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NucleosidesPurine NucleosidesPyrimidine NucleosidesNucleoside Transport ProteinsEquilibrative Nucleoside Transporter 1ThioinosinePurine-Nucleoside PhosphorylaseGuanosineNucleoside-Diphosphate KinaseInosineUridineNucleoside QEquilibrative-Nucleoside Transporter 2Nucleoside-TriphosphataseCytidineRibonucleosidesNucleotidesAdenosineFormycinsPentosyltransferasesNM23 Nucleoside Diphosphate KinasesReverse Transcriptase InhibitorsEquilibrative Nucleoside Transport ProteinsDeoxyribonucleosidesDeoxyadenosinesAdenineDilazepKineticsDideoxynucleosidesTubercidinZidovudineArabinonucleosidesAntiviral AgentsPurinesDeoxycytidine KinaseOrganophosphonatesPyrimidine PhosphorylasesThymidineThionucleosidesRibonucleotidesDeoxyuridineZalcitabineUridine PhosphorylaseAnti-HIV AgentsDipyridamoleHIV Reverse TranscriptaseThymine NucleotidesAcid Anhydride HydrolasesSubstrate SpecificityAdenosine TriphosphateDideoxynucleotidesNucleoside DeaminasesHypoxanthineStavudineGuanineBiological TransportDeoxyguanosineMolecular Sequence DataThiouridinePurine NucleotidesMembrane Transport ProteinsMolecular StructureCytidine TriphosphateDrug Resistance, ViralPhosphotransferasesDidanosineEscherichia coliHypoxanthinesAdenine NucleotidesDeoxyribonucleotidesPyrophosphatasesArabinofuranosyluracilAdenosine Deaminase InhibitorsDeoxyguanine NucleotidesRNA, TransferProdrugsAdenosine KinaseNucleotidasesUracil NucleotidesBase SequenceCladribineThymidine KinaseApyraseStructure-Activity RelationshipPyrimidinonesDeoxycytidineLamivudineRiboseMutationCytosineUridine KinaseHIV-1Adenosine MonophosphateFloxuridine5'-NucleotidaseAmino Acid SequenceOrganophosphorus CompoundsGuanosine TriphosphateOligonucleotidesAcyclovir
NucleotidesAnalogsAnaloguesPurine nucleosideSynthesisNucleobasesPhosphateAntiviralUridineRibonucleosidesProteinsDeoxyuridineTriphosphatesMonophosphatesPhosphorylaseSyntheticNRTINucleobaseInhibitorsAntiretroviralPyrimidineOligonucleotidesReactiveCatalyticMoleculeFluorescentAdenosineDerivativesReverseInfectionProductsChemicalFormActivityResearchRapidCombination
Nucleotides2
  • Nucleoside polyphosphates and their conjugates, such as nucleoside triphosphates, nucleoside tetraphosphates, sugar nucleotides, dinucleoside pyro- and higher order polyphosphates, 2',3'-cyclic nucleoside monophosphates, and 2´-deoxynucleoside-5´-tetraphosphates in which a fluorescent label is attached to the terminal phosphate have many biological roles and have been developed into drugs. (uwaterloo.ca)
  • Poster session presented at RSC Symposium on Nucleosides and Nucleotides: synthetic and biological chemistry, London, United Kingdom. (qub.ac.uk)
Analogs7
  • Nidetzky, B. Biocatalytic cascade transformations for the synthesis of C-nucleosides and N-nucleoside analogs. (beilstein-journals.org)
  • The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches. (nih.gov)
  • Nucleoside analogs ( NA s) are used to treat numerous viral infections and cancer. (plos.org)
  • Nucleoside analogs ( NA s) represent an important drug class for the treatment of viral infections and cancer. (plos.org)
  • von Kleist M, Metzner P, Marquet R, Schütte C (2012) HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection. (plos.org)
  • CONCLUSION: Combination antiretroviral therapy during pregnancy with two nucleoside analogs was well-tolerated by mothers and newborns, with no significant short-term toxicities or side effects noted. (jefferson.edu)
  • macologic classes: nucleoside analogs, interferons, The aim of this study was to investigate whether a panel protease inhibitors, reverse transcriptase inhibitors, and of currently available antiviral agents exhibit in vitro neuraminidase inhibitors. (cdc.gov)
Analogues6
  • The importance of nucleoside analogues in a number of areas of drug discovery and chemical biology continues to act as a spur to develop practical and efficient synthetic methods for accessing these compounds. (thieme.de)
  • Rauter, A. P. Nucleoside analogues: N-glycosylation methodologies, synthesis of antiviral and antitumor drugs and potential against drug-resistant bacteria and Alzheimer's disease. (beilstein-journals.org)
  • Bepirovirsen, an antisense oligonucleotide therapy aided in long-term prevention of chronic hepatitis B in patients on and not on nucleoside/nucleotide analogues in a Phase II trial. (europeanpharmaceuticalreview.com)
  • Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. (elsevierpure.com)
  • The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-C-nucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. (elsevierpure.com)
  • Explore our uniquely large collection of reagents that contains popular nucleoside building blocks, nucleosides that facilitate epigenetics research and a family of pseudouridine analogues. (biosearchtech.com)
Purine nucleoside5
  • In purine nucleoside phosphorylase deficiency, similar changes occur, resulting in elevated deoxy-GTP (dGTP) levels. (medscape.com)
