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  • resistance
  • Less than 1% of diagnosed patients survive 5 years with an average survival time of only 4-8 months.The novel antimetabolite zebularine shows promise, inducing apoptosis and arresting cellular growth in various pancreatic cancer cell lines.However, resistance to these antimetabolites remains a problem highlighting the need to discover and develop new antimetabolites that will improve a patient's overall survival. (nih.gov)
  • However, resistance to these antimetabolites remains a problem highlighting the need to discover and develop new antimetabolites that will improve a patient's overall survival. (nih.gov)
  • tumor
  • Notably recent studies have shown that the ABC transporter ABCG2 [which is expressed in many tumor types ( 22 )] exports both purine nucleoside monophosphates and nucleosides ( 18 , 23 ).This suggests an ABC transporter could affect the intracellular nucleoside monophosphate concentration by reducing both the amount of nucleoside available for phosphorylation as well as the amount phosphorylated. (aacrjournals.org)
  • Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor growth. (wikipedia.org)
  • leukemia
  • Antimetabolite drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well as other types of cancers. (wikipedia.org)
  • cellular
  • The novel antimetabolite zebularine shows promise, inducing apoptosis and arresting cellular growth in various pancreatic cancer cell lines. (nih.gov)
  • treat
  • Antimetabolites, particularly mitomycin C (MMC), are commonly used in America and Japan as an addition to trabeculectomy , a surgical procedure to treat glaucoma . (wikipedia.org)