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  • antiviral
  • Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. (wiley.com)
  • PMID
  • The tsx gene of Escherichia coli encodes an outer membrane protein, Tsx, which constitutes the receptor for colicin K and Bacteriophage T6, and functions as a substrate-specific channel for nucleosides and deoxy-nucleosides [ PMID: 2265760 ]. (ebi.ac.uk)
  • molecular
  • Similar catalytic domains are present in a variety of proteins, including: ATP synthase Myosin, and other molecular motor proteins G protein and other proteins involved in signal transduction Helicases for unwinding DNA and RNA Pyrimidine metabolism When a phylogenetic tree composed of members of the nucleoside-phosphate kinase family was made, it showed that these enzymes had originally diverged from a common ancestor into long and short varieties. (wikipedia.org)
  • enzymes
  • They retain many of the biological properties of the original nucleosides with respect to recognition by various enzymes and receptors. (wikipedia.org)
  • ribose
  • In a nucleoside, the base is bound to either ribose or deoxyribose via a beta-glycosidic linkage. (wikipedia.org)
  • The nucleosides, in turn, are subsequently broken down: in the lumen of the digestive system by nucleosidases into nucleobases and ribose or deoxyribose. (wikipedia.org)
  • The term nucleoside refers to a nitrogenous base linked to a 5-carbon sugar (either ribose or deoxyribose). (wikipedia.org)
  • analogue
  • the binding mechanism of a transition state analogue (DADMe-immucillin-H) to the purine nucleoside phosphorylase (PNP ) enzyme, is reported. (antikoerper-online.de)
  • Abacavir, was developed from racemic (±)-carbovir which was reported in 1988 by Robert Vince as the first carbocyclic nucleoside analogue to show potent activity against HIV with low cytotoxicity. (wikipedia.org)
  • The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic analogue of an unnatural nucleoside to exhibit greater anti-herpes activity against the herpesviruses HSV-1 and HSV-2 in-vitro than its furanose parent. (wikipedia.org)
  • For example, azidothymidine (AZT) is a nucleoside analogue used to prevent and treat HIV/AIDS. (wikipedia.org)