AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Receptors, Cytoplasmic and NuclearRepressor ProteinsNuclear Receptor Subfamily 4, Group A, Member 1Nuclear Receptor Co-Repressor 1Transcription FactorsNuclear Receptor Subfamily 4, Group A, Member 2Receptors, SteroidOrphan Nuclear ReceptorsNuclear Receptor Subfamily 1, Group D, Member 1Nuclear Receptor Subfamily 1, Group F, Member 1Nuclear Receptor Coactivator 2Nuclear Receptor CoactivatorsNuclear Receptor Co-Repressor 2Nuclear Receptor Coactivator 1Nuclear Receptor Subfamily 2, Group C, Member 2DNA-Binding ProteinsReceptors, Thyroid HormoneReceptors, Retinoic AcidNuclear Receptor Subfamily 2, Group C, Member 1DAX-1 Orphan Nuclear ReceptorNuclear Receptor Subfamily 1, Group F, Member 2Transcription, GeneticMolecular Sequence DataPromoter Regions, GeneticLac RepressorsOperator Regions, GeneticBase SequenceRetinoid X ReceptorsProtein BindingGene Expression RegulationTranscriptional ActivationNuclear Receptor Coactivator 3Steroidogenic Factor 1Binding SitesLigandsAmino Acid SequenceNuclear ProteinsNuclear Receptor Subfamily 6, Group A, Member 1Fushi Tarazu Transcription FactorsResponse ElementsCell NucleusTrans-ActivatorsCell LineHepatocyte Nuclear Factor 4Histone AcetyltransferasesRetinoid X Receptor alphaRNA, MessengerNuclear Receptor Subfamily 1, Group F, Member 3Protein Structure, TertiaryMutationCo-Repressor ProteinsSignal TransductionCOUP Transcription Factor IIPPAR gammaGenes, ReporterTransfectionCOUP Transcription Factor IHistone DeacetylasesTwo-Hybrid System TechniquesRecombinant Fusion ProteinsReceptors, EstrogenDimerizationTretinoinGene Expression Regulation, DevelopmentalBacterial ProteinsPeroxisome Proliferator-Activated ReceptorsDNAPPAR alphaReceptors, CalcitriolHomeodomain ProteinsCarbon DioxidePlasmidsEscherichia coliMediator Complex Subunit 1COS CellsOperonEcdysoneXenobioticsTriiodothyronineChromatin ImmunoprecipitationNuclear Receptor Subfamily 4, Group A, Member 3COUP Transcription FactorsDrosophila ProteinsSequence Homology, Amino AcidLiverGene Expression Regulation, BacterialCloning, MolecularViral Regulatory and Accessory ProteinsEstrogen Receptor alphaAmino Acid MotifsReverse Transcriptase Polymerase Chain ReactionZinc FingersMice, KnockoutElectrophoretic Mobility Shift AssayReceptors, GlucocorticoidCell Line, TumorHeLa CellsDNA PrimersCells, CulturedGenes, Regulator
ProteinsProteinCorepressorHormone receptorGenesPeroxisome proliRepressionNCOR1RetinoicLigand-activated transcription factorTranscription factorsPPARCoactivatorSignal transductionLigandsMediatesOrphan nuclear receptorRegulatesCoregulatorySuppressionMiceMutationsUnderlie2023ArylActivatorInducesMetabolismConstitutiveImmunityDifferentiationVitaminPathwayUnclearComplexActivatesGene expressionInterplayActivateRegulating factorSignalingCyclinRegulationIdentification
Proteins7
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Mechanistically, nuclear receptor co-repressor 1 (NCoR1), which interacts with PPARα to suppress its transactivation, binds to the autophagosomal GABARAP family proteins and is degraded by autophagy. (elsevierpure.com)
  • In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)
  • Heme associates with the ligand-binding domains of the REV-ERB receptors with a 1:1 stoichiometry and enhances the thermal stability of the proteins. (omicsdi.org)
  • Insights from a diverse group of Ah receptor interacting proteins. (xenbase.org)
  • The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription. (liquorrs.com)
  • Liver-enriched nuclear receptor (NR) proteins regulate the expression and activity of several pivotal hepatic biochemical pathways including the uptake, metabolism and excretion of cholesterol, bile acids, glucose, and xenobiotic compounds from the body. (ku.edu)
Protein19
  • The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene. (wikipedia.org)
  • NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. (wikipedia.org)
  • the other human protein that is a member of that family is Nuclear receptor co-repressor 2. (wikipedia.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • Jun dimerization protein-2 (JDP-2) is a progesterone receptor (PR) coregulatory protein that acts by inducing structure and transcriptional activity in the disordered amino-terminal domain (NTD) of PR. (nih.gov)
  • To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
  • We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
  • The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
  • Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)
  • Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
  • Peroxisome proliferator-activated receptor-binding protein (PBP), also known as thyroid hormone receptor-associated protein 220/vitamin D receptor-interacting protein 205/mediator 1, an anchor for multisubunit mediator transcription complex, functions as a transcription coactivator for nuclear receptors. (wustl.edu)
  • The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
  • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
  • More modestly induced target genes, encoding aryl hydrocarbon receptor repressor ( AHRR ), spectrin repeat-containing nuclear envelope protein 1 (SYNE-1), and gap junction protein gamma 1 ( GJC1 ), were regulated solely by AHR1α. (xenbase.org)
  • Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
  • VDR is a gene which codes for a vitamin D receptor protein. (liquorrs.com)
  • Itis the human homolog of the Xenopus Staf protein (selenocysteine tRNA genetranscription-activating factor) known to regulate the genes encoding small nuclear RNA andselenocysteine tRNA. (oscars2019info.com)
  • Studies on post-translational modification of PXR indicate how this protein is converted from a positive regulator in drug metabolism into a transcriptional repressor in inflammatory response. (ku.edu)
Corepressor2
  • Nuclear receptor corepressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT) are the best characterized transcriptional co-repressors from a molecular point of view. (escholarship.org)
  • In the absence of retinoid acid, RARA is bound by nuclear corepressor factor, and this causes transcriptional repression. (medscape.com)
Hormone receptor4
  • Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using various novel in vitro and in vivo models. (e-enm.org)
  • Two intriguing studies using novel models of thyroid hormone receptor alpha ( THRA ) mutations, which cause thyroid hormone resistance syndrome (RTH), were published in 2020. (e-enm.org)
  • 1 ] demonstrated the essential actions of thyroid hormone receptor alpha (TRα) on the normal development of the human cerebral cortex. (e-enm.org)
  • Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. (kpu.ac.jp)
Genes8
  • Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su[H]) to mediate transcription of target genes. (sdbonline.org)
  • Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
  • Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
  • Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the NCoR/HDAC3 co-repressor complex to a co-activator of AP-1 and NF-κB target genes that are required for mouse osteoclast differentiation. (bvsalud.org)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • Results from experiments of heme depletion in mammalian cells indicate that heme binding to REV-ERB causes the recruitment of the co-repressor NCoR, leading to repression of target genes including BMAL1 (official symbol ARNTL), an essential component of the circadian oscillator. (omicsdi.org)
  • Subfunctionalization of Paralogous Aryl Hydrocarbon Receptors from the Frog Xenopus Laevis: Distinct Target Genes and Differential Responses to Specific Agonists in a Single Cell Type. (xenbase.org)
  • The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. (liquorrs.com)
Peroxisome proli2
  • ZNF746) was initially identified as a novel co-substrate of parkin and PINK1 that leads to Parkinson's disease (PD) by disrupting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma (PPARγ) coactivator -1α (PGC-1α) suppression. (nature.com)
  • Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma. (mpg.de)
Repression3
  • The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. (bvsalud.org)
  • In the same paper we also demonstrated that accumulating PARIS acts on PGC-1α, the master regulator of mitochondrial biogenesis, along the NRF1/2-TFAM axis to intervene in mitochondrial biogenesis, and that the transcriptionally inactive PARIS mutant (C571A) lacks repression capacity to induce the phenotype. (nature.com)
  • Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. (xenbase.org)
NCOR12
Retinoic6
  • Receptor for retinoic acid. (abcam.com)
  • The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. (kpu.ac.jp)
  • Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes. (kpu.ac.jp)
