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  • important
  • These studies lead to new information regarding the steps involved in interactions between dCK and its most important ligands and provide a possible general model for nucleoside kinase action. (slu.se)
  • dNTPs
  • More specifically, this pathway recycles preformed nucleosides from degrading DNA molecules to synthesize dNTPs for the cell. (wikipedia.org)
  • resistance
  • There are, however, several different nucleoside analogue drugs and resistance to one of them is usually overcome by switching to another drug of the same kind (e. g. famciclovir, penciclovir, valaciclovir). (wikipedia.org)
  • catalyzes
  • This has deemed the "closed" conformation as the catalytically active conformation since it catalyzes the phosphoryl transfer between phosphoryl donors and receiving nucleosides. (wikipedia.org)
  • cell
  • also known as cN-II and high K m 5′-nucleotidase) and cytoplasmic 5′-nucleotidase III (NT5C3) are involved in the final step of dephosphorylation before export of nucleosides out of the cell. (aspetjournals.org)
  • catalyze
  • Similarly, "open" conformation is generally referred to as the catalytically inactive form since Glu53 is not in close proximity to nucleoside 5' hydroxyl group and will not catalyze the phosphoryl transfer. (wikipedia.org)
  • Chain
  • Glu53 performs base catalysis to deprotonate the hydroxyl group, which allows the now nucleophilic oxygen from the nucleoside 5' hydroxyl group to attack the end of the phosphate chain (gamma phosphate) on the phosphoryl donor (e.g. (wikipedia.org)
  • The most commonly used is acyclovir, although its inclusion in this category is uncertain, because it acts as a nucleoside but contains no actual sugar, as the sugar ring is replaced by an open-chain structure. (wikipedia.org)