• The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. (wikipedia.org)
  • The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. (wikipedia.org)
  • The encoded protein acts as a nuclear transcription factor. (nih.gov)
  • Mutations in the activation function-2 of LXR, an important protein-protein interaction site in all nuclear receptors, was found to result in exclusion of LXRβ from the nucleolus. (spandidos-publications.com)
  • Also, gene expression signatures of phenoxbenzamine were consistent with several agents in each case that were known to suppress tumor proliferation, notably, protein kinase C inhibitors, Heat Shock Protein inhibitors, epidermal growth factor receptor inhibitors, and glycogen synthase kinase inhibitors. (fortuneonline.org)
  • The VDR gene provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond to vitamin D. This vitamin can be acquired from foods in the diet or made in the body with help from sunlight exposure. (medlineplus.gov)
  • This interaction allows VDR to partner with another protein called retinoid X receptor (RXR). (medlineplus.gov)
  • Estradiol also acts as a potent agonist of G Protein-coupled Estrogen Receptor (GPER), which has recently been recognized as a major mediator of estradiol's rapid cellular effects 9 . (drugbank.com)
  • Loss of LXR-beta function is associated with an increase in the expression of UNCOUPLING PROTEIN 1 as well as OBESITY. (bvsalud.org)
  • We developed the HTP SurFlexDock, a web server that improves SBVS campaigns by the use of ensemble docking pipeline in order to simulate the protein receptor flexibility. (ab3c.org.br)
  • HN - 2022 BX - Adolescent Motherhood BX - Teen Mothers BX - Teenage Mothers FX - Pregnancy in Adolescence MH - ADP-Ribosylation Factor 6 UI - D000089982 MN - D8.811.277.40.330.300.400.100.50 MN - D12.776.157.325.515.100.550 MN - D12.776.476.338.400.100.50 MS - A member of GTP-binding protein of the large ras superfamily involved in regulation of membrane trafficking by modulating ENDOCYTOSIS and ACTIN CYTOSKELETON remodeling. (nih.gov)
  • The catenin beta 1 gene (CTNNB1) encodes the β-catenin protein, and mutations in CTNNB1 occur widely in HB. (biomedcentral.com)
  • A-kinase interacting protein 1 [Source:H. (gsea-msigdb.org)
  • adaptor related protein complex 1 subuni. (gsea-msigdb.org)
  • BAI1 associated protein 3 [Source:HGNC S. (gsea-msigdb.org)
  • GATA binding protein 1 [Source:HGNC Symb. (gsea-msigdb.org)
  • The protein encoded by this gene is a receptor for glucocorticoids and can act as both a transcription factor and a regulator of other transcription factors. (affbiotech.com)
  • The encoded protein can bind DNA as a homodimer or as a heterodimer with another protein such as the retinoid X receptor. (affbiotech.com)
  • This study aimed to assess the possible association between rs41423247 (Bcl-I) polymorphism in the gene for the human glucocorticoid receptor (GR) called Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) with obesity in Egyptian children with and without Down syndrome. (nih.gov)
  • Synthetic peptide corresponding to Human Glucocorticoid Receptor beta aa 728-742. (abcam.co.jp)
  • Detects a band of approximately 90 kDa (predicted molecular weight: 83 kDa).Can be blocked with Human Glucocorticoid Receptor beta peptide (ab39765) . (abcam.co.jp)
  • Among many RXR-associated nuclear receptors, activation of peroxisome proliferator-activated receptor δ (PPARδ) and nuclear hormone receptor 77 (Nur77) suppressed cytokine production by BMDMs. (nih.gov)
  • Among the genes that were regulated differentially by VPA depending on genotype was peroxisome proliferator-activated receptor delta ( Ppard ), whose expression was upregulated in response to VPA treatment in WT, but not in Wfs1 KO mice. (hindawi.com)
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. (thermofisher.com)
  • LXR/RXR heterodimer is bound to LXREs in the promoters of target genes and in complex with co-repressors such as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor co-repressor (N-COR). (spandidos-publications.com)
  • The research in this project is focusing on the study of the retinoic acid-related orphan receptors RORα and RORγ, the latter of which was discovered by our laboratory. (nih.gov)
  • His research has been focusing on the study of the mechanisms of action and the physiological functions of members of the GLI-similar (GLIS) transcription factor and retinoic acid-related orphan receptor (ROR) subfamilies, and their roles in disease, including metabolic syndrome, diabetes, cystic kidney and inflammatory diseases, and cancer. (nih.gov)
  • NR4A1 binding also promotes acetylation of histone 3 at lysine 27 (H3K27ac), leading to activation of tolerance-related genes. (wikipedia.org)
