Loading...
  • novel
  • For the first time in fifty years, research has identified an effective means for drugs to bind to a novel site on a nuclear receptor and thus inhibit it, explains Luc Brunsveld, TU/e professor of Chemical Biology. (eurekalert.org)
  • human nuclear receptor
  • On Monday 7 December the journal Nature Communications published the research findings of Eindhoven University of Technology (TU/e), Merck Research Laboratories (Merck is known as MSD outside the US and Canada) and Leiden University concerning an entirely new way of antagonizing a human nuclear receptor. (eurekalert.org)
  • Endocrinology
  • The study of nuclear receptors owed a debt to decades of historical endocrinology and pathology, and prior to their discovery there was a wealth of empirical evidence that suggested their existence. (wikipedia.org)
  • She has made major contributions in understanding cancer, endocrinology, and women's health, focusing on nuclear receptors and on improving the effectiveness of endocrine therapies in breast cancer. (wikipedia.org)
  • specific nuclear receptors
  • Titled "Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity," the research shows that two specific nuclear receptors - LXRalfa and LXRbeta - act in such a way as to indicate they have a crucial role in regulating energy homeostasis, which is important to maintain the stability of normal biological states during adjustments to environmental changes. (uh.edu)
  • metabolic
  • Estrogen-related receptors (ERRs) have emerged as major metabolic regulators in various tissues. (asm.org)
  • Altered signaling by this subset of receptors, either through chronic ligand excess or genetic factors, may cause an imbalance in these homeostatic circuits and contribute to the pathogenesis of common metabolic diseases such as obesity, insulin resistance and type 2 diabetes, hyperlipidemia and atherosclerosis, and gallbladder disease. (epfl.ch)
  • These receptors hence may function as metabolic sensors. (wikipedia.org)
  • Signaling
  • Substantial evidence indicates that nuclear receptor signaling is integral to dynamic changes in the cardiac mitochondrial phenotype in response to developmental cues, in response to diverse postnatal physiologic conditions, and in disease states such as heart failure. (jci.org)
  • In the article, titled "Estrogen Signaling via Estrogen Receptor Beta," the group found that this regulatory molecule prevents what is called epithelial-to-mesenchymal transition, or EMT, in the prostate gland. (uh.edu)
  • Since 2009, his primary duties are as the Robert A. Welch Professor in UH's biology and biochemistry department and director of the Center for Nuclear Receptors and Cell Signaling, a collaborative effort between UH and The Methodist Hospital Research Institute. (uh.edu)
  • heterodimers
  • Prior to ligand binding, receptor heterodimers are located in the nucleus as part of complexes with histone deacetylases (HDACs) and other co-repressors that keep target DNA in a tightly wound conforma- tion, preventing exposure to transacting factors. (cellsignal.com)
  • Estrogen Rece
  • In an invited review in the Journal of Biological Chemistry, the most-cited biomedical research journal in the world, Gustafsson and his team summarize the most recent results pertaining to the function of a nuclear receptor called estrogen receptor beta, or ERbeta, the biological and medical importance of which Gustafsson and his associates discovered in 1995. (uh.edu)