• detection
  • Thermal denaturation of probe-target hybrid is highly reproducible, and which makes probe melting point analysis reliable in the detection of mutations, polymorphisms and epigenetic differences in DNA. (biomedcentral.com)
  • The PNA probes offer advantage of improved flexibility in probe design, which could be used in various applications in mutation detection among a wide range of spectrums. (biomedcentral.com)
  • First of all, traditional probe systems that have been used in SNP detection use two or more fluorescence channels for one mutation loci. (biomedcentral.com)
  • These characteristics make PNA probe more acceptable to use in mutation detection studies because PNA probe makes a large difference in ΔTm between perfect match and single mismatch, including even insertion and deletion. (biomedcentral.com)