  • In a further description of the mechanism of T-cell depletion in purine nucleoside phosphorylase deficiency, Arpaia et al reported increased in vivo apoptosis of T cells and increased in vitro sensitivity to gamma irradiation in a murine model. (medscape.com)
  • [ 4 ] The immune deficiency in purine nucleoside phosphorylase deficiency may be the result of inhibited mitochondrial DNA repair due to the accumulation of dGTP in the mitochondria. (medscape.com)
  • Diagnosis of purine nucleoside phosphorylase deficiency is by DNA analysis. (msdmanuals.com)
  • Treatment of purine nucleoside phosphorylase deficiency is with bone marrow or stem cell transplantation. (msdmanuals.com)
Synthesis13
  • Several novel and efficient approaches to the synthesis of nucleoside polyphosphates and their conjugates were developed. (uwaterloo.ca)
  • Finally an entirely new approach to the synthesis of nucleoside tetraphosphates (Np4's), dinucleoside pentaphosphates (Np5N's) and nucleoside tetraphosphates in which a fluorescent dye is attached to the terminal phosphate is described employing an activated form of cyclic trimetaphosphate as a novel phosphorylating agent. (uwaterloo.ca)
  • Paolo Quadrelli presents the synthesis of N,O-nucleosides from (nitrosocarbonyl)mesitylene. (thieme.de)
  • Rusinov, V. L. Approaches to the synthesis of heterocyclic C-nucleosides. (beilstein-journals.org)
  • Banerjee, S. Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity. (beilstein-journals.org)
  • A convenient selective synthesis of 2′,3′-di-O-acetyl-nucleo- tide-5′-phosphates, 2′,3′-di-O-acetyl-nucleotide-5′-triphosphates and 2′,3′,5′-tri-O-acetyl-nucleosides in water has been developed. (ucl.ac.uk)
  • Nucleosides are precursors for nucleic acid synthesis and are essential for metabolism and cell growth. (biosearchtech.com)
  • We offer over 300 nucleosides, precursors, and reagents to synthesise nucleosides and make them incorporation-ready for oligo synthesis. (biosearchtech.com)
  • Use our reagents to generate reactive nucleosides for oligo synthesis. (biosearchtech.com)
  • Synthesis, Base Pairing Properties, and Biological Activity Studies of Platinum(II) Complexes Based on Uracil Nucleosides. (bvsalud.org)
  • The synthesis and base pairing properties of platinum complexes based on uridine and deoxyuridine nucleosides and preliminary studies of their antiproliferative activity are described. (bvsalud.org)
  • First, the synthesis was performed with protected nucleosides to generate complexes 1 and 2, which were deprotected under basic conditions, affording complexes 3 and 4 in good yields. (bvsalud.org)
  • The synthesis with the unprotected nucleosides was also performed and provided complexes 3 and 4 effectively. (bvsalud.org)
Nucleobases1
  • Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. (ganoherb.com)
Phosphate2
  • Following a drug repurposing approach, we aimed to investigate and compare the antibacterial and antibiofilm activities of different classes of phosphate prodrugs (HepDirect, cycloSal, SATE and mix SATE) of antiviral and anticancer FDA-approved nucleoside drugs [zidovudine (AZT), floxouridine (FUDR) and gemcitabine (GEM)] against a variety of pathogenic Gram-positive and -negative bacteria. (nih.gov)
  • Nucleotide is a compound consisting of a nucleoside linked to a phosphate group. (broadpharm.com)
Antiviral2
  • Cytarabine Vidarabine Nelarabine Fludarabine Clofarabine Sorivudine Clevudine W. E. Müller: "Rational design of arabinosyl nucleosides as antitumor and antiviral agents", Jpn J Antibiot. (wikipedia.org)
  • The interactions of two antiviral, acyclic nucleoside phosphonates, adefovir and cidofovir, with xenobiotic transporters was studied in intact killifish ( Fundulus heteroclitus ) renal proximal tubules by using fluorescent substrates, confocal microscopy, and quantitative image analysis. (aspetjournals.org)
Uridine2
  • Nucleosides: Having the highest uridine content. (ganoherb.com)
  • Introduction: Institute of Chinese Medical Sciences, University of Macau and Hong Kong Baptist University jointly proved in Journal of Pharmaceutical and Biomedical Analysis that uridine is a nucleoside whose content is highest in Ganoderma samples. (ganoherb.com)
Ribonucleosides1
  • Attempts to prepare nucleoside triphosphates by subjecting unprotected ribonucleosides and 2'-deoxyribonucleosides to activated cyclic trimetaphosphate failed. (uwaterloo.ca)
Proteins3
  • Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in this website by year, and whether "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins" by people in Profiles. (umassmed.edu)
Deoxyuridine1
  • Deoxyuridine nucleosides embodied into diarylethenes form an especial class of photoswitchable compounds that are designed to stack and pair with DNA bases. (jascoinc.com)
Triphosphates1
  • The procedure is rapid, produces a wide variety of nucleoside polyphosphates and their conjugates in high yield, does not require protection and subsequent deprotection of the nucleotide donors or acceptors and can be used to activate nucleoside mono-, di-, and triphosphates and a wide variety of acceptors. (uwaterloo.ca)
