Nuclear rna binding protein. Medical search. Frequent questions

Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins. (embl.de)
The feasibility of using human autoimmune antibodies to isolate and characterize specific nuclear ribonucleoprotein (nRNP) complexes was investigated. (eurekamag.com)
There were no polypeptides in the isolated antigen which corresponded in MW to the core proteins of heterogeneous nuclear ribonucleoprotein (hnRNP) particles described by other investigators. (eurekamag.com)
These events regulate the inclusion of repetitive GY-SLiMs within nearly all members of the heterogeneous nuclear ribonucleoprotein (hnRNP) A and D families of RNA binding proteins. (cam.ac.uk)
The protein produced from this gene, called heterogenous nuclear ribonucleoprotein K (hnRNP K), attaches (binds) to DNA or its chemical cousin RNA and to other proteins, acting as a docking station for these molecules so they can interact. (medlineplus.gov)

2022). Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. (upenn.edu)
These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. (origene.com)
Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. (nih.gov)
As a whole, RBPs play a role in governing RNA metabolism and post-transcriptional processes related to mRNA polyadenylation, alternative splicing, nucleocytoplasmic trafficking, stability, and translation initiation and elongation 7-10 , which ultimately affects protein synthesis 11 . (orthojournal.org)

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. (wikipedia.org)
This transport includes RNA and ribosomal proteins moving from the nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signaling molecules, and lipids moving into the nucleus. (atlasantibodies.com)
L, L-polymerase protein. (cdc.gov)
A - D, conserved RNA-dependent RNA polymerase motifs. (cdc.gov)
Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity. (cdc.gov)
Modeling the Binding Mechanism of Remdesivir, Favilavir, and Ribavirin to SARS-CoV-2 RNA-Dependent RNA Polymerase. (cdc.gov)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). (origene.com)
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (origene.com)

it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. (thermofisher.com)
Binds tenaciously to poly(C) sequences. (nih.gov)

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. (nih.gov)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)
ASF binds two motifs: a C-rich and a purine rich motif. (nih.gov)

This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes (Ruppert, 2017). (sdbonline.org)
Although snRNP profiles are not perturbed in SMN-depleted cells, we found that SMN depletion gives rise to cytoplasmic accumulation of a GFP-SmB reporter protein. (cnrs.fr)
This nuclear-cytoplasmic trafficking might contribute to neurological disorders. (atlasantibodies.com)
Dysfunctional nuclear-cytoplasmic trafficking of RNA-binding proteins might contribute to neurological disorders. (atlasantibodies.com)
She employs human patient-derived induced pluripotent stem cells to elucidate the nuclear-cytoplasmic trafficking mechanisms in neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (atlasantibodies.com)
Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. (rupress.org)
Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis. (ucas.ac.cn)
The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including PRKRA, TRBP, and Dicer. (hindawi.com)
PRKRA is contained in the cytoplasmic RNA-induced silencing complex (RISC) together with transactivation response RNA binding protein (TRBP) and Dicer [ 4 - 6 ]. (hindawi.com)
Nuclear and cytoplasmic staining of CNS neurons demonstrates the presence of these antibodies. (medscape.com)

We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay. (rupress.org)
These results suggest that GAPDH exerts other functions beyond glycolysis, and that oxidatively modified GAPDH regulates its cellular functions by changing its interacting proteins, i.e. the RNA splicing by interacting with the p54nrb-PSF complex. (elsevierpure.com)
Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis. (cdc.gov)
Together, these findings indicate that lncRNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote cell malignant transformation and lung carcinogenesis. (cdc.gov)

The hnRNP proteins have distinct nucleic acid binding properties. (origene.com)

