Nucleic acid complexes. Medical search. Frequent questions

These molecules include DNA, RNA and proteins although, in general, nuclear molecules exist as complexes of proteins and nucleic acids inside the cell. (frontiersin.org)
Biomolecules such as proteins and nucleic acids are at the heart of virtually all fundamental cellular processes. (loria.fr)

MMDB and VAST+: tracking structural similarities between macromolecular complexes. (nih.gov)
J Med Chem 2005) and extended it to macromolecular complexes involving proteins and protein-RNA complexes beyond topoisomerases (Pommier et al. (cancer.gov)
Macromolecular complex annotations are imported from the Complex Portal . (yeastgenome.org)
When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. (yeastgenome.org)
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). (yeastgenome.org)
The EMBL-EBI Complex Portal (www.ebi.ac.uk/intact/complex) is a central service that provides manually curated information on stable, on macromolecular complexes from model organisms. (stanford.edu)

The main goal of this PhD project is to elucidate the conformational dynamics of protein-RNA complexes and to develop a method for understanding their allosteric communications. (loria.fr)
This approach is a prerequisite for the design of new therapeutics that target protein-RNA complexes. (loria.fr)
In this PhD the goal is to design and implement a method for characterizing the conformational dynamics of protein-RNA complexes using the set of trajectories generated from MD simulations in a systematic way. (loria.fr)
In the proposed PhD project, the main goal is to adapt such methods to analyse protein-RNA complexes. (loria.fr)

Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. (yeastgenome.org)
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. (yeastgenome.org)
Let's face it, RNA is a pretty complex set of molecules. (genengnews.com)
In the pathogenesis of SLE, immune complexes containing nuclear molecules play a key role in the inflammation characteristic of this disease, especially in the kidney ( Rekvig ). (frontiersin.org)
The recent improvements of such parameters have made them suitable for the analysis of nucleic acids and for characterizing conformational changes in RNA molecules. (loria.fr)
Essay, Research Paper Viruses: Complex Molecules or Simple Life Forms? (referat.ru)
Because of all these factors, it is debatable whether viruses are the most complex of molecules or the simplest life forms. (referat.ru)
This complex is a ribonuclease, which means it is an enzyme that helps break down molecules containing RNA, a chemical cousin of DNA. (medlineplus.gov)
In particular, the RNase H2 complex normally helps break down molecules in which one strand of RNA is combined with one strand of DNA (RNA-DNA hybrids) when these molecules are no longer needed. (medlineplus.gov)

The only essential histone acetyltransferase (HAT) in yeast, Esa1, is part of the 1-MDa NuA4 complex, which plays pivotal roles in both transcription and DNA-damage repair. (nature.com)
NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. (nature.com)
Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. (nature.com)
The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. (nature.com)

When evaluating the plausibility of abiogenesis scenarios, it's critical to carefully consider the substances that would be needed for the formation of the first biomolecules: purines, pyrimidines, amino acids, sugars, and lipids. (icr.org)
They also speculate that the air must have been rich in nitrogen, hydrogen, and carbon monoxide in order to assist the spontaneous appearance of basic life building blocks such as amino acids, sugars, and nucleotides. (icr.org)
Apparatus used in Stanley Miller's amino acid genesis experiments. (icr.org)

Complex lasso proteins (also called pierced lasso bundles or tadpoles) are proteins in which a covalent loop (portion of the backbone closed with a covalent bridge) is pierced by another piece of the backbone. (wikipedia.org)
Complex lassos can be divided according to the number of piercings through the minimal surface spanned on the covalent loop. (wikipedia.org)
A hypothesis relating ionization potentials to covalent bond stabilities and to organic/inorganic complexes to explain elemental carcinogenesis at a molecular level is presented. (cdc.gov)
The authors suggest that these metals are carcinogens by virtue of hypothetical ability to form exceptionally stable, four membered, covalent, coordination complexes with nucleic acids and other organic compounds. (cdc.gov)