Monophosphates2
  • In the first approach dinucleoside polyphosphates (NpnN's where n = 2-4) are prepared via in situ trifluoroacetate protection and imidazolium activation of nucleoside 5'-monophosphates. (uwaterloo.ca)
  • In the presence of Ca2+, NTPDase4 hydrolyzes nucleoside diphosphates UDP, GDP, CDP and dTDP to nucleoside monophosphates UMP, GMP, CMP and dTMP, respectively (Wang and Guidotti 1998). (reactome.org)
Phosphorylase4
  • [ 2 , 3 ] One disorder is adenosine deaminase (ADA) deficiency, which is Online Mendelian Inheritance in Man (OMIM) subject number 102700, and the other is purine nucleoside phosphorylase (PNP) deficiency, which is OMIM subject number 164050. (medscape.com)
  • In both adenosine deaminase and purine nucleoside phosphorylase deficiencies, thymocytes are thought to be selectively destroyed because of elevated levels of dATP and dGTP. (medscape.com)
  • Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors. (lu.se)
  • Thymidine phosphorylase breaks down thymidine into smaller molecules, which helps regulate the level of nucleosides in cells. (medlineplus.gov)
Synthetic1
  • Phosphoramidite is a synthetic nucleoside derivative containing a phosphite ester group. (broadpharm.com)
NRTI1
Nucleobase1
  • Nucleoside is comprised of a nucleobase and a five-carbon sugar (ribose or 2'-deoxyribose). (broadpharm.com)
Inhibitors4
  • Comparison of the inhibitory potencies of the nucleoside phosphonates with other substrates and inhibitors showed them to be moderate inhibitors of OAT1- and Mrp2-mediated transport. (aspetjournals.org)
  • Our model correctly predicts for HIV-1 that resistance against nucleoside analog reverse transcriptase inhibitors (NRTIs) can be conferred by decreasing their incorporation rate, increasing their excision rate, or decreasing their affinity for the polymerase enzyme. (plos.org)
  • Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine. (aspetjournals.org)
  • Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). (hiv.gov)
Antiretroviral2
  • 4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. (adooq.com)
  • Demographic, laboratory, and pregnancy outcome data were collected for 39 women whose antiretroviral treatment regimens were expanded to include more than one nucleoside analog for maternal indications. (jefferson.edu)
Pyrimidine1
  • In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a pyrimidine. (broadpharm.com)
Oligonucleotides1
Reactive1
  • These molecules permit the sequential addition of new bases to the chain in a highly efficient reaction, to avoid undesired side reactions, reactive hydroxy and exocyclic amino groups present in nucleosides are appropriately protected. (broadpharm.com)
Catalytic1
Molecule1
Fluorescent1
  • Incorporate fluorescent nucleosides into your oligo to observe the transition between DNA structural types. (biosearchtech.com)
Adenosine1
  • Adenosine signaling is terminated by its uptake through equilibrative nucleoside transporters (ENTs). (ozgene.com)
Derivatives1
  • Arabinosyl nucleosides are derivatives of the nucleosides. (wikipedia.org)
Reverse3
  • Poor reduction of HIV-1 RNA titres in nucleoside reverse transcriptase inhibitor experienced patients treated with indinavir combination therapy. (bmj.com)
  • METHODS: Samples of semen and blood were obtained from a cohort of 12 nucleoside reverse transcriptase inhibitor experienced men before and during 25-68 weeks of combination therapy, which included the protease inhibitor indinavir. (bmj.com)
  • CONCLUSIONS: These data show that stable reduction of blood and seminal fluid viral titres is not achievable in a significant proportion of nucleoside reverse transcriptase inhibitor experienced men. (bmj.com)
Infection1
  • Initial multicenter experience with double nucleoside therapy for human immunodeficiency virus infection during pregnancy. (jefferson.edu)
Products1
  • LGC, Biosearch Technologies offers the largest range of specialised products for nucleosides on the market. (biosearchtech.com)
Chemical1
  • The chemical reactions and pathways involving any phosphorylated nucleoside. (yeastrc.org)
Form1
  • Nucleoside-modified messenger RNA (modRNA) is a modified form of mRNA that encodes the spike (S) glycoprotein of the SARS-CoV-2 virus, the virus that causes COVID-19. (republicbroadcasting.org)
Activity1
  • The prodrugs showed decreased antibacterial activity compared with the parent nucleosides. (nih.gov)
Research1
  • Dive into the research topics of 'Imino-sugar-based nucleosides. (elsevierpure.com)
Rapid1
  • Aldrich, C. C. 1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides. (beilstein-journals.org)
Combination1
  • OBJECTIVE: To study maternal and neonatal effects of combination nucleoside analog therapy administered to human immunodeficiency virus (HIV)-infected pregnant women for maternal indications. (jefferson.edu)