ProteinFarnesoid X ReceptRetinoicProteinsThyroid hormoneRetinoid X ReceptoHormone receptor familyOrphan receptorTranscriptionalNR4A2AntigenLigand-bindinSuperfamilyLipid MetabolismBile AcidPPARsMetabolismNR1H2CoactivatorOlfactoryFamilyLiverHomeostasisSelectiveInteractionsGenesBindsCircadian clockEstrogenGeneLigandsPolyclonal AntibodyTranscription factorHumanPromoterRegulatesGammaMetabolicEnsembl
Protein10
- The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
- The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
- Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
- Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
- Further, emerging evidence suggests that nicotine can also regulate the expression of genes/proteins involved in various functions such as ERK1/2, CREB, and c-FOS [ 20 - 22 ], as well as the expression state of multiple biochemical pathways, for example, mitogen-activated protein kinase (MAPK), phosphatidylinositol phosphatase signaling, growth factor signaling, and ubiquitin-proteasome pathways [ 23 - 25 ]. (hindawi.com)
- By Western blot, this antibody detects an ~56 kDa protein representing PPAR gamma 2 from NIH-3T3 cell lysate. (thermofisher.com)
- G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. (bvsalud.org)
- Besides, it is a nuclear receptor protein that is encoded by the THRB gene in humans. (immune-system-research.com)
- The nuclear receptor-related 1 protein is mostly expressed in the subplate in the dorsal cortex, but also in lower layer 6 in the lateral and perirhinal cortex, and can be detected from 12 PCW. (ox.ac.uk)
- In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
Farnesoid X Recept2
- The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. (cancerindex.org)
- My laboratory is studying how these metabolite levels are regulated by the bile acid signal-sensing nuclear receptors, Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP), and epigenomic regulators, including SIRT1, JMJD3, and DNMT3A and microRNAs, in normal conditions and how their functions are dysregulated in metabolic diseases. (illinois.edu)
Retinoic1
- PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. (thermofisher.com)
Proteins1
- Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. (thermofisher.com)
Thyroid hormone11
- Baxter JD, Webb P. (2009) Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. (guidetopharmacology.org)
- Bernal J. (2007) Thyroid hormone receptors in brain development and function. (guidetopharmacology.org)
- 2011) Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. (guidetopharmacology.org)
- 2010) Mini-review: Cell surface receptor for thyroid hormone and nongenomic regulation of ion fluxes in excitable cells. (guidetopharmacology.org)
- The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors. (guidetopharmacology.org)
- 2009) Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. (guidetopharmacology.org)
- Grover GJ, Mellström K, Malm J. (2007) Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes. (guidetopharmacology.org)
- Liu YY, Brent GA. (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. (guidetopharmacology.org)
- Thyroid hormone receptor beta (THR-β) , also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2). (immune-system-research.com)
- In addition, THR-β is a receptor that binds thyroid hormone. (immune-system-research.com)
- Resmetirom (MGL-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC 50 value of 0.21 μM. (immune-system-research.com)
Retinoid X Recepto2
- 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. (thermofisher.com)
- Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. (bvsalud.org)
Hormone receptor family2
- The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
- Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). (thermofisher.com)
Orphan receptor1
- The TR4 orphan receptor is a member of the nuclear receptor superfamily that modulates gene expression via binding to the AGGTCA direct repeat hormone response element. (tmu.edu.tw)
Transcriptional1
- EMBO J, 2017), we found that the fed-state sensing nuclear receptor FXR and the fasting transcriptional activator CREB coordinately regulates the hepatic autophagy gene network and that CREB and FXR oppositely regulate autophagic degradation of lipid (lipophagy). (illinois.edu)
NR4A22
- Data expand the understanding of the mechanism by which the NR4A2 nuclear receptor can facilitate DNA DSB repair. (cusabio.com)
- Degeneration of dopaminergic neurons in Parkinson's disease (PD) is associated with decreased expression of the orphan nuclear receptor Nurr1 (NR4A2), which is critical for both homeostasis and development of dopamine (DA) neurons. (houstonmethodist.org)
Antigen1
- BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
Ligand-bindin1
- GST-tagged Estrogen-related receptor beta ligand-binding domain (ESRRB-LBD) consists of a 218 a.a. (abvector.com)
Superfamily1
- The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. (wikipedia.org)
Lipid Metabolism1
- Pramfalk C, Pedrelli M, Parini P. (2011) Role of thyroid receptor β in lipid metabolism. (guidetopharmacology.org)
Bile Acid2
PPARs1
- PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. (caslab.com)
Metabolism1
- Little is known about the effects of the vitamin D receptor (VDR) on hepatic activity of human cholesterol 7α-hydroxylase (CYP7A1) and cholesterol metabolism. (nih.gov)
NR1H21
- LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). (wikipedia.org)