Photosensitizers to date have to a large extent been based on metal complexes and in particular such ones based on rare and expensive metals, and in particular ruthenium. (lu.se)
Current work in the group includes studies of platinum-, gold- and ruthenium-based anticancer active drugs and their influence on nucleic acid structure, transcription and protein translation. (lu.se)
Studies of polyamines and antimetastatic ruthenium complexes - influence on nucleic acid structure and function. (lu.se)

The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)
In this research field we focus on the development of robust chemical tools that can be used in integrative structural biology approaches that target ribonucleoprotein (RNP) particles or RNA protein complexes with high molecular weight in general. (uibk.ac.at)
In detail, we want to introduce the methyl TROSY technique in combination with deuteration to nucleic acid NMR spectroscopy to expand the addressable molecular weight of RNA protein complexes. (uibk.ac.at)

It is not known if the complex lasso motif is functional in general. (wikipedia.org)
The analysis of the shape of complex lasso proteins compared to the polymeric models with similar size shows, that some classes of complex lasso proteins may also be functional. (wikipedia.org)
Fig. 1: Functional validation of RBM39 and DCAF15-DDB1-DDA1 complexes. (nature.com)
Functional control of Eco1 through the MCM complex in sister chromatid cohesion. (yeastgenome.org)

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. (yeastgenome.org)
Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes. (yeastgenome.org)
Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. (medlineplus.gov)

Fig. 1: Structure of the yeast NuA4 core complex. (nature.com)
The yeast KEOPS protein complex comprising Kae1, Bud32, Cgi121, Pcc1 and Gon7 is responsible for the essential tRNA threonylcarbamoyladenosine (t(6)A) modification. (nih.gov)
A study, led by a team of researchers based in the School of Life Sciences, has revealed the 3-dimensional structure of the budding yeast Smc5/6 complex using the technique of cryogenic electron microscopy (cryo-EM). (sussex.ac.uk)
Whilst the study provides structural information for the yeast 'version' of the complex, there is sufficient similarity in terms of its cellular functions to directly inform studies examining its importance to human health. (sussex.ac.uk)

The demand for clinical signs or symptoms of pulmonary or sensitivity, specificity and speed of M. tu- extra-pulmonary TB) which had been sent berculosis detection led to the development to the TB laboratory at the Saudi-British of nucleic acid-based amplification tests to Laboratories for MTBC testing. (who.int)
Among nucleic acid-based techniques extra-pulmonary TB or in order to exclude available for the diagnosis of M. tuberculo- the possibility of TB infection. (who.int)

Fig. 2: Structural analysis of the human DCAF15-DDB1-DDA1-RBM39(RRM2) complex with indisulam. (nature.com)

The database currently holds approximately 2000 complexes with the majority from Saccharomyces cerevisiae, human and mouse. (stanford.edu)

Subclass of complex lasso proteins are Lasso peptides in which the loop is formed by post-translational amide bridge. (wikipedia.org)
Most of the complex lasso proteins have a disulfide-based loop, however, the amide-based (lasso peptides) and ester-based complex lasso proteins are known. (wikipedia.org)

Abnormal functioning of this complex may disrupt transcription, DNA replication, DNA repair, cell death (apoptosis), or other processes. (medlineplus.gov)

Further, the simple spin topologies (e.g. isolated 1 H- 13 C spin pairs) facilitates the application of relaxation dispersion techniques that give insights into nucleic acid dynamics underlying their function in ligand binding or catalysis. (uibk.ac.at)

They adopt complex dynamic behavior and their functions are directly linked to the arrangement of atoms in 3D (structure) and dynamics. (loria.fr)