Mechanistically, we further confirmed that MFJHQ inhibits MCT-induced phosphatidylinositide 3-kinases/protein kinase B (PI3K/Akt) pathway predicated by network pharmacology and RNA-sequencing analysis to reduce the proliferation of pulmonary arteries and promote pulmonary artery apoptosis in lung tissues. (bvsalud.org)
PRKRA, a protein kinase, interferon-inducible double stranded RNA dependent activator protein kinase, also known as PACT, a protein activator of the interferon-induced protein kinase, is a product of PRKRA gene [ 1 , 2 ] and is a member of the dsRNA binding protein family [ 3 ]. (hindawi.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

The SMN protein is ubiquitously expressed and is present both in the cytoplasm and in the nucleus where it localizes in Cajal bodies. (cnrs.fr)
The nuclear membrane contains nuclear pore complexes, the bilateral gateways connecting the nucleoplasm and cytoplasm that allow transporting material into and out of the cellular nucleus. (atlasantibodies.com)
These intracellular aggregations of misfolded proteins, such as the nuclear TAR DNA-binding protein of 43 kDa (TDP-43) that accumulates in the cytoplasm, are toxic to the affected neurons and are thought to contribute to neuronal cell death. (atlasantibodies.com)
In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)

To carry out their diverse roles, DBHS proteins form homodimers and heterodimers, but how this dimerization influences DBHS localization and function is unknown. (edu.au)
Previously, we investigated the localization of several nuage-resident proteins in the nuage structures of spermatogenic cells by immunoelectron microscopy (IEM) [ 22 - 26 ]. (hindawi.com)
The interaction of ABHD11-AS1 with SART3 promotes USP15 (ubiquitin specific peptidase 15) nuclear localization. (cdc.gov)

Using the yeast three hybrid assay, we selected RNA molecules that retain Tap binding activity from a pool of randomized CTE sequences. (princeton.edu)
This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. (origene.com)
Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules. (nih.gov)
Usually, the NOE and NMRD in B-DNA is expected to be less ``integral'' than methods can only provide bounds on the residence water molecules buried inside proteins. (lu.se)

Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)

Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. (nuclearproteomics.org)
VAPB (vesicle-associated membrane protein-associated protein B) is a tail-anchored protein that's current at a number of contact websites of the endoplasmic reticulum (ER). (nuclearproteomics.org)
They also need a protein's assistance, like a channel protein or some other transmembrane protein, to cross the cell membrane. (atlasantibodies.com)
Progerin lacks this crucial cleavage site, resulting in a permanently farnesylated protein that accumulates in, and causing thickening of, the nuclear membrane. (aad.org)

As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. (nih.gov)
Some lncRNAs (referred to as long intergenic non-coding RNAs, lincRNAs) are transcribed from separate loci, whereas others are transcribed divergently from promoters of protein-coding genes or in antisense direction to these. (biomedcentral.com)

Cross-species analysis of RNA editing in several tissues revealed that species, rather than tissue type, is the primary determinant of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation. (nih.gov)
The regulation of expression of X-box-binding protein-1 (XBP1), a transcriptional factor, involves an unconventional mRNA splicing that removes the 26 nucleotides intron. (mdpi.com)
Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
The differential inclusion of these exons impacts the formation of hnRNP-driven higher-order protein assemblies required for the regulation of target AS events. (cam.ac.uk)
RNA-binding proteins of the DBHS (Drosophila Behavior Human Splicing) family, NONO, SFPQ, and PSPC1 have numerous roles in genome stability and transcriptional and posttranscriptional regulation. (edu.au)
Down-regulation of cold-inducible proteins including RBM3 in prostate cancer cells by exposure to hyperthermia enhanced cancer cell response to chemotherapy [ 13 ]. (biomedcentral.com)
These proteins process pre-microRNAs into mature microRNAs (miRNAs) that target specific mRNA species for regulation. (hindawi.com)

Negative elongation factor E is a protein that in humans is encoded by the RDBP gene. (wikipedia.org)
A Hang-related protein, ZNF699, is associated with alcoholism in humans (Riley, 2006), supporting the idea that a cellular stress mechanism underlying ethanol tolerance is evolutionarily conserved between humans and D. melanogaster. (sdbonline.org)

Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. (nih.gov)

