• Well-studied biological nucleic acid molecules range in size from 21 nucleotides (small interfering RNA) to large chromosomes (human chromosome 1 is a single molecule that contains 247 million base pairs). (wikipedia.org)
  • Nucleic acids are linear polymers (chains) of nucleotides. (wikipedia.org)
  • Nucleic acid types differ in the structure of the sugar in their nucleotides-DNA contains 2'-deoxyribose while RNA contains ribose (where the only difference is the presence of a hydroxyl group). (wikipedia.org)
  • The basic components of the nucleic acids, the nucleotides are structurally formed from three major units. (herbs2000.com)
  • Genetic information is stored along the nucleic acid chain because all the bases in the nucleotides form hydrogen bonds with each other in a specific way - this ensures what is called base pairing. (herbs2000.com)
  • Now, the monomers, or the building blocks that are used to build new clay ic acid polymers are referred to as nucleotides, and so you can see that there is a resemblance between new click acids and nucleotides. (pearson.com)
  • Among the list of the artificial nucleotides, bridged nucleic acids (BNAs) appear to be the most promising new generation BNAs to date in view of the usage for applications. (biosyn.com)
  • An isolated nucleic acid, as claimed in Myriad's patent, is a sequence of nucleotides derived from DNA or RNA that has been removed from its naturally occurring cellular environment. (claytonutz.com)
  • The global nucleic acid isolation and purification market size was valued at USD 5.11 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 10.06% from 2023 to 2030. (grandviewresearch.com)
  • LPI (LP Information)' newest research report, the "Isothermal Nucleic Acid Amplification Technology (INAAT) Industry Forecast" looks at past sales and reviews total world Isothermal Nucleic Acid Amplification Technology (INAAT) sales in 2022, providing a comprehensive analysis by region and market sector of projected Isothermal Nucleic Acid Amplification Technology (INAAT) sales for 2023 through 2029. (marketresearch.com)
  • Nucleic Acids Res;2023 Oct 11. (bvsalud.org)
  • NAATs for SARS-CoV-2 specifically identify the RNA (ribonucleic acid) sequences that comprise the genetic material of the virus. (cdc.gov)
  • Secondary structure can be predicted from one or several nucleic acid sequences. (wikipedia.org)
  • Incorporating Locked Nucleic Acid into oligonucleotides increases thermal duplex stability 2 and improves the specificity of oligonucleotide hybridization to target sequences. (sigmaaldrich.com)
  • The bold letters in the sequences denote Locked Nucleic Acid bases. (sigmaaldrich.com)
  • Specifically, Locked Nucleic Acid oligonucleotides can be designed to address traditionally problematic target sequences, such as AT- or GC-rich regions. (sigmaaldrich.com)
  • A method is described for visualizing three nucleic acid sequences simultaneously by in situ hybridization using a new blue immunofluorescent label, amino methyl coumarin acetic acid (AMCA), in combination with green and red fluorescing FITC and TRITC. (nih.gov)
  • Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently accumulates nucleic acid sequences at constant temperature. (marketresearch.com)
  • This document gives the general requirements for validation and verification of multiplex molecular tests which simultaneously identify two or more nucleic acid target sequences of interest. (clsi.org)
  • It provides information for both qualitative and quantitative detection of nucleic acid target sequences. (clsi.org)
  • This document is intended as guidance for multiplex examinations that either detect and/or quantify human nucleic acid target sequences or microbial pathogen nucleic acid target sequences from human clinical specimens. (clsi.org)
  • Here is another: fragments of DNA sequences , the nucleic acids that make up DNA, are another type of molecule found in the bloodstream in greater amounts in old individuals . (fightaging.org)
  • Nucleic Acid-Based Identification Methods for Infectious Disease Nucleic acid-based methods detect organism-specific DNA or RNA sequences extracted from the microorganism. (msdmanuals.com)
  • The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). (wikipedia.org)
  • deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ). (khanacademy.org)
  • There are two forms of nucleic acid - DNA or deoxyribonucleic acid and RNA or ribonucleic acid, both of these forms are the basis of all life and occur in all living cells. (herbs2000.com)
  • In healthy people, the molecule Toll-like receptor 7 (TLR7) inside of cells recognizes the ribonucleic acid (RNA) from viruses and other pathogens that have invaded a person's cells, while leaving a person's own RNA untouched. (lupusresearch.org)