All vertebrate ORF1ps contain a coiled coil (CC) domain and we previously showed that a CC-retrotransposition null mutant prevented formation of stably bound ORF1p complexes on ssNA. (nsf.gov)
the second is slower, consistent with formation of tightly compacted complexes by NA-bound ORF1p. (nsf.gov)
A six-lobed membrane spanning cellulose synthesis complex (CSC) containing multiple cellulose synthase (CESA) glycosyltransferases mediates cellulose microfibril formation. (osti.gov)
and results in the formation of a large nucleo-protein complex (the partition complex) around the parS site on the DNA to be partitioned. (biorxiv.org)
As early studies showed, levels of anti-DNA antibodies can rise with disease activity, often in association with depression of complement, indicative of immune complex formation. (frontiersin.org)
While the formation of immune complexes consisting of DNA and anti-DNA does not necessitate a change in levels of extracellular DNA, in fact, DNA levels also rise concomitant with the increases in anti-DNA. (frontiersin.org)
Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. (yeastgenome.org)

In August 2013, the Food and Drug Administration (FDA) permitted marketing of the Xpert MTB/RIF assay (Cepheid, Sunnyvale, California) to detect DNA of the Mycobacterium tuberculosis complex (MTBC) and genetic mutations associated with resistance to rifampin (RMP) in unprocessed sputum and concentrated sputum sediments ( 1 ). (cdc.gov)

Targeting ∼7000 genes with this methodology, we discovered SAGA complex members Tada2b and Taf5l as key regulators of HSC lineage commitment. (biorxiv.org)
SAGA complex member expression is significantly reduced in aged HSCs and upregulated with heterochronic parabiosis, suggesting a novel mechanism of age-associated hematopoietic decline and rejuvenation. (biorxiv.org)

In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. (nih.gov)
Our demonstrating that the CC governs the ability of NA-bound retrotransposition-competent trimers to form tightly compacted complexes reveals the biochemical phenotype of these coiled coil mutants. (nsf.gov)
F-plasmid partition complexes containing ParB F and parS F move by generating and following a local concentration gradient of nucleoid-bound ParA F . However, the process through which ParB F activates ParA F -ATPase has not been defined. (biorxiv.org)
We studied CTP- and parS F -modulated ParA F -ParB F complex assembly, in which DNA-bound ParA F -ATP dimers are activated for ATP hydrolysis by interacting with two ParB F N-terminal domains. (biorxiv.org)

Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. (yeastgenome.org)
Some evolutionists might try to claim that "extremophile" microorganisms live in these environments today, but these creatures contain highly specialized and complex cellular systems that allow this-there is nothing primitive about them. (icr.org)
Viruses have been defined as "entities whose genomes are elements of nucleic acid that replicate inside living cells using the cellular synthetic machinery, and cause the synthesis of specialised elements that can transfer the genome to other cells. (referat.ru)
The RNase H2 complex is also thought to be involved in DNA replication, error repair, and other cellular processes, including helping to prevent inappropriate immune system activation. (medlineplus.gov)

ABSTRACT We evaluated the COBAS AMPLICOR polymerase chain reaction (PCR) based test for the detection of Mycobacterium tuberculosis complex in 866 respiratory and non-respiratory samples. (who.int)

Here we report the structure of the Pichia pastoris NuA4 complex, with its core resolved at 3.4-Å resolution. (nature.com)
To delineate the precise mechanism by which indisulam mediates the DCAF15-RBM39 interaction, we solved the DCAF15-DDB1-DDA1-indisulam-RBM39(RRM2) complex structure to a resolution of 2.3 Å. (nature.com)
Structure of the eukaryotic MCM complex at 3.8 Å. (yeastgenome.org)
Here, we present the cryo-EM structure of this bifunctional complex at a resolution of ~7 Å using a new reconstruction protocol. (elifesciences.org)
It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)

Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K . The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. (le.ac.uk)

Recent studies further support NAA test use in the United States to avoid delays in diagnosis and treatment, especially for patients with suspected TB and sputum smears negative for acid-fast bacilli on microscopy. (cdc.gov)

Like many resistance proteins, variants of the MLA coiled-coil nucleotide-binding leucine-rich repeat (CC-NLR) receptor often require the HRS complex (HSP90, RAR1, and SGT1) to function. (nsf.gov)

