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  • gene
  • In this study, we defined a novel function of nuclear ErbB2 in enhancing rRNA gene transcription by RNA polymerase-I (RNA Pol I). Nuclear ErbB2 physically associates with β-actin and RNA Pol I, coinciding with active RNA Pol I transcription sites in nucleoli. (aacrjournals.org)
  • RNAs
  • The nuclear ribosomal repeats for the 18S, 5.8S, and 26S RNAs of two closely related Picea (spruce) species were characterized by restriction mapping and Southern blot hybridization. (unh.edu)
  • rRNA
  • Immunoelectron microscopy and UV cross-linking localize Arx1 close to the ribosomal exit tunnel, in direct contact with ES27, a highly dynamic eukaryotic rRNA expansion segment. (biomedsearch.com)
  • In contrast, wild-type ErbB2 augmented pre-rRNA level, protein production, and cell size/cell growth, but not by an ErbB2 mutant that is defective in nuclear translocation. (aacrjournals.org)
  • Together, our findings indicate that nuclear ErbB2 functions as a regulator of rRNA synthesis and cellular translation, which may contribute to tumor development and progression. (aacrjournals.org)
  • biological
  • Although it has been known that nuclear RTKs associate with functions in RNA Pol II transcriptional regulation, DNA repair, and DNA replication ( 12-16 , 20 , 26-32 ), the biological significance and functions of the nuclear RTKs, including ErbB2, is still far from clear. (aacrjournals.org)
  • study
  • Our study described herein identified a novel function of nuclear ErbB2 in enhancing cellular translation, and thereby cell growth, which may contribute to tumorigenesis. (aacrjournals.org)