  • Results We found that a shared network of genes/proteins is overrepresented by immune response-related pathways, post-translational modifications of nuclear receptors, and platelet-related processes, including activation and platelet signalling. (medscape.com)
  • Ligand binding triggers a conformational change that promotes interaction with coactivator proteins and facilitates the activation of specific target genes ( 1 , 2 ). (spandidos-publications.com)
  • Simple SPARQL queries could easily identify hub genes, i.e., those gene whose gene products participate in many pathways (query 1) or interact with many other gene products (query 2). (nih.gov)
  • The identification of the genes expressed in the brain (query 3) turned out to be more difficult, due to the lack of a common identification scheme for proteins. (nih.gov)
  • In Experiment 2 the aim is to evaluate the effect of estradiol (E2) during proestrous in the modulation of the expression of the same genes listed in Experiment 1 and at the occurrence of anticipated luteolysis. (fapesp.br)
  • PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. (thermofisher.com)
  • This integrative network includes receptors and transcription factors, biotransformation enzymes, transporters, antioxidants, and metal- and heat-responsive genes, and is collectively known as the chemical defensome . (springer.com)
  • Teleost fish is the largest group of vertebrate species and can provide valuable insights into the evolution and functional diversity of defensome genes. (springer.com)
  • The intrinsic defense against toxic chemicals largely depends on a set of genes and proteins collectively known as the chemical defensome 1 . (springer.com)
  • Furthermore, genes near the chromosome-12q13 breakpoint exhibited increased expression of GG-62 including ERBB3, NR4A1 (nuclear receptor subfamily 4, group A, member 1), cyclin-dependent kinase 2 (CDK2), and alpha 5 integrin (ITGA5). (elsevierpure.com)
  • Nuclear receptor 4A1 and the rest of the NR4A family are structurally similar to other nuclear receptor superfamily members, but contain an extra intron. (wikipedia.org)
  • From NCBI Gene: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. (nih.gov)
  • Mangelsdorf, DJ Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. (bindingdb.org)
  • HN - 2022 BX - COVID-19 Vaccine Johnson & Johnson MH - Adjuvants, Vaccine UI - D000089582 MN - D26.650.64.500 MN - D27.505.696.477.67.500 MN - D27.720.744.64.500 MS - Substances consist of different components, e.g. aluminum salts, EMULSIONS such as MF59 and AS03, Toll-like receptor (TLR) agonist or combinations of IMMUNOPOTENTIATORS (QS-21 and MPL in AS01), that helps increase the magnitude of an ADAPTIVE IMMUNE RESPONSE to a VACCINE. (nih.gov)
  • Cholesterol 7α-hydroxylase (CYP7A1) is a member of the cytochrome P450 family of enzymes and the rate-limiting enzyme in the classical pathway of bile acid synthesis, and is the first direct target of LXRs. (spandidos-publications.com)
  • cytochrome P450 family 3 subfamily A mem. (gsea-msigdb.org)
  • Similar to other members of the nuclear receptor family, these proteins contain a zinc finger DNA-binding domain that accommodates specific small lipophilic molecules. (spandidos-publications.com)
  • The function of nuclear proteins can be affected by their sequestration in the nucleoli. (spandidos-publications.com)
  • The GLI-Similar 1-3 (GLIS1-3) proteins form a subfamily of Krüppel-like zinc finger transcription factors discovered by our laboratory. (nih.gov)
  • To obtain further insights into their regulation of gene transcription and biological functions of GLIS proteins, our current research is focusing on identifying the role of GLIS1-3 in the regulation of cell-type specific functions and chromatin structure using single cell sequencing and ATAC-Seq, and cell type-specific knockout and overexpression of GLIS1-3 in mice. (nih.gov)
  • Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses effector gene expression by inhibiting AP-1 function. (wikipedia.org)
  • Nuclear receptor 4A1 has the systematic HUGO gene symbol NR4A1. (wikipedia.org)
  • The DNA-binding domain at exons 3 and 4 of the NR4A1 gene is conserved among all members of the nuclear receptor. (wikipedia.org)
  • The frequency of heterozygous carriers of mutations in the WFS1 gene is remarkably high-1% of the general population [ 20 ] and heterozygosity for the WFS1 mutations has been reported to be a significant risk factor for psychiatric illnesses [ 20 , 21 ]. (hindawi.com)
  • An extensive comparison of PBZ with suberanilohydroxamic acid (SAHA) and trichostatin A (TSA) demonstrated gene expression enrichment scores (connectivity) for PBZ that compared equal to or greater than those for SAHA and TSA for several gene expression signatures in MSigDB that are associated with histone modifications [1]. (fortuneonline.org)
  • When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. (drugbank.com)
