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  • RNAs
  • Biomolecular nuclear magnetic resonance (NMR) spectroscopy allows the characterisation of structural and dynamic properties of ribonucleic acids (RNAs) in solution. (els.net)
  • The NMR‐based determination of high‐resolution three‐dimensional (3D) structures by NMR spectroscopy in solution is especially useful for small‐to‐medium sized RNA molecules like aptamers and small ribozymes, but has also been achieved for RNAs up to about 100 nucleotides in total size. (els.net)
  • SERS
  • 9. The system of claim 8 , wherein said SERS label comprises at least one selected from the group consisting of cresyl fast violet, cresyl blue violet, rhodamine-6G, para-aminobenzoic acid, phthalic acids, erythrosin and aminoacridine. (google.com)
  • hydrogels
  • Three dimensional scaffolds such as collagen-based hydrogels or poly-lactic-co-glycolic acid (PLGA)-based polymer foams, have demonstrated considerable potential, but the long-term outcomes of therapies employing these scaffolds are far from satisfactory. (blogspot.com.au)
  • novel
  • Nucleic acid-based technologies have received significant interest in recent years as novel theranostic strategies for various diseases. (thno.org)
  • These successful clinical translations demonstrate the potential of nucleic acid-based technologies and provide scope for developing novel therapeutics for AD. (thno.org)
  • Claims
  • 6. The RNA aptamer according to any one of claims 1 to 5, consisting essentially of the sequence of SEQ ID No:2. (freepatentsonline.com)
  • 13. The aptamer according to any one of claims 9 to 11, wherein the cell is a breast cancer stem cell, a prostate cancer stem cell, a pancreatic cancer stem cell, a colon cancer stem cell, a liver cancer stem cell, a lung cancer stem cell, an ovarian cancer stem cell, or a head and neck cancer stem cell. (freepatentsonline.com)
  • 16. An isolated RNA aptamer according to any one of claims 1 to 13, or the diagnostic agent according to claim 14 or 15 for use in histological examination of biological samples. (freepatentsonline.com)
  • 17. An anticancer agent comprising the RNA aptamer according to any one of claims 1 to 13 coupled to a moiety. (freepatentsonline.com)
  • 19. A method for isolating, purifying or enriching a EpCAM expressing cell(s) and/or cancer stem cell(s) from a biological sample obtained from a subject, the method comprising contacting the cell with an RNA aptamer according to any one of claims 1 to 13 or the diagnostic agent according to claim 14 or 15. (freepatentsonline.com)
  • complex
  • We then discuss the opportunities for using aptamers in other complex pathways, including Wnt/β-catenin, and focus on Transforming Growth Factor-β/Smad family signaling. (mdpi.com)
  • determination
  • Diagram describing the stepwise procedure for solution structure determination of ribonucleic acid (RNA) by nuclear magnetic resonance (NMR) spectroscopy. (els.net)
  • efficient
  • Despite the fact that non-viral nucleic acid delivery systems are generally considered to be less efficient than viral vectors, they have gained much interest in recent years due to their superior safety profile compared to their viral counterpart. (mdpi.com)
  • drug
  • The approval by the United States Food and Drug Administration (FDA) of Nusinersen, an antisense oligonucleotide drug, for the treatment of spinal muscular dystrophy highlights the potential of nucleic acids to treat neurological diseases, including Alzheimer's disease (AD). (thno.org)
  • The nucleic acid aptamer drug Macugen was approved for age-related macular degeneration [ 4 ]. (thno.org)
  • potential
  • In this review we focus on the potential of nucleic acid therapeutic, diagnostic, and research strategies that target both Aβ and tau pathologies to help diagnose and treat AD. (thno.org)
  • surface
  • The conserved sites G 133 K 134 and D 138 K 139 R 140 of C-terminal SmpB were identified by interacting with N-terminal SN, and concurrently the residue K 62 of ArfA was recognized by interacting with the surface loop of the specific peptide aptamer PA-2. (frontiersin.org)
  • sample
  • Diagram outlining a general approach for preparation of an nuclear magnetic resonance (NMR) sample of ribonucleic acid (RNA). (els.net)
  • growth
  • A sensitive aptamer-functionalized biosensor (aptasensor) has been developed by controlled growth of gold nanostructures (AuNS) over a gold substrate (pAu/AuNS). (biomedcentral.com)