• The nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein that in humans is encoded by the NR4A2 gene. (wikipedia.org)
  • G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. (bvsalud.org)
  • By Western blot, this antibody detects an ~56 kDa protein representing PPAR gamma 2 from NIH-3T3 cell lysate. (thermofisher.com)
  • The nuclear receptor-related 1 protein is mostly expressed in the subplate in the dorsal cortex, but also in lower layer 6 in the lateral and perirhinal cortex, and can be detected from 12 PCW. (ox.ac.uk)
  • Liver X Receptor Alpha (LXRα) is a nuclear receptor protein encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). (indigobiosciences.com)
  • The immunogen of 22576-1-AP is androgen receptor Fusion Protein expressed in E. coli. (ptglab.com)
  • adhesion G protein-coupled receptor E5. (gsea-msigdb.org)
  • Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)
  • The following product was used in this experiment: PPAR gamma-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA1-824, RRID AB_2166200. (thermofisher.com)
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Androgen Receptor (AR). (avivasysbio.com)
  • Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Androgen Receptor (AR). (avivasysbio.com)
  • After TMB substrate solution is added, only those wells that contain Androgen Receptor (AR), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (avivasysbio.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • The concentration of Androgen Receptor (AR) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (avivasysbio.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Androgen Receptor (AR) were tested 20 times on one plate, respectively. (avivasysbio.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Androgen Receptor (AR) were tested on 3 different plates, 8 replicates in each plate. (avivasysbio.com)
  • This assay has high sensitivity and excellent specificity for detection of Androgen Receptor (AR). (avivasysbio.com)
  • No significant cross-reactivity or interference between Androgen Receptor (AR) and analogues was observed. (avivasysbio.com)
  • High-Load Resistance Exercise Augments Androgen Receptor-DNA Binding and Wnt/β-Catenin Signaling without Increases in Serum/Muscle Androgens or Androgen Receptor Content. (avivasysbio.com)
  • AIS;androgen receptor;AR8;DHTR;dihydrotestosterone receptor;HUMARA;HYSP1;KD;NR3C4;nuclear receptor subfamily 3 group C member 4;SBMA;SMAX1;TFM. (avivasysbio.com)
  • Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). (avivasysbio.com)
  • Androgen receptor (AR) also konwn as Dihydrotestosterone receptor (DHTR), Nuclear receptor subfamily 3 group C member 4 (NR3C4).It is one of steriod hormoen receptors, which are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (ptglab.com)
  • PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
  • Receptor for retinoic acid. (abcam.com)
  • Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. (thermofisher.com)
  • The NK cell research toolkit product contains three classes of genes: ligands, surface receptors, and transcription factors. (freegenes.org)
  • The genes listed here can be expressed on NK cells, feeder cells, or tumor cells to study individual NK cell signaling pathways, strengths of activation of different receptor-ligand interactions, and whether certain NK cells are more or less resistant to inhibitory cues from cancer cells. (freegenes.org)
  • Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. (biomedcentral.com)
  • Cellular response to estrogens is mediated through estrogen receptors (ERα and ERβ), which upon binding to ligand and DNA hormone response elements, recruit coactivator and corepressor proteins that regulate the expression of steroid hormone target genes. (biomedcentral.com)
  • In this study, we systematically screened the coding exons of steroid hormone receptor coactivator and corepressor genes in a multiethnic panel of women with breast cancer in an attempt to identify and catalogue potentially functional coding polymorphisms that may serve as genetic markers of breast cancer risk. (biomedcentral.com)
  • There are thirteen subfamilies of Wnt genes in metazoans and t. (biomedcentral.com)
  • These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)
  • We used logistic regression to estimate odds ratios for allelic effects in ethnic-pooled analyses as well as in subgroups defined by disease stage and steroid hormone receptor status. (biomedcentral.com)
  • Data expand the understanding of the mechanism by which the NR4A2 nuclear receptor can facilitate DNA DSB repair. (cusabio.com)
  • NR4A2 is a member of the nuclear receptor family of intracellular transcription factors. (wikipedia.org)
