GenesRetinoicSuperfamilyRetinoid X receptoLigandRegulates expressionGeneAntibodyOrphan receptorsRegulators of macrophageGlucocorticoid receptorLigandsMetabolismAgonistsKinaseNR4A2MelanocortinHormoneMonomerTranscription FactorsPrimary AntibodiesMeSHPathwayInflammatoryTumorSelectiveFamilyLiverInsulinObesityHumanAssays
Genes1
- It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. (utsouthwestern.edu)
Retinoic3
- Retinoids regulate gene expression through binding to the nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). (nih.gov)
- In contrast, no ligands for the retinoic acid receptor-related orphan receptors beta and gamma (ROR beta and gamma) have been identified, yet structural data and structure-function analyses indicate that ROR beta is a ligand-regulated nuclear receptor. (nih.gov)
- Receptor for retinoic acid. (abcam.com)
Superfamily3
- Nuclear receptor 4A1 and the rest of the NR4A family are structurally similar to other nuclear receptor superfamily members, but contain an extra intron. (wikipedia.org)
- The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors. (guidetopharmacology.org)
- The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. (utsouthwestern.edu)
Retinoid X recepto1
- Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. (bvsalud.org)
Ligand4
- The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. (wikipedia.org)
- The C-terminal ligand-binding domain is conserved to a lesser extent at 60% and the N-terminal AB region is not conserved, differing in each member. (wikipedia.org)
- The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding. (bindingdb.org)
- Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. (guidetopharmacology.org)
Regulates expression1
- A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. (wakehealth.edu)
Gene7
- The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. (wikipedia.org)
- Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses effector gene expression by inhibiting AP-1 function. (wikipedia.org)
- Nuclear receptor 4A1 has the systematic HUGO gene symbol NR4A1. (wikipedia.org)
- The DNA-binding domain at exons 3 and 4 of the NR4A1 gene is conserved among all members of the nuclear receptor. (wikipedia.org)
- The glucocorticoid receptor (GR) is essential for the correct functioning of the HPA axis, thus alterations in the expression of the GR through altered methylation of the GR gene ( NR3C1 ) (and more specifically exon 1F) might contribute to the development of NSSI in individuals with a history of ACEs, as has been reported for different other mental disorders. (karger.com)
- Voyager Therapeutics Inc. has selected a lead development candidate for its superoxide dismutase 1 (SOD1)-mutated amyotrophic lateral sclerosis (ALS) gene therapy program. (bioworld.com)
- Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity. (cdc.gov)
Antibody1
- The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
Orphan receptors1
- It belongs to a group of three closely related orphan receptors, the NR4A family (NR4A). (wikipedia.org)
Regulators of macrophage2
- A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. (guidetomalariapharmacology.org)
- The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. (utsouthwestern.edu)
Glucocorticoid receptor1
- Zhi, L 5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators. (bindingdb.org)
Ligands1
- Radionetics Oncology Inc. has patented new melanocortin MC2 receptor ligands reported to be useful for the diagnosis and treatment of cancer. (bioworld.com)
Metabolism1
- Pramfalk C, Pedrelli M, Parini P. (2011) Role of thyroid receptor β in lipid metabolism. (guidetopharmacology.org)
Agonists2
- Serotonin 5-HT2 receptor agonists have shown efficacy in treating seizure disorders, such as epilepsy. (bioworld.com)
- Grover GJ, Mellström K, Malm J. (2007) Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes. (guidetopharmacology.org)
Kinase1
- 2009) Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. (guidetopharmacology.org)
NR4A22
- The other two members are Nuclear receptor 4A2 (NR4A2) and Nuclear receptor 4A3 (NR4A3). (wikipedia.org)
- Data expand the understanding of the mechanism by which the NR4A2 nuclear receptor can facilitate DNA DSB repair. (cusabio.com)
Melanocortin1
- Rhythm Pharmaceuticals Inc. has presented preclinical data on its new drug candidate, RM-718, a next-generation melanocortin MC4 receptor (MC4R) agonist for weekly administration with a potential development path for hypothalamic obesity. (bioworld.com)
