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  • Transplantation
  • Eggan's research goals at Harvard were to understand how nuclear transplantation works, and to make stem cells that carry genes for specific diseases such as Parkinson's disease, amyotrophic lateral sclerosis (Lou Gehrig's disease), and Alzheimer's. (wikipedia.org)
  • stem cells
  • a)iPS, to make stem cells, were found to have major problems, ranging from genetic aberrations, to risks of tumors and cancer b)THE PROOF for NT came from Oregon University, where researchers made stem cells via Nuclear Transfer, followed by Dr. Robert Lanza of ACT (Advanced Cell Technology), using a slightly different - but also NT - approach. (worldhealth.net)
  • Altered Nuclear Transfer is an alternative method of obtaining embryonic-like, pluripotent stem cells without the creation and destruction of human embryos. (wikipedia.org)
  • Wilmut
  • In 1966, Wilmut spent 8 weeks working in the laboratory of Christopher Polge, who is credited with developing the technique of cryopreservation in 1949. (wikipedia.org)
  • developmental
  • Genome reprogramming in early mouse embryos is associated with nuclear reorganization and particular features such as the peculiar distribution of centromeric and pericentric heterochromatin during the first developmental stage. (nih.gov)
  • cell
  • 2007. Interspecies nuclear transfer: implications for embryonic stem cell biology. (koreascience.or.kr)
  • The zygote-specific nuclear organization observed during the first cell cycle of mouse embryos obtained by natural fertilization is characterized by the association of centromeres with the peripheries of nucleolar precursor bodies (NPBs, Figure 1b-arrowhead). (nih.gov)
  • Eggan's work as of 2007[update] has succeeded in developing a technique of merging stem and skin cells that has obtained considerable public attention as a possible avenue to avoid moral objections regarding stem cell research in the context of serious illness. (wikipedia.org)
  • gene
  • Morpholinos are synthetic oligonucleotides that can be used to inhibit nuclear RNA splicing or mRNA translation and are the common gene inhibition reagent in Xenopus as neither siRNA or miRNA have yet been shown to reproducibly function in frog embryos. (wikipedia.org)
  • Furthermore, the PPL teams based in Roslin, Scotland and Blacksburg (USA) used the technique to produce the first gene targeted domestic animals as well as a range of animals producing human therapeutic proteins in their milk. (wikipedia.org)
  • pregnancy
  • Had it been the latter (a technique almost universally condemned as unethical), the researchers could have attempted to initiate a pregnancy by implanting the cloned embryos in a womb. (washingtontimes.com)
  • Using this technique for primates had never been successful and no pregnancy had lasted more than 80 days. (wikipedia.org)
  • sequence
  • He worked out the complete amino acid sequence of insulin and devised techniques to sequence DNA, believing that sequencing is a key to understanding living matter. (brighthub.com)