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  • inhibit
  • Many antimicrobial substances, both synthetic chemicals and natural products, inhibit the biosynthesis of nucleic acids. (springer.com)
  • Study hypothesis: The initiation of NRTI-containing, PI-sparing therapy will inhibit mitochondrial DNA (mtDNA) synthesis and lead to a decrease in mtDNA content in adipose tissue, skeletal muscle and peripheral blood mononuclear cells (PBMCs), will cause deterioration in mitochondrial function, will increase fat apoptosis and oxidative damage biomarkers, and will lead to progressive decrease in body fat content. (clinicaltrials.gov)
  • Antimicrobials with significant PAEs against susceptible gram-negative bacilli are limited to carbapenems and agents that inhibit protein or DNA synthesis. (wikipedia.org)
  • While the mechanism of action of betaenone B has yet to be elucidated, betaenone C has been shown to inhibit RNA and protein synthesis. (wikipedia.org)
  • The viral thymidine kinases differ completely from the mammalian enzymes both structurally and biochemically and are inhibited by inhibitors that do not inhibit the mammalian enzymes. (wikipedia.org)
  • These drugs act as both: competitive nonselective phosphodiesterase inhibitors which raise intracellular cAMP, activate PKA, inhibit TNF-α and leukotriene synthesis, and reduce inflammation and innate immunity and nonselective adenosine receptor antagonists which inhibit sleepiness-inducing adenosine. (wikipedia.org)
  • precursor
  • It is possibly the simplest of the nucleic acids, so making it a hypothetical precursor to RNA. (wikipedia.org)
  • While a complete de novo synthesis of betaenone B has yet to be reported, Daniel Pratt and Paul Hopkins in 1988 proposed a method for synthesizing a precursor of betaenone B from methoxybenzoquinone and 1,3-butadiene via a Diels-Alder reaction and Claisen chemistry[clarification needed]. (wikipedia.org)
  • gene expression
  • The precise mechanism of action is not yet clear, but it appears that hydroxycarbamide increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal hemoglobin (HbF) production (which does not polymerize and deform red blood cells like the mutated HbS, responsible for sickle cell disease). (wikipedia.org)
  • Applications include alteration of gene expression - both as inhibitor and promoter in different cases, antigene and antisense therapeutic agent, anticancer agent, antiviral, antibacterial and antiparasitic agent, molecular tools and probes of biosensor, detection of DNA sequences, and nanotechnology. (wikipedia.org)
  • viral
  • Virological response is defined as (observed) plasma viral load less than 50 human immunodeficiency virus-type 1 (HIV-1) ribonucleic acid (RNA) copies per ml at the last on-treatment visit (post-Week 96). (clinicaltrials.gov)
  • prevents
  • It has been found that use of this DNA methyltranferase inhibitor prevents atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages. (wikipedia.org)
  • cell
  • This diminishes both B cell clone expansion and antibody synthesis. (wikipedia.org)
  • Folate is necessary for the cell to synthesize nucleic acids (nucleic acids are essential building blocks of DNA and RNA), and in its absence cells will be unable to divide. (wikipedia.org)
  • Thymidine kinases have a key function in the synthesis of DNA and therefore in cell division, as they are part of the unique reaction chain to introduce thymidine into the DNA. (wikipedia.org)
  • system
  • This serves to maintain a balanced amount of TTP available for nucleic acid synthesis, not oversaturating the system. (wikipedia.org)
  • described a trans-acting DNA-based amphiphatic delivery system for convenient delivery of poly A tailed uncharged nucleic acids (UNA) such as PNAs and morpholinos, so that several UNA's can be easily screened ex vivo. (wikipedia.org)
  • shown
  • While it was also shown that betaenone B could be converted to betaenone A by oxidation by PCC followed by exposure to base, it wasn't until 1988 that a semi-complete total synthesis was reported. (wikipedia.org)