  • Degeneration of dopaminergic neurons in Parkinson's disease (PD) is associated with decreased expression of the orphan nuclear receptor Nurr1 (NR4A2), which is critical for both homeostasis and development of dopamine (DA) neurons. (houstonmethodist.org)
  • Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
  • Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
  • The NK Cell Research Toolkit enables researchers to examine the effects of distinct molecules on NK cells' targeting and eradication of discrete tumor cell types, and to design novel chimeric antigen receptors to modify endogenous signaling pathways. (freegenes.org)
  • PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
  • The Liver X Receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. (indigobiosciences.com)
  • Ectopic olfactory receptors (ORs) are GPCRs expressed in extra-nasal tissues which have recently emerged as new mediators in the metabolic control of cardiac function. (bvsalud.org)
  • This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor.Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS). (ptglab.com)
  • Coupled with the loss of dopamine receptor neurons, this can result in the onset of symptoms for Parkinson's Disease. (wikipedia.org)
  • The synthetic, phytochemical-based compound, 1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane (C-DIM12) activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. (houstonmethodist.org)
  • 12 , 13 ] Polymorphic variants in these mediators of hormonal responsiveness could affect the functional activity of estrogen receptors following stimulation by endogenous or exogenous (i.e. (biomedcentral.com)
  • The activating or inhibitory receptors can similarly be transduced or transfected into NK cells to perturb their behavior. (freegenes.org)
  • Fas apoptotic inhibitory molecule 2. (gsea-msigdb.org)
  • Left ventricular tissue from heart failure patients (n = 18) and non-failing heart samples (n = 4) were subjected to a two-step transcriptome analysis consisting of the quantification of 372 distinct OR transcripts on real-time PCR arrays and simultaneous determination of global cardiac gene expression by RNA sequencing. (bvsalud.org)
  • Here we demonstrate that the human subplate also expresses α2zinc-binding globulin and Alpha-2-Heremans-Schmid glycoprotein/human fetuin. (ox.ac.uk)
  • alpha 2-HS glycoprotein [Source:HGN. (gsea-msigdb.org)
  • The principle application of this LXRα assay product is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against the human liver x receptor alpha. (indigobiosciences.com)
  • pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Maehr, H.' 1 'Rochel, N.' 2 'Suh, N.' 3 'Uskokovic, M.' 4 # _citation.id primary _citation.title 'Diastereotopic and deuterium effects in gemini. (rcsb.org)
  • The primary TDCPP metabolite, bis(1,3-dichloro-2-propyl) phosphate (BDCPP), is detectable in the urine of over 90 % of Americans. (indigobiosciences.com)
  • loop_ _audit_author.name _audit_author.pdbx_ordinal 'Delfosse, V.' 1 'Grimaldi, M.' 2 'Bourguet, W.' 3 # _citation.id primary _citation.title ;Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. (rcsb.org)
  • In the first group (pulmonary arterial hypertension [PAH]), the primary disorder affects the small pulmonary arterioles. (msdmanuals.com)
  • Ensembl chr 4:124,608,960. (mcw.edu)
  • Ensembl chr 2:7,553,891. (mcw.edu)
  • This strategy led to the identification of >160 ORs expressed in the human heart, including 38 receptors differentially regulated with heart failure. (bvsalud.org)
  • Our results suggest that connective tissue growth factor- and nuclear receptor-related 1-positive cells are two distinct cell populations of the human subplate. (ox.ac.uk)
  • This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Liver X Receptor Alpha (LXR). (indigobiosciences.com)
  • It is a member of the beta-herpesvirus subfamily, which also includes the roseolaviruses, human herpesvirus type 6, and human herpesvirus type 7. (medscape.com)
  • However, several high-risk groups, including immunocompromised organ transplant recipients and individuals infected with human immunodeficiency virus (HIV), are at risk of developing life-threatening and sight-threatening CMV disease. (medscape.com)
  • To use as WB control, resuspend the lyophilizate in 50 µL of LDS* Sample Buffer to have a final concentration of 2 mg/ml. (abcam.com)
  • Boehm, MF Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. (bindingdb.org)
  • Epidemiological studies show sex-specific associations between urinary BDCPP levels and metabolic syndrome, which is an established risk factor for type 2 diabetes, heart disease, and stroke. (indigobiosciences.com)