Hormone5
- RORa (Retinoid-related Orphan Receptor alpha ) is a member of the NR1 nuclear hormone receptor family. (novusbio.com)
- Bernal J. (2007) Thyroid hormone receptors in brain development and function. (guidetopharmacology.org)
- 2011) Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. (guidetopharmacology.org)
- 2010) Mini-review: Cell surface receptor for thyroid hormone and nongenomic regulation of ion fluxes in excitable cells. (guidetopharmacology.org)
- Liu YY, Brent GA. (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. (guidetopharmacology.org)
Monomer2
- NR4A1 may play a role in Drug-induced gingival overgrowth associated with exposure to phenytoin, nifedipine, and cyclosporine A. Nuclear receptor 4A1 binds as a monomer or homodimer to response element NBRE and as a homodimer to NurRE. (wikipedia.org)
- Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. (affbiotech.com)
Transcription Factors1
- Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. (wikipedia.org)
Primary Antibodies1
- Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)
MeSH1
- Nuclear Receptor Subfamily 1, Group D, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Pathway1
- Our results identify ROR beta as a retinoid-regulated nuclear receptor, providing a novel pathway for retinoid action. (nih.gov)
Inflammatory3
- Nuclear receptor 4A1 plays a key role in mediating inflammatory responses in macrophages. (wikipedia.org)
- Along with the two other NR4A family members, NR4A1 is expressed in macrophages following inflammatory stimuli. (wikipedia.org)
- genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
Tumor1
- Overexpression of Nuclear receptor 4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against tumor and chronic virus. (wikipedia.org)
Selective1
- At the recent American College of Neuropsychopharmacology meeting, Trevena Inc. presented preclinical data for the novel selective sphingosine 1-phosphate S1P1 receptor modulator TRV-045, being developed for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). (bioworld.com)
Family3
- The binding sites on the response elements for NR4A1, which are common to the two other members of the NR4A family, are: NBRE - 5'-A/TAAAGGTCA, NurRE - a AAAT(G/A)(C/T)CA repeat, RXR - DX, a motif. (wikipedia.org)
- Nuclear receptor 4A1 has a high degree of structural similarity with other family members at the DNA-binding domain with 91-95% sequence conservation. (wikipedia.org)
- 200 other members unpublished data on experimental TPMV infection in small in this virus family, most of which have arthropod vectors, laboratory animals. (cdc.gov)
Liver5
- Bełtowski J, Semczuk A. (2010) Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. (guidetomalariapharmacology.org)
- Calkin AC, Tontonoz P. (2010) Liver x receptor signaling pathways and atherosclerosis. (guidetomalariapharmacology.org)
- Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. (affbiotech.com)
- A liver X receptor that is expressed primarily by cells in the liver and other metabolically-active tissues. (bvsalud.org)
- A liver X receptor that is ubiquitously expressed. (bvsalud.org)
Insulin1
- In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
Obesity1
- Loss of LXR-beta function is associated with an increase in the expression of UNCOUPLING PROTEIN 1 as well as OBESITY. (bvsalud.org)
Human5
- Recombinant full length protein corresponding to Human Retinoid X Receptor beta/RXRB. (abcam.com)
- Ageing is accompanied by a progressive decline in immune function that may significantly impact overall human health, increasing the risk of autoimmune disorders, infection, and mortality [ 1 ]. (biomedcentral.com)
- Human cytomegalovirus (CMV) is 1 of 8 human herpesviruses. (medscape.com)
- It is a member of the beta-herpesvirus subfamily, which also includes the roseolaviruses, human herpesvirus type 6, and human herpesvirus type 7. (medscape.com)
- However, several high-risk groups, including immunocompromised organ transplant recipients and individuals infected with human immunodeficiency virus (HIV), are at risk of developing life-threatening and sight-threatening CMV disease. (medscape.com)
Assays1
- Although radioligand binding assays have been described for these receptors, the radioligands are not commercially available. (guidetopharmacology.org)