We have identified the cold shock RNA binding protein, RNA-binding motif protein 3 (RBM3) as a critical regulatory node in the control of skeletal muscle mass and herein, we review our current knowledge of its actions in skeletal muscle. (orthojournal.org)
Our laboratory has identified the cold shock RNA binding protein (RBP), RNA-binding motif protein 3 (RBM3) as a regulatory node in the control of skeletal muscle mass 5,6 , suggesting it may be a promising target for therapies combating muscle atrophy. (orthojournal.org)
RNA-binding motif protein 3 (RBM3), involved in cell survival, has paradoxically been linked to both oncogenesis as well as an increased survival in several cancers, including urothelial carcinoma (UCA). (biomedcentral.com)

Of particular interest with regard to skeletal muscle atrophy is understanding how RBPs augment cellular responses to stress via their impact on RNA stability. (orthojournal.org)
As an example, RBPs selectively protect mRNAs related to cell survival to preserve their translation in response to a DNA damage event that causes global reductions in protein synthesis 21 . (orthojournal.org)
Similar preservation of select RNAs via RBPs occurs in response to hypoxic conditions and allows for the RNAs complexed with RBPs to evade the impact of RNA degradation and reduced translation caused by hypoxia 22 . (orthojournal.org)

abstract = "The human Tap protein has been proposed to mediate Mason Pfizer monkey virus constitutive transport element (CTE)-dependent nuclear RNA export and may also play a role in global mRNA export. (princeton.edu)

2023). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. (upenn.edu)
2023). Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. (upenn.edu)
2023). A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity. (upenn.edu)

Further analysis of the GTEx data revealed several potential regulators of editing, such as AIMP2, which reduces editing in muscles by enhancing the degradation of the ADAR proteins. (nih.gov)

These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (nature.com)

Moreover, speci®c hy- found in narrow minor groove regions in a variety dration patterns seem to play a role in nucleotide sequence recognition by proteins (Otwinowski of oligonucleotide duplexes (PriveÂ et al. (lu.se)

G-quadruplexes have been shown to be involved in a range of processes including telomere stability and RNA transcription, splicing, translation and transport. (nature.com)
In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
In this talk, I will describe how exons regulated by alternative splicing show a strong tendency to modulate low affinity and transient short linear motif (SLiM)-mediated protein-protein interactions. (cam.ac.uk)
We identified the interacting proteins of oxidized inactive GAPDH as p54nrb (54 kDa nuclear RNA-binding protein) and PSF (polypyrimidine tract-binding protein-associated splicing factor), both of which are known to exist as heterodimers and bind to RNA and DNA. (elsevierpure.com)
One problem with identifying binding sites for splicing factors arises from the transient role of RNA in gene expression. (nih.gov)
The primary role of most splicing factors is to bind pre-mRNA co-transcriptionally and participate in the extremely rapid process of splice site selection and catalysis. (nih.gov)
As many splicing factors also bind mRNA to some degree, these substrates tend to dominate the output of location studies. (nih.gov)
We screen approximately 4000 alternatively spliced exons and the entire Hepatitis C genome for binding of ASF/SF2, the only splicing factor demonstrated to function as an oncogene. (nih.gov)
Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. (edu.au)
Argonaute proteins' binding in human nuclear RNA and its effects on alternative splicing in colon cancer model systems. (almaden.io)
Nuclear localized USP15 interacts with pre-mRNA processing factor 19 (PRPF19) to increase CD44 RNA alternative splicing activating β-catenin and enhancing cancer stemness. (cdc.gov)

Binds the conventional octamer sequence in double-stranded DNA. (nih.gov)
He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (embl.de)
Mechanistically, it was found that ABHD11-AS1 directly binds SART3 (spliceosome associated factor 3, U4/U6 recycling protein). (cdc.gov)

In nonmegaloblastic macrocytosis, the marrow is not megaloblastic, but in myelodysplasia and advanced liver disease there are megaloblastoid RBC precursors with dense nuclear chromatin that differ from the usual fine fibrillar pattern in megaloblastic anemias. (msdmanuals.com)

