
Aging, for instance, disrupts the nucleosome landscape, destabilizing the genome, and mutations in nucleosomes are drivers of cancers. (tu-dresden.de)
We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)

Therefore, the goal of my dissertation work was to address how nucleosomes contribute to control of transcription termination. (pitt.edu)

Transcription is controlled by factors that remove or modify nucleosomes, allowing RNA polymerase II to contact otherwise occluded DNA. (pitt.edu)

Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome. (umassmed.edu)
Many processes in parasite biology involve changes at the chromatin level, including regulation of transcription along a complex life cycle, delimitation of functional elements in the genome, and antigenic variation. (plos.org)
Regulation of nucleosome density is therefore an important mechanism to enable the transcription machinery to access the DNA. (asm.org)
Within the genome, many processes occur almost simultaneously so that the regulation of possibly chaotic access is tightly controlled. (birmingham.ac.uk)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)

Xu, W., Aparicio, J. G., Aparicio, O. M. & Tavaré, S. Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae . (nature.com)
Widom and Segal found there are certain DNA sequences that favor or disfavor the location of these nucleosomes. (nanowerk.com)
Using this system, the Segal group demonstrated that sequences favoring the formation of nucleosomes do indeed have a significantly negative impact on transcription. (nanowerk.com)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)

The textbook description of chromatin, the condensed form DNA takes when it is not in use, consists of rigid building-blocks called nucleosomes, which act as spindles on which inactive DNA can be spooled and archived. (ucsf.edu)

Gene expression can mean the difference between a functional and non-functional genome, between health and disease, and with the development of transgenic crops, the difference between survival and starvation. (nhbs.com)

Pausing is now recognized to be a pervasive feature of promoters in mammals and Drosophila melanogaster , and the evidence supporting this from genome-wide studies is presented. (nature.com)

Some also even the spacing between nucleosomes, setting a characteristic nucleosome-to-nucleosome distance. (tu-dresden.de)

Nucleosomes are one of the main structures that help keep our DNA folded up neatly and packed away or help to unfold it. (genome.gov)
The genome atlases allowed for distinguishing distinct DNA structures and highlighted suspicious high transcription zones. (mdpi.com)
If you look at crystal structures of the conventional model of the nucleosome, there's no slack, no room for the DNA to be pulled out. (ucsf.edu)

They develop cutting-edge technology to visualize individual nucleosome patterns in single cells, to deduce systems-level properties of tens of thousands of nucleosomes in cells, and to dissect the mechanism of nucleosome remodeling genome-wide in vivo and in vitro. (tu-dresden.de)

Their analyses suggest the simultaneous presence of tens or hundreds of thousands of loops in the genome of individual cells, indicating that the vast majority of human DNA is enclosed in loops maintained by cohesin. (pasteur.fr)
Nucleosomes are crucial to human health. (tu-dresden.de)
Several attempts have been made toward identification of S/MARs in genomes of various organisms including human. (researchgate.net)
However, a comprehensive genome-wide map of human S/MARs is yet not available. (researchgate.net)

Multiple lines of evidence support the idea that Pol II and nucleosomes compete for promoter binding and suggest that a crucial role of paused Pol II involves maintenance of accessible promoter chromatin architecture. (nature.com)

The nucleosome core regulates DNA-templated processes through the highly conserved nucleosome acidic patch. (biorxiv.org)

In this study, we undertook extensive genome-wide comparative analyses of twelve species that conform the Pectobacterium genus. (mdpi.com)
To investigate the function of this histone mark in early fly development, the team performed a panel of genome-wide analyses. (mpg.de)
This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)

Meiotic DSBs are not randomly distributed within the genome but mostly occur at discrete regions, called hotspots (Baudat et al. (springer.com)

The Mueller-Planitz lab studies the core components of chromatin - the nucleosomes and the machinery that places them in the genome. (tu-dresden.de)
Mitochondrial Genome, Structure and Function - Oxidative Metabolism in the Mitochondrion - The Role of Mitochondria in the formation of ATP - Translocation of Protons and the Establishment of a proton-motive force - The Machinery for ATP formation - Peroxisomes. (amrita.edu)

But Sinha, Gross and Narlikar's new study promises to change this paradigm, demonstrating that nucleosomes are capable of shifting like putty in response to as-yet unknown signals. (ucsf.edu)

Therefore, these data will help toward better understanding of genome functioning and designing effective anti-viral therapeutics. (researchgate.net)
Marburg virus (MARV) is a lipid-enveloped virus harboring a negative sense RNA genome, which has caused sporadic outbreaks of viral hemorrhagic fever in Sub-Saharan Africa. (uci.edu)

While in humans such eviction of nucleosomes is specific to only some sections of the DNA strand and performed only when needed, in Plasmodium the situation is vastly different. (sciencedaily.com)

The late Jonathan Widom of Northwestern is senior author of the Nature paper that describes a new method for mapping nucleosomes. (nanowerk.com)
This is another example of how Jon's great knowledge in biochemistry and biophysics allowed him to suggest a way to scale up an existing experimental technique into modern tools that would allow genome-wide mapping of nucleosomes," Segal said. (nanowerk.com)

rDNA coding regions are also depleted of nucleosomes, relative to the rDNA spacer. (asm.org)
Coding regions of active rDNA were initially thought to be devoid of nucleosomes, as suggested by electron microscopy and psoralen cross-linking experiments ( 4 ). (asm.org)
CpG-rich regions are unevenly distributed in the genome, and they often appear in gene promoter regions. (creativebiomart.net)

We show that stable 3D genome structure is an effective tool to guide searches for regulatory elements and, conversely, that regulatory elements in genetically diverse populations provide a means to infer 3D genome structure. (elifesciences.org)

Anatomy15

Organisms9

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes87

Disciplines and Occupations3

Information Science10

Proteins13

Epigenetic14

Organization11

Locations of nucleosomes2

Sequence9

Histones7

Genes6

Eukaryotic genomes2

Occupancy4

Compaction2

Genomic3

Chromatin structure3

Budding yeast genome1

Transcriptional regulation2

Chromosome2

Fundamental1

Chromosomes1

Methylation2

Determinants1

Linear genome1

Replication4

Saccharomyces1

Histone modification1

Instability1

Genomics2

Interactions5

Nucleus5

Protein5

Modifications1

Mutations3

Control of transcription1

Polymerase1

Regulation5

Sequences4

Consists1

Gene expression1

Promoters1

Characteristic1

Structures3

Mechanism1

Human4

Crucial1

Processes1

Analyses3

Occur1

Machinery2

Paradigm1

Viral2

Humans1

Mapping2

Regions3

Stable1