Nuclear protein kinase c beta. Medical search. Frequent questions

p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. (umbc.edu)
On the other hand, PQQ did not inhibit the signaling pathway from RANK/RANKL binding to NFATc1 activation, including NF-κB and mitogen-activated protein kinases (MAPKs). (nih.gov)

Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor. (wikipedia.org)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
Binding insulin to the insulin receptor recruits PI3K to the plasma membrane which then activates the central mediator of insulin's effects, Akt-1 also called protein kinase B. Protein kinase B inhibits apoptosis, stimulates myocyte hypertrophy/fibrosis, and nitric oxide (NO) production. (thepmc.org)
Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. (thermofisher.com)
Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
The effect of pyrroloquinoline quinine (PQQ) on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation was examined using RAW 264.7 macrophage-like cells. (nih.gov)
PQQ augmented the expression of type I interferon receptor (IFNAR) and enhanced the IFN-β-mediated janus kinase (JAK1) and signal transducer and activator of transcription (STAT1) expression. (nih.gov)
Of them, SARS-CoV-2 S protein binds to its cellular receptor, angiotensin-converting enzyme 2 (ACE2) [ 8 , 9 ], to enter the cells. (ijbs.com)
Additionally, the host serine protease TMPRSS2 is important for priming of the S protein for receptor interactions and entry [ 9 ]. (ijbs.com)
Receptor for Wnt proteins. (xenbase.org)
One of Chakravarti's major research interests is to determine the mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription. (northwestern.edu)
Nuclear receptor and epigenomic regulation of Uterine Fibroids (Mol. (northwestern.edu)
The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
Amyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor. (u-paris.fr)

NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl.de)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)

Olsson PO, Gustafsson R, In 't Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S. The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma. (lu.se)

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase. (umbc.edu)
Serine/Threonine Kinases (STKs), p38 subfamily, catalytic (c) domain. (umbc.edu)
The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
HLE-B3 cells, maintained in a continuous hypoxic environment (1% oxygen), were treated with SB216763, a specific inhibitor of glycogen synthase kinase-3β (GSK-3β) catalytic activity. (molvis.org)

Chakravarti's laboratory identifies and characterizes the role of chromatin signal transducer proteins including the recently identified INHAT proteins in gene regulation. (northwestern.edu)

The helical domain of phosphoinositide 3-kinase. (eu.org)

p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. (umbc.edu)
Mechanistically, our study suggests that Trim8 deficiency may elicit hepatic protective effects by inhibiting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38/JNK signalling pathways. (ijbs.com)
Trim8 promotes K63-linked polyubiquitination of transforming growth factor β-activated kinase 1 (TAK1), leading to the activation of TAK1 and enhanced inflammatory responses in Pseudomonas aeruginosa induced keratitis [ 9 ]. (ijbs.com)

Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. (embl.de)
GTPase activating proteins: critical regulators of intracellular signaling. (ucsf.edu)
Transforming growth factor-beta(1) regulation of surfactant protein B gene expression is mediated by protein kinase-dependent intracellular translocation of thyroid transcription factor-1 and hepatocyte nuclear factor 3. (ucsf.edu)

During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)

A hypoxia-inducible factor-1α (HIF-1α) translation inhibitor and an HIF-2α translation inhibitor were independently employed to evaluate the effect of hypoxia inducible factor inhibition on EMT marker protein and VEGF expression. (molvis.org)

Diminished phosphorylation, enhanced abundance, and nuclear localization of the transcriptional coactivator Yes-associated protein 1 (Yap1) is evident in Mst1/Mst2-deficient intestinal epithelium, as is strong activation of beta-catenin and Notch signaling. (harvard.edu)
Although biallelic deletion of Yap1 from intestinal epithelium has little effect on intestinal development, inactivation of a single Yap1 allele reduces Yap1 polypeptide abundance to nearly wild-type levels and, despite the continued Yap hypophosphorylation and preferential nuclear localization, normalizes epithelial structure. (harvard.edu)
The neurodevelopmental stages in which the cerebellar calcium-dependent protein kinase (CaMKII) is localized, the possible existence of interactions between CaMKII and other proteins localized at the same sites, and the extent to which the localization of these proteins has changed during the course of brain development, have not been studied in detail. (benningtonfol.org)