Also binds single-stranded DNA and RNA at a site independent of the duplex site. (nih.gov)
Can also bind poly(C) single-stranded DNA. (nih.gov)

Conservation of genome organization, regulatory sequences, and protein domains of Borna disease virus (BDV) in novel strains from parrots 1034, 1322, and 1367. (cdc.gov)
He has contributed significantly to the state-of-the-art by frequently presenting novel ideas, methods and results and have pioneered several important proof-of-concepts relevant for the project, including the conceptualization of DNA, RNA and protein variation to Variation Ontology (Vihinen, Genome Res . (lu.se)
Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and in-tegrated into the genome of human cells. (lu.se)

For this, the Sfmbt protein complex was affinity purified from the nuclear extract, followed by highly specific peptide sequencing (IP/LC-MS). As a result, a number of previously uncharacterized Sfmbt interactions were discovered. (sdbonline.org)
Here we present an in-vitro method for screening RNA protein interactions that circumvents these problems. (nih.gov)

By regulating certain genes and proteins, the hnRNP K protein plays a role in the normal development and function of several body systems, including the brain. (medlineplus.gov)

The recovered RNA sequences differed only minimally from the wild-type CTE yet all displayed lower affinity for Tap both in vivo and in vitro. (princeton.edu)
G-rich sequences have a propensity for forming highly stable quadruplex structures in both RNA and DNA termed G-quadruplexes. (nature.com)

The stability of mRNAs determines not only their half-life, but the capacity of RNAs to be translated 11 . (orthojournal.org)
As such, the RBP cytosolic poly(A)-binding protein 1 (PABPC1) elevates protein synthesis and causes hypertrophy in cardiac muscle by increasing RNA stability and translational efficiency in a transcript-specific manner 23,24 . (orthojournal.org)

Polycomb group (PcG) proteins are chromatin-associated factors involved in the repression of gene transcription. (sdbonline.org)

Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)

Together with PSPC1, required for the formation of nuclear paraspeckles. (nih.gov)

Mauno Vihinen is well-known for his experience and interest in investigating variations and their effects whether they emerge at molecular levels (DNA, RNA protein), in structural context or in the cellular networks and pathways. (lu.se)
to other RNAs may initiate epige- cleus pathways. (who.int)

None of the 4 sera contained antibodies to DNA, histones, RNA, DNA histone complexes, or nonhistone chromosomal proteins. (eurekamag.com)

The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. (nih.gov)
Immunohistochemistry using antibody binding to LINE-1 open. (lu.se)
Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. (lu.se)

The neuronal proteins are homologous to the embryonic lethal abnormal visual (ELAV) protein in Drosophila species. (medscape.com)

Here, we have used in vivo assays, in both yeast and human cells, together with in vitro assays, to further characterize the RNA binding properties of Tap, which has been proposed to contain a novel leucine-rich RNA binding motif. (princeton.edu)

This study analysed the transcriptome derived from RNA-seq data of leukocytes obtained from Holstein cows in early lactation with respect to lactation number. (biomedcentral.com)

A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression. (uiowa.edu)
Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation. (uiowa.edu)

We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. (lu.se)

The function of RBM3 as a RNA stabilizing agent is cold-inducible, hence referring to the RNA-binding protein as a "cold-shock" protein. (orthojournal.org)

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. (nih.gov)
In this article, we have used an RNA interference approach in order to analyse the effects of SMN depletion on snRNP assembly in HeLa cells. (cnrs.fr)
We also demonstrate that the SMN protein depletion induces defects in Cajal body formation with coilin being localized in multiple nuclear foci and in nucleolus instead of canonical Cajal bodies. (cnrs.fr)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Classes for this protein according to Protein ANalysis THrough Evolutionary Relationships (PANTHER) Classification System. (nih.gov)