  • Reverse-transcriptase polymerase chain reaction revealed an in-frame fusion between the Ewing sarcoma gene (EWS) codon 325 and the activating transcription factor 1 gene (ATF1) codon 65 which permits the production of chimeric EWS-ATF1 oncoproteins. (elsevierpure.com)
  • It belongs to a group of three closely related orphan receptors, the NR4A family (NR4A). (wikipedia.org)
  • NR4A1 may play a role in Drug-induced gingival overgrowth associated with exposure to phenytoin, nifedipine, and cyclosporine A. Nuclear receptor 4A1 binds as a monomer or homodimer to response element NBRE and as a homodimer to NurRE. (wikipedia.org)
  • Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. (cusabio.com)
  • Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3, 4)P2 and PI(3, 4, 5)P3. (neobiotechnologies.com)
  • Estradiol binds to both subtypes of the Estrogen Receptor: Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). (drugbank.com)
  • Thymus-specific isoform of retinoid-related orphan receptor gamma. (nih.gov)
  • ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. (thermofisher.com)
  • Fc gamma receptor Ib, pseudogene [Source. (gsea-msigdb.org)
  • Fc gamma receptor IIIb [Source:HGNC Symb. (gsea-msigdb.org)
  • As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in various tissues and organs such as the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain. (drugbank.com)
  • Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor level. (drugbank.com)
  • Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. (drugbank.com)
  • Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. (wikipedia.org)
  • Whereas most nuclear receptors have a hydrophobic surface that results in a cleft, NR4A1 has a hydrophilic surface. (wikipedia.org)
  • Along with the two other NR4A family members, NR4A1 is expressed in macrophages following inflammatory stimuli. (wikipedia.org)
  • Overexpression of Nuclear receptor 4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against tumor and chronic virus. (wikipedia.org)
  • The binding sites on the response elements for NR4A1, which are common to the two other members of the NR4A family, are: NBRE - 5'-A/TAAAGGTCA, NurRE - a AAAT(G/A)(C/T)CA repeat, RXR - DX, a motif. (wikipedia.org)
  • Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. (nih.gov)
  • LXRs have two subtypes: LXRα (nuclear receptor subfamily 1, group H, member 3, NR1H3) and LXRβ (nuclear receptor subfamily 1, group H, member 2, NR1H2). (spandidos-publications.com)
  • Nuclear receptor 4A1 can be induced by many physiological and physical stimuli. (wikipedia.org)
  • however, these receptors were 'adopted' following the discovery that metabolites of cholestorol oxysterols bind to and activate these receptors at physiological concentrations. (spandidos-publications.com)
  • IL-21 and IL-23 induced the orphan nuclear receptor RORgammat, which in synergy with STAT3 promoted IL-17 expression. (nih.gov)
  • We have previously shown that the xenosensing pregnane x receptor ( pxr , nr1i2 ) is lost in many teleost species, including Atlantic cod ( Gadus morhua ) and three-spined stickleback ( Gasterosteus aculeatus ), but it is not known if compensatory mechanisms or signaling pathways have evolved in its absence. (springer.com)
  • For example, we have previously shown that several losses of the pregnane x receptor ( pxr , or nr1i2 ) have occurred independently across teleost evolution 9 . (springer.com)
  • Wfs1 KO mice exhibit impaired glucose tolerance and they are significantly smaller than their wild type littermates despite elevated growth hormone (GH) and insulin-like growth factor (IGF-1) levels [ 35 ]. (hindawi.com)
  • Chow-fed apoE-deficient mice were exposed to 1) chronic intranasal infection with C. pneumoniae (Cpn group), 2) recurrent intravenous infection with A. actinomycetemcomitans (Aa group), 3) a combination of both types of infection (Cpn + Aa group), or 4) infection with the vehicle (control group). (biomedcentral.com)
  • The transcriptomics data revealed significant enrichment in inflammation-associated biological pathways in both AT depots derived from the Aa and Cpn + Aa treated mice compared with the control group. (biomedcentral.com)
  • These mice were subjected to a chronic stimulation of MC receptors (MCRs) with MC analogue Nle4-D-Phe7-alpha-melanocyte stimulating hormone (NDP-alpha-MSH, 340 mu g/kg, i.p. (unimore.it)
  • Objectives: This study focuses on the possible neuroprotection of a chronic treatment with an H2S donor and sulfurous water (rich of H2S) in a severe transgenic 3×Tg-AD mice model. (unimore.it)
  • Method: 3×Tg-AD mice at 2 different ages (6 and 12 months) were daily treated intraperitoneally with an H2S donor and sulfurous water (rich of H2S) for 3 months consecutively. (unimore.it)
  • Results: Three months of treatments with H2S significantly protected against impairment in learning and memory in a severe 3×Tg-AD mice model, at both ages studied, and reduced the size of Amyloid β plaques with preservation of the morphological picture. (unimore.it)
