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  • guanosine
  • Antiviral Carbocyclic Purine nucleosides (-)Carbovir Abacavir Entecavir Carbocyclic 2′-ara-fluoro-guanosine Entecavir, a guanosine analog, was reported in 1997 as a potent and selective inhibitor for the hepatitis B virus, and approved by the FDA in March 2005 for oral treatment of hepatitis B infection. (wikipedia.org)
  • The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic analogue of an unnatural nucleoside to exhibit greater anti-herpes activity against the herpesviruses HSV-1 and HSV-2 in-vitro than its furanose parent. (wikipedia.org)
  • reverse transcrip
  • It's a nucleoside reverse transcriptase inhibitor, or an NRTi, in AIDS speak. (wordnik.com)
  • All three drugs are known as non- nucleoside reverse transcriptase inhibitor drugs, or NNRTIs. (wordnik.com)
  • The researchers enrolled 94 patients naive to antiretroviral treatment to receive either a regimen of atazanavir and raltegravir twice a day (63 patients) or, for 31 patients, a once-daily regimen of atazanavir boosted with ritonavir (Norvir) plus the nucleotide reverse transcriptase inhibitor tonofovir (Viread) and the nucleoside reverse transcriptase inhibitor emtricitabine (Emtriva). (medpagetoday.com)
  • compounds
  • Although some bisamidites were reported as thermally unstable compounds, 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite, the amidite used for the preparation of commercial nucleoside phosphoramidites, is relatively stable. (wikipedia.org)
  • Nucleoside phosphoramidites are relatively stable compounds with a prolonged shelf-life when stored as powders under anhydrous conditions in the absence of air at temperatures below 4 °C. The amidites will withstand mild basic conditions. (wikipedia.org)
  • The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. (wiley.com)
  • In looking for a way to designate the ring face of a simple ring compound such as G6P or of the two rings of a nucleoside , or of fused ring compounds such as sterols, we realized that a universal method could be devised using the established rules for numbering the atoms of rings as contained in standard chemical handbooks15. (wordnik.com)
  • selective
  • When an acyl-protected ribose is employed, selective formation of the β-nucleoside (possessing the S configuration at the anomeric carbon) results from neighboring group participation. (wikipedia.org)
  • NRTIs
  • In addition, the RBC analyst believes Gilead's Emtriva will continue to dominate the market for NRTIs, or nucleoside reverse transcriptase inhibitors. (wordnik.com)
  • There are two classes of drugs that target the HIV-1 RT enzyme, nucleoside/nucleotide reverse-transcriptase inhibitors (NRTIs/NtRTIs) and non-nucleoside reverse-transcriptase inhibitors (NNRTIs). (wikipedia.org)
  • nucleic acid
  • 1. In a method for nucleic acid analysis, which includes a high temperature polymerase reaction of a nucleic acid template, a primer, a nucleic acid polymerase, and at least one nucleoside polyphosphate, the improvement comprising conducting said polymerase reaction in the presence of at least one thermally stable terminally blocked nucleoside polyphosphates, wherein said nucleic acid analysis is chain terminator DNA sequencing. (google.es)