  • Nucleic acid amplification (NAA) tests, such as polymerase chain reaction (PCR) and other methods for amplifying DNA and RNA, may facilitate rapid detection of microorganisms. (cdc.gov)
  • Locked Nucleic Acid PCR primers and qPCR probes are compatible with all real-time thermocyclers and end-point analytical detection instruments. (sigmaaldrich.com)
  • Various experimental approaches exist for the study of nucleic acid-protein interactions in vitro and in vivo , but the detection of such interactions at the subcellular level remains challenging. (nature.com)
  • This webinar will provide a technical overview of ddPCR from technical and workflow related perspectives as well as review key applications such as copy number variation (CNV) analysis, rare mutation detection (RMD) analysis, and standard free (stand-alone) absolute quantification of nucleic acids. (atcc.org)
  • Currently, there are three basic types of tests to determine if an individual has been infected with SARS-CoV-2: viral nucleic acid (RNA) detection, viral antigen detection, and detection of antibodies to the virus. (medscape.com)
  • Viral tests (nucleic acid or antigen detection tests) are used to assess acute infection, whereas antibody tests provide evidence of prior infection with SARS-CoV-2. (medscape.com)
  • Wooden shafts or calcium alginate swabs may contain substances that inhibit some viruses and nucleic acid detection reactions. (medscape.com)
  • Monomeric Cyanine Nucleic Acid stains allow ultrasensitive fluorescence detection of double-stranded nucleic acids. (thermofisher.com)
  • They are ideally suited for nuclear staining in flow cytometry and fluorescence microscopy applications in fixed cells, along with nucleic acid detection on solid supports and in electrophoresis applications. (thermofisher.com)
  • The purpose of this study was to develop a real time polymerase chain reaction ( PCR ) assay for the detection of the JAK2 V617F mutation that could be used in diagnostic laboratories .Sanger sequencing and a newly developed locked nucleic- acid , real-time PCR assay were used to detect the JAK2V617F mutation . (bvsalud.org)
  • The "gold standard" for COVID-19 detection is nucleic acid amplification for use of Ag-RDT testing (NAAT) where viral genomes are detected indicating the presence of the virus in an individual. (who.int)
  • Droplet Digital PCR (ddPCR) is an elegant technology that permits accurate and absolute quantification of target nucleic acid molecules. (atcc.org)
  • Nucleic acids are generally very large molecules. (wikipedia.org)
  • many molecules have several possible three-dimensional structures, so predicting these structures remains out of reach unless obvious sequence and functional similarity to a known class of nucleic acid molecules, such as transfer RNA (tRNA) or microRNA (miRNA), is observed. (wikipedia.org)
  • Nucleic acid is constructed from simpler molecules called bases. (historyoftheuniverse.com)
  • If this water also contained sugars and other groups called phosphates then perhaps it was relatively easy for them to be dry-joined together to make the molecules we now call nucleic acids. (historyoftheuniverse.com)
  • For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
  • ALL recombinant or synthetic nucleic acid molecules or materials that contain these molecules must be decontaminated before disposal. (uwm.edu)
  • Double-stranded nucleic acid molecules (DNA-DNA or DNA-RNA) which contain regions of nucleotide mismatches (non-complementary). (umassmed.edu)
  • This recent work offers a fascinating new mechanism of age-related mutagenesis, highlighting the fate and effects of free nucleic acids within our body. (fightaging.org)
  • It is commonly used to amplify nucleic acids at a constant temperature, thereby eliminating the need for thermocycler equipment. (marketresearch.com)
  • The chemical methods also enable the generation of altered nucleic acids that are not found in nature, for example peptide nucleic acids. (wikipedia.org)
  • Privatization of the production of therapeutics with commercial potential, such as vaccines and peptide-based drugs, to suffice healthcare needs is driving the demand for large-scale separation instruments Thus, the nucleic acid isolation and purification industry exhibits lucrative growth potential. (grandviewresearch.com)
  • Peptide nucleic acid (PNA) amphiphiles: synthesis, self-assembly, and duplex stability. (umassmed.edu)
  • Here, we present a 3D-printable kit for the construction of DNA and peptide nucleic acid (PNA). (allenpress.com)