Reversible protein phosphorylation is an essential regulatory mechanism in eukaryotes. (eu.org)
Using biochemical, molecular and cellular analyses, we demonstrated that histone H3 serine 10 phosphorylation functions as a module that promotes release of key cellular proteins such as SRp20, and heterochromatin protein HP1. (northwestern.edu)
We also identified a WD repeat protein WDR5, which is a key subunit of the MLL/Set1 histone methyltransferase complex, as a transducer of histone H3 threonine 11 phosphorylation in prostate cancer cells. (northwestern.edu)
Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation. (lu.se)

Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)

p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. (umbc.edu)
After mRNA processing, most transcripts are exported to the cytoplasm for translation into protein. (berkeley.edu)
Each mRNA transcript can serve as template for repeated translation into protein by ribosomes. (berkeley.edu)
The number of protein products produced by any single mRNA can vary widely. (berkeley.edu)

STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)

Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory cells throughout the small and large intestine. (harvard.edu)

MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. (thermofisher.com)

In colon-derived cell lines where Yap is overabundant, its depletion strongly reduces beta-catenin and Notch signaling and inhibits proliferation and survival. (harvard.edu)
In innate immune system, N protein inhibits IFN-β production and RNAi pathway for virus survival. (ijbs.com)

PHOSPHTASE AND TENSIN HOMOLOGUE = PTEN is a tumor suppressor and many cancers have a loss of function or mutation of PTEN which regulates proto-oncogenic phosphatidylinositol 3- kinase (PI3K). (thepmc.org)

When phosphorylated by an active IkB kinase (IKK) complex, IkB proteins are degraded by proteasomes, resulting in the release and nuclear translocation of active NFkB. (rndsystems.com)

In humans there exist five isoforms of the B56 type regulatory subunit and they bind to their interacting proteins through a conserved LxxIxE motif. (eu.org)
Therefore, we examined the immunolocalization of CaMKII, protein kinase C (PKC) isoforms, growth-associated protein 43 (GAP43) and proliferating cell nuclear antigen (PCNA) during the embryonic and postnatal rat cerebellum. (benningtonfol.org)

NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)
Western blot analysis was employed to detect the cytoplasmic and nuclear levels of β-catenin, as well as the total lysate content of fibronectin and α-SMA. (molvis.org)

MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)
Domain commonly found in eukaryotic signalling proteins. (embl.de)

Protein dephosphorylation by the PP2A phosphatase is mainly achieved through the interaction of its regulatory subunit with the associated proteins. (eu.org)

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. (wikipedia.org)
The C2 domain is a Ca 2+ -dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. (embl.de)
SARS-CoV-2 genome consists of 14 functional open reading frames (ORFs), including two regions (ORF1a and ORF1b) for 16 non-structural proteins (Nsp1-Nsp16), nine regions for nine putative accessory proteins, and other regions for four structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins [ 5 - 7 ]. (ijbs.com)

The inhibitory IkB proteins (alpha, beta, epsilon) complex with and sequester NFkB family members in the cytoplasm, rendering these transcription factors inactive. (rndsystems.com)

PP2A-mediated protein dephosphorylation is involved in a broad range of cellular processes including cell-cycle progression, cytoskeletal dynamics, and growth factor signalling. (eu.org)
HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. (eu.org)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
PQQ inhibited the activation of nuclear factor of activated T cells (NFATc1), a key transcription factor of osteoclastogenesis, in RANKL-stimulated cells. (nih.gov)
Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. (ucsf.edu)
The purpose of this study was to identify potential therapeutic strategies to slow down or prevent the expression of early-onset epithelial to mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing the synthesis and accumulation of the prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens epithelial (HLE) cells. (molvis.org)
These mechanisms include a role for the human -1607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of beta-arrestin1/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1/2. (duke.edu)

The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. (xenbase.org)

Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Both pathways seem to involve interactions with G-proteins. (xenbase.org)

This domain occurred 379 times on human genes ( 870 proteins). (umbc.edu)
We, in a dogma changing study demonstrated that key cell cycle genes are regulated by HCFC1 cofactor recruitment not by the E2F proteins but by a THAP11-ZNF143 transcriptional complex. (northwestern.edu)