Critical to DBHS activity is their recruitment to distinct subnuclear locations, for example, paraspeckle condensates, where DBHS proteins bind to the long noncoding RNA NEAT1 in the first essential step in paraspeckle formation. (edu.au)

RBM3 expression is elevated in response to cellular and body temperature dropping below 37 o C and can provide a transcript-specific preservation of RNA important for cell survival and metabolic function during periods of cold stress 17,26-28 . (orthojournal.org)

HNRNPK gene mutations that cause Au-Kline syndrome result in the production of little or no hnRNP K protein. (medlineplus.gov)

In particular, Sfmbt top-interacting proteins include the DNA-binding protein Hangover and components of the SWI/SNF family of chromatin remodelers (Erokhin, 2021). (sdbonline.org)

Polyclonal immunoglobulin G (IgG) anti-Hu antibodies or type 1 antineuronal nuclear antibodies are most prevalent (~50%), although several other circulating autoantibodies have been identified. (medscape.com)
Anti-Hu antibodies may alter the production of these proteins, which are essential for the development, maturation, and maintenance of the vertebrate nervous system. (medscape.com)
In one report, a subset of patients with limbic encephalitis associated with a systemic neoplasm previously attributed to antibodies against voltage gated potassium channel antibodies actually recognize LGI1 protein complex epitopes and do not represent a channelopathy. (medscape.com)
In a recent report, a subset of patients with limbic encephalitis associated with a systemic neoplasm previously attributed to antibodies against voltage gated potassium channel antibodies actually recognize LGI1 protein complex epitopes and do not represent a channelopathy. (medscape.com)

It is therefore not surprising that RBM3 is involved in various cell types, with a variety of functions that are mostly protective or beneficial which include, enhancing translational efficiency and protein synthesis 8,12,13 , miRNA biogenesis 14 , cell migration 15 , response to hypoxia 16 , and protection against necrosis and apoptosis 17-19 . (orthojournal.org)
Moreover, muscle mass does not decrease as expected in response to the lack of physical activity, reduced protein synthesis, and very low caloric intake 35-37 . (orthojournal.org)
A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. (uiowa.edu)

DNA- and RNA binding protein, involved in several nuclear processes. (nih.gov)

The secondary structure of the hexanucleotide repeat is very likely to be involved in determining the proteins it interacts with. (nature.com)

The hang gene encodes a large, approximately 210-kDa nuclear zinc finger protein that is expressed in most, if not all, neurons in the adult brain (Scholz, 2005). (sdbonline.org)

Neuronal degeneration in spinal muscular atrophy (SMA) is caused by reduced expression of the survival of motor neuron (SMN) protein. (cnrs.fr)
Taken together, our data demonstrate that fALS-associated mutations enhance the propensity of SFPQ to bind zinc and form aggregates, leading to the dysregulation of AMPA receptor subunit composition, which may contribute to neuronal dysfunction in ALS. (edu.au)

Anatomy15

Organisms14

Diseases2

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes71

Information Science4

Health Care1

Ribonucleoprotein5

Metabolism4

Polymerase6

Heterogeneous2

Tenaciously to poly2

Motifs5

Cytoplasmic11

Regulates4

Nucleic acid1

Kinase3

Cytoplasm4

Localization3

Molecules4

Ribosomal proteins1

Membrane4

Long intergenic2

Regulation7

Humans2

SnRNA1

Motif protein3

RBPs3

Abstract1

20233

Degradation1

Mitochondrial2

Nucleotide1

Splicing11

Double-stranded2

Spliceosome2

Precursors1

Single-stranded2

Genome3

Interactions2

Genes and proteins1

Sequences2

Stability2

Transcription1

MRNA translation1

PSPC11

Pathways2

Histones1

Antibody3

ELAV1

Assays1

Transcriptome1

Poly2

Gene expression1

Cold-shock1

Depletion3

Classification2

Distinct1

Transcript1

HNRNPK1

Chromatin1

Antibodies4

Synthesis3

Processes1

Interacts1

Zinc finger1

Neuronal2