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  • human
  • We have identified a component of the human nuclear pore complex and have shown that it is the product of a gene involved in oncogenic activation. (umassmed.edu)
  • An exact match was found with the human tpr (for translocated promoter region) gene, a gene shown previously to be involved in the oncogenic activation of several protein kinases. (umassmed.edu)
  • nucleoplasmic
  • On the nucleoplasmic face of the NPC, so-called nuclear baskets or fishtraps are seen ( 7 - 9 ) that consist of eight fibrils that extend 100 nm from a ring at the nucleoplasmic face of the NPC and are connected by a narrower ring at their termini. (pnas.org)
  • transiently
  • Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. (genecards.org)
  • Molecular
  • To unravel this striking difference, we present coarse-grained molecular dynamics simulations that reveal that FG-pores exhibit a high-density, nonuniform protein distribution, in contrast to a uniform and significantly less-dense protein distribution in the SG-mutant. (elifesciences.org)
  • interacts
  • This study shows that Nup82, a protein required for poly(A) + RNA export ( 18 , 19 ), also is located on the cytoplasmic face of the NPC and interacts physically with Nup159. (pnas.org)
  • Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (rupress.org)
  • NTF2 interacts with at least one additional cytosolic transport activity, indicating that it could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. (rupress.org)
  • motifs
  • The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. (nih.gov)
  • subcomplex
  • Moreover, depletion of Nup82 does not affect classical NLS-mediated protein import, providing evidence for a new yeast NPC subcomplex specifically involved in RNA export. (pnas.org)
  • given protein
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. (phosphosite.org)
  • fusion protein
  • pGEX-2TK (Pharmacia) and pGST-NUP82 (the coding region of NUP82 , flanked by Bam HI sites, amplified by PCR and ligated in-frame into the Bam HI site of pGEX-2TK) were used to express glutathione S -transferase (GST) and a GST-Nup82 fusion protein, respectively, in bacteria. (pnas.org)
  • large
  • This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. (nih.gov)