C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl.de)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
Besides the function in viral life cycle, N protein can bind GSDMD to antagonize pyroptosis but promotes cell death via the Smad3-dependent G1 cell cycle arrest mechanism. (ijbs.com)
Finally, how the proteins bind to the ECM may differ, with some being sequestered while others are left free to signal. (forex-consultant.com)

The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. (embl.de)

We present a comprehensive list of 54 C1 domains occurring singly or doubly in 34 different proteins. (embl.de)

These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. (eu.org)
Poly-L-lysine (PLL) of extracellular matrix proteins is a small natural homopolymer of the essential amino acid L-lysine that is used to coat culture substrates. (hindawi.com)

It is a progressive, irreversible, and incurable neurodegenerative disorder that disrupts the synaptic communication between millions of neurons, resulting in neuronal death and functional loss due to the abnormal accumulation of two naturally occurring proteins, amyloid β (Aβ) and tau. (frontiersin.org)

Regions with significant homology [ ( PUBMED:7559667 ) ] to the C2-domain have been found in many proteins. (embl.de)
Taxonomy and function of C1 protein kinase C homology domains. (embl.de)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)

Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)

Transcriptional regulation of surfactant proteins SP-A and SP-B by phorbol ester. (ucsf.edu)
Short interfering RNA mediated beta-arrestin1/2 knockout eliminated formation, subsequent nuclear trafficking of phosphorylated ERK1/2, and resulting MMP-1 transcriptional activation. (duke.edu)

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis. (u-paris.fr)

We have identified key nuclear receptors that influence leiomyoma. (northwestern.edu)

After being entry, the viral and host membranes can fuse together and then release the positive sense, single-stranded RNA genome of SARS-CoV-2 that directly translates into the structural and nonstructural proteins [ 9 ]. (ijbs.com)

In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. (hmdb.ca)
The F-box protein, Ufo1, recruits Ho endonuclease to the SCF(Ufo1) complex for ubiquitylation. (bvsalud.org)
The primary roles of N protein are to assemble with genomic RNA into the viral RNA-protein (vRNP) complex and to localize to the replication transcription complexes (RTCs) to enhance viral replication and transcription. (ijbs.com)

The higher degree of plasticity of the motif and the transient interaction provides a regulatory mechanism that acts to secure a proper balance between phosphatase and kinase activity in a given signaling network. (eu.org)
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. (embl.de)

The N-terminal fragment of adaptin alpha-C and beta subunits. (eu.org)

These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl.de)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)

The lab is also characterizing members of a novel THAP domain protein family regarding their roles in gene regulation, chromatin signaling, cell growth and differentiation and cancer. (northwestern.edu)

Enlarged fat cells also become resistant to insulin and the excess fat that is available is then stored in muscle, liver, and pancreatic beta cells = "lipo-toxicity" that damages beta cells, magnifying insulin deficiency. (thepmc.org)
PAK1 has also been implicated for maintenance of glucose homeostasis in pancreatic beta cells and skeletal muscle. (thehealthyplanet.com)

Increasing evidence indicates that pro-inflammatory mediators, protein degradation-associated factors, and some other circulating mediators drive this process ( 18 ). (spandidos-publications.com)

The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
Most of the B56 binding proteins contain a conserved motif LxxIxE which acts as a docking site for B56. (eu.org)
Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). (embl.de)

Anatomy5

Diseases1

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes12

Information Science3

Mitogen-Activat2

Receptor15

Domain-containi2

Structural Classifi2

TYROSINE KINASE IN1

Catalytic4

Signal transducer1

Phosphoinositide1

Tak13

Intracellular3

Hepatocyte Nuclear Factor1

Hypoxia-induci1

Localization3

Phosphorylation4

Cytokines1

MRNA4

Serine1

Mst21

Cell differentiation1

Inhibits2

Phosphatidylinositol1

Translocation1

Isoforms2

Cytoplasmic2

Found in eukaryotic2

Regulatory subunit1

Membrane3

Epsilon1

Factor7

Inhibition1

Interactions2

Genes2

Bind4

Apoptosis1

Different proteins1

Substrates2

Accumulation1

Homology3

Cytoskeletal1

Transcriptional2

Regulate1

Receptors1

Nonstructural1

Complex3

Interaction2

Subunits1

Phorbol ester1

Putative1

Gene regulation1

Pancreatic beta cells2

Mediators1

Motif3