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  • residues
  • IC1 has a unique primary structure, the N-terminal part is homologous to the sequence of thioredoxin, the middle part consists of three repetitive sequences homologous to the sequence of nucleoside diphosphate kinase, and the C-terminal part contains a high proportion of negatively charged glutamic acid residues. (embl-heidelberg.de)
  • Apart from the conserved lysine, a feature of the P-loop used in phosphate binding is a compound LRLR nest comprising the four residues xxGK, as above, whose main chain atoms form a phosphate-sized concavity with the NH groups pointing inwards. (wikipedia.org)
  • There are also protein kinases that phosphorylate other amino acids, including histidine kinases that phosphorylate histidine residues to create acid and heat-labile phosphoramidate bonds. (wikipedia.org)
  • Activity of MAP kinases is restricted by a number of protein phosphatases, which remove the phosphate groups that are added to specific serine or threonine residues of the kinase and are required to maintain the kinase in an active conformation. (wikipedia.org)
  • acceptor
  • This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. (wikipedia.org)
  • thymidylate
  • Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays. (nih.gov)
  • signals
  • Kinases are used extensively to transmit signals and regulate complex processes in cells. (wikipedia.org)
  • The addition and removal of phosphoryl groups provides the cell with a means of control because various kinases can respond to different conditions or signals. (wikipedia.org)
  • Important subgroups are the kinases of the ERK subfamily, typically activated by mitogenic signals, and the stress-activated protein kinases JNK and p38. (wikipedia.org)
  • amino
  • Following the evolution of long and short varieties of NMP-kinases, smaller changes in the amino acid sequences resulted in the differentiation of subcellular localization. (wikipedia.org)
  • Protein kinases can be classed as catalytically active (canonical) or as pseudokinases, reflecting the evolutionary loss of one or more of the catalytic amino acids that position or hydrolyse ATP. (wikipedia.org)
  • family
  • Apical localization of the Crumbs (Crb) transmembrane protein requires a PDZ-mediated interaction with Pals1 (protein-associated with Lin7, Stardust, MPP5), a member of the p55 family of membrane-associated guanylate kinases (MAGUKs). (nih.gov)