  • [ 1 ] The discovery and elucidation of the molecular pathogenesis for APL has led to the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) therapies, which improved the prognosis of APL patients significantly. (medscape.com)
  • The retinoic acid alpha receptor gene ( RARA ) is encoded by the long arm of chromosome 17. (medscape.com)
  • The fusion gene product causes the retinoic acid receptor to bind more tightly to the nuclear co-repressor factor. (medscape.com)
Ligand-activated transcription factor1
  • We capitalize on a recent genome duplication in Xenopus laevis (African clawed frog) to interrogate possible functional differentiation between alloalleles of the aryl hydrocarbon receptor ( AHR ), a ligand-activated transcription factor that mediates toxicity of dioxin-like compounds and plays a role in the physiology and development of the cardiovascular, hepatic, and immune systems in vertebrates. (xenbase.org)
Transcription factors4
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. (biomedcentral.com)
  • NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
PPAR2
  • The results demonstrated that PPARγ functions as a master regulator of PARIS-induced molecular changes at the transcriptome level, confirming that PARIS acts primarily on PGC-1α to lead to neurodegeneration in PD. (nature.com)
  • NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. (senescence.info)
Coactivator2
  • Cyclin-dependent kinase 2 (Cdk2)/cyclin A is a novel PR coregulator that binds the NTD and acts by phosphorylating steroid receptor coactivator-1 and modulating steroid receptor coactivator-1 interaction with PR. (nih.gov)
  • Although the full-length PBP only minimally increased CAR transcriptional activity, a truncated form of PBP (amino acids 487-735) functioned as a dominant negative repressor, establishing that PBP functions as a coactivator for CAR. (wustl.edu)
Signal transduction1
Ligands4
  • The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands. (omicsdi.org)
  • Heme extends the known types of ligands used by the human nuclear receptor family beyond the endocrine hormones and dietary lipids described so far. (omicsdi.org)
  • Here, we report that targeted deletion of PBP in liver parenchymal cells (PBP Liv-/- ) results in the abrogation of hypertrophic and hyperplastic influences in liver mediated by constitutive androstane receptor (CAR) ligands phenobarbital (PB) and 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene, and of acetaminophen-induced hepatotoxicity. (wustl.edu)
  • The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. (icr.ac.uk)
Mediates2
Orphan nuclear receptor1
  • The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17 + T helper cells. (nature.com)
Regulates1
  • 1 ], using THRA mutant patient-derived induced pluripotent stem cell (iPS) models in combination with a quantitative lineage analysis, gene expression analysis, and novel assays of neuro-epithelium formation, showed that THRA regulates the balance between progenitor self-renewal and neurogenesis, thereby affecting the overall brain mass and especially the cortex. (e-enm.org)
Coregulatory1
  • It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). (icr.ac.uk)
Suppression1
  • SR1001 binds specifically to the ligand-binding domains of RORα and RORγt, inducing a conformational change within the ligand-binding domain that encompasses the repositioning of helix 12 and leads to diminished affinity for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors' transcriptional activity. (nature.com)
Mice7
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
  • However, promoter activity of Dax-1 5'-flanking sequences did not require this potential SF-1-responsive element, and Dax-1 expression was unimpaired in knockout mice lacking SF-1, establishing that SF-1 is not required for Dax-1 gene expression in these settings. (duke.edu)
  • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. (xenbase.org)
  • Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. (senescence.info)
  • Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell failure, suggesting that insulin signaling is required to maintain an adequate beta cell mass. (nih.gov)
  • We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased expression of the pancreatic transcription factor pancreas/duodenum homeobox gene-1 (Pdx1). (nih.gov)
Mutations2
  • Mutations of the orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, cause complex endocrine phenotypes that include impaired adrenal development and hypogonadotrophic hypogonadism. (duke.edu)
