In the ptrX-overexpressing R20291 strain, PtrX influenced the expression of flagellar genes and the sigma factor gene sigD, possibly through an increased flagellar phase ON configuration ratio. (bvsalud.org)
Thus, organisms cannot survive in the absence of glucocorticoid action, as observed in the mouse model in which the glucocorticoid receptor (GR) gene is genetically deleted [3]. (brainimmune.com)
Knockout mice with heterozygous deletion of the Chicken Ovalbumin Upstream Promoter- Transcription Factor II (COUP-TFII) gene or complete disruption of the Hepatocyte Nuclear Factor 4 alpha (HNF4alpha) gene in pancreatic beta cells have similar insulin secretion defects leading us to hypothesize that there is transcriptional cross-talk between these two nuclear receptors. (lonza.com)
A stable association of the endogenous HNF4alpha with a region of the COUP-TFII gene promoter that contains a direct repeat 1 (DR-1) binding site was revealed by chromatin immunoprecipitation. (lonza.com)
Finally, hCOUP-TFII overexpression showed that there is direct COUP-TFII autorepression as COUP-TFII occupies the proximal DR-1 binding site of its own gene in vivo. (lonza.com)
Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
Genes5
There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII encoded by the NR2F1 and NR2F2 genes respectively. (wikipedia.org)
This is an important study demonstrating distinct roles for the nuclear receptor genes COUP-TFI and COUP-TFII in hippocampal development. (elifesciences.org)
In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
Retinoic3
It was determined that Ear2 negatively regulates renin expression by competing with retinoic acid receptor/ retinoid X receptor (RAR/RXR) for binding to the retinoic acid response elements (RARE) on the renin enhancer [ 13 ]. (biomedcentral.com)
0.05) decreased mRNA and protein expression of retinoic acid signaling pathway elements, including retinoic acid receptor alpha and retinoic acid receptor beta, with the greatest number of changes observed between postnatal days 3-5. (biomedcentral.com)
0.05) decreased retinoic acid-induced binding and activation of the retinoic acid receptor response element in A549 cells. (biomedcentral.com)
Overexpression2
Further studies demonstrated that proinflammatory cytokines, via suppression of COUP-TFII level, induce VEGF-C overexpression. (endometriosistreatmentreport.com)
This positive regulation of HNF4alpha by COUP-TFII was confirmed by adenoviral overexpression of human (h)COUP-TFII which increased HNF4alpha mRNA in 832/13 INS-1 cells and in mouse pancreatic islets. (lonza.com)
Transactivation1
Mutation experiments showed that this DR-1 site is essential for HNF4alpha transactivation of COUP-TFII. (lonza.com)
Transcriptional1
The prospero related homeobox-1 (PROX1) transcriptional factor and vascular endothelial growth factor receptor-3 (VEGFR3) are responsible for their differentiation into lymphatic endothelial cells. (basicmedicalkey.com)
Promoter4
The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors. (wikipedia.org)
Bioinformatic analysis and molecular biological characterization revealed that VEGF-C is negatively regulated by an orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). (endometriosistreatmentreport.com)
Here we show specific HNF4alpha activation of a reporter plasmid containing the COUP-TFII promoter region in transfected pancreatic beta cells. (lonza.com)
Endogenous2
Dominant negative suppression of HNF4alpha function decreased endogenous COUP-TFII expression and specific inactivation of COUP-TFII by short interfering (si)RNA caused HNF4alpha mRNA levels to decrease in 832/13 INS-1 cells. (lonza.com)
Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
Superfamily2
These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
In brief, vascular endothelial growth factor-A (VEGF-A), which is a part of a large superfamily of growth factors, is required for differentiation of endothelial precursor cells. (basicmedicalkey.com)
Ligand2
8 The sprouting of endothelial cells is regulated by Notch signaling receptors and their Delta-like 4 (DLL4) ligand. (basicmedicalkey.com)
2017 , "Minute Impurities Contribute Significantly to Olfactory Receptor Ligand Studies: Tales from Testing the Vibration Theory" , eNeuro. (fleming.gr)
Cells3
Herein, we identified that vascular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endometriotic cells and contributes to increased lymphangiogenesis. (endometriosistreatmentreport.com)
Therefore COUP-TFII could contribute to the control of insulin secretion through the complex HNF4alpha/maturity-onset diabetes of the young 1 (MODY1) transcription factor network operating in beta cells. (lonza.com)
During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Inflammation1
Taken together, we identify the vicious cycle of inflammation, COUP-TFII, VEGF-C, and lymphangiogenesis in the endometriotic microenvironment, which opens up new horizons in understanding the pathophysiology of endometriosis. (endometriosistreatmentreport.com)
Epigenetic1
Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
Proteins1
Eukaryotic High-Mobility Group B (HMGB) proteins alter DNA elasticity while facilitating transcription, replication and DNA repair. (shengsci.com)
Mechanisms1
2017 , "Metabolic pathway and cell adaptation mechanisms revealed through genomic, proteomic and transcription analysis of a Sphingomonas haloaromaticamans strain degrading ortho-phenylphenol. (fleming.gr)
Vascular1
The standard vascular markers used in pathologic differential diagnosis of vascular conditions include von Willebrand factor (vWF), factor VIII-associated protein, platelet endothelial cell adhesion molecule-1 (CD31), human hematopoietic progenitor cell antigen (CD34), v- ets avian erythroblastosis virus E26 oncogene homolog (ERG), human herpes virus 8 (HHV-8), latency-associated nuclear antigen (LANA1), podoplanin (D2-40), and PROX1. (basicmedicalkey.com)
Expression1
the venous expression signature includes the COUP transcription factor 2 (COUP-TFII), Notch signaling, and ephrin-B4. (basicmedicalkey.com)
Human1
C-C chemokine receptor 5 (CCR5) has attracted wide concern for its critical role in the progression of human immunodeficiency virus type 1 (HIV-1) infection. (biomedcentral.com)
Activation1
The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. (shengsci.com)
Development1
Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. (omeka.net)
Response1
Lavigne MD, Konstantopoulos D, Ntakou-Zamplara KZ, Liakos A, Fousteri M. 2017 , "Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate" , Nat Commun. (fleming.gr)
Study2
Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
A three-dimensional (3D) mineralizing culture system using hollow fiber bioreactors has been developed to study the early stages of endochondral ossification by proton nuclear magnetic resonance (NMR) microscopy. (omeka.net)
Primary1
The primary virulence factors of C. difficile are toxin A and toxin B. These toxins damage the cell cytoskeleton and cause various diseases, from diarrhea to severe pseudomembranous colitis. (bvsalud.org)