  • some examples are avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), neuregulin 1 (NRG1), fibroblast growth factor 9 (FGF9), and fibroblast growth factor receptor-1 (FGFR1). (elsevierpure.com)
  • Feldman D, J Malloy P. Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets. (medlineplus.gov)
  • Malloy PJ, Feldman D. The role of vitamin D receptor mutations in the development of alopecia. (medlineplus.gov)
  • j - k ) Apoptosis of CNE-1 and 5-8F cells under MSC-AS1 silence was detected by caspase-3 activity and TUNEL staining (scale bar = 200 μm). (biomedcentral.com)
  • Immunotherapy with indoleamine 2,3-dioxygenase inhibitors after chemotherapy could promote immunological responses and reduce regulatory T lymphocyte infiltration, which could improve the survival rate. (bvsalud.org)
  • Structure-Based Virtual Screening (SVBS) is an essential tool that may be used to delimit a sub-set of the more specific inhibitors for a receptor of interest during the early stages of drug discovery studies. (ab3c.org.br)
  • Our studies suggest that GLIS1-3 pathways might provide novel therapeutic targets in the management of multiple diseases. (nih.gov)
  • This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000. (thermofisher.com)
  • Ischemic stroke (IS), which constitutes more than 80% of strokes, generally results from reduced blood supply to cerebral tissue resulting in a number of pathological reactions such as oxidative stress, inflammation, and neuronal cell death [ 1 ]. (springer.com)
  • Anton M. Jetten, Ph.D., is Head of the Cell Biology Group in the Immunity, Inflammation, and Disease Laboratory, and holds a secondary appointment in the NIEHS Epigenetics and Stem Cell Biology Laboratory . (nih.gov)
  • He is Deputy Chief of the Immunity, Inflammation, and Disease Laboratory and Head of the Cell Biology Group. (nih.gov)
  • In normal hepatocytes, the β-catenin N-terminal serine and threonine residues encoded by CTNNB1 exon 3 are phosphorylated by the APC regulator of WNT signaling pathway/Axin/ glycogen synthase kinase 3 beta (APC/Axin/GSK3β) complex and then recognized by the ubiquitin-conjugating complex and ubiquitinated. (biomedcentral.com)
  • We demonstrate here that IL-6 induced expression of IL-21 that amplified an autocrine loop to induce more IL-21 and IL-23 receptor in naive CD4(+) T cells. (nih.gov)
  • VPA has also been shown to regulate the expression of other members of the ER stress pathway in vitro [ 12 , 13 ] and in vivo [ 14 ]. (hindawi.com)
  • 3. Low expression of lncRNA MEG3 promotes the progression of oral squamous cell carcinoma by targeting miR-21. (nih.gov)
  • The AT dysfunction, followed by the spill-over of free fatty acids (FFAs) into the circulation via enhanced lipolysis and dysregulated expression of adipokines, modifies immune responses and contributes to metabolic disorders such as metabolic syndrome and type 2 diabetes [ 1 , 2 ]. (biomedcentral.com)
  • Jindarojanakul P, Kobayashi Y, Kamimoto H, Niki Y, Chan Myo A, Satrawaha S, Moriyama K. Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells. (tmdu-mort.com)
  • Given that DHA exhibits agonistic activity on retinoid X receptor (RXR), activation of RXR could be a therapeutic strategy for IBD. (nih.gov)
  • Pediatric research 2021 8 92 (1): 216-224. (cdc.gov)
  • Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 2021 7 37 (3): 507-508. (cdc.gov)
  • Cureus 2021 2 13 (1): e12426. (cdc.gov)
  • Nuclear receptor 4A1 has a high degree of structural similarity with other family members at the DNA-binding domain with 91-95% sequence conservation. (wikipedia.org)
  • GLIS2/3 transcriptional activity appears to be controlled by primary cilium-associated signaling pathways. (nih.gov)
  • HB may originate from primary hepatoblasts or from less differentiated liver stem cells or human fetal liver multipotent progenitor cells (hFLMPCs) [ 3 ]. (biomedcentral.com)
  • A liver X receptor that is expressed primarily by cells in the liver and other metabolically-active tissues. (bvsalud.org)
  • A liver X receptor that is ubiquitously expressed. (bvsalud.org)
  • The role of the methylation-regulating enzymes DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) family members enzymes in the methylation changes of HB was analyzed, and it was speculated that the occurrence of HB is partly due to the obstruction of liver differentiation in the early stage of differentiation. (biomedcentral.com)
  • Hepatoblastoma (HB) is the most common malignant liver tumor in children, accounting for more than 80% of all pediatric malignant liver tumors and 1% of all pediatric tumors. (biomedcentral.com)
  • Steroidogenic Factor 1 (SF-1) is considered an orphan nuclear receptor that belongs to subfamily 5. (neobiotechnologies.com)