  • These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Underlie2
  • The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. (embl.de)
  • This review examines the evidence that alterations in transcriptional regulation of the 5-HT1A receptor could underlie its dys-regulation in mental illness. (biomedcentral.com)
20231
Aryl4
  • Two forms of aryl hydrocarbon receptor type 2 in rainbow trout (Oncorhynchus mykiss). (xenbase.org)
  • Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. (xenbase.org)
  • Amino acid sequence of the ligand-binding domain of the aryl hydrocarbon receptor 1 predicts sensitivity of wild birds to effects of dioxin-like compounds. (xenbase.org)
  • In this study, Aryl hydrocarbon receptor (AhR) expression was associated with lymph node and distant metastasis in patients with gastric cancer and was correlated with clinicolpathological pattern. (oncotarget.com)
Activator1
Induces1
  • Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. (mpg.de)
Metabolism1
  • Endocrinology and Metabolism 2021;36(1):36-40. (e-enm.org)
Constitutive1
  • Foxo1 and Pdx1 exhibit mutually exclusive patterns of nuclear localization in beta cells, and constitutive nuclear expression of a mutant Foxo1 is associated with lack of Pdx1 expression. (nih.gov)
Immunity1
  • CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
Differentiation4
  • Our data demonstrate the feasibility of targeting the orphan receptors RORα and RORγt to inhibit specifically T H 17 cell differentiation and function, and indicate that this novel class of compound has potential utility in the treatment of autoimmune diseases. (nature.com)
  • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. (nature.com)
  • Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. (nature.com)
  • In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
Vitamin1
Pathway5
  • These similar phenotypes suggest that SF-1 and DAX-1 act in the same pathway(s) of endocrine development. (duke.edu)
  • The striking colocalization of SF-1 and Dax-1 supports the model that they are intimately linked in a common pathway of endocrine development. (duke.edu)
  • Although the precise mechanisms remain to be established and may be multifactorial, our results strongly suggest that these two orphan nuclear receptors interact in a common pathway of endocrine development. (duke.edu)
  • Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. (kpu.ac.jp)
  • 9 ] who proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNFα, which is induced by IRF3 (this latter activated by the TLR4/TRIF-mediated pathway in the first response to LPS) and signals through the TNFα receptor (TNFR)/RIP1 pathway to activate NF-κB. (biomedcentral.com)
Unclear1
  • However, the mechanisms underlying these differential changes in 5-HT1A receptor expression remain unclear. (biomedcentral.com)
Complex1
  • 5FMC is a nuclear complex that can only be recruited by Chtop when the latter is arginine-methylated by Prmt1. (embl.de)
Activates1
  • Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). (icr.ac.uk)
Gene expression1
  • Throughout development, or in response to environmental stimuli, gene expression patterns are tightly regulated by the dynamic interplay between transcription activators and repressors. (escholarship.org)
Interplay2
  • Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. (embl.de)
  • Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. (embl.de)
Activate1
  • The slightly earlier onset of SF-1 expression and its ability to bind specifically to a conserved sequence in the Dax-1 5'-flanking region suggested that SF-1 may activate Dax-1 expression. (duke.edu)
Regulating factor1
  • transcriptional regulating factor 1. (nig.ac.jp)
Signaling1
  • A dynamic role for the Ah receptor in cell signaling? (xenbase.org)
Cyclin1
  • In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)
Regulation1
  • Taken together, these results highlight an integrated regulation of 5-HT1A autoreceptors that differs in several aspects from regulation of post-synaptic 5-HT1A receptors, and could be selectively targeted to enhance serotonergic neurotransmission. (biomedcentral.com)
Identification2
  • Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. (omicsdi.org)
  • Identification of pathogen-associated molecules, such as dsRNA and lipopolysaccharide (LPS), by host pattern recognition receptors (PRRs) is a critical step in innate immune response (IIR). (biomedcentral.com)