• Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. (wikipedia.org)
  • Proteomics revealed Orf6 interacts with nucleopore proteins (RAE1, XPO1, RANBP2 and nucleoporins). (biomedcentral.com)
  • The polymerization of amino acids into peptides and interactions between peptides are of interest because peptides and proteins participate in complex interaction networks in extant biology. (bvsalud.org)
  • Trafficking between the nucleus and cytoplasm occurs through nuclear pore complexes (NPCs), which consist of ca. thirty distinct proteins called nucleoporins. (nih.gov)
  • Our current studies on this complex focus on functional dissection of the multiple domains within this large protein and on interacting proteins that may be essential for the function of the RanBP2 complex. (nih.gov)
  • The asymmetrical distribution of Ran-GTP and Ran-GDP drives cargo transport between the nucleus and cytoplasm through karyopherins, a family of nuclear transport carrier proteins that bind to Ran-GTP. (nih.gov)
  • Surface properties determining passage rates of proteins through nuclear pores. (mpg.de)
  • Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene. (wikipedia.org)
  • The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. (wikipedia.org)
  • NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy. (atlasgeneticsoncology.org)
  • The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. (utsouthwestern.edu)
  • It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. (utsouthwestern.edu)
  • Several other nucleoporins that do not associate with kinetochores have also been shown to have important mitotic roles, including Nup214, Nup98, and TPR. (nih.gov)
  • This complex is transported to the nucleus where the viral cDNA integrates into a host cell chromosome, a key step that is under the control of the retroviral enzyme IN [ 7 - 9 ]. (biomedcentral.com)
  • Ran is a Ras-family GTPase that plays critical roles in multiple cellular processes including nucleo-cytoplasmic transport, nuclear envelope assembly and mitotic spindle assembly. (nih.gov)
  • Assembly and architecture of invertebrate intermediate filaments reconcile features of vertebrate cytoplasmic and nuclear lamin-type intermediate filaments. (mpg.de)
  • We show here that NS1 forms an inhibitory complex with NXF1/TAP, p15/NXT, Rae1/mrnp41, and E1B-AP5, which are key constituents of the mRNA export machinery that interact with both mRNAs and nucleoporins to direct mRNAs through the nuclear pore complex. (elsevierpure.com)
  • Furthermore, influenza virus down-regulates Nup98, a nucleoporin that is a docking site for mRNA export factors. (elsevierpure.com)
  • The NUP98/KDM5A fusion protein contains the Phe-Gly (FG) repeats of the N-terminal part of NUP98. (atlasgeneticsoncology.org)
  • Elucidation of the mechanism of this association will not only allow us to test the importance of RanBP2 complex formation in a non-vertebrate system, but also provide a convenient alternative mechanism for formation of this complex that can be used to understand its importance in vertebrate cells. (nih.gov)
  • Functional principles of the permeability barrier that guards vertebrate nuclear pore complexes. (mpg.de)
  • these residues correspond to S608 and S839 of NUP98 splice variant NUP98-3), are phosphorylated on NUP98 isolated from mitotic HeLa cells (human cervical cancer cell line). (reactome.org)
  • Because Nup98 and Rae1 are induced by interferons, down-regulation of this pathway is likely a viral strategy to promote viral replication. (elsevierpure.com)
  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (wikipedia.org)
  • 2003), the reaction shows a portion of NUP98 being released to the cytosol, and a portion of NUP98 dissociating into the nucleus, similar to what is observed by immunocytochemistry (Laurell et al. (reactome.org)
  • Our functional analysis of HIV-1 IN mutants reveals distinct structural basis for TNPO3 interaction and suggests that the interaction between IN and TNPO3 is not a major determinant of nuclear import but could take place at a nuclear step prior to integration. (biomedcentral.com)
  • Barrier-properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length. (mpg.de)
  • During mitosis, metazoan NPCs disassemble, and at least a third of nucleoporins associate with kinetochores, including the RanBP2 complex and the Nup107-160 complex. (nih.gov)
  • Much of our current work concerns the RanBP2 complex, which consists of RanBP2 (a large nucleoporin that is also known as Nup358), SUMO-1-conjugated RanGAP1 (the activating protein for the Ran GTPase), and Ubc9 (the conjugating enzyme for the SUMO family of ubiquitin-like modifiers). (nih.gov)
  • The RanBP2 complex associates with kinetochores in a microtubule-dependent manner that also requires Crm1, a Ran-dependent nuclear export receptor. (nih.gov)
  • 2011). As NUP98 localizes to both sides of the NPC, cytosolic and nucleoplasmic (Griffis et al. (reactome.org)
  • The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. (mpg.de)
  • The exportin Xpo4 recognizes eIF5A through its unique amino acid hypusine for nuclear export. (mpg.de)
  • Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities. (atlasgeneticsoncology.org)
  • Following the entry of the HIV-1 viral core into the cytoplasm of a target cell, reverse transcription of the retroviral RNA into a linear double strand cDNA copy takes place within the reverse transcription complex (RTC) [ 1 , 2 ]. (biomedcentral.com)
  • These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. (utsouthwestern.edu)
  • From up to down: NUP98, JARID1A and the putative chimeric NUP98-JARID1A structure. (atlasgeneticsoncology.org)
  • Crystal structure of Nup62.58.54 nucleoporin complex. (mpg.de)
  • Most of the mutant viruses were essentially impaired for the integration step whereas the amount of 2-LTR circles, reflecting the nuclear import of the viral DNA, was not significantly affected. (biomedcentral.com)
  • In short, our modeling has highlighted challenges and opportunities toward understanding the behaviors of complex prebiotic chemical experiments. (bvsalud.org)
  • Chemical cross-linking indicates a staggered and antiparallel protofilament of desmin intermediate filaments and characterizes one higher-level complex between protofilaments. (mpg.de)
  • The supramolecular assembly of intrinsically disordered nucleoporin domains is tuned by inter-chain interactions. (mpg.de)
  • We showed that these complexes play important roles in kinetochore function. (nih.gov)
  • The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity. (mpg.de)
  • 2012). From another validation cohort of 22 non-DS pediatric AMKL, 9 DS AMKL, and 8 adult AMKL, a NUP98/KDM5A fusion was characterized in two patients (Thiollier et al. (atlasgeneticsoncology.org)