(D) Nucleoplasmic lamin A interacts with chromatin in the nuclear interior. (frontiersin.org)
RNA from the cytoplasmic and nucleoplasmic lysates as well as the chromatin pellet was purified using Qiagen RNeasy columns according to manufacturer protocol. (nih.gov)
We have observed that after induction of 8-oxoG in the cellular DNA, OGG1, APE1 and XRCC1 are recruited from a soluble nucleoplasmic fraction to the chromatin, following a kinetics that is in good correlation with the repair rate. (cea.fr)
Microscopy, biochemical fractionation and chromatin immunoprecipitation reveal a diffuse nucleoplasmic distribution, weak association with chromatin and high expression levels for HP1β in ESCs. (biomedcentral.com)
(G) BCBL1 cells were treated with puromycin for 3 and 6 hr, subcellular fractionation was performed, and cytoplasmic, nucleoplasmic and chromatin fractions were analyzed by Western blotting. (figshare.com)
Cytoplasmic2
larger doses can clear the tissues even faster, and may also assist in the cytoplasmic and nucleoplasmic clearance of viral DNA. (nanomedicine.com)
There's the cytoplasmic outer ring (yellow), the inner rings (purple, blue), the membrane ring (brown), and the nucleoplasmic outer ring (yellow). (nih.gov)
Nucleolar1
Traditionally, the nucleolar Pol I and nucleoplasmic Pol III are viewed as the sole mammalian RNA polymerases that directly mediate housekeeping ribosome biogenesis. (nature.com)
Inhibition2
At 75-85% inhibition, only a uniform nucleoplasmic fluorescence was observed. (edu.hk)
We find that AKT phosphorylation of NPM-Ser48 prevents oligomerization that results in nucleoplasmic localization of ARF, constitutive MDM2 inhibition and stabilization of p53. (oncotarget.com)
Membrane1
SENP2I8D dropped association with multiple membrane proteins and obtained brand-new nucleoplasmic interactors. (conferencedequebec.org)
Nuclear1
This subgroup corresponds to the RRM1 of raver-1, a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP) that serves as a co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. (nih.gov)
Incubation2
Time course of incubation indicate a new mechanism for patulin-induced nucleoplasmic bridge formation. (uni-wuerzburg.de)
Only after a much longer incubation (24 hr) with actinomycin 4-4′-gly was nucleoplasmic fluorescence observed. (edu.hk)
Formation1
Patulin caused the formation of micronuclei and nucleoplasmic bridges in a dose-dependent manner. (uni-wuerzburg.de)
Loss1
2008): Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. (boku.ac.at)
Complex1
Pilat U, Dechat T, Bertrand AT, Woisetschläger N, Gotic I, Spilka R, Biadasiewicz K, Bonne G, Foisner R (2013): The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice. (fh-krems.ac.at)
Cytoplasmic and nucleoplasmic4
Cytoplasmic and nucleoplasmic [Ca2+]i transients (CaTs) were enlarged in SHR. (uni-marburg.de)
Cytoplasmic and nucleoplasmic CaTs were augmented (as in young hypertrophic SHR). (uni-marburg.de)
RNA from the cytoplasmic and nucleoplasmic lysates as well as the chromatin pellet was purified using Qiagen RNeasy columns according to manufacturer protocol. (nih.gov)
Seminal fluorescence photobleaching research exposed distinct cytoplasmic and nucleoplasmic swimming pools of BAF, each which got high diffusional flexibility [21]. (biopaqc.com)
Proteins5
Following purification, cardiac nuclei were fractionated into biologically relevant fractions including acid-soluble proteins, chromatin-bound molecules and nucleoplasmic proteins. (umn.edu)
Additionally, on the nucleoplasmic side of the inner nuclear membrane, SUN proteins interact with A-type lamin components of the nuclear lamina. (biomedcentral.com)
May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. (nih.gov)
Two host proteins shown to be essential for capsid nuclear entry that directly bind to the capsid are cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and nucleoporin 153 (Nup153, an NPC protein present on the nucleoplasmic face of the complex). (drugbank.com)
mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-bound ribosomes, with ER localization being conferred by the signal-recognition particle pathway. (duke.edu)
Protein4
3. c-Jun N-terminal kinase regulates the nucleoplasmic translocation and stability of nucleolar GLTSCR2 protein. (nih.gov)
DAXX is a 740 amino acid ~81 kDa nucleoplasmic protein. (anobase.org)
The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. (origene.com)
This involves UV damage provoked nucleoplasmic relocalization of a nucleolar protein, nucleophosmin (NPM, B23) and its rapid and transient interactions with both p53 and HDM2. (johnshopkins.edu)
Interphase1
While nucleoplasmic lamin A forms from BUN60856 recently indicated pre-lamin A during digesting and from soluble mitotic lamins inside a LAP2-3rd party way, binding of LAP2 to lamin A/C during interphase inhibits development of higher purchase constructions, keeping nucleoplasmic lamin A/C inside a cellular state 3rd party of lamin A/C S22 phosphorylation. (edrc2013.org)
Distinct1
Besides the well characterized localization at nuclear membranes, lamins display also a nucleoplasmic localization with distinct roles [27C30]. (careersfromscience.org)
Particles1
Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). (nih.gov)
Nuclear pore co2
Nup153 is located at the nucleoplasmic face of the nuclear pore complex (NPC), in the distal basket structure, and functions in mRNA export. (embl.de)
In this model the center of the rosette is the cyclomere, the detachable nucleoplasmic part of the nuclear pore complex and the loop origins are the cyclosomes, the nucleoplasmic subunits of the pore complexes, which forms the scaffold around which the nucleosome fibers are folded to higher order structures. (nih.gov)
Cardiac1
IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. (icm-mhi.org)
Bridges1
Workers had a 2.5-fold higher MN frequency, and nucleoplasmic bridges (NPBs) and nuclear buds (Nbuds) were increased 7-fold and 3-fold, respectively. (nih.gov)
Increases1
Increases in nucleoplasmic [Ca2+] may activate Ca2+-dependent enzymes and transcription factors modulating gene expression and may be critical for the pathogenesis of hypertrophy and heart failure. (uni-marburg.de)
Binds1
At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. (nih.gov)
Transcription1
Increased nucleoplasmic Ca2+ signaling was associated with activation of the CaMKIIδ-HDAC5 pathway and increased histone acetylation, suggesting increased gene transcription. (uni-marburg.de)
In subgenomic and genomic analyses of subcellular mRNA partitioning, we report an overlapping subcellular distribution of cytosolic/nucleoplasmic and topogenic signal-encoding mRNAs, with mRNAs of both cohorts displaying noncanonical subcellular partitioning patterns. (duke.edu)
Cells1
Dex was found to improve the nucleoplasmic accumulation of soluble Lamin A/C and was capable of managing the large chromatin Lamin A/C scaffolds contained complex, thus regulating epigenetics in treated cells. (nih.gov)