  • The technology known as triplex-forming peptide nucliec acids (PNAs) are a DNA mimic that involve bases modified with polyamide backbones that are resistant to degradation and can target and bind sequence where it induces site specific recombination with a donor template. (epigenie.com)
  • We then examine theoretical approaches to the description of nucleic acids based on: i) a rigid or quasi-rigid description of the molecule, ii) molecular mechanics optimization, and iii) molecular dynamics. (ub.edu)
  • Special emphasis is made ion current state of the art molecular dynamics simulations of nucleic acids structures. (ub.edu)
  • Nucleic acid molecular weight markers contain nucleic acids of several pre-defined molecular weights for use as size standards in gel electrophoresis. (thermofisher.com)
  • The quantification of nucleic acids samples is a major need in any genetic and molecular biology laboratory. (bmglabtech.com)
  • Nucleic acid isolation and purification is a routine procedure of molecular biology techniques such as sequencing, cloning, sequencing, polymerase chain reaction, and others. (futuremarketinsights.com)
  • Hence, increasing nucleic acid isolation and purification applications in the field of molecular diagnostics, life science research, genetic engineering, and forensics is estimated to favor the growth in the market. (futuremarketinsights.com)
  • The isothermal nucleic acid amplification technology (INAAT) is used in molecular biology and recombinant DNA technologies for detecting and identifying nucleic acids. (marketresearch.com)
  • Nucleic acid-based (molecular) identification. (msdmanuals.com)
  • Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. (wikipedia.org)
  • Nucleic acids, and DNA in particular, are key macromolecules for the continuity of life. (khanacademy.org)
  • Nucleic acids are the most important macromolecules for the continuity of life. (libretexts.org)
  • All genetic information needed for life and the inheritance of characters is encoded in biomolecules known as nucleic acids. (herbs2000.com)
  • In addition, the improved hybridization of the PCR primer or qPCR probe to its target may increase the melting temperature (T m ) by up to 8 °C per Locked Nucleic Acid monomer substitution in medium salt conditions compared to native-state DNA oligonucleotides 4 ( Table 1 ). (sigmaaldrich.com)
  • Due to Locked Nucleic Acid's improved hybridization characteristics with accompanied increase in T m , Locked Nucleic Acid oligonucleotides can be synthesized to be shorter, which overcomes certain design limitations that occur with native-state DNA oligonucleotides. (sigmaaldrich.com)
  • in vitro, they are formed by nucleic acid hybridization. (umassmed.edu)
  • In addition, this session will also deal with the photo-repair of nucleic acids and proteins. (rsc.org)
  • Now, nucleic acid polymers similar to proteins, have directionality in their chain, meaning that one end of the chain will be chemically different than the other end of the chain. (pearson.com)
  • About the JournalNucleic Acids Research (NAR) publishes the results of leading edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions. (scijournal.org)
  • For instance, in April 2020 QIAGEN and Gilson collaborated to make manual nucleic acid extraction more efficient and reproducible. (grandviewresearch.com)
  • Recently evidence was provided that the integration of cell-free nucleic acid with host cells occurs in vivo as well as in vitro . (fightaging.org)
  • The term nucleic acid is the overall name for DNA and RNA, members of a family of biopolymers, and is synonymous with polynucleotide. (wikipedia.org)
  • Whether you are a researcher in an academic, commercial or standardized testing lab, our Sample to Insight solutions for automated nucleic acid extraction - combined with optimized chemistries - will standardize every step of your workflow and deliver the reproducible, high-quality data you need to compare your results to those from laboratories around the world. (qiagen.com)
  • Moreover, increasing collaboration and expansion undertaken by leading market players to bolster their nucleic acid extraction modalities is another factor propelling industry growth. (grandviewresearch.com)
  • This collaboration integrated QIAGEN's manual nucleic acid extraction kits and TRACKMAN Connected digital bench tool to enhance yield as well as efficiency. (grandviewresearch.com)
  • These kits are used in the extraction of nucleic acids from tissue, blood, cells, and plants. (grandviewresearch.com)
  • For instance, Thermo Fisher Scientific offers PrepSEQ 1-2-3 Mycoplasma Nucleic Acid Extraction Kit designed for the extraction of mycoplasma genomic DNA from samples. (grandviewresearch.com)