Coactivator1
- The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding. (bindingdb.org)
Olfactory1
- Ectopic olfactory receptors (ORs) are GPCRs expressed in extra-nasal tissues which have recently emerged as new mediators in the metabolic control of cardiac function. (bvsalud.org)
Family6
- Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. (wikipedia.org)
- Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. (wikipedia.org)
- This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. (caslab.com)
- Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. (guidetopharmacology.org)
- Rubella virus is the sole member of the Rubivirus genus (Togaviridae family) and is a single-stranded RNA virus. (medscape.com)
- 200 other members unpublished data on experimental TPMV infection in small in this virus family, most of which have arthropod vectors, laboratory animals. (cdc.gov)
Liver5
- Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. (wikipedia.org)
- Liver X receptor beta has been shown to interact with NCOA6 and Retinoid X receptor alpha. (wikipedia.org)
- FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)
- A liver X receptor that is expressed primarily by cells in the liver and other metabolically-active tissues. (bvsalud.org)
- A liver X receptor that is ubiquitously expressed. (bvsalud.org)
Homeostasis1
- Tienen una función importante en la regulación de la homeostasis del colesterol, el METABOLISMO ENERGÉTICO, la INFLAMACIÓN y la respuesta inmunitaria. (bvsalud.org)
Selective1
- ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
Interactions1
- Nicotine, as the primary psychoactive component of tobacco smoke, produces diverse neurophysiological, motivational, and behavioural effects through interactions with nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). (hindawi.com)
Genes1
- The most direct way to link divergent natural selection to reproductive isolation is via 'magic traits', i.e., traits under selection that also contribute to non-random mating or genes under selection that pleiotropically affect non-random mating [ 2 , 3 ]. (biomedcentral.com)
Binds1
- Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. (affbiotech.com)
Circadian clock2
- Previous studies have shown that NLRP3 transcription is regulated indirectly by REV-ERB α (a nuclear receptor of the circadian clock) in macrophages [1][2]. (smb.org)
- A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. (wakehealth.edu)
Estrogen2
- In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)
- Estrogen-related receptor beta (ESRRB, ERRβ, ERR2) is also known as nuclear receptor subfamily 3, group B, member 2 (NR3B2). (abvector.com)
Gene3
- Ecological speciation is the process by which barriers to gene flow evolve between populations as a result of ecological based divergent selection between environments [ 1 , 2 ]. (biomedcentral.com)
- The glucocorticoid receptor (GR) is essential for the correct functioning of the HPA axis, thus alterations in the expression of the GR through altered methylation of the GR gene ( NR3C1 ) (and more specifically exon 1F) might contribute to the development of NSSI in individuals with a history of ACEs, as has been reported for different other mental disorders. (karger.com)
- Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity. (cdc.gov)
Ligands1
- Also, SHP has been designated an orphan nuclear receptor, but whether its activity can be modulated by ligands has been a long-standing question. (illinois.edu)
Polyclonal Antibody1
- The following product was used in this experiment: PPAR gamma-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA1-824, RRID AB_2166200. (thermofisher.com)
Transcription factor2
- JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. (genereg.net)
- Nuclear receptor subfamily 2 group F member 2 (NR2F2 or COUP-TF2) encodes a transcription factor which is expressed at high levels during mammalian development. (childrensmercy.org)
Human6
- Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
- PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma 2 from human and mouse tissues. (thermofisher.com)
- PA1-824 immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2. (thermofisher.com)
- This strategy led to the identification of >160 ORs expressed in the human heart, including 38 receptors differentially regulated with heart failure. (bvsalud.org)
- Our results suggest that connective tissue growth factor- and nuclear receptor-related 1-positive cells are two distinct cell populations of the human subplate. (ox.ac.uk)
- Here we demonstrate that the human subplate also expresses α2zinc-binding globulin and Alpha-2-Heremans-Schmid glycoprotein/human fetuin. (ox.ac.uk)
Promoter2
- In addition, chromatin immunoprecipitation analysis of livers from mice showed that injection of 1,25(OH)2D3 increased recruitment of Vdr and rodent retinoid X receptor to the Shp promoter. (nih.gov)
- Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses. (cancerindex.org)
Regulates1
- Nuclear receptor subfamily 1 group D member 1 regulates circadian activity of NLRP3 inflammasome to reduce the severity of fulminant hepatitis in mice. (smb.org)
Gamma1
- PA1-824 inhibits PPAR gamma 2 DNA binding. (thermofisher.com)
Metabolic1
- Our group has shown that SIRT1 is a critical determinant of acetylation levels of FXR and SREBP-1c and modulate their activity in regulation of metabolic pathways. (illinois.edu)