Fig. 3: DDA1 stabilizes the DCAF15-DDB1 complex and impacts degradation of RBM39 by indisulam. (nature.com)
In sialidosis, the deficiency of lysosomal alpha- N -acetyl neuraminidase prevents the normal degradation of glycoproteins containing sialic acid residues. (medscape.com)

Identifying conserved protein complexes between species by constructing interolog networks. (yeastgenome.org)

S. aureus clonal complex 9 (CC9), for example, has been reported as a dominant LA-SA lineage in Asia and has been described as an emerging clone in some areas with intensive industrial livestock production in the United States ( 9 - 11 ). (cdc.gov)

Mizushima N (2010) The role of the Atg1/ULK1 complex in autophagy regulation. (yeastgenome.org)
the regulation of the microprocessor complex [Spadotto et al. (iit.it)

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ORF1p binds single-stranded nucleic acid (ssNA) and exhibits NA chaperone activity. (nsf.gov)

We propose that ParB F in the partition complex adopts a conformation that enhances ParB F -ParB F and ParA F -ParB F interactions promoting efficient partitioning. (biorxiv.org)
Interactions of the human MCM-BP protein with MCM complex components and Dbf4. (yeastgenome.org)

Magnetic-tweezers experiments showed that CTP promotes multiple ParB F loading onto parS F -containing DNA, generating condensed partition complex-like assemblies. (biorxiv.org)
Abnormal samples can increase risk for poor data quality,15 we cardiac development appears to occur through a were interested in replicating these experiments process that is heterogeneous and complex, with using fresh frozen cardiac tissue instead of formalin both environmental and genetic risk factors.1 fixed tissue after decades of storage. (cdc.gov)

The nucleic acid core is composed of either DNA or in the case of retroviruses, RNA, but never both. (referat.ru)

We also focus on how naturally occurring RNA modifications, such as simple methylations but also more complex side chains like the 5-oxyacetic acid modification influence the folding landscape of RNA. (uibk.ac.at)

These target antigens include DNA, RNA and protein-nucleic acid complexes. (frontiersin.org)

This concerns toxic, antimicrobial, defensin-like or immune system related with L1 motif The current list of complex lasso proteins may be found in the LassoProt database, which allows also uploading and analyzing own data. (wikipedia.org)

Only systems containing nucleic acids are capable of this phenomenon. (referat.ru)

Acid-fast staining and culture on Lowenstein-Jensen medium were also performed on all samples. (who.int)

Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. (yeastgenome.org)

The RNASEH2B gene mutations that cause Aicardi-Goutières syndrome likely result in a dysfunctional RNase H2 complex. (medlineplus.gov)

Buehl CJ, Goff NJ, Hardwick SW, Gellert M, Blundell TL, Yang W, Chaplin AK , Meek K. Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. (le.ac.uk)

Apart from structures with only one pierced loop, there may be also chains with several complex lasso structures. (wikipedia.org)
The size of the complex, its oligomeric state and the structures of its periplasmic N-terminal domains vary considerably between organisms. (elifesciences.org)

Anatomy5

Organisms12

Diseases3

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes59

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture9

Information Science12

Health Care4

Proteins and nucleic acids2

Macromolecular6

Protein-RNA complexes4

Molecules9

Histone4

Amino3

Covalent4

Ruthenium3

Molecular4

Functional4

Subunits3

Yeast4

Pulmonary2

Structural1

Saccharomyces1

Peptides2

Transcription1

Ligand1

Dynamics1

Formation7

MTBC1

SAGA2

Bound4

Cellular4

Mycobacterium1

Structure5

Nuclear2

Sputum1

Function1

Degradation2

Species1

Lineage1

Regulation2

Partners1

Activity1

Interactions2

Experiments2

Core1

Influence1

Target1

Database1

Systems1

Samples1

Electron1

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Long-range1

Structures2