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  • vitro
  • We have characterized a set of related proteins from the model plant Arabidopsis that associate with MAR DNA in vitro. (openthesis.org)
  • Fackelmayer FO, Dahm K, Renz A, Ramsperger U, Richter A (1994) Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro. (springer.com)
  • Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo (1997) Scherzinger Eberhard et al. (naver.com)
  • Recently we have shown that in vitro binding of the proximal part of the human tyrosine hydroxylase gene to the nuclear matrix is correlated with its transcriptional activity. (edu.pl)
  • bind
  • Specific DNA sequences that bind to the nuclear matrix are called matrix attachment regions (MARs) and these sequences have been postulated to form the base of chromosomal loops. (nii.ac.jp)
  • Regulation of AS is dictated primarily by RNA‐binding proteins (RBPs) that can bind to specific RNA sequence elements and which can act as either activators of repressors (Coelho & Smith, 2014 ). (embopress.org)
  • genes
  • Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY, Kohwi-Shigematsu T (2000) The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. (springer.com)
  • The nuclear matrix protein EAST affects the transcription of Drosophila melanogaster genes. (deepdyve.com)
  • In the present study, we analyzed the effects of different concentrations of EAST protein on the expression of different genes of Drosophila. (deepdyve.com)
  • It was demonstrated that the effect of EAST protein on the expression of different genes was not always directly associated with the presence of MDG4 sequences. (deepdyve.com)
  • The data obtained suggested that EAST protein belonged to a new regulatory system, which was common to most of the genes, and repressed transcription of the genes located in the euchromatin regions of the chromosomes. (deepdyve.com)
  • Our rationale for choosing the NIS and TPO genes is based on the fact that intracellular iodide retention in the normal thyroid is enhanced by TPO -mediated incorporation of iodide into protein. (aacrjournals.org)
  • We conclude that even if the position of the matrix binding region is conserved among the tyrosine hydroxylase genes in mammals, its tissue specificity and/or function is not preserved or is achieved by different mechanisms. (edu.pl)
  • 1983) Actively transcribed genes are associated with the nuclear matrix. (edu.pl)
  • Cell
  • Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinson's disease, on cell motility. (biologists.org)
  • Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell carcinoma of the bladder. (semanticscholar.org)
  • Nuclear matrix proteins (NMP) are useful markers in diagnosing and monitoring the stage of malignancy of a cell, and in treating cell proliferative disorders associated with the NMP. (google.com)
  • Double immunofluorescence staining and laser‑scanning confocal microscopy demonstrated that 14‑3‑3ε was co‑localized with B‑cell lymphoma‑2 (Bcl‑2), Bcl‑2‑associated‑X protein, p53 and c‑FOS transcription factor in MG‑63 cells. (spandidos-publications.com)
  • Previous studies have revealed that certain isoforms of 14-3-3 protein family may inhibit cell apoptosis ( 16 - 20 ). (spandidos-publications.com)
  • Second, nuclear matrix proteins from various cell lines representing the four classes of human lung carcinoma were analyzed. (wayne.edu)
  • Western and immunocytochemical analyses provided evidence to suggest that this protein was common and could be found in all cell lines and tissues that were analyzed. (wayne.edu)
  • Cell identity was based on nuclear size/position relative to WGA-stained membrane ( Frentzou et al. (biologists.org)
  • Western and Northern blots reveal the presence of multiple AML-related proteins and AML-1 transcripts in several osseous cell lines. (umassmed.edu)
  • Objective To investigate arsenic trioxide (As2O3)-induced apoptosis and the effects on cell nuclear matrix related protein promyelocytic leukaemia (PML). (bjmu.edu.cn)
  • Confocal images demonstrated that the expression, of PML protein in HepG2 cell nuclei decreased after treatment with 2 mumol/L As2O3, and micropunctates characteristic of PML protein in HepG2 cell nuclei disappeared after treatment with 5 mumol/L As2O3. (bjmu.edu.cn)
  • As2O3 may degrade the PML protein in HepG2 cell nuclei. (bjmu.edu.cn)
  • Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. (abcam.com)
  • Fey EG, Penman S. (1988) Nuclear matrix proteins reflect cell type of origin in cultured human cells. (edu.pl)
  • mRNA
  • The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. (abcam.com)
  • In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1) and down-regulation of survivin at both mRNA and protein levels. (aacrjournals.org)
  • chromatin
  • Chesnokov IN, Schmid CW (1995) Specific Alu binding protein from human sperm chromatin prevents DNA methylation. (springer.com)
  • Compared to that of wild-type E2 (E2WT), the chromatin-bound pool of E2Y131A was decreased, concomitant with an increase in nuclear matrix-associated protein. (sussex.ac.uk)
  • At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. (abcam.com)
  • localisation
  • G) Nuclear localisation of ectopic CIZ1 was demonstrated by GFP fluorescence (green) in fresh sections of 3-week-old Tg hearts, confirmed by β-gal protein staining (blue). (biologists.org)
  • We have investigated the subnuclear localisation of the protein product of the c-myc oncogene. (ox.ac.uk)
  • Alteration
  • Finally, the alteration of the EAST concentrations had no substantial effect on transgene repression if they were inserted either in heterochromatin or in telomeric regions of chromosome 4, as well as on the repression induced by Polycomb group proteins. (deepdyve.com)
  • A similar alteration between the subcellular pools of the E2WT protein occurred upon ChlR1 silencing. (sussex.ac.uk)
  • ELISA
  • OBJECTIVE To report the rapid (5 min) and simple detection of a nuclear matrix protein (NMP) in the urine of patients with bladder cancer, using a newly developed office‐based dot‐enzyme‐linked immunosorbent assay (ELISA). (naver.com)
  • 1997
  • Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system (1997) Yan Q et al. (naver.com)