  • Key developments in the market include the adoption of magnetic beads-based nucleic acid purification and nucleic acid extraction filter plate technology. (futuremarketinsights.com)
  • The market displays a surge in the BPS values owed to the increased commercial extraction of nucleic acids for a propulsive goal to isolate and develop novel therapeutics for infectious disease proliferation around the globe. (futuremarketinsights.com)
  • This basic-level eLearning course, Module 3, provides information on nucleic acid extraction. (cdc.gov)
  • Topics covered include extraction method selection, basic extraction steps, and nucleic acid analysis. (cdc.gov)
  • This online course is designed for public health and clinical laboratory staff and persons interested in nucleic acid extraction. (cdc.gov)
  • With Isothermal Nucleic Acid Amplification Technology (INAAT) sales broken down by region, market sector and sub-sector, this report provides a detailed analysis in US$ millions of the world Isothermal Nucleic Acid Amplification Technology (INAAT) industry. (marketresearch.com)
  • This Insight Report provides a comprehensive analysis of the global Isothermal Nucleic Acid Amplification Technology (INAAT) landscape and highlights key trends related to product segmentation, company formation, revenue, and market share, latest development, and M&A activity. (marketresearch.com)
  • This report also analyzes the strategies of leading global companies with a focus on Isothermal Nucleic Acid Amplification Technology (INAAT) portfolios and capabilities, market entry strategies, market positions, and geographic footprints, to better understand these firms' unique position in an accelerating global Isothermal Nucleic Acid Amplification Technology (INAAT) market. (marketresearch.com)
  • This Insight Report evaluates the key market trends, drivers, and affecting factors shaping the global outlook for Isothermal Nucleic Acid Amplification Technology (INAAT) and breaks down the forecast by type, by application, geography, and market size to highlight emerging pockets of opportunity. (marketresearch.com)
  • With a transparent methodology based on hundreds of bottom-up qualitative and quantitative market inputs, this study forecast offers a highly nuanced view of the current state and future trajectory in the global Isothermal Nucleic Acid Amplification Technology (INAAT). (marketresearch.com)
  • Global key players of Isothermal Nucleic Acid Amplification Technology (INAAT) include Abbott, BioMerieux and Hologic, etc. (marketresearch.com)
  • North America is the largest market of Isothermal Nucleic Acid Amplification Technology (INAAT), with a share nearly 80%, followed by Europe. (marketresearch.com)
  • This report presents a comprehensive overview, market shares, and growth opportunities of Isothermal Nucleic Acid Amplification Technology (INAAT) market by product type, application, key players and key regions and countries. (marketresearch.com)
  • Structure of Locked Nucleic Acid and native-state DNA monomers. (sigmaaldrich.com)
  • In this way the monomers are interlinked to form a nucleic acid polymer holding all the genetic information necessary for life. (herbs2000.com)
  • Yeah, so let's take a look at our example down below at the formation of nucleic acids from nucleotide monomers. (pearson.com)
  • And so nucleic acids we know are one of the major classes of bio molecule polymers, and it turns out that nucleic acids can have a variety of different types of functions. (pearson.com)
  • However, when it comes to new Clegg acid polymers, the directionality is indicated with a five prime and and a three prime end and moving forward. (pearson.com)
  • Now, once again, it's also important to note that nucleic acid polymers they have directionality, which means one end of the chain is gonna be chemically different than the other end of the chain. (pearson.com)
  • A common problem for researchers working with RNA is to determine the three-dimensional structure of the molecule given only a nucleic acid sequence. (wikipedia.org)
  • The instructions on how to do this are stored in the other type of molecule essential for life: the nucleic acids. (historyoftheuniverse.com)
  • The isolated nucleic acid bears the DNA sequence of the molecule that existed within the cellular environment, but is no longer part of the structure that fits within the cell nucleus. (claytonutz.com)
  • Rapidly evolving biotechnological applications in various industries, such as food processing, agriculture, recycling & waste management, and energy & environmental, are projected to drive the adoption of nucleic acid isolation and purification. (grandviewresearch.com)
  • To address these challenges, companies are introducing novel isolation kits to facilitate the recovery of nucleic acids. (grandviewresearch.com)
  • The demand for kits used in the isolation and purification of nucleic acids is on the rise, driven by the increasing number of research studies focused on comprehending genome-based diseases such as Huntington's disease, polyketonuria, and others. (grandviewresearch.com)
  • The global nucleic acid isolation and purification market is expected to reach US$ 994 Million by 2022. (futuremarketinsights.com)
  • The global nucleic acid isolation and purification market is estimated to create an absolute dollar opportunity of US$ 1,452.9 Million by 2029, exhibiting growth at a CAGR of 5.6% during the forecast period 2022 to 2029. (futuremarketinsights.com)
  • Future Market Insights (FMI) states that North America and East Asia are anticipated to collectively account for more than half of the global nucleic acid isolation and purification sales by the end of 2029. (futuremarketinsights.com)
  • However, A positive BPS growth in H1-2022 over H1-2021 by 12 Basis Point Share (BPS) is demonstrated by the nucleic acid isolation and purification market. (futuremarketinsights.com)
  • The demand in the global nucleic acid isolation and purification market grew at 4.0% CAGR between 2014 and 2021. (futuremarketinsights.com)
  • Using amino acids and protein synthesis, the specific sequence in DNA of these nucleobase-pairs helps to keep and send coded instructions as genes. (wikipedia.org)
  • We have just seen that to build a protein , life needs to know which amino acids to join together and in what order. (historyoftheuniverse.com)
  • Many genes encode protein products, meaning that they specify the sequence of amino acids used to build a particular protein. (khanacademy.org)
  • A Nucleic Acid Amplification Test, or NAAT, is a type of viral diagnostic test for SARS-CoV-2, the virus that causes COVID-19. (cdc.gov)
  • This Research Topic will focus on materials as non-viral vectors for cellular uptake and delivery of genes and nucleic acids in order to achieve potential benefits to human health and advance gene therapy prospects. (frontiersin.org)
  • The aim of this Research Topic is to report current and future advancements in the use of materials, chemicals and particles as non-viral alternatives for nucleic acid delivery. (frontiersin.org)
  • Le VRS demeure un agent étiologique viral important au Maroc, responsable de syndromes de type grippal et d'infections respiratoires aiguës sévères, en particulier chez les nourrissons. (who.int)
  • Table 1 Increasing the number of Locked Nucleic Acid bases in an oligonucleotide increases the T m . (sigmaaldrich.com)
  • Pink) mutant DNA analysis with Locked Nucleic Acid mutant probe (16mer with 3 Locked Nucleic Acid bases). (sigmaaldrich.com)
  • Purple) wild-type DNA with Locked Nucleic Acid mutant Probe (16mer with 3 Locked Nucleic Acid bases). (sigmaaldrich.com)
  • Nucleic acids are also generated within the laboratory, through the use of enzymes (DNA and RNA polymerases) and by solid-phase chemical synthesis. (wikipedia.org)
  • Nucleic acids were named for their initial discovery within the nucleus, and for the presence of phosphate groups (related to phosphoric acid). (wikipedia.org)
  • Although first discovered within the nucleus of eukaryotic cells, nucleic acids are now known to be found in all life forms including within bacteria, archaea, mitochondria, chloroplasts, and viruses (There is debate as to whether viruses are living or non-living). (wikipedia.org)
  • The basic component of biological nucleic acids is the nucleotide, each of which contains a pentose sugar (ribose or deoxyribose), a phosphate group, and a nucleobase. (wikipedia.org)
  • One flat, heterocyclic, nitrogen rich organic base and lastly one phosphate group - this last unit of the nucleic acid polymer is responsible for the acidic nature of the nucleic acid as it is very negative in charge. (herbs2000.com)
  • The addition of the phosphate group also covalently connected to the sugar unit completes the basic component of the nucleic acid polymer. (herbs2000.com)
  • From the inner workings of the cell to the young of a living thing, they contain and provide information via the nucleic acid sequence. (wikipedia.org)
  • Nucleic acid structure prediction is a computational method to determine secondary and tertiary nucleic acid structure from its sequence. (wikipedia.org)
  • Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids. (umassmed.edu)
  • Utilizing all four nucleobases, sequence-defined click nucleic acids (CNAs) were synthesized using a simple and scalabale solution-phase approach. (rsc.org)
  • All of the nucleic acids claimed in the patent will possess a gene sequence or portion of a sequence, either derived from or substantially similar to that of a natural BRCA1-encoding gene. (claytonutz.com)
  • NAATs detect genetic material (nucleic acids). (cdc.gov)
  • However, in our biology course, we're going to focus on the primary function of nucleic acids, which is really to store and encode genetic information or information that could be passed down from one generation down to the next generation of life and so an example of a nuclear gas. (pearson.com)
  • These high-affinity dyes have low background and bright fluorescence when bound to nucleic acid. (thermofisher.com)
  • New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied. (mdpi.com)
  • The effect on structure was investigated for LNPs with a benchmark lipid composition and containing different cargos: calf thymus DNA (DNA) and two model mRNAs, polyadenylic acid (polyA) and polyuridylic acid (polyU). (lu.se)
  • Experimental studies of nucleic acids constitute a major part of modern biological and medical research, and form a foundation for genome and forensic science, and the biotechnology and pharmaceutical industries. (wikipedia.org)
  • Building on previous research, representative nucleic acid duplexes were split into logical monomer segments, and atomic coordinates were used to create solid models for 3D printing. (allenpress.com)
  • Mice were injected intravenously with human cfDNA and Cfs and analysis of heart, lung, liver, and brain of the mice sacrificed 7 days after injection revealed genomic localization of nucleic acids, with Cfs localizing more efficiently than cfDNA. (fightaging.org)
  • A purine always pair with a pyrimidine and vice versa in a nucleic acid. (herbs2000.com)
  • Gel electrophoresis is a method used for separation of nucleic acid using a porous gel matrix depending on the size of the nucleic acid. (cdc.gov)
  • The test is approved for use in conjunction with culture for respiratory specimens that are positive for acid-fast bacilli (AFB) on microscopy and were obtained from untreated patients. (cdc.gov)
  • There are numerous exceptions, however-some viruses have genomes made of double-stranded RNA and other viruses have single-stranded DNA genomes, and, in some circumstances, nucleic acid structures with three or four strands can form. (wikipedia.org)
  • Amplifying those nucleic acids enables NAATs to detect very small amounts of SARS-CoV-2 RNA in a specimen, making these tests highly sensitive for diagnosing COVID-19. (cdc.gov)
  • The University of California libraries, via the California Digital Library, maintain an institutional membership with Nucleic Acids Research. (universityofcalifornia.edu)
  • The fully open access journal, Nucleic Acids Research , published by Oxford University Press. (universityofcalifornia.edu)
  • The UC Libraries pay a yearly fee for membership with Nucleic Acids Research to secure this discount for UC-affiliated authors. (universityofcalifornia.edu)
  • For more information about NAR, see About Nucleic Acids Research . (universityofcalifornia.edu)
  • As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. (allenpress.com)
  • Locked Nucleic Acid Dual-Labeled Probes discriminate better than DNA Dual-Labeled Probes in SNP genotyping analysis9. (sigmaaldrich.com)
  • Different theoretical methods for the description of nucleic acid structures are reviewed. (ub.edu)
  • Firstly, we introduce the concept of classical force-field in the context of nucleic acid structures, discussing their accuracy. (ub.edu)
  • Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. (allenpress.com)
  • These circulating nucleic acids are thought to arise from the destruction of cells, though given that cells are capable of creating and releasing quite complex structures into the surrounding tissues - consider extracellular vesicles for example - it is perhaps plausible that dysfunctional cells could be exporting nucleic acids while still intact. (fightaging.org)
  • The presence of a single base mismatch has a greater destabilizing effect on the duplex formation between an Locked Nucleic Acid oligonucleotide and its target than with a native-state DNA oligonucleotide. (sigmaaldrich.com)
  • Is the Growing Presence of Fragmented Nucleic Acids in Aging Tissues a Contributing Cause of Aging? (fightaging.org)
  • Myriad Genetics Inc ( Myriad ) succeeded in isolating the nucleic acid of the BRCA1 gene from the environment in which it naturally occurs in human cells, allowing screening for the mutations, and was granted a patent in